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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Uji Aktivitas Antibakteri Minyak Atsiri Kulit Jeruk Pontianak (Citrus nobilis Lour. var. microcarpa) terhadap Bakteri Staphylococcus aureus dan Staphylococcus mutans meri ropiqa; Ika Ristia Rahman; Hadi Kurniawan; Erwan kurnianto
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18170

Abstract

Antibacterial is a substance that can inhibit the growth of bacteria and can kill bacteria that cause infection. Currently increasing resistance to antibiotics is an opportunity to utilize bioactive compounds from the diversity of plants in Indonesia, one of which is by utilizing Pontianak orange peels. Based on some literature, it is stated that essential oils from Pontianak orange peels can inhibit the growth of several types of bacteria. In this study, antibacterial tests were carried out on S.aureus and S.mutans bacteria. The essential oil of Pontianak orange peel was first tested for phytochemical screening and then an antibacterial test was carried out with several concentrations of 5%, 10%, 25%, and 50%, the antibacterial activity test was carried out using the disc diffusion method. The results of the phytochemical screening test showed that the essential oil of Pontianak orange peel contains flavonoids, saponins, and terpenoids. Furthermore, in testing the S.aerues bacteria, the essential oil of orange peel can have an inhibition zone with a range of 9-11 mm which is included in the strong antibacterial category, while in testing the inhibition of S. mutans bacteria, it is included in the moderate category, namely in the range of 7-10 mm. In the statistical test, there was no significant difference in the inhibition of S. mutans and S.aereus bacteria in inhibiting the growth of the orange peel essential oil as indicated by the diameter of the inhibition zone in the different treatment groups according to the concentration of orange peel essential oil.
Standarisasi Parameter Spesifik Ekstrak Etanol Daun Jarak Pagar (Jatropha Curcas L) sebagai Vasorelaxan Fahmi Sadik; Muhammad Zulfian A. Disi
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18187

Abstract

Jarak pagar (Jatropha curcas L.) is traditionally used as a medicinal plant and can be used scientifically to treat various diseases based on the scientific results of herbal medicine. This study aims to prove that the ethanol extract of Jarak pagar leaves (Jatropha curcas L.) meets the specific parameters for extract standardization. The ethanol extract of Jarak pagar (Jatropha curcas L.) leaves was obtained by maceration method, and then the extract was observed for specific parameters, which included an organoleptic test, identification of chemical content, determination of water-soluble juice content, and ethanol-soluble juice content, as well as other tests to see the activity of Jatropha curcas as a vasorelaxant using experimental methods. The results and data of specific parameter characteristics show that the extract made has met the requirements of Indonesian Medical Materials, which means that the ethanol extract of Jatropha curcas leaves made has met the standards, and based on activity testing, it is known that Jarak pagar leaves (Jatropha curcas L.) have the same activity as Vasorelaxan.
Analisis Pengelolaan Obat di Puskesmas X Provinsi Kalimantan Selatan Nida Anisah; Sendi Lia Yunita; Ika Ratna Hidayati
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.17046

Abstract

Drug is an important aspect that needs to be considered in health services. Proper drug management is needed so that the availability of drugs is guaranteed and the quality of drugs is maintained. The purpose of this study was to determine drug management which includes planning, requesting, receiving and storing drugs at X Health care Center. This research is a quantitative research with a descriptive observational research design, using secondary data sources LPLPO and RKO as well as primary data sources by direct observation and 13 indicators were used. The results of the analysis of indicators of conformity of items with Fornas 91.10%, accuracy of planning 18.14%, suitability of items and number of requests 105% and 37.18%, suitability of items and number of receipts 96.83%, storage according to dosage forms 99.19% , storage according to pharmacology 0%, storage in alphabetical order 98.37%, storage according to temperature 97,56%, storage of narcotics and psychotropics according to regulations 83.33%, storage of drugs not used for other storages that cause contamination 100%, arrangement paying attention to FEFO 100% , 83.33% high-alert drug storage, 88% LASA drug storage. It can be concluded that drug management at the X Health Center has met the standard in some indicators.
Evaluasi Stabilitas Formulasi Krim Ekstrak Propolis Geniotrigona thoracica Paula Mariana Kustiawan; Deasy Nur Chairin Hanifa; Muhammad Alib Batistuta; Azzah Fatimah Zulfa
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.14239

