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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Potensi Ekstrak Enzim Daun Pepaya (Carica papaya L.) Sebagai Agen Fibrinolitik Dengan Metode Clot Lysis in Vitro Hervina Warninghiyun; Ana Indrayati; Pudiastuti RSP
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21326

Abstract

Stroke is a disease caused due to blockage of blood vessels. Health department in 2013 stated that 15,4% of people died from strokes. One of the treatment therapies that can be used is fibrinolytic. Fibrinolytic agents have a role in lysing blood clots, these agents can be obtained from microbes, plants and animals. This study aims to determine the protein content contained in papaya leaf enzyme extract (Carica papaya L.), and to determine the potential of the enzyme extract at certain concentrations as an alternative to natural fibrinolytic drugs. The study began with plant determination, sampling, enzyme extraction using a blender, purification of the extract by precipitation using ammonium sulphate, protein content determination using the Lowry method, and testing the fibrinolytic activity of the clot lysis method in vitro. Three series of test concentrations were made, namely 20, 40, and 80%. The results of the research on papaya leaf extract showed that the protein content in purification pellet 1 was 196,22 µg/ml and purification pellet 2 was 306,33 µg/ml. In papaya leaves, fibrinolytic activity was proven with the optimal percentage of blood clot lysis in purification pellet 2 with a concentration of 80% which was 79%.
Evaluasi Kepatuhan Pengobatan Menggunakan Google Form Pasien Pneumonia di Wilayah Kota Pontianak Robby Najini; Shoma Rizkifani; M. Akib Yuswar; Yeni Utari Ningsih; Ade Ferdinan
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21945

Abstract

Pneumonia is an acute infection with the first line of treatment is antibiotics, so it is necessary to study patient adherence in undergoing treatment using the Medication Adherence Rating Scale (MARS) questionnaire through the Google Form. This study aims to determine the percentage of characteristic descriptions including age, gender, and treatment regimen, know the percentage level of patient adherence in undergoing treatment, as well as knowing the significant difference between monotherapy and combination therapy groups on treatment adherence to pneumonia patients under five in Pontianak City. The method used is an observational method with a cross sectional research design that is analytic. The data was collected by filling out the MARS questionnaire through the Google Form and the data were analyzed using the Chi-Square test method. The results showed that patients aged 4 years (56.1%), male patients (73.7%), monotherapy (70.2%), and high adherence (80.7%). The results of the Chi-Square test showed that there was no significant difference between the monotherapy and combination therapy groups on compliance with pneumonia patients, with values (RR = 0.354; 95% CI = 0.125-1.004). The conclusion of this study the use of Google Form as a survey medium is the percentage of pneumonia sufferers is greater in patients aged 4 years, male, the most commonly prescribed therapy regimen is monotherapy, and patient adherence falls into the high adherence category. There was no significant difference between monotherapy and combination therapy groups on compliance with pneumonia patients in Pontianak City.
Aktivitas Kombinasi Krim Daun Pare (Momordica charantia L) dan Kulit Jeruk (Citrus nobilis) dalam Penyembuhan Luka Bakar I Made Agus Sunadi Putra; Made Dwik Lestari; Ni Nyoman Wahyu Udayani; Ketut Agus Adrianta; Nyoman Budiartha Siada
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.21269

Abstract

Burns are injuries to the skin caused by heat, fire, hot steam, exposure to chemicals, solar radiation, or electric shock. Burns need to be treated immediately because they can cause infection in the skin. Healing burns can be done by utilizing several types of existing plants, namely bitter melon leaves and orange peels which are known to be able to help heal burns because they contain secondary metabolites such as flavonoids, tannins, saponins, steroids, alkaloids, and terpenoids which can be used for wound healing. The purpose of this study was to determine the effect of a combination of bitter melon leaf extract cream and orange peel as healing burns in white rats. This research is a quantitative study using laboratory experimental methods with a post test only control group design. In this study, male white rats were made with wounds on the back skin. Using 20 white rats divided into 5 different treatment groups. The negative control was given a cream base, the positive control was given Burnazin cream, F1 3% : 5%, F2 ie 4% : 4%, F3 ie 5% : 3%. The wound was smeared with preparations according to group division and carried out for 14 days. Based on the results of observations of the effect of a combination of bitter melon leaf extract and orange peel cream at F1 concentrations with a concentration ratio of 3%: 5%, it has a faster healing effect on burn area. Based on the results of the Kruskal wallis test on the healing of second degree burns in male white rats, there was a significant difference. The p value or sig is 0.014, so it can be concluded that there is a significant difference between the healing areas of burns in white rats.
Pengaruh Faktor Komunikasi, SDM, Disposisi Dan Struktur Birokrasi Dalam CDAKB Serta Dampaknya Terhadap Kinerja Usaha PAK Astuti, Dewi; Aritonang, MGS; Fuad Afdhal, Ahmad
Journal Syifa Sciences and Clinical Research (JSSCR) Vol 6, No 2 (2024): Volume 6 Edisi 2 2024
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v6i2.27574

