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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
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Evaluasi Drug Related Problems (DRPs) Antibiotik pada Pasien Sepsis di Rumah Sakit di Yogyakarta SAMUEL BUDI; ZULLIES IKAWATI; IWAN DWIPRAHASTO; TITIK NURYASTUTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Sepsis is a manifestation of the most severe acute infections that can lead to the various organ failure generally ends with death in 30-50% of cases. The number of sepsis deaths in developed countries can be reduced to 11-15%, but in developing countries it was reported above 45%. Proper and adequate use of empirical antibiotics may decrease the risk of death in sepsis and may at least shorten patient duration of care in the hospital. Aim to this study was determine the pattern of antibiotic use, the incidence of Drug Related Problems (DRPs) and clinical outcomes in septic patients in hospital X at Yogyakarta. An observational study was carried out during the period of January-December 2015 in hospital X at Yogyakarta. Data were collected retrospectively among patients with sepsis, age > 15 years old, hospitalized during the the study period. From 632 cases, 162 patients were diagnosed as sepsis and met the inclusion criteria of the study. The antibiotics used were cephalosporin (42.58%), quinolone (17.46%), carbapenem (10.77%), aminoglycoside (9.33%), imidazole (8.85%) and macrolide (4.88%). Poor clinical outcomes associated with DRPs (64.29%) were greater than those that showed good clinical outcomes (35.71%). The incidence of DRPs in sepsis treatment is still high (60.49%), and is generally associated with antibiotic needs, the inappropriate selection of antibiotics, inadequate dosage and the presence of antibiotic interactions.
Isolation and Identification of Flavonoid Compounds in n-Butanol Phase Mulberry Leaves (Morus alba L.) using Spectrophotometry RATNA DJAMIL; FATIMAH BAKRIYYAH
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Murbei (Morus alba L.), suku Moraceae adalah salah satu tanaman yang tumbuh di Indonesia dan banyak digunakan dalam pengobatan secara tradisional. Daun murbei banyak mengandung senyawa kimia seperti flavonoid yang menunjukkan berbagai khasiat farmakologi dan aktivitas biologi. Tujuan penelitian ini untuk mengetahui senyawa flavonoid yang terdapat pada daun murbei. Berdasarkan hasil pemeriksaan penapisan fitokimia dari fase n-butanol daun murbei menunjukkan adanya senyawa flavonoid, saponin, tanin dan kumarin. Telah dilakukan isolasi dan identifikasi senyawa flavonoid dalam fase n-butanol dari ekstrak metanol daun murbei dengan cara kromatografi kertas menggunakan eluen n-butanol-asam asetat-air (4:5:1). Hasil identifikasi dengan spektrofotometer ultraviolet-cahaya tampak diduga mengandung senyawa flavonoid, yaitu isolat NB III merupakan senyawa flavonol dengan gugus OH pada posisi 5, 4’, dan o-diOH pada cincin A serta gugus prenil pada posisi 6. Isolat NB IV merupakan senyawa flavonol dengan gugus OH pada posisi 5, 4’, dan o-diOH pada cincin A serta gugus prenil pada posisi 6. Isolat NB V merupakan senyawa flavonol dengan gugus o-diOH pada cincin A (6,7 atau 7,8). Isolat NB VI merupakan senyawa dihidroflavonol dengan adanya gugus o-diOH pada cincin A (6,7 atau 7,8) dan gugus OH pada posisi 4’.
Aktivitas Antioksidan Ekstrak Daun Sirih Merah (Piper crocatum) Hasil Optimasi Pelarut Etanol-Air AGATHA BUDI SUSIANA LESTARI; YOHANES DWIATMAKA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Red bettle (Piper crocatum) is one of the plants which is extensively explored and has many biological activity. In this research, it is done the optimization of 96% ethanol and water composition as solvents in the process of extraction of red bettle leaves in percentage ratio of 100:0 (P1), 75:25 (P2), 50:50 (P3), 25:75 (P4), and 0:100 (P5) using Simplex Lattice Design (SLD). The aim of this research were to find the optimum composition of solvent which can obtain extract with the highest antioxidant activity. The antioxidant activity of red bettle leaves extract was measured by radical scavenging method using DPPH (diphenylpicryl hydrazyl), and assessed using parameter of EC50. The result showed that red bettle leaves extract which produced with ethanol-water as a solvent in percentage (%) of 75:25 (P2) has the higest antioxidant activity, with the smallest EC50’s value of 301,10 μg/ml.