Abstract

Methanolic extract of Geniotrigona thoracica propolis has been reported as strong antioxidant. This potential can be applied as cream product. This aims of this study is to evaluate the physical stability of the formulation of G. thoracica propolis cream which has antioxidant activity. The extract was obtained from propolis through the maceration method and then formulated into a cream dosage form. Detemination of the physical properties of cream product were included organoleptic test, homogeneity test, pH test, dispersibility test and adhesion test. The results of the stability evaluation of G. thoracica propolis cream showed a light brown color consistency, a weak characteristic odor and a soft semi-solid texture, homogeneous, pH 7, 6.5 cm spreadability and 260 seconds stickiness. The preparation of the G. thoracica propolis extract cream met the requirements of the physical tests performed. In addition, the G. thoracica propolis has good physical stability during storage.
Formulasi dan Uji Kestabilan Fisik Lilin Aromaterapi Minyak Atsiri Bunga Melati (Jasminum sambac L) Besse Yuliana; Andi Makkulawu; Annisa Ramadhani Amal
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18874

Abstract

Aromatherapy candles are alternative medicine (inhalation) namely inhalation, aroma vapor produced form a few drops esensial oils. Jasmine flower (Jasminum sambac L.) is used widely as Aromatherapy for the manufacture of essential oils, generally brownish yellow in  color with the characteristic odor. Contains chemical compounds of jasmine oil, namely lynalol 10. 13%, nerolidol 19.95%, and indole 4. 05%. Jasmine Flower essential oil Aromatherapy candle (Jasminum sambac L.) This type oh the research was experimental, including physical burning point tests, melting point tests and hedonic tests. The results showed that the preparations had made white and yellow colors, different aromas according to the concentration of the essential oil, the melting point 52-59℃ according to the requirements according to SNI, namely 42-60℃, the fastest burning time was the old formula K(-), formula 2and 3 the fastest burning time, and in the hedonic test, formulation 3 was the most favored by the panelists and the K(-) formulation was less favored by the panelists. The conclusion oh this research is that jasmine essential oil (Jasminum sambac L.) can be formulated aromatherapy candles preparations, jasmine flower essential oil (Jasminum sambac L.) in aromatherapy candles is physical stable and jasmine essential oil aromatherapy candles  (Jasminum sambac L.) has high level of liking by the panelists.
Bioactivity of Purple Sweet Potato (Ipomea batatas) as Anti Inflammatory Agent: Review Shella Carlina Tasya; Paula Mariana Kustiawan
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.14240

Abstract

This Inflammation is a defensive response to tissue damage that occurs locally. NSAID (Non Steroid Anti-Inflammatory Drugs) and AIS (Antiinflammatory Steroids) have been used in Indonesia to treat inflammation but have side effects on the body. Purple sweet potato leaf (Ipomoea batatas) is one of the herbal medicines used by the community to treat inflammation. This research is a literature review by collecting information from Google Scholar, PubMed, Scopus, and Garuda. The results showed that the active anti-inflammatory compounds in purple sweet potato leaves were flavonoids. Flavonoids can work as anti-inflammatory compounds by passing through several pathways such as inhibition of cyclooxygenase (COX) and lipoxygenase enzyme activities, inhibition of neutrophil degranulation, inhibition of histamine increase, and inhibition of leukocyte accumulation. Purple sweet potato (Ipomoea batatas) leaves are scientifically proven to have anti-inflammatory activity as evidenced by the presence of compounds that have anti-inflammatory effects and can be developed into products for inflammation.
Gambaran Penggunaan Antidepresan Pada Pasien Lanjut Usia Danang Sigit Widianto; Nurmainah Nurmainah; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15940

Abstract

Depression is a common mental disorder characterized by a loss of interest or pleasure. The types of drugs used in the use of antidepressants include selective serotonin reuptake inhibitors (SSRIs), selective serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclics. The purpose of this study was to describe the patient's description, the level of depression, and the types of antidepressant drugs used in elderly patients hospitalized at Sei Bangkong Hospital, Pontianak. Methods This research is a descriptive observational study with a cross sectional design. Data collection was carried out by using medical record data during the 2021 period using antidepressants. The results showed that the age of patients 61-65 years old who used antidepressants were 20 people (51.28%), while for 65 years who used antidepressants were 19 people (48.71%). The level of minor depression was 20 people (51.28%), while for major depression it was 19 people (48.71%). The types of drug classes used are SSRI group, SNRI group, and tricyclic group. The conclusion of this study is that there are more patients aged 61-65 years than patients 65 years who are depressed, female and male with minor and major depression levels. The types of drug classes used are SSRI group, SNRI group, and tricyclic group.
Uji Aktivitas Antioksidan Ekstrak Etanol Umbi Keladi Tikus (Typhonium Flagelliforme (L.) Blume) Elvira Santi; Andi Juaella Yustisi; Nurfitria Junita
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18573