Abstract

Medical devices are instruments, apparatus, machines and implants that do not contain drugs that are used to prevent, diagnose, cure and relieve disease, treat sick people, restore human health and form the structure and improve body function. In the Minister of Health Regulation Number 4 of 2014 article 2 paragraph (1) it is stated that "Every medical equipment distributor and medical equipment distribution branch in carrying out distribution activities is obliged to implement Good Medical Device Distribution Methods". The aim of this research is to determine the influence of communication, resource, disposition and structural factors on how to distribute medical devices well and their impact on the business performance of medical equipment distributors. The research method used is descriptive research with a quantitative approach. Data was obtained through interviews and filling out questionnaires with 92 respondents from medical equipment distribution businesses. The results of the research show that the factors of communication, resources, disposition and bureaucratic structure have a positive influence on the implementation of Good Medical Device Distribution Methods, the implementation of Good Medical Device Distribution Methods has a positive influence on the business performance of Medical Equipment Distributors and the communication, resources, disposition and The bureaucratic structure has a positive influence on the business performance of Medical Equipment Distributors. Based on the research results, it can be concluded that the variables of communication, resources, disposition and bureaucratic structure have a positive effect on the implementation of CDAKB and PAK. The variables of CDAKB implementation, communication, resources, disposition and bureaucratic structure also have a positive influence on PAK's business performance.
Aktivitas Antioksidan Daun Sirsak (Annona muricate L.): A Systematic Review Rahayu, Rinoa Sahda; Wulandari, Cyntia
Journal Syifa Sciences and Clinical Research (JSSCR) Vol 7, No 1 (2025): Volume 7 Edisi 1 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i1.29345

Abstract

Antioxidants are compounds that can ward off free radicals that can affect health. This study aims to identify antioxidant compounds in soursop leaves through a literature review writing method with reference to PRISMA. Which was conducted between 12 and 14 December 2024 online through Dimension with the keywords "soursop leaves"; OR/AND "antioxidants". According to the findings of this review, three journals were identified that discuss the antioxidant activity of soursop leaves (Annona muricata L.) using the DPPH method, as indicated by the IC50 results. There were 3 articles that were included in the selection and the results showed that soursop leaves are used as a source of natural antioxidants that are effective in fighting free radicals.
Analisis Cemaran Logam Berat Merkuri (Hg), Timbal (Pb), dan Tembaga (Cu) pada Sungai Provinsi Gorontalo H. Hutuba, Ariani; Maku, Mohamad Aditya; Taupik, Muhammad; Adam Mustapa, Mohamad; Andy Suryadi, A. Mu'thi
Journal Syifa Sciences and Clinical Research Vol 7, No 1 (2025): Volume 7 Edisi 1 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i1.29865

Abstract

Heavy metals are a group of elements with high density (5 g/cm³) and unique chemical properties. They can be toxic and hazardous to the environment and human health. Heavy metal contamination in river waters is commonly caused by mercury (Hg), lead (Pb), and copper (Cu). This study aims to analyze the concentration of these metals in several rivers in Gorontalo Province using Atomic Absorption Spectrophotometry (AAS). Water samples were collected from four different rivers at a depth of 0.5 meters. The results showed that Hg concentration in the Bulango River exceeded the established quality standards, while Pb and Cu levels in the Bone River were within safe limits. The Limboto and Hulawa Rivers also met the quality standards.
Analisis In Silico Senyawa Curcuma xanthorrhiza dan Moringa oleifera sebagai Kandidat Antiinflamasi Syamsi, Lusi Nursilawati; Syamsudin, Syamsudin; Mumpuni, Esti; Widowati, Wahyu; Nursanti, Okta; Qodriah, Rahmatul
Journal Syifa Sciences and Clinical Research (JSSCR) Vol 7, No 1 (2025): Volume 7 Edisi 1 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i1.30385