Efek Serbuk Eestrak Etanol Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Terhadap Jumlah Sel CD4 Pada Sukarelawan Sehat Dini Mardhiyani; Endang Darmawan; Akrom Akrom
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Roselle flower (Hibiscus sabdariffa L.) is beneficial as an immunostimulant because of its antioxidant property. Antioxidants in roselle flower are hibiscus anthocyanin, quercetin, L-ascorbic acid and protocatechuic acid. Any potential plants for pytopharmacy should be proven beneficial and safe through preclinical and clinical trial. The purpose of this clinical trial was to determine the effect of ethanol extract of roselle (Hibiscus sabdariffa L.) to lymphocyte and CD4 cell count in healthy volunteer for 30 days. This study used pre-post treatment design. A total of 21 healthy volunteer were chosen according to inclusion and exclusion criteria and filled informed consent. Healthy volunteer were given 500 mg roselle ethanol extract powder every day for 30 days. Lymphocyte and CD4 cell count was conducted using hematology analyzer and flowcytometer. Results were analyzed using paired t test, if the distribution is not normal than Wilcoxon test will be used on 95% confidence interval. Results showed that there was no significant effect (p>0,05) of CD4 cell absolute count and there was a significant effect of CD4 percentage (p<0,05). Results on day 45 (14 days after the treatment was interrupted) showed no significant effect (p>0,05) of CD4 cell absolute count and CD4 cell percentage. The effect of CD4 cell percentage on day 31 was in normal range. This study concluded that 500 mg roselle petal ethanol extract powder (Hibiscus sabdariffa L.) given everyday for 30 days showed some effect on d increasing CD4 cell percentage.
Karakterisasi Glukoamilase Hasil Produksi Aspergillus niger BCS dengan Penyangga Fermentasi Sekam dan Dedak Mahyudin A. Rahman; Koesnandar Koesnandar; Gany H.; Ahmad Marasabessy; Ali Rohman; Usman Sumo FT
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Glucoamylase, the enzyme which converts starch to dextrins and glucose, is used in the starch-processing industry, especially for the production of glucose crystal and high fructose syrup. The aim of this work was to produce glucoamylase by Aspergillus niger BCS using rice husk as solid substrate support. For this purpose, rice husk added to the mixture was optimized on a fixed weight ratio of cassava starch and rice bran. After that, using optimum rice husk concentration, optimization of the weight ratio of cassava starch and rice bran was carried out. Glucoamylase A. niger produced in this work was characterized by determining its optimum pH and temperature, its stability under various pH and temperature, its kinetic parameters, its hydrolysis products using soluble starch as substrate, and its molecular weights. The optimum conditions for glucoamylase production by A. niger obtained when the weight ratio of cassava starch: rice bran was 1:1 (dry basis, db) and the rice husk concentration in the fermentation medium was 20% by weight (db). Under these optimized conditions, enzyme units as high as 1774 U/g dry fermented substrate was obtained when fermentation was carried out for 5 days at 30°C. Optimum pH of glucoamylase A. niger was 4.5 and its optimum temperature activity was 65°C. This enzyme was stable at pH 3.0 - 7.0 and at a temperature up to 50°C.
