cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Muhammad Taupik, M.Sc
Contact Email
muhammad@ung.ac.id
Phone
-
Journal Mail Official
info.jsscr@ung.ac.id
Editorial Address
-
Location
Kota gorontalo,
Gorontalo
INDONESIA
Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
 16   17   18   19   20 
Penentuan Kadar Flavonoid Daun Rumput Knop (Hyptis capitata Jacq.) Menggunakan Spektrofotometri UV-Vis Hamsidar Hasan; A. Mu'thi Andy Suryadi; Syamsul Bahri; Ni Luh Widiastuti
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.19371

Abstract

Knop grass (Hyptis capitata Jacq.) is a weed used as a tradisional medicine, especially for the leaves. Flavonoids are one of the secondary metabolites contained in the Knop Grass (Hyptis capitata Jacq.) leaves, wich function as anti-inflammatory, analgesic, antipyretic and anti-diabetic. The amount of extracted flavonoids is optimized by choosing the right extraction method, as it will determine the amount of substance that can be attracted and obtain a high content of active substansces. This research aimed to compare the flavonoid levels in the methanol extract of Knop Grass (Hyptis capitata Jacq.) leaves in two different maceration methods: multilevel maceration and total maceration. Multilevel maceration employed n-hekxane, ethyl acetat and methanol solvents, while total maceration employed methanol solvent. In the meantime, the qualitative analysis in this reaserch used the color reagent test method, whereas the thin layer chromatography used the eluent, namely n-hexane : ethyl acetate with a ratio (7:3). In addition, the quantitative analysis used the UV-Vis spectrophotometry method at a maximum wavelength of 435 nm with standard quercetin as a comparison. The result signified that the average flavonoid level in the methanol extract of Knop Grass (Hyptis capitata Jacq.) leaves using the multilevel maceration method was 2,9750%. The total maceration method was 4,8822%. Furthermore, the total maceration method donated the highest concentration obtained from the methanol extract of Knop Grass (Hyptis capitata Jacq.) leaves.
Skrining Fitokimia dan Uji Antioksidan Ekstrak Daun Cabai Rawit (Capsicum frutescens L.) Esti Febri Fatwami; Sri Royani
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20896

Abstract

Chili is a plant that is widely cultivated in indonesia. Chili leaves are knowon to have many health benefits. This has something to do with the content of secondary metabolites in it. This research was conducted to determine the content of secondary metabolites in chili leaves. The method used was in the form of phytochemical screening and antioxidant activity test using the DPPH method. The identification of the phytochemicals carried out included the identification of alkaloids, flavanoids, saponins, triterpenoids, quinones and phenols. The results of the phytochemical screening showed that the compounds contained in cayenne pepper leaf extract that extracted using 96% alcohol were alkaloids, flavonoids, and phenols. While the antioxidant test results on cayyenne pepper leaf extract showed an IC50 value of 78,03 µg/ml.
Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Semangka Merah Sebagai Krim Antijerawat Tri Puspita Yuliana; Hasratul Kusuma; Puspawan Hariadi; Baiq Maylinda Gemantari
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.19590

