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Jurnal Farmasi Higea

higea
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Published by Sekolah Tinggi Ilmu Farmasi Padang

ISSN : - EISSN : 25413554 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 347 Documents

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Isolasi Senyawa Kimia Utama Dari Fraksi Aktif Sitotoksik Spon Laut Petrosia sp (MN05) Dian Handayani; Corry Handayani; Krisyanella Krisyanella
Jurnal Farmasi Higea Vol 4, No 1 (2012)
Publisher : STIFARM Padang

Isolation of major compound (CH-05-SP) from cytotoxic fraction of marine sponge Petrosia sp (MN 05) using maceration, fractionation, column chromatography and recrystallization methods has been conducted. The result of physical and chemical analysis showed that the isolated compound was white crystal, melted at 180º-183ºC and including as terpenoid.

PERBANDINGAN JENIS, KOMPOSISI DAN JUMLAH PELARUT TERHADAP UJI TOTAL FLAVONOID DARI DAUN JAWER KOTOK (Plectranthus scutellarioides(L.) R.Br.) Sylvia Rizky Prima; Fetri cary munarsih; Ulia Nailis Saadah
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

Tanaman Jawer Kotok (Plectranthus scutellarioides (L.) R.Br.) adalah tanaman obat tradisional yang digunakan oleh masyarakat untuk mengobati berbagai penyakit. Salah satu senyawa yang berperan penting dalam mengobati berbagai penyakit tersebut adalah senyawa flavonoid. Tujuan dari Penelitian ini adalah untuk memperoleh jenis pelarut, komposisi dan jumlah pelarut yang optimal mengahsilkan total flavonoid dari daun jawer (Plectranthus scutellarioides) (L.) R.Br. Pada penelitian ini digunakan jenis pelarut etanol dan aseton dengan komposisi perbandingan pelarut : air mulai dari 96: 4, 80:20, 70:30, 60:40 dan 50:50. Jumlah pelarut yang digunakan yaitu dengan perbandingan pelarut 5x berat sampel, 10x berat sampel dan 15x berat sampel. Metode ekstraksi yang digunakan adalah metode maserasi. Metode pengujian total flavonoid yang digunakan adalah metode kolorimertri dengan pembanding Quersetin. Dari hasil penelitian diperoleh bahwa pelarut terbaik untuk mengekstraksi total flavonoid adalah pelarut Aseton : Air (70 : 30). Berdasrakan analisa data dengan menggunakan SPPS v24, perbandingan jumlah pelarut 5x, 10 dan 15x berat sampel tidak memiliki perbedaan yang signifikan.

Uji Efek Antiinflamasi Ekstrak Etanol Rimpang Jahe (Zingiber officinale Roscoe) pada Tikus Putih Jantan Surya Dharma; Eka Santi Adelinda; Netty Suharti
Jurnal Farmasi Higea Vol 1, No 2 (2009)
Publisher : STIFARM Padang

Effect of antiinflamantory extract ginger rhizome ethanol has been observed on white male mice. Extract is given buccally with dose 30, 100, 300 mg/kg BB, while preparation is becoming with dose 360 mg/kg BB. Parameter antiinflamantory observed with calculating ability of extract and preparation thus ginger lessens or depress degree of oedema during certain. Level of oedema volume happened is measured by means of pletisnometer. The result of research indicates that ginger ethanol extract at dose 30, 100, 300 mg/kg BB and preparation thus ginger with dose 360 mg/kg BB gives effect antiinflamantory. Highest effect given by ginger extract with dose 300 mg/kg BB with inhibition percentage happened at to 6 at day ke-10 that is 84%. And result of statistician examination in analysis variansi ( ANOVA) to oedema volume after giving of ethanol extract and preparation became ginger to give effect antiinflamantory which real is different if it is compared to control.