Evaluasi Penerapan CDOB sebagai Sistem Penjaminan Mutu pada Sejumlah PBF di Surabaya VANNINA AGUSTINI; WAHYU UTAMI; WAHONO SUMARYONO; UMI ATHIYAH; ABDUL RAHEM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Good Pharmaceutical Distribution Practice is called as CDOB in Indonesia is a guidelines to ensure pharmaceutical product quality throughout the distribution chain..This guideline consist of nine aspects, and pharmaceutical wholesalers (PBF) are required to implement the principle in the guideline as part of compliance to the pharmaceutical wholesaler regulation. The purpose of this research is to assess the extent of the implementation of Good Pharmaceutical Distribution Practices in the pharmaceutical daily operation.This research is descriptive with random sampling technique to determine which pharmaceutical wholesalers to be selected. The samples were 41 pharmaceutical wholesalers in Surabaya and they were given questionnaire they need to answer.. The data were collected in the period of August until September 2015, where the CDOB certifi cation was not mandatory yet. According to data collected, results show that 40 out of 41 (97.56%) PBF do not possessed CDOB certifi cate. From 41 PBFs, 18 (43.90%) PBF has met ≥80% CDOB, 16 (39.02%) PBF has met ≥65 - <80% CDOB, 6 (14.63%) PBF met ≥ 50 - <65% CDOB and 1 (2.44%) PBF met <50% CDOB. There was 1 (2.44%) PBF never conduct a study of the quality management, 4 (9.76%) offi cial pharmacist of respective PBF had never attended CDOB’s training and 5 (12.20%) PBF all their personnel have not been trained CDOB, 5 (12.20%) PBF never check the registration number, there are 2 (4.88%) PBF rarely keep the appropriate medication storage temperature indicated on the drug packaging.Overall, it may be said that not all the PBF in Surabaya implemented 9 aspects of CDOB. This could aff ect directly or indirectly to the quality of pharmaceutical products they distributed. CDOB certifi cation however, just became mandatory in November 2017.
Curcuminoids Content and α-Glucosidase Inhibition of ExtractPromising Lines of Curcuma xanthorrhiza RoxB. WARAS NURCHOLIS; LAKSMI AMBARSARI; GIA PERMASKU; LATIFAH k DARUSMAN; POPI ASRI KURNIATIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Temulawak merupakan salah satu tanaman obat Indonesia yang termasuk dalam keluarga Zingiberaceae. Kurkuminoid merupakan salah satu senyawa bioaktif dalam temulawak yang dilaporkan memiliki aktivitas biologi. Pada penelitian ini dilakukan evaluasi kandungan kurkuminoid dan penghambatan enzim α-glukosidase dari ekstrak empat aksesi temulawak asal Jawa Barat (Sukabumi), Jawa Tengah (Wonogiri dan Karanganyar), Jawa Timur (Ngawi), dan satu ekstrak asal Bogor-Jawa Barat. Simplisia temulawak tersebutdiekstraksi secara bertahap dengan etanol dan n-heksan. Kandungan kurkuminoid diukur dengan menggunakan metode HPLC. Aktivitas penghambatan enzim α-glukosidase dilakukan secara in vitro dengan microplate reader pada 410 nm. Aksesi temulawak asal Wonogiri menunjukkan kandungan kurkuminoid tertinggi, dengan hasil pengukuran antara 35,57- 85,19 mg/g. Nilai IC50 untuk aktivitas penghambatan enzim α-glukosidase antara 333,27̵908,35 μg/mL, dengan IC50 terbaik adalah temulawak aksesi Wonogiri.Berdasarkan penelitian ini, aksesi temulawak asal Wonogiri sangat baik dalam hal kandungan kurkuminoid dan aktivitas penghambatan enzim α-glukosidase dibandingkan dengan aksesi asal Sukabumi, Karanganyar dan Ngawi, maupun dengan varietas asal Bogor.
