cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Syafira Dwi Cahyani
Contact Email
adminjifi@univpancasila.ac.id
Phone
+6287780957284
Journal Mail Official
syafira.ffup@univpancasila.ac.id
Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.
Location
Kota adm. jakarta selatan,
Dki jakarta
INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
 6   7   8   9   10 
Sensitivitas Metode Bioautografi Kontak dan Agar Overlay dalam Penentuan Senyawa Antikapang ENI KUSUMANINGTYAS; ESTIE ASTUTI; DARMONO DARMONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1614.853 KB)

Abstract

Bioautography method is a laboratory technique to detect substances inhibiting the growth of tested microorganisms. The sensitivity of contact and agar overlay bioautography Was compared to define a recommended method for detecting antifungal compound. In contact bioautography, n-hexane extract of Alpinia galanga was eluted with dichloromethane and toluene on a thin layer chromatography plate (silica gel GF254). The separated compounds were diffused from chromatogram spots to a Thrichophyton menzagrophytes inoculated Sabouraud Dextrose Agar plate. The plate was incubated at 37°C for 3 days. Inhibition zone was observed and the hRf value was defined. Agar overlay bioautography Was performed by covering chromatogram spots With a molten Sabouraud Dextrose Agar medium seeded by Trichophyton mentagrophytes. After solidification, the chromatogram plate was incubated at 37°C overnight and then was stained with Methyl Thiazole Tetrazolium. The inhibition growth bands were visualized and hRfs value were recorded. A contact bioautography produces oneband while agar overlay bioautography produces four bands. Agar overlay bioautography was therefore more sensitive than contact bioautography.
Sintesis Hidrogel Poli(N-Vinil-2-Pirolidon-Asam Tartrat) secara Iradiasi Gamma dan Karakterisasinya SWASONO R. TAMAT; ERIZAL ERIZAL; CHAIRIL GUNAWAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1681.749 KB)

Abstract

Synthesis of poly(N-vinyl pyrolidone-g-tartaric acid) hydrogel using gamma irradiation had been carried out in two steps. First, irradiation of various concentrations of N-vinyl pyrolidone (NVP) byvarious irradiation doses. The yield of this process was determined by a gravimetric method. Hydrogel with the highest yield was selected for the second step: immersion in various concentrations of tartaric acid (TA) solution followed by irradiation. The yield (grafting percentage) was indirectly determined by a titrimetric method. All hydrogels were tested for their swelling ability (%) in solution of Various pH. The results showed that both NVP concentration and irradiation dose, and also interaction of the two, influenced the yield (gel fraction). The highest gel fraction (99.52%) was obtained from 70% NVP and 40 kGy dose. The result also showed that both TA concentration and irradiation dose, as well asinteraction of the two, influenced the grafting percentage. The highest grafting percentage (42.03%) was obtained by 0.8% TA and 40 kGy dose; while this hydrogel swelled 44.41 times in a pH 8 solution and swelled 42.2 times in a saline solution. The swelling capacity was slightly higher than the SNI 16- 6363-2000 requirement for sanitary napkins, however, lower than the ISO 17190-5-2001 requirement for baby napkins.
Senyawa Imunomodulator dari Myrmecodia pendens Merr & Perry TRIANA HERTIANI; MARIA ULFAH; EDIATI SASMITO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (660.071 KB)

Abstract

Myrmecodia pendens Merr & Perry (Rubiaceae) is widely used in Papua as traditional medicine against various diseases. Preliminary study revealed that ethyl acetate fraction has potency to increase mice Balb/c lymphocyte proliferation in vitro. This study aimed to investigate the active compound responsible for the activity. Dried powders of plant tubers were macerated in ethanol 95% followed by solvent evaporation. The crude extract was further fractionated by liquid-liquid partition with n-hexane, ethyl acetate and water, successively. The ethyl acetate fraction was subjected to a silica gel column and separated by vacuum. The subfraction yields were tested on mice Balb/c lymphocytes to observe the influence on lymphocyte proliferation by MTT assay. Total phenolic content of subfractions were determined by Folin-Ciocalteau method. Chemical characteristics of active compound was identified by GC-MS, UV-Vis spectroscopy, IR and H-NMR. The result showed that total phenolic content has no significant correlation to the lymphocyte proliferation activity. Subfraction 7 yielded from ethyl acetate-methanol (7:3v/v) contained a major constituent (78% by GCMS, 83.75% by Densitometry). GCMS and UV spectra suggested a phenolic substructure. IR and H-NMR suggested that the phenolic was glycosilated and had aliphatic moiety.
Uji Iritasi Sediaan Gel Penyembuh Luka Ekstrak Etanol Daun Binahong Menggunakan Slug Irritation Test SRI HARTATI YULIANI; YUMI RAHMADANI; ENADE PERDANA ISTYASTONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2884.528 KB)

