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Majalah Patologi Indonesia
Published by Perhimpunan Ahli Patologi Indonesia
ISSN : 02157284     EISSN : 25279106     DOI : https://doi.org/10.55816/
Core Subject : Health,
Health Professions Public Health
Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 8 Documents
 1 
Search results for , issue "Vol. 34 No. 2, Mei 2025" : 8 Documents clear
The Correlation of Clinicopathological Characteristics in Clear Cell Renal Cell Carcinoma (ccRCC) with Immunohistochemical Expression of Light Chain 3 B (LC3-B) Rezeki, Dewi Sri; Alferraly, T. Ibnu; Chrestella, Jessy; l, Lidya Imelda; Lukito, Joko S.
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.680

Abstract

Background: Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype in RCTs. This tumor is very aggressive and is often diagnosed at an advanced stage. LC3-B is a specific autophagy marker that plays a role in ccRCC. Research regarding the relationship between clinicopathological characteristics of ccRCC and LC3-B expression is still very limited and controversial. Objective: To assess the relationship between clinicopathological characteristics of ccRCC and LC3-B immunohistochemical expression. Materials and methods: This study used 22 slide samples/paraffin blocks of ccRCC cases that had been diagnosed histopathologically at the Anatomic Pathology Unit of H. Adam Malik General Hospital, Medan from January 2017 to April 2023. All clinicopathological data was taken from medical records/pathology archives. LC3-B expression was assessed in the cytoplasm of tumor cells with assessment semiquantitatively based on the multiplication of intensity and percentage of expressed tumor cells. Statistical analysis was carried out using Fischer's Exact and Kruskal Wallis tests. Results: Among the 22 ccRCC samples, weak expression of LC3-B was found in the age group ≤60 years, male gender, tumor size >10 cm, positive LVI, negative PNI, grade IV, severe stromal TILs, mild intratumoral TILs and low budding in intratumoral budding tumors. Fischer's Exact and Kruskal Wallis statistical tests showed that there was no significant relationship between gender, tumor size, LVI, PNI, ISUP grading, TILs and peritumoral tumor budding with LC3-B expression. Conclusion: There was no significant relationship between clinicopathological characteristics of ccRCC with LC3-B expression (The Null Hypothesis is accepted (H0 ρ=0)). Key words: clinicopathology, ccRCC, LC3-B
Imunohistokimia S100 Dapat Mengidentifikasi Pola Kerusakan Saraf Tepi Pada Morbus Hansen Tipe Pausibasiler dan Multibasiler Citra, Dandy; Sriwidyani, Ni Putu; Saputra, Herman
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.605

Abstract

Background Morbus Hansen (MH) is a granulomatous infectious disease of the skin caused by Mycobacterium leprae, which induces skin lesions and peripheral nerve injuries that can cause physical disabilities. The basis of the diagnosis of MH is based on classic clinical signs, characteristic histopathological findings and demonstration of acid-fast bacilli in skin biopsies. However, determining neurovascular involvement in a granulomatous reaction is challenging in pathologic diagnosis. S100, a marker of pheripheral nerve, may aid MH diagnosis. The aim of this study to determine different pattern of S100 immunostaining in paucibacillary and multibacillary type MH. Methods This research was an analytic cross-sectional study. Sample was MH patients who underwent a skin biopsy and was examined for histopathology by routine H&E staining and Ziehl Neelsen (ZN) staining at the Anatomical Pathology Laboratory, Faculty of Medicine, Udayana University/Prof.Dr. I.G.N.G Ngoerah hospital, Denpasar from 2017 to 2022. Clinical information, histopathological examination results and ZN stain data were obtained. Pattern of neurovascular damage was determined by S100 immunohistochemistry and catagorized into intact infiltrated pattern and reduced/fragmented infiltrated patterns. The association between MH type and S100 staining pattern was analyzed by Chi-square test with a significance value of p<0.05. Results The results showed that the staining pattern in paucibaciler type MH was mostly reduced/fragmented infiltrated pattern, meanwhile in multibacillary type MH was mostly intact infiltrated pattern. There was a significant different S100 immunostaining pattern in Paucibaciler and Multibaciler MH (p=0.001). Conclusion S100 immunostaining can identify differences in staining patterns in cases of paucibacillary and multibacillary MH types. S100 may used as aditional testing to determine neurovascular involvement.
KEMAMPUAN PEWARNAAN ZIEHL-NEELSEN DAN FITE FARACO UNTUK MENDETEKSI MYCOBACTERIUM SP. PADA SAMPEL JARINGAN : A LITERATURE REVIEW Dwi Putri, Riska; Usman, Hermin Aminah; Agustina, Hasrayati
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.625