Gambaran Terapi Kombinasi Ranitidin Dengan Sukralfat Dan Ranitidin Dengan Antasida Dalam Pengobatan Gastritis di SMF Penyakit Dalam Rumah Sakit Umum Daerah (RSUD) Ahmad Mochtar Bukittinggi Isna Wardaniati; Almahdy Almahdy; Azwir Dahlan
Jurnal Farmasi Higea Vol 8, No 1 (2016)
Publisher : STIFARM Padang

Gastritis is the most common disease found in the community. Everyday frequently we can find patients with upper gastrointestinal problems visit health installation service to cure their disease, such as pain problems or burning sensation in epigastrum area, sometimes followed by regurgitation, stomach heartburn, bloating sensation and early satiety. In gastritis medications, a single therapy is usually preferred, but there are also some using the combination of two drugs. The common drugs being used is based on gastritis conditions level. In this research, the observed drug combination were ranitidine with sucralfat and ranitidine with antacids. The description of drugs used was being judged based on clinical symptoms and endoscopy examination. The confirmed gastritis patients were divided into two groups. Afterwards, the patient were given the therapy( ranititidine and sucralfat) and (ranitidine and antacids) for two weeks. After 4 months since the therapy was being given, the evaluations of patients conditions was done, including the pain in gastrointestinal tract, nausea, regurgitate, smarting before and after meal, burning sensation in the stomach, early satiety and bloating. From evaluations examinations in to the two groups, we founds the results that in groups I the complaint was dissolved about 100 % and in groups II was about 80 %.

Mikroenkapsulasi Parasetamol Dengan Metode Penguapan Pelarut Menggunakan Polimer Natrium Karboksimetil (NaCMC) Auzal Halim; Oktavia Arianti; Salman Umar
Jurnal Farmasi Higea Vol 3, No 2 (2011)
Publisher : STIFARM Padang

Has been researched about microencapsulation of paracetamol with solvent evaporation method using polymer sodium carboxymetil cellulose (NaCMC). Determination of paracetamol level carried out by UV Spectrophotometer at a wavelength of 243,5 nm, the dissolution test using solution phosphate buffer with pH 5,8 and the method used is Metoda Dayung. From the research result, obtained dissolution rate microcapsules of paracetamol on formula 1 is higher than formula 2 and 3. This is because in formula 2 and formula 3 show the addition of coating as a microcapsule wall – forming wich will reduce the speed of drug release. Model kinetics of active ingredient release from microcapsules of paracetamol following the zero order and first order.

BIJI MELINJO (Gnetum gnemon L.) : AKTIVITAS SEBAGAI ANTIDIARE Widya Kardela; Fitra Fauziah; Sonya Mayesri
Jurnal Farmasi Higea Vol 10, No 1 (2018)
Publisher : STIFARM Padang

Salah satu tumbuhan obat Indonesia yang masih dibutuhkan pengujian efek farmakologinya adalah Melinjo (Gnetum gnemon L.). Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol biji melinjo (Gnetum gnemon L.) terhadap diare pada mencit putih jantan yang diinduksi dengan minyak jarak (Oleum ricini). Metode yang digunakan untuk pengujian antidiare adalah pola defekasi dan metode transit intestinal. Parameter yang diamati meliputi frekuensi defekasi, konsistensi feses, berat feses setiap 30 menit selama 4 jam, dan panjang marker norit pada usus mencit. Ekstrak diberikan secara oral dengan dosis 150 mg/kBB, 300 mg/kg BB dan 600 mg/kg BB,sebagai pembanding digunakan loperamid HCl dosis 2 mg/kgBB. Dari hasil penelitian didapat bahwa ekstrak etanol biji Melinjo (Gnetum gnemon L.) pada dosis 600 mg/kgBB memberikan pengaruh antidiare lebih baik dibandingkan dengan dosis 300 mg/kgBB dan dosis 150 mg/kg BB. Peningkatan aktivitas antidiare terlihat seiring dengan peningkatan dosis pemberian ekstrak etanol biji Melinjo (Gnetum gnemon L.) (P < 0,05).