Abstract

Penyembuhan luka adalah proses dinamik yang rumit dan belum sepenuhnya dimengerti. Proses penyembuhan luka terdiri dari 3 fase yaitu fase inflamasi, fase pembentukan jaringan dan fase remodeling. Lama fase inflamasi memegang peranan penting pada proses penyembuhan luka. Fase inflamasi yang panjang akan menyebabkan penundaan proses penyembuhan luka. Iritan dapat memperpanjang waktu pelepasan interleukin-1 and TNF-α. Hal tersebut akan menyebabkan matriks ekstraseluler yaitu suatu material penting dalam pembentukan jaringan baru terdegradasi. Sediaan penyembuh luka tidak boleh mengandung iritan, sehingga semua sediaan penyembuh luka harus diuji potensi iritasinya. Potensi iritasi gel penyembuh luka ekstrak etanol daun binahong telah diuji menggunakan slug irritation test. Validasi terhadap metode ini telah dilakukan dengan hasil sensitivitas dan spesifisitas masing-masing 100% pada nilai batas produksi mukus 8,79%. Metode ini valid untuk menentukan potensi iritasi terhadap suatu produk. Produksi mukus sediaan gel penyembuh luka ekstrak etanol daun binahong adalah 4,55% sehingga dapat disimpulkan sediaan tersebut tidak menimbulkan iritasi pada kulit.
Skrining Bakteriosin dari beberapa Galur Bakteri Asam Laktat Isolat Lokal Genus Streptococcus dan Weissella RAFIKA SARI; CESILIA ANITA; MAKSUM RADJI; AMARILA MALIK
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (447.795 KB)

Abstract

Many lactic acid bacteria (LAB) are known to produce antimicrobial peptides, termed bacteriocins. Bacteriocins are ribosomally synthesized antimicrobial peptides which kill closely related bacteria. Bacteria producing bacteriocin are also known to produce bacteriocin immunity protein (bip). This study aimed to identify bacteriocins activity in an attempt to isolate the bacteriocin and the bip. In this study, genus Streptococcus and Weissella from our LAB collection were screened on well diffusion agar for antagonism assay. Growth inhibition zone observation has been carried out by antagonism assay using Leu. mesenteroides TISTR 120, Leu. mesenteroides JCM 6124, Staphylococcus aureus FNCC 0047, Bacillus subtilis FNCC 0061, Escherichia coli FNCC 0183, Salmonella typhi FNCC 0165, Pseudomonas aeruginosa FNCC 0063, and Listeria monocytogenes FNCC 0156 as indicator strains. Protease K, catalase, and trypsin were also used following the first screening assay for confirmation test. Results showed that both Strep. macedonicus MBF10-2 and W. confusa MBF8-1 posses bacteriocin activity although both against Leu. mesenteroides only, the TISTR 120 and JCM 6124 indicator strains
Perbandingan Efi kasi dan Efek Samping Antara Albendazol, Albendazol-Levamisol dan Mebendazol-Levamisol Terhadap Infeksi Soil-Transmitted Helminths pada Anak Usia Sekolah Dasar Negeri Kabupaten Deli Serdang Endy Julianto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (898.168 KB) | DOI: 10.35814/jifi.v15i2.511