Abstract

Histopathology is an essential method for disease diagnosis. It is crucial for clinicians to have an ideal diagnostic method that is simple, specific, and highly sensitive. The sensitivity and specificity of a test can be determined by comparing it with other tests. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Mycobacterium tuberculosis is diagnosed using Ziehl-Neelsen staining, which dif erentiates acid-fast bacilli from non-acid-fast bacilli. The Fite Faraco staining technique is used to detect Mycobacterium sp in tissue specimens. All reviewed articles show that Ziehl-Neelsen staining has a sensitivity between 21% - 97.6%, specificity between 85.7% - 92%, NPV between 34.3% - 75%, PPV between 30.9% - 100% in detecting Mycobacterium sp in tissue samples. Fite Faraco staining shows a sensitivity between 50% - 74.6%, specificity between 84% - 100%, NPV between 33.6% - 56.7%, PPV 38.1% in detecting Mycobacterium sp in tissue samples.It is detected that Ziehl-Neelsen and Fite Faraco can be used to detect bacteria, Mycobacterium sp especially bacteria Mycobacterium tuberculosis and Mycobacterium leprae. However, Ziehl-Neelsen staining has better ability in terms of sensitivity, PPV, and NPV than Fite Faraco in detecting bacteria Mycobacterium sp, especially Mycobacterium tuberculosis. As Fite-Faraco staining is superior in terms of specificity. Other things that must be Considered in carrying out Ziehl-Neelsen and Fite Faraco staining are specific types of samples, making modifications such as modifying microwave heating on the Ziehl-Neelsen staining method and combining examination with H&E staining and multiplex PCR to increase the validity of the two staining methods.
Comparison of Peritumoral Budding Features in Colorectal Adenocarcinoma NOS by Hematoxylin-Eosin (HE) Staining and Pancytokeratin (AE1/AE3) Immunohistochemistry Listiyaningsih, Listiyaningsih; Laksmi, Lidya Imelda; Mariedina, Causa Trisna; Betty, Betty; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.639

Abstract

Background Colorectal adenocarcinoma is defined as a malignant epithelial tumor of the large intestine (colon and rectum) that shows glandular and mucinous differentiation, accompanied by invasion through the muscular mucosae into the submucosal layer. Peritumoral budding refers to tumor budding at the leading edge of the tumor and can be considered one of the prognostic factors. Immunohistochemistry Pancytokeratin (AE1/AE3) is observed in the epithelium, and most carcinomas (tumors originating from epithelial cells) are stained in the cytoplasm. Method The analytical study involved 48 paraffin block samples diagnosed as colorectal adenocarcinoma NOS at Haji Adam Malik Central General Hospital in Medan and the laboratory of the Faculty of Medicine, Universitas Sumatera Utara. The assessment of tumor budding using hematoxylin-eosin staining and pan-cytokeratin (AE1/AE3) immunohistochemical staining was classified equally into three categories: low budding category if 0-4 buds of tumor budding were observed, intermediate budding category if 5-9 buds of tumor budding were observed, and high budding category if ≥10 buds of tumor budding were observed. Results There is no difference in assessing peritumoral budding using Hematoxylin-Eosin (HE) staining and pan-cytokeratin (AE1/AE3) immunohistochemical staining. Conclusion Assessment of peritumoral budding is recommended using Hematoxylin-Eosin (HE) staining.
Clinicopathological Characteristics of Ocular Surface Squamous Neoplasia in National Eye Center, Cicendo Eye Hospital Bandung from 2019 to 2022 Nia Nuraeni; Aminah, Hermin; Agustina, Hasrayati; Mardianty, Friska
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.649

Abstract

Introduction Ocular surface squamous neoplasm (OSSN) comprises a broad spectrum of dysplastic alterations of the squamous epithelium of the conjunctiva, ranging from conjunctival squamous intraepithelial neoplasm (CSIN) to squamous cell carcinoma (SCC). The aim of this study was to describe the clinicopathological characteristics of OSSN at National Eye Center, Cicendo Eye Hospital Bandung from January 2019 to December 2022. Methods We collected OSSN data from 2019 to 2022. The collected data were the patient's age, gender, education, occupation, laterality, clinical features, recurrence, and classification of tumor according to the 2022 WHO classification. Results: A total of 128 cases were collected. The most common tumor identified was SCC (48.4%), followed by CSIN with severe dysplasia (25%), moderate dysplasia, and mild dysplasia (14.8% and 11.7%, respectively). The average patient’s age was 53.1 years (M = 53.1, SD =16.9), predominantly males (68%), education completed elementary school (52.3%), and more patients worked outdoor (59.4%). The most common affected site was the left eye (53.9%), and the tumor located in the nasal region (78.1%) with clinical features is papilliform (64.1%). Conclusion OSSN was predominant in elderly male patients. The majority of cases were seen in the left eye, primarily in the nasal area. The majority of patients had completed elementary school and worked outdoors. Additionally, the clinical symptoms showed that most patients had papilliform. In patients with OSSN, SCC was the most common anatomical pathology discovered. Moreover, recurrence was higher in SCC cases.
Prognosis Factor and KRAS Mutation Status in Association with Overall Survival in Patients with Colorectal Adenocarcinoma in Hasan Sadikin General Hospital Ichfa Namira; Aminah, Hermin; Yulianti, Herry
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.655