Abstract

Acne is a problem caused by Propionibacterium acnes bacteria. Red watermelon rind contains lycopene compounds, antioxidants, has tannin and flavonoid compounds and is very good for skin care, free from acne, functions as an antibacterial. The purpose of this study was to formulate ethanol extract of red watermelon rind into anti-acne cream preparation and determine the inhibition zone and determine the red watermelon rind cream has the best antibacterial activity against Propionibacterium acnes bacteria. The method used in this study was experimental, extract concentration of 15%, 20%, 25%. The antibacterial activity test was conducted using the pitting method and evaluated the physical properties of the cream preparation including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results showed that the evaluation of the physical properties of the cream preparation had characteristics in accordance with the evaluation of the preparation carried out at each concentration, including organoleptic examination, pH test, homogeneity test, adhesion test, spreadability test. The results of the antibacterial activity test of ethanol extract of red watermelon rind F1, F2, F3 are: 6.76 mm, 8.33 mm, 8.73 mm. The results of the antibacterial activity test of the cream preparation of ethanol extract of red watermelon rind F1, F2, F3 are: 4.47 mm, 6.04 mm, 8.17 mm. It can be concluded that the cream preparation of ethanol extract of red watermelon rind meets the characteristics of cream preparation stability, meets the criteria of good physical properties at concentrations of 15%, 20%, 25%, has weak to moderate category antibacterial activity against Propionibacterium acnes bacteria.
Article Review : Potensi Antioksidan Ekstrak Batang Bambu Kuning (Bambusa Sp) Sebagai Pencegahan Penyakit Asma Ardilah Ardilah; Ishmah Ulya; Sri Wahyuni; Anggi Aulia Nur Fazri; Mhd. Zaky Daniyal; Panji Ramadhani Panjaitan; Adhika Dwiputri Ilafi; Nurul Adila Damanik
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21005

Abstract

Asthma one of the most common non-communicable diseases in the world characterized by varied as well as recurrent symptoms, airflow obstruction, bronchial hyperresponsiveness, and inflammation. Asthma the most common chronic disease (4,6%), followed by golden and mood disorders (4,1%), attention deficit hyperactivity disorder (3,6%), abdominal pain (2,8%), presence (2,8%), learning disorders (2%), congenital skeletal deformities (1,6%), migraine (1,4%), morbid obesity (1,4%), and autism spectrum disorders (1,1%). Worldwide, it is estimated that around 300 million people are affected by asthma, and by 2025 the number of affected patients is growing exponentially with the addition of 100 million people affected by the condition. With the increase in asthma makes motivation and desire high to seek and find effective first-aid solutions for asthma prevention. So this solution aims to provide first aid in the prevention of asthma. In this article, the idea is given in the form of antioxidant benefits of yellow bamboo stem extract (Bambusa sp) as first aid for the prevention of asthma. Yellow bamboo stems contain antioxidants that are useful for preventing asthma. So it is hoped that this idea will have a good impact on people with asthma and be able to provide first aid for the prevention of asthma.
Isolasi Dan Identifikasi Terpenoid Fraksi Heksan Daun Premna serratifolia L. Menggunakan GC-MS Ricky Midi Candra; Isnindar Isnindar; Sri Luliana
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.15311

Abstract

Buas-buas (Premna serratifolia L.) is a plant that belongs to the Verbenaceae family. Terpenoid compounds that exist in buas-buas plants have bioactivity as medicine. Terpenoid compounds are soluble compounds in n-hexane. The purpose of this study was to isolate and identify the terpenoid compounds contained in the n-hexane fraction of buas-buas leaves using the GC-MS method. The buas-buas leaves were macerated with 96% ethanol solvent and then fractionated using a separating funnel with n-hexane as solvent. The n-hexane fraction of buas-buas leaves was isolated using column chromatography with a gradient mobile phase combination of n-hexane and ethyl acetate, then identified using the GC-MS instrument. The terpenoid compounds found in the n-hexane fraction of buas-buas leaves are estimated to be neophytadiene; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; and 2 hydroxy-4a,5-dimethyl-3-(prop-1-en-2-yl) octahydronaphthalen-1-(2H)-one.
Hubungan Self-Management Pengobatan Terhadap Kadar Gula Darah Pada Pasien Rawat Jalan Diabetes Melitus Tipe 2 Di Puskesmas Umul Farida; Kumala Sari Poespita D. W; Dianty Putri Millania Paringsih
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20833

