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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Studi Fenomenologi : Pengalaman Keyakinan Diri Terhadap Penyembuhan Covid-19 Arizki Rahman Hakim; Ichsan Budiharto; Muhammad Ali Maulana
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.19122

Abstract

The Covid-19 pandemic requires every exposed community to selfisolate, including nursing students. When required to self-isolate, nursing students have many stressors that affect their self-confidence (Self Efficacy). Objective to explore the self-efficacy experience of nursing students at X University during the self-isolation process. Using a qualitative design with a phenomenological approach as many as six participants with the snowball sampling method. Collecting data using a semi-structured interview method for 10-20 minutes using thematic analysis. There were four themes identified from the thematic analysis, namely (1) exposure to Corona Virus Disease (Covid-19) which explained how participants were exposed to Covid-19, when participants were Covid-19, and the signs and symptoms that participants felt; (2) self efficacy enhancement strategies in the form of fulfilling basic needs, fulfilling information needs, and coping mechanisms; (3) self efficacy factors, namely the support of the surrounding environment, expectations, motivation, and level of knowledge; and (4) Barriers to increasing self efficacy in the form of changes in physical condition, stress load, and interaction and communication. The description of the experience of nursing students' beliefs when doing independent isolation is influenced by several aspects including exposure to Covid-19, improvement strategies, self efficacy, self efficacy factors, and barriers to increasing self efficacy.
Analisis Kandungan Flavanoid Daun Sambang Darah (Excoecaria cochinchinensis L) Ariani H. Hutuba; A. Mu'thi Andy Suryadi; Faramita Hiola
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.7157

Abstract

Flavonoids are chemical compounds derived from plants which are a group of secondary metabolites. Flavonoids Flavonoid compounds are polyphenolic compounds that have 15 carbon atoms arranged in a C 6 -C 3 -C 6 configuration, namely two aromatic rings connected by 3 carbon atoms that can or cannot form a third ring. Flavonoids are widely distributed in angiosperms, gymnosperms, and pteridopites. These flavonoids provide physiological and pharmacological effects on living things. The purpose of this study was to identify the flavonoid compounds present in the leaf extract of the blood sambang plant (Excoecaria cochinchinensis L). In this study, a multilevel maceration extraction was used using n-hexane, ethyl acetate and methanol solvents and then the filtrate was evaporated using an evaporator. Positive phytochemical screening results indicated the presence of flavonoids in methanol extract and negative in n-hexane and ethyl acetate extracts. From the methanol extract, TLC was carried out with an eluent ratio of methanol ethyl acetate (8: 2), it was obtained the separation of two stains where one of the stains had the same Rf value as the Rf value of flavonoids, then performed a UV-Vis spectrophotometric analysis resulting in three absorption wavelengths, namely band I (350 nm) and band II (255 nm and 267 nm). the spectrum obtained is a class of flavone compounds.
Potensi Ekstrak Biji Pala (Myristica fragrans L) Terhadap Penyembuhan Luka Bakar pada Mencit (Mus musculus) Widy Susanti Abdulkadir; Endah Nurrohwinta Djuwarno; Dizky Ramadani Putri Papeo; Zulkarnain Marhaba
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18996

Abstract

The Nutmeg Plant (Myristica Fragrans L) is one of the spices plants empirically used as a therapeutic option for injury healing. Burn injury is damage to the skin's integrity caused by contact with a source with a high-temperature difference. This research aimed to determine the effectiveness of Nutmeg (Myristica Fragrans L) Seed extract on burn injury healing in Male Mice (Mus Musculus). Extraction was carried out through Maceration with Methanol solvent. Eighteen mice were divided into 6 groups: negative control (Na-CMC), positive control (Bioplacenton), and treatment groups with concentrations of 3%, 5%, 7%, and 10%. Burn injury was created using a 2 cm x 2 cm iron plate on the mice's back, and the healing of the burn injury diameter was observed from day 1 to day 20, with observation intervals at day 5, 10, 15, and 20. The data were analyzed using one-way ANOVA followed by an LSD test to determine the differences between test groups. The resalts indicate that the ethanol extract of Nutmeg (Myristica Fragrans L) see haseng effect on burn injury, with the most effective concentration being the extraet onoration of 10%, with a burn injury healing rate of up to 89,15%.
Kepatuhan Penggunaan Obat Asma Terhadap Kualitas Hidup Pasien Asma Rawat Jalan Rumah Sakit X Gorontalo Teti Sutriyati Tuloli; Nur Rasdianah; Sitti Nurul Wildan Basrudin
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.7278