Abstract

Inflammation is the body's immune response to pathogens, tissue injury, or exposure to toxic substances. The search for effective anti-inflammatory agents remains a key focus in pharmaceutical and healthcare research. Temulawak (Curcuma xanthorrhiza) and Moringa (Moringa oleifera) have been widely used in traditional medicine due to their bioactive compounds with potential anti-inflammatory effects. This study aims to evaluate the molecular interactions between curcumin from temulawak, as well as quercetin and kaempferol from moringa, against inflammatory targets using an in silico approach through molecular docking and molecular dynamics simulations.
Hubungan Pola Makan dengan Kejadian Gastroesophageal Reflux Disease pada Mahasiswa di ITSK RS dr.Soepraoen Malang Alaya, Vandela Nikita; Permata, Agung; Rahmawati, Siti
Journal Syifa Sciences and Clinical Research Vol 7, No 1 (2025): Volume 7 Edisi 1 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i1.30681

Abstract

College students are a vulnerable group that experiences gastroesophageal reflux disease (GERD), because it is influenced by factors such as psychological stress and unhealthy eating habits. Factors that make students susceptible to GERD are influenced by unhealthy eating habits. This is caused by a fairly heavy academic load, such as a busy lecture schedule, high frequency of exams and assignments, and limited rest time. This disease is characterized by the entry of stomach acid into the esophagus, which is caused by dysfunction in the lower part of the esophagus. which is characterized by symptoms of chest pain such as heartburn, regurgitation, difficulty swallowing, and sore throat. This condition contributes to digestive system disorders, so that the incidence of GERD is increasing. This study aims to reveal the relationship between diet and the incidence of gastroesophageal reflux disease (GERD) among college students. This study applies a non-experimental correlative quantitative approach and uses a cross-sectional design. Data were collected using a purposive sampling technique, involving 75 respondents who were final year students at the Faculty of Science and Health, dr. Soepraoen Hospital Malang. The measuring instruments used in this study were the Gastroesophageal Reflux Disease Questionnaire (GERDQ) and the Diet History Questionnaire (DHQ), which were distributed via Google Form. The results of the statistical analysis showed that 30 students (40.00%) had gastroesophageal reflux disease (GERD), 45 students (60.00%) did not have GERD, while 32 students (42.67%) had poor diet and 43 students had good diet with a percentage (57.33%). Data analysis using the Spearman rank correlation test found that there was a significant relationship between diet and the incidence of GERD, with a significance value of 0.000, 0.05. The results of the indicated correlation strength were strong, with a value of 0.638
The Impact of Nutrition Education Intervention on Parental Knowledge to Prevent Child Stunting Laksmi Puspa Sari, Gusti Ayu Putu; Ari Kusuma Yana, I Gusti Agung; Irawati Wibowo, Yosi
Journal Syifa Sciences and Clinical Research Vol 7, No 2 (2025): Volume 7 Edisi 2 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i2.30531

Abstract

Stunting remains a significant health problem among children worldwide. Stunting has an impact on children's physical and cognitive development; if it is not addressed in the earliest stage, it can lead to decreased national productivity and economic growth. Whilst parents play a crucial role in preventing stunting in children, ensuring they have adequate knowledge is essential. This study aimed to determine the effect of educational intervention on the level of knowledge among parents in preventing child stunting. This is a pre-experimental study using a pretest and posttest design. This study involved a sample of 93 respondent in an area in the Bali area. The educational intervention involving a single session of health education focused on increasing knowledge about childhood stunting. Pre-test dan post-test was conducted before and after the intervention, and the results were categorized into good, simply and less. Pre-test and post-test data was analysed using a paired t-test. The results showed a significant increase in the percentage of parents with good knowledge from 11.8% in the pre-test to 30.1% in the post-test (p-value 0.001). This finding showed the effectiveness of educational interventions to enhance parental knowledge, which might increase their participation in preventing the risk of child stunting.
In Silico Study of Acmella uliginosa Leaf Compounds Interaction with Human Glucosidase Marlina Kurnia, Nia
Journal Syifa Sciences and Clinical Research Vol 7, No 2 (2025): Volume 7 Edisi 2 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i2.30890

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or action. Glucokinase (GK) plays a crucial role in glucose homeostasis and is considered a promising therapeutic target for DM treatment. This study aims to evaluate the in silico interaction between the bioactive compound N-(2-phenylethyl)(2E,6Z,8E)-decatrienamide from Acmella uliginosa (Sw.) and the human GK crystal structure (PDB ID: 1V4S) using Molegro Virtual Docker software. Molecular docking analysis revealed that N-(2-phenylethyl)(2E,6Z,8E)-decatrienamide exhibits a high binding affinity to GK. Physicochemical and pharmacokinetic predictions using pkCSM indicate that this compound has a favorable pharmacokinetic profile, including high intestinal absorption and the ability to cross the blood-brain barrier. These findings suggest that N-(2-phenylethyl)(2E,6Z,8E)-decatrienamide is a promising candidate for the development of natural product-derived antidiabetic drugs. However, further in vitro and in vivo studies are required to validate its biological activity and safety.

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