Abstract

This study aims to evaluate the relationship between the level of self-management of medication and blood glucose levels in outpatient type 2 diabetes mellitus patients at the Kediri City Health Center. The research falls under the category of quantitative research with an observational study approach, using a cross-sectional design. Diabetes mellitus (DM) is a chronic condition characterized by hyperglycemia and various metabolic abnormalities due to hormonal disorders, which can lead to long-term complications in the eyes, kidneys, nerves, and blood vessels. Data were collected using the DSME Questionnaire (Diabetes Self Management Education) to assess the level of self-management of medication.The results showed that 12 respondents (13.8%) had poor self-management of medication and poor blood glucose control. There were 14 respondents (22.2%) with moderate self-management of medication and uncontrolled blood glucose. Meanwhile, 18 respondents (28.6%) had moderate self-management and blood glucose within the normal range. A total of 31 respondents (49.2%) had moderate self-management and normal blood glucose levels. Only 12 respondents (13.8%) had good self-management and blood glucose within the normal range.The Spearman rank test results indicated a significant relationship between self-management of medication and blood glucose levels in type 2 diabetes mellitus patients. With α = 0.05, the obtained P-value was 0.000, which is smaller than 0.05. Therefore, the alternative hypothesis (H1) is accepted, while the null hypothesis (H0) is rejected. This suggests the presence of a relationship between self-management of medication and blood glucose levels, with a Spearman rank correlation coefficient of 0.598.
Kajian Literatur: Etnomedisin sebagai Analgesik di Indonesia Mahacita Andanalusia; Neneng Rachmalia Izzatul Mukhlishah
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21477

Abstract

Ethnomedicine has a major role in the development of new drugs. Based on ethnomedicine studies, it is known that some plants’ biological activity has potential as a therapy. One of its activities is as an analgesic, which can help to deal with frequent pain incidents in the world. The purpose of this literature review was to collect information on the use of ethnomedicine as an analgesic in several regions in Indonesia. The method used was narrative review using the Google Scholar database with publication limits from 2019 to 2023. There were nine studies that meet the criteria and represent the western, central and eastern parts of Indonesia. A total of four studies show that Zingiber officinale is used as an analgesic with UV 0.02-1.0. Three studies show Alpinia galanga and Piper betle are used as analgesic with UV 0.4-1.77 and 0.06-1.20, respectively. Two studies show that Oriza sativa and Curcuma longa are used by the local people as analgesics with a UV of 0.04-1.40 and 0.13-0.45, respectively. Other plants that have high UV in several regions include Orthosiphon aristatus (0.80); Curcuma viridiflora (4.00); Ficus septica (0.43), and Emelia ribes (0.60) Based on the results, it is known that Zingiber officinale, Alpinia galanga, Piper betle, Oriza sativa, and Curcuma longa are the plants most widely used as analgesics in several regions in Indonesia. This literature review can be used as a consideration in finding analgesic support therapy using ethnomedicine.
Deteksi Bakteri Salmonella sp. dengan Kultur Darah Pada Pasien Widal Positif di Laboratorium Klinik X Nurul Istiqomah; Novia Agustina; Salsa Bellamilenia Putri
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21497

Abstract

Until now, the gold standard test for diagnosing typhoid fever is a bacterial culture or also known as a gall culture examination. Blood cultures have the best sensitivity (40–60%) when performed in the first-early second week. Purpose: this study aims to identify the presence of Salmonella sp. in the blood of Widal positive patients. Method: this research is a descriptive study with a cross-sectional approach. This study used the blood culture method. The media used in this study were oxgall, SSA, KIA and IMViC media. The results showed that 20% of Salmonella typhi bacteria were found, 7% of other bacteria and 73% of bacteria did not grow on the media. The macroscopic characteristics of salmonella bacteria found were round colonies, clear in color, convex surface, flat colony edges, semi mucoid consistency, no reduction of tellurit. The microscopic characteristics are rod-shaped, spread arrangement, red in color and are Gram negative. Cultivation on IMViC media showed Indole -, MR +, VP -, Citrate -, KIA medium alkaline slope, acid base, H2S +, gas -. Conclusion: Salmonella thypi was found in the blood cultures of positive widal patients.
Analisis Kandungan Formalin dan Boraks Pada Bakso dan Tahu di Wilayah Kota Malang Lukky Jayadi; Dwipajati Dwipajati; Nurma Sabila
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.17998