Abstract

Asthma, a chronic disease, is characterized by the inflammation in the respiratory tract, followed by coughing, wheezing, and difficulty breathing. This cross-sectional research was intended to explore the effect of medical compliance on the quality of life of outpatients with asthma. It employed a non-experimental analysis. All 30 respondents were outpatients visiting Gorontalo x hospital they were selected purposively. The compliance level was examined using a relevant questionnaire, while the quality of life was examined using Mini-AQLQ questionnaire. The result of the chi-square test, revealing that 95% of confidence interval; ? = 0.05, where p 0.405 (p ?) OR 2.216, suggesting that the medical compliance did not affect the quality of life. One can argue that this notion, thereby, signifies the necessity to view the quality of life of patients with asthma as a complex issue from multiple perspectives
Evaluasi Tingkat Terhadap Pengetahuan Sikap dan Tindakan terhadap Swamedikasi : Studi Kasus Kecamatan Una-Una Provinsi Sulawesi Tengah Dizky Ramadani Putri Papeo; Teti Sutriati Tuloli
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.9817

Abstract

Self-medication is an attempt to use drugs by a person to treat ailments or minor symptoms such as fever, dizziness, cough, influenza, and other diseases using modern and traditional medicines without a doctor's prescription or recommendation.The purpose of this study was to describe the knowledge, attitudes, and actions of self-medication carried out by the community. This was a descriptive cross-sectional study with a total sample of 93 respondents taken by purposive sampling. Data were collected by filling out a questionnaire that had been tested for validity and reliability.The results showed that the majority of respondents in Una-Una District, Central Sulawesi Province were women (57%) with a majority age range between 40 - 50 years (33%), with High School/Vocational/Islamic High School educational background (33%), and had different jobs (40%). The level of knowledge, attitudes, and actions of the community regarding self-medication was classified as good with the percentage of the knowledge level of 61%, the attitude level of 57%, and the level of action of 74%.
Pengukuran Kualitas Hidup Penderita Hipertensi Menggunakan Instrumen EQ-5D-5L Abang Raffli; Muhammad Akib Yuswar; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18103

Abstract

Hypertension can affect the quality of life. Poor quality of life is caused by complications with comorbid conditions such as heart disease, kidney disease, and diabetes mellitus. Hypertension occurs when a person's blood pressure is above the normal or optimal limit, namely 120 mmHg for systolic and 80 mmHg for diastolic. This study aims to determine the quality of life of patients with hypertension. This research is an observational study with a prospective cross sectional study design. Data were collected by purposive sampling at the x Health Center that met the inclusion criteria using the European Quality of Life 5 Dimensions 5 level (EQ5D5L) Questionnaire instrument. The data is then converted into a single summary index using the index calculator EQ 5D. From the results of the study, there were 68 cases of hypertension that matched the inclusion criteria, based on gender, it was dominated by 70.5% women with ages 55 to 65 years by 82% with the highest index score percentage 1 (29.41%) and the lowest 0.592. (8.82%) Measuring the quality of life of hypertensive patients at the x Health Center using the EQ5D5L instrument is categorized as good if the EQ5D5L index obtained is 0.5.
Studi Penjaminan Mutu (Quality Assurance) Internal Dalam Pelayanan Kefarmasian Madania Madania; A. Mu’thi Andy Suryadi; Faramita Hiola; Rahmawati Marjun
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20359

Abstract

Pharmaceutical services in hospitals aim to improve the quality of pharmaceutical services, protect patients from irrational drug use to maintain patient safety, and ensure legal certainty for pharmacists. Quality Assurance (QA) is used in measuring service quality, whereas QA in IFRS aims to provide assurance of product quality and the quality of pharmaceutical services provided to patients. This research employs descriptive research with a cross-sectional method, and primary date are obtained from questionnaires with the framework of QA standard indicators in pharmaceutical services at the primary Installastion of Mother and Child Hospital Kasih Fatimah Kotamobagu, with five respondents. The results indicate that internal quality assurance in pharmaceutical services at the Fatimah Kotamobagu Mother and Child Hospital Kasih Fatimah Kotamobagu Pharmacy Installation was in accordance with quality assurance standards, especially in the aspects of organizational structure, quality measures, and safety assurance, as well as drug distribution with an overall value in the criteria, are (75%), moderately appropriate are (15%) and not appropriate are (10%).
Isolasi, Karakterisasi, dan Uji Antioksidan Fungi Endofit dari Tanaman Batang Kunyit (Curcuma domestica Val.,) Mahdalena Sy. Pakaya; Nur Ain Thomas; Hamsidar Hasan; Ariani H. Hutuba; Grasela Mbae
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20341