VALIDASI METODE ANALISIS Α-MANGOSTIN DALAM PLASMA DARAH MANUSIA SECARA IN VITRO DENGAN KROMATOGRAFI LAPIS TIPIS-DENSITOMETRI Fitra Fauziah; Widya Kardela; Roslinda Rasyid; Multi Silvi
Jurnal Farmasi Higea Vol 9, No 2 (2017)
Publisher : STIFARM Padang

Penelitian ini dilakukan bertujuan untuk memvalidasi metode analisis penetapan kadar α-mangostin dalam plasma darah manusia secara in vitro dengan metode KLT-densitometri. α-Mangostin diekstraksi dari plasma yang sebelumnya ditambahkan dengan larutan α-mangostin dengan metode pengendapan protein menggunakan metanol sehingga diperoleh supernatannya. Pemisahan dilakukan dengan KLT dengan fase diam silika gel 60 F254 dan fase gerak kloroform : etil asetat (9 : 1), kemudian dilakukan scanner dengan densitometri. Validasi metode analisis menunjukkan bahwa metode ini memenuhi persyaratan parameter validasi. Akurasi diperoleh rata-rata persen perolehan kembali yaitu 96,0591%, presisi intraday dari konsentrasi 50 ppm, 100 ppm dan 150 ppm diperoleh rata-rata persen RSD yaitu 1,6440%, 2,1993% dan 1,6389%, presisi interday yaitu 2,8533%, 1,4208%, 3,0985%, linearitas yaitu 0,9922, batas deteksi yaitu 37,8323 ppm dan batas kuantitasi yaitu 110,8014 ppm. Hasil penetapan kadar α-mangostin dalam plasma darah manusia yang sebelumnya ditambahkan dengan larutan α-mangostin secara invitro dari kadar sampel 120 ppm yaitu 115,2709 ± 3,7990 ppm

Pengaruh Cara Pengeringan terhadap Perolehan Kadar Senyawa Fenolat dan Aktivitas Antioksidan pada Tumbuhan Meniran (Phyllanthus niruri, Linn.) Harrizul Rivai; Nining Hijrahwati; Mahyuddin Mahyuddin
Jurnal Farmasi Higea Vol 1, No 2 (2009)
Publisher : STIFARM Padang

The effect of drying methods on gaining of phenolic content and antioxidant activity of Phyllanthus niruri herbs have been investigated. The phenolic content was determined by using Folin-Ciocalteu method and antioxidant activity was determined by DPPH method. Result of this investigation showed that phenolic content of fresh, air drying, 400C oven drying, and 600C oven drying were 4.965 mg/g; 0.972 mg/g; 2.022 mg/g and 1.625 mg/g, respectively. IC50 of these sample were 0.445 mg/mL; 4.030 mg/mL; 0.697 mg/mL and 1.875 mg/mL.

Mikroenkapsulasi Karbamazepin dengan Polimer HPMC Menggunakan Metoda Emulsifikasi Penguapan Pelarut Rina Wahyuni; Auzal Halim; Yustina Susi Irawati
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

Microencapsulation of Carbamazepine using HPMC as a polymer by emulsification solvent evaporation method had been studied. Microcapsules had been made into 3 formulation with 3 ratio variation between Carbamazepine and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were evaluated by SEM, DTA, FT-IR, particle sized distribution, drug content and dissolution profile. The evaluation result showed that HPMC as a polymer of sustained release was influence characteristic microcapsules of Carbamazepine. Microcapsules were white to slightly yellow and almost perfectly spherical. Disolution profiles of microcapsules showed that the formula containing the greatest amount of HPMC gave the slower release of Carbamazepine. Resistance release of biggest drug shown by formula 3 giving disolution during 6 hour counted 24.5296 %. Dissolution kinetics of microcapsules allowed Higuchi equation, where the realese of Carbamazepine from microcapsules were controlled by diffution process.

Pengaruh Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Terhadap Kadar LDL Pada Mencit Putih Jantan Surya Dharma; Oki Supanda; Elisma Elisma
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

Study about the influence of the aethanolic extract of Annona muricata L on male mice induced by high fat diet and propylthiouracil has been done. The aethanolic extract of Annona muricata L was given orally one a day for 7, 14, and 21 days. The doses used were 2, 6, 18 mg/20 g body weight respectively. Negative control group was given standard food. Parameters were measured blood levels of LDL. Result showed that the giving of the aethonalic extract of Annona muricata could decrease blood levels of LDL significantly (p> 0.05). Whereas the factors of the days does not show significantly (p> 0.05).

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