Abstract

The main danger posed by formalin and boric acid or often called borcas if exposed continuously is that it can irritate the respiratory tract if inhaled, cause skin blisters if in contact with skin, nausea, vomiting, diarrhea, possible bleeding, abdominal pain, headache, hypotension, fainting. to coma. In addition, formalin can cause degenerative changes in the liver, heart, brain, other organs and can trigger genetic mutations resulting in cell damage or cell death which can result in the growth of cancer cells. This study aims to identify the content of formalin and boric acid or borkas in food samples of meatballs and tofu. The method used in this research is to test for boric acid or borcass by using AgNO3 and Paper Test Kit and for testing Formalin using KMnO4 and Reagent Test Kit. This method is used as a qualitative test for the presence of formalin and borax or boric acid in the sample. A positive result for the presence of borax or boric acid with AgNO3 with the occurrence of a white precipitate and using a paper test kit will turn brown. To identify formalin, a positive result with KMnO4 is indicated by a change in color to brown and using a test kit reagent is indicated by a change in the color of the positive sample to purple. The samples tested were 3 meatball samples and 3 tofu samples. The results of the identification of formalin and borax or boric acid in all meatball and tofu samples were obtained using qualitative tests, no meatball and tofu samples containing formalin and borax or boric acid were found.
Gambaran Interaksi Obat Pada Pasien Diabetes Mellitus Tipe 2 di Rumah Sakit X Fajrin Noviyanto; Rita Mintarsih; Farahdina Chairani
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21578

Abstract

Diabetes mellitus is a chronic condition characterized by higher than normal blood glucose levels and problems with protein, carbohydrate, and lipid metabolism caused by a relative or total lack of the hormone insulin. In addition, as a result of more prescriptions being written, the danger of drug interactions increases due to potential interactions among diabetic inpatients. The purpose of this study was to describe drug interactions in patients with Type 2 Diabetes Mellitus at X Hospital in the period January-March 2023. Data taken retrospectively from medical records were used in this kind of study, and Lexicomp Interact Online was used to evaluate drug interaction data. The results of this study showed that females 46-55 experienced. Most drug interactions in the hospital. Based on lexicomp interact online, drug interactions were categorized into 3 categories, B minor (23.6%), C moderate (62.5%) and D major (13.9%). This study may encourage healthcare workers to increase their awareness to counteract drug interactions in diabetic patients with complications to improve their clinical outcomes.

Page 18 of 20 | Total Record : 196

 16   17   18   19   20 

Filter by Year

2019 2025


Reset
Filter By Issues
All Issue Vol 7, No 3 (2025): Volume 7 Number 3 2025 Vol 7, No 2 (2025): Volume 7 Edisi 2 2025 Vol 7, No 1 (2025): Volume 7 Edisi 1 2025 Vol 6, No 2 (2024): Volume 6 Edisi 2 2024 Vol 5, No 2 (2023): Volume 5 Edisi 2 2023 Vol 5, No 1 (2023): Volume 5 Edisi 1 2023 Vol 4, No 3 (2022): Volume 4 Edisi 3 2022 Vol 4, No 2 (2022): Volume 4 Edisi 2 2022 Vol 4, No 1 (2022): Volume 4 Edisi 1 2022 Vol 3, No 2 (2021): Volume 3 Edisi 2 2021 Vol 3, No 1 (2021): Volume 3 Edisi 1 2021 Vol 2, No 2 (2020): Volume 2 Edisi 2 2020 Vol 2, No 1 (2020): Volume 2 Edisi 1 2020 Vol 2, No 1 (2020): Maret 2020 Vol 1, No 2 (2019): Volume 1 Edisi 2 2019 Vol 1, No 1 (2019): March More Issue