Abstract

Endophytic fungi live in mutualistic symbiosis and can produce secondary metabolites similar to their host. This research aims to isolate, characterize, and test the antioxidant activity of secondary metabolites from turmeric stems. This research is experimental research where the method used for endophytic fungi isolation is the direct planting method, and antioxidant activity is tested using qualitative and quantitative methods with DPPH (1.1-diphenyl-2-picylhydrazyl). One fungal isolate was obtained with the fungal isolate code (BK). Based on macroscopic and microscopic characterization, the BK fungal isolate indicates the Deuteromycota class's characteristics. The qualitative antioxidant test results indicate that the fraction of BK endophytic fungal isolate indicates antioxidant activity, indicated by the yellow color against a purple background on the TLC plate observed under visible light. The respective ICso values for the ethyl acetate and n-hexane fractions were 52.989 µg/ml and 89.725 µg/ml, categorized as strong antioxidants. The methanol fraction had an ICso value of 119.02 µg/ml, categorized as moderate, while the pure supernatant fraction had an ICso value of 156.86 µg/ml, categorized as weak antioxidant activity.
Uji Penyembuhan Luka Bakar Gel Enzim Bromelin Menggunakan Carbopol 940 Secara In Vivo Nur Ain Thomas; Muhammad Taupik; Endah Nurrohwinta Djuwarno; Dizky Ramadani Putri Papeo; Nabila Novreini Djunaidi
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20364

Abstract

Bromelain is a proteolytic enzyme or natural protease found in tissues, including the stem, fruit, and leaves of pineapple (Ananas comosus var. comosus) and other plant species of the Bromeliaceae family. Bromelain is known as an efficient debdriding agent because it is beneficial in  burn healing and tissue regeneration. This research aims to determine the effectiveness of bromelain enzyme for burns wounds in rabbits (Oryctolagus cuniculus). This research began with the optimization of carbopol 940 base preparations with variations in concentration, namely Formula 1 (F1) for 0,5%, Formula 2 (F2) for 1%, and Formula 3 (F3) for 1,5%. The evaluation of the gel formulation includes an organoleptic test, homogeneity test, pH test, viscosity test, adhesive force test, and spreadability test. The evaluation result indicates the base concentration in Formula 1 (F1) at 0,5% has met the requirements for a gel preparation. Formula 1 (F1) for 0,5, then combined with varying concentration of bromelain, namely Formula 1A (0,1%), Formula 1B (0,5%), and Formula 1C (1%). The gel formulation wa re-evaluated, including an organoleptic test, homogeneity test, pH test, viscosity test, adhesion test, spreadability test, irritation test, and in vivo test. In vivo effectiveness testing and irritation testing were conducted on five treatment groups, namely a positive control group (Bioplacenton®), Formula 1A (0,1%), Formula 1B (0,5%), Formula 1C (1%), and a group without treatment, then observed for 15 days. The observation data were processed using the One Way ANOVA test. Based on the results of the irritation test, Formula 1A (0,1%). Formula 1B (0,5%) and Formula 1C (1%) did not cause skin irritation. In the in vivo test, Formula 1C (1%) indicated the fastest recovery compared to other treatment groups, as evidenced by the decrease in wound diameter and visual observation, where the wound had started to close completely on day 15 of observation.
Potensi Interaksi Obat Antidiabetes Melitus Tipe-2 dengan Obat Antihipertensi Widy Susanti Abdulkadir; Endah Nurrohwinta Djuwarno; Nur Rasdianah; Juliyanty Akuba; Mimi Fauziah Tahir
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.18042

Abstract

The effect caused by the use of antidiabetic and antihypertensive drugs combination needs to be considered. The treatment therapy of the patient has the potential risk of drug interactions that are beneficial or detrimental to the patient. This study aims to determine the potential drug interactions in combinations of antidiabetic and antihypertensive drugs. This research is a descriptive study with a cross-sectional design and retrospective data collection. The sample used is medical records of diabetes mellitus patients with comorbid hypertension from January to December 2021 at Batudaa Public Health Center, Gorontalo Regency. The results showed that there were more female patients than male patients. Based on this study. there were 49 female patients (70%), while the largest age group of 50-59 years included 29 patients (41,43%). Whereas, those with the highest potential for drug interactions were metformin and amlodipine, totaling 54 patients (77%). The mechanism of interaction in this study was the pharmacodynamic phase, and the potential to cause the effect was hypoglycemic through the severity of the interaction was moderate level. 

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