Abstract

Intestinal worm infection in particular of Soil Transmitted Helminth is still a global problem with high prevalence on the tropic and subtropic regions including Indonesia especially in the rural community. Double Blind Randomized Trial that started from April to June 2015 in which the samples are collected from public elementary school children on the Deli Serdang Regency to compare the effectivity and side effect of STH infection treatment by using Albendazole 400 mg, Albendazole 400 mg-Levamisol 50 mg/100 mg, Mebendazole 500 mg-Levamisol 50 mg/100 mg. The samples of Albendazole, Albendazole-Levamisol and Mebendazole-Levamisol groups consist of 60 children in each group in which the ones that have STH infection are Ascariasis 92 children 51.11%, Trichuriasis 37 children 20.55%, and mixed infection 51 children 28.33%. In this research, researcher doesn’t found hookworm infection in any of the groups. From the result ofstool examination, researcher found 100% of cure rate for A. lumbricoides infection on all groups, cure rate of T. trichiura infection 66.7%, 94.7%, 92.3% for each Albendazole, Albendazole-Levamisol, and Mebendazole-Levamisol groups meanwhile cure rate for mixed infection are 28.6%, 85.7%, and 66.7% for each Albendazole, Albendazole-Levamisoland Mebendazole- Levamisol groups. For mild T.trichiura infection treatment with singledose of Albendazole-Levamisolgroup is better than both of Albendazole and Mebendazole- Levamisole groups (p=0.01). In this research, researcher found nausea and diarrhea as treatment of side effect and no signifi cant difference of side effect in all groups of treatment.
Studi Interaksi Obat dan Reaksi Obat Merugikan pada Pasien HIV/AIDS dengan Koinfeksi Tuberkulosis di RSUP Dr. Hasan Sadikin Bandung ALEXANDRA VANIA ANDI; LIA AMALIA; RUDI WISAKSANA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1306.397 KB)

Abstract

HIV/AIDS and tuberculosis require combination therapy that can lead to drug interactions and unwanted drug effects or adverse drug reactions (ADRs). This study was aimed to determine the potential drug interactions, estimate the occured ADRs and provide treatment recommendations for HIV/AIDS patients with tuberculosis. This research was a descriptive study which was conducted retrospectively in forty eight HIV/AIDS patients with tuberculosis receiving treatments in the Teratai clinic, Dr. Hasan Sadikin Bandung Hospital in 2013. From these forty eight patients, there were 109 incidences of potential drug interactions with major significance, 299 incidence of with moderate significance and 58 with minor significance. Estimated ADRs with the greatets number found in this study was 8 incidences of gastrointestinal disorders, 5 incidences of drug eruption, 5 drug-induced liver injury (DILI) incidences and 4 peripheral neuropathy incidences. Patients receiving category 1 tuberculosis therapy was recommended to use tenofovir, lamivudine, and efavirenz as antiretroviral therapy, whereas patients receiving category 2 tuberculosis therapy was recommended to use zidovudine, lamivudine, and efavirenz.
Pengaruh Proses Pengembangan dan Revisi Formularium Rumah Sakit terhadap Pengadaan dan Stok Obat YUSI ANGGRIANI; DWI PUDJANINGSIH; DWI SURYAWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (839.841 KB)

Abstract

Appropriate selection of medicines is needed to support its rational use. Medicines selection based upon a hospital formulary is an attempt to uncreate the medicine efficiency management. The objective of this study Was to evaluate and compare the intrinsic value of seven grade C-hospital formularies in Yogyakarta, also concerning the development and revision of the used fonnularies. The result showed that the percentage of purchase of non-formularium medicines and that of the non-formularium medicines in stock were influenced by the frequency of revision of the formulary itselfand drug policy in relation to the addition and deletion process of the used fonnulary. Non-formulary medicines purchase was low in hospitals which frequently revised the formulary, but hospital With no policy concerning addition and deletion increased the purchase of non formulary medicines. Besides that the use of brand name products in hospitals of the state was much lesser than that used in non-state hospitals (296-532 vs 573-1575). Fonnulary evaluation of state hospitals in comparison with non-state hospitals Were as follows: essential medicines (41-71% vs 20-28%), medicines with primary literature (73-90% vs 67-73%), drugs with single component (41-71% vs 20-28%) The quality of formulary in state and non-state grade C-hospitals in Yogyakarta must be improved.
Produksi dan Penetapan Kadar B-glukan dari Tiga Galur Saccharomyces cerevisiae dalam Media Mengandung Molase Kusmiati Kusmiati; Swasono R. Tamat; S. Nuswantara; Nita Isnaini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1458.348 KB)