Abstract

Rodent tuber (Typhonium flagelliforme (L.) Blume) is a medicinal plant used by the community as a drug. This plant is nutritious because one of chemical contents is triterpenoid which is having a role as the free radical scavenger that can lead to degenerative diseases. The aim of the research is to determine the extract antioxidant activities of rodent tuber (Typhonium flagelliforme (L.) Blume) based on the binding of free radicals of 1,1-diphenyl-2-picrylhydrazyl. Extract of rodent tuber (Typhonium flagelliforme (L.) Blume) was obtained by maceration method, the sample was macerated by using ethanol of 96%. This research used DPPH method. The antioxidant activity against free radical were measured by mean of UV-Vis spectrophotometry at a wavelength of 516 nm and calculated the value of IC50. The results showed that each rodent tuber extract (Typhonium flagelliforme (L.) Blume) has IC50 for the ethanol extract was 74.359 µ/mL and the comparison of quercetin with the value IC50 was 10.298 µg/mL respectively
Hubungan Kepatuhan Konsumsi Kalsium Karbonat terhadap Kadar Fosfat Pasien Gagal Ginjal dengan Hemodialisis Fika Nuzul Ramadhani
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.19121

Abstract

Non-adherence to renal failure treatment increases the risk of disease complications, such as metabolic disorders of calcium and phosphate. Education is one of way to increase medication adherence. Education is one way to increase patient compliance in therapy. One way of conducting education is by giving leaflets. This study aims to determine the correlation between compliance with consumption of calcium carbonate and phosphate levels in patients with kidney failure on hemodialysis. This research were experimental and prospective study at PKU Muhammadiyah General Hospital, Yogyakarta City for 4 weeks using the one-group pretest posttest design to test patients' phosphate levels pre and post administation of leaflets increase adherence. Sample consisted of 70 kidney disease patients with hemodialysis were divided into 2 groups, each consisting of 35 patients. The intervention group were given education leaflets and checking phosphate levels, while the control group were not given leaflets. Data were obtained from medical records, questionnaire instruments and phosphate laboratory data. The level of patient adherence in taking calcium carbonate medication assessed by MMAS questionnaire and phosphate levels of patients. Data were analysis using the Wilcoxon test and Spearman test.The results of the analysis between adherence and phosphate levels showed no relationship between adherence and phosphate levels p=0.591 (p0.05). Overall, it can be concluded that there is no correlation between adherence to calcium carbonate consumption and phosphate levels
Pengaruh Edukasi Kesehatan Tentang Protokol Kesehatan Covid-19 Terhadap Pengetahuan Dan Sikap Ayu Nurintan; Faisal Kholid Fahdi; Muhammad Ali Maulana
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.19063

Abstract

Covid-19 is an infectious disease that affects and infects the respiratory system. From minor respiratory issues like the flu to major ones like pneumonia, lung failure, and even death, Covid-19 can cause a variety of respiratory issues. Close contact and the splash of saliva from an infected individual's talking, coughing, or sneezing can spread Covid-19 from one person to another. Nearly every region of Indonesia has been affected by the Covid-19 illness. To reduce the rate of transmission, the government has set a health protocol policy for daily activities. This can be accomplished by offering health education. Covid-19 and the 5M health regimen, which include utilizing masks, keeping hands, keeping distance, avoiding, and decreasing movement, are two examples of the types of education that can be provided. The purpose of this study was to find out how health education influences changes in students' knowledge and attitudes towards the Covid-19 health protocol. Method: This study is quantitative and uses a pretest-posttest design without a control group as a quasi-experimental approach. With 62 respondents, sequential sampling was the sample technique employed. The Wilcoxon test is the statistical procedure employed. With a significant value of 0.000 (p 0.05) between the pre-test and post-test-1 knowledge variables and a significant value for the pretest attitude variable toward post-test, the results of the various tests using the Wilcoxon test demonstrated that there was a difference in knowledge before and after receiving health education about the Covid-19 protocol. Test-1 is 0.000 (p0.05), indicating that the Covid-19 protocol-related health education had an impact on the attitude variable as well. Conclusion: Students' knowledge and attitudes towards the Covid19 health regimen are influenced by health education.

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