Synergistic Effect of Areca catechu L. Ethanolic Extract and Its Chloroform Fraction with Doxorubicin on MCF7 EDY MEIYANTO; SRI HANDAYANI; ENDAH PUJI SEPTISETYANI; RATNA ASMAH SUSIDARTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Ekstrak etanol biji buah pinang (Areca catechu L.) menunjukkan efek sitotoksik pada sel kanker MCF7 dan WiDr. Penelitian ini bertujuan untuk mempelajari efek sinergisme antara ekstrak etanol biji buah pinang (AE) dan fraksi kioroforrnnya (ACF) dengan doxorubicin (Dox) dalam pemacuan apoptosis sel MCF7. Ekstrak etanol dipartisi dengan n-heksan dan kloroform untuk mendapatkan fraksi kloroforin. Efek sitotoksik.AE, ACF, dan Dox pada perlakuan tunggal dan kornbinasi ditentukan dengan metode MTT. Penganiatan apoptosis dilakukan dengan pengecatan DNA dengan akridin oranye-etidium bromida (double staining). Imunositokimia dilakukan untuk melihat ekspresi COX-2 dan Bax. Kombinasi Dox 100, 250, 334, dan 500 nM dengan AE 8 µg/ml; Dox 100 nM dengan AE 20 µg/ml; serta Dox 100 dan 250 nM dengan ACF 7 dan 18 µg/ml memperlihatkan efek sinergistis yang kuat (CI 0,1-0,3). Sernentara itu, kombinasi Dox 250, 334, dan 500 nM dengan AE 20, 27, dan 40 µg/ml; Dox 100 nM dengan AE 27 dan 40 µg/ml; Dox 100 nM dengan AE 20 µg/mi; Serta 500 nM dengan ACF 24 dan 35 µg/ml menunjukkan efek sinergistis (CI 0,3-0,7). Secara keseluruhan, kombinasi AE dan ACF dengan Dox memperiihatkan efek sinergistis pada MCF7 dengan indeks kombinasi (CI) kurang dari 0,9 (P<0,05). Periakuan kombinasi juga memacu apoptosis. Penekanan ekspresi Bcl-2 terjadi padaperlakuan kombinasi ACF-Dox. Hasil penelitian ini menunjulckan bahwa koinbinasi AE dan ACF dengan Dox memberikan efek sinergistis dalam pemacuan apoptosis dengan kemungkinan mekanisme meialui penekanan ekspresi Bcl-2.
Metode Kromatografi Cair Kinerja Tinggi Menggunakan Kolom Oktil Silika Fully Endcapped Residual Silanol pada Pemisahan Kotinin dan 3-Hidroksikotinin dalam Sampel Urin CHRISTINE PATRAMURTI; SUDIBYO MARTONO; SUGIYANTO SUGIYANTO; ARIEF NURROCHMAD
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Cotinine (COT) and 3-hydroxycotinine (3-HCOT) are nicotine metabolite excreted in urine. Mediated by the enzyme cytochrome P450 2A6 (CYP 2A6), nicotine will be metabolized to COT and 3-HCOT. The activity of CYP 2A6 can be predicted from the ratio 3-HCOT to the COT, therefore the ratio of 3-HCOT and COT can be used as phenotyping and polymorphism studies of the enzyme. In this study, isolation COT and 3-HCOT of urine samples was carried out by liquid-liquid back extraction. Simultaneous analysis of COT and 3-HCOT using High Performance liquid Chromatography (HPLC) was performed by a reversed-phase octyl silica column (C8; Shimadzu 250 × 4.6 mm, 5 μm) fully endcapped residual silanol. The internal standard solution (SI) was acetanilide. The mobile phase which separate COT, 3-HCOT and SI was methanol : ammonium acetate 5 mM (50:50) at a flow rate 0.8 mL/min. Retention time (tR) of the three compounds was less than 10 minutes, with peak tailing factor (tf) was less than 2. The resolution (Rs) 3-HCOT to COT was 2.67, while the Rs COT to SI was 8.836.
Efek Gel Putih Telur terhadap Penyembuhan Luka Bakar pada Tikus Putih (Rattus novergicus) Lucia Hendriati; Iwan Sahrial Hamid; Teguh Widodo; Chintya Wandasari; Putu Mirah Risata
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.513 KB) | DOI: 10.35814/jifi.v16i2.532

Abstract

Egg whites traditionally used for the treatment of burns. In this research, egg white was formulated as gel dosage form for easy to use and covered unpleasant odor. The aim of the study was to determined effectivity of egg white in gel dosage form against the healing of superficial partial thickness burns (second degree) on white rats (Rattus novergicus) Wistar strain with parameters were macrophages, fibroblasts, collagen deposit density and wound healing. Research subject were male white rats aged 3 months. Second degree burns on the back of rat with a diameter of 2 cm were made by using a hot coin with temperature 80 ° C for 20 seconds. 18 white rats divided into 3 groups of treatment that is negative control using 0.9% NaCl, positive control using Bioplacenton®, and 40% egg white gel as treatment. Based on the experimental results, white egg gel given topically decreased the number of macrophages and increase the number of fibroblasts, increase the density of collagen deposits and speed up wound healing on second degree burns. White egg gel had significantly difference with negative control of NaCl 0.9% and no significantly difference with Bioplasenton as positive control.

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