Abstract

Beta-glucan extracted from the cell membrane of Saccharomyces cerevisiae has been used as food and medical ingredients. Molase as a waste-product of the cane sugar industry, containing 4-9% of glucose and other nutrients, has been investigated to substitute glucose in the YPG fermentation media of Saccharomyces cerevisiae, and to improve the yield of B-glucan by three strains of Saccharomyces cerevisiae (RTA, RN4, and SC). Beta-glucan and protein concentration were determined by spectrophotometric method at a 490 nm and 750 nm respectively. The results showed that molase can be used as glucose-substitute in the YPG media for the production of B-glucan by three strains of Saccharomyces cerevisiae. The best yield for each strain was as follows: RTA strain in a media containing molase (8% v/v glucose equivalent) produced 61,79% w/w of B-glucan; RN4 strain in a media containing molase (1% v/v glucose equivalent) produced 98,42% w/w of B-glucan; SC strain in a media containing molase (2% v/v glucose equivalent) produced 56,48% w/w of B-glucan. One-way Anova followed by the Tukey-Bonferroni test indicated that molase can be used as substitute of glucose source in the YPG fermentation media, and significantly increased the B-glucan yield by all the three strains of Saccharomyces cerevisiae, as well as reducing the protein contents. The highest ß-glucan yield (98,42% w/w) was attained by the RN4 strain in a media containing molase (1% v/v glucose equivalent) with a protein impurity of only 10,53% w/w, while the RN4 and RTA strains produced a higher B-glucan yield than that of the SC strain.
Peningkatan Laju Disolusi Trimetoprim dengan Teknik Co-Grinding Menggunakan Polimer Polivinilpirolidon K-30 AUZAL HALIM; SYUKRAN HAMDENI; ERIZAL ZAINI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1085.687 KB)

Abstract

Improvement of the dissolution rate of trimethoprim (TMP) as a model for a poorly water-soluble drug by solid state co-grinding technique with hydrophilic polymer polyvinylpyrrolidone K-30 (PVP K-30) using ball milling apparatus have been investigated. The ratios of drug to hydrophilic polymer were 1:1, 1:3 and 1:5. The solid state interaction of co-ground and physical mixture were characterized by powder X-ray diffraction, thermal DTA, SEM and FT-IR spectroscopy analysis. The dissolution studies were carried out in USP type I apparatus. The result of powder X-ray diffraction analysis showed that the co-grinding of TMP with PVP K-30 decreased the drug’s crystalinity. The endothermic peak of TMP of co-ground products shifted to lower temperature and peak intensity decreased significantly. Powder X-ray diffraction and DTA analysis indicated transformation of crystalline state of TMP to amorphous form by co-grinding with PVP K-30. FT-IR Spectra indicated that no chemical interaction between TMP and PVP K-30 in the co-grounds. Significant enhancement in dissolution rates were observed with the co-ground products of TMP and PVP K-30 as compared to the intact TMP and its physical mixture. In general, the dissolution rates of TMP in the co-grounds were enhanced as the polymer ratio increased.

Page 8 of 68 | Total Record : 680

 6   7   8   9   10 

Filter by Year

2003 2025


Reset
Filter By Issues
All Issue Vol 23 No 2 (2025): JIFI Vol 23 No 1 (2025): JIFI Vol 22 No 2 (2024): JIFI Vol 22 No 1 (2024): JIFI Vol 21 No 2 (2023): JIFI Vol 21 No 1 (2023): JIFI Vol 20 No 2 (2022): JIFI Vol 20 No 1 (2022): JIFI Vol 19 No 2 (2021): JIFI Vol 19 No 1 (2021): JIFI Vol 18 No 2 (2020): JIFI Vol 18 No 1 (2020): JIFI Vol 17 No 2 (2019): JIFI Vol 17 No 1 (2019): JIFI Vol 16 No 2 (2018): JIFI Vol 16 No 1 (2018): JIFI Vol 15 No 2 (2017): JIFI Vol 15 No 1 (2017): JIFI Vol 14 No 2 (2016): JIFI Vol 14 No 1 (2016): JIFI Vol 13 No 2 (2015): JIFI Vol 13 No 1 (2015): JIFI Vol 12 No 2 (2014): JIFI Vol 12 No 1 (2014): JIFI Vol 11 No 2 (2013): JIFI Vol 11 No 1 (2013): JIFI Vol 10 No 2 (2012): JIFI Vol 10 No 1 (2012): JIFI Vol 9 No 2 (2011): JIFI Vol 9 No 1 (2011): JIFI Vol 8 No 2 (2010): JIFI Vol 8 No 1 (2010): JIFI Vol 7 No 2 (2009): JIFI Vol 7 No 1 (2009): JIFI Vol 6 No 2 (2008): JIFI Vol 6 No 1 (2008): JIFI Vol 5 No 2 (2007): JIFI Vol 5 No 1 (2007): JIFI Vol 4 No 2 (2006): JIFI Vol 4 No 1 (2006): JIFI Vol 3 No 2 (2005): JIFI Vol 3 No 1 (2005): JIFI Vol 2 No 2 (2004): JIFI Vol 2 No 1 (2004): JIFI Vol 1 No 2 (2003): JIFI Vol 1 No 1 (2003): JIFI More Issue