Abstract

Introduction: Colorectal adenocarcinoma is a malignant epithelial tumor originating from the colon. Colorectal adenocarcinoma is the most common colorectal carcinoma. We aim to analyze the association between prognostic factors and KRAS mutation status with overall survival in patients with colorectal adenocarcinoma in Hasan Sadikin General Hospital. Methods: This retrospective analysis investigated the prognostic factors and KRAS mutation status in 27 patients with stage III and IV colorectal adenocarcinoma. KRAS mutations were assessed using PCR. Results: A total of 27 cases were collected and analyzed. Patients dominated with female patients (74.1%), with more than half of the patients aged>50 years old (55.6%). Most patients had tumors in their right colon (48.1%) and stage III when they were diagnosed (81.5%). 55.6% of patients had a mutation dominated by KRAS codon 12 (25.9%). The median overall survival was 13 months. Age and tumor site were statistically significant to overall survival (p<0,05); the median OS was seven months for patients whose diagnosis was < 50 years old. The median OS of patients with tumors in the right colon had a median OS of 30.6 months. Gender, KRAS mutation, and stage at diagnosis had no statistical significance on overall survival. Conclusions: Adenocarcinoma colorectal in Hasan Sadikin Hospital from 2016 until 2020 mainly occurred in women over 50 years old, with the most common location being in the right colon and most of the patients were at stage III when they were diagnosed. Most of patient’s in this study have mutation in KRAS. Age and tumor site had statistical significance on overall survival. Keywords: Adenocarcinoma colorectal, KRAS mutation, overall survival, prognostic factor
Correlation between GATA3 Immunohitsochemistry and TP53 on some Ovarium Carcinoma Histopathology Subtype Alamanda, Intan Nefia; Betty, Betty; Delyuzar, Delyuzar; Chrestella, Jessy; Soekimin, Soekimin
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.665

Abstract

Background Ovarian carcinoma is a cancer with high mortality in women, although comprehensive treatment with surgery and chemotherapy is at an advanced stage, survival rates are still low. GATA3 and p53 are predictors of some malignancies, but results vary in ovarian carcinoma. Objective To examine correlation between immunohistochemical expression of GATA3 and p53 in patients with ovarian carcinoma with various histopathological subtypes. Materials and Methods Cross sectional design is the method of this study conducted on slides of 28 ovarian carcinoma patients in several subtypes of hitopathology. Each slide was stained with hematoxylin and eosin (H&E) to assesses hitopathological subtypes and stained with GATA3 and p53 antibodies. Expression GATA3 was assessed using H-score and p53 quick score. A logistic regression assay (p<0.005) was used to assessed the association of GATA3 and TP53 immunohistochemical expression in several histopathological subtypes of ovarian carcinoma. Statistical analysis between GATA3 and p53 was performed using the eta correlation test is used because the data is nominal-ordinal. Results Among 28 specimens in patients with ovarian carcinoma, Cases was most prevalent in the age group >50-60 years (age range 58 years), history of nullipara parity, and most in the group of stage III ovarian malignancy. Positive immunohistochemical p53 expression is more prevalent in serous carcinoma. Positive GATA3 immunohistochemical expression is more prevalent in serous carcinoma. Conclusion There is no significant relationship. Immunohistochemical expression of GATA3 and TP53 in some histopathological subtypes of ovarian carcinoma. However, immunohistochemical expression of GATA3 high p53 positive tends to be found in high-grade serous carcinoma. Keywodrs: GATA3, p53, karsinoma ovarium, Serous carcinoma, Mucinous carcinoma, Endometrioid carcinoma, Clear cell carcinoma.
English: English Ramkita, Nora; Krisna Murti; Citra Dewi
Majalah Patologi Indonesia Vol. 34 No. 2, Mei 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i2.668

Abstract

Background A frozen section or vries coupe (VC) is an examination procedure performed by a pathologist during a patient operation on the surgical table. VC provides immediate information to surgeons regarding the benign or malignant status of a tissue, as well as determines the incision margin free from tumor mass. Objective This study aimed to evaluate diagnostic accuracy using the slide preparation archives of VC and histopathology at the Anatomic Pathology Department of Dr. Mohammad Hoesin Central General Hospital (RSUP), Palembang. Methods: Samples of patients were collected from 1 January 2021 to 1 October 2023, while sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for VC were assessed compared to the definitive diagnosis of histopathology. A reassessment was conducted by two pathologists on slide preparations with unmatched results between VC and histopathological diagnosis. Result VC examination showed sensitivity, specificity, PPV, and NPV of 99.7%, 99.7%, 98.3%, and 98.3% for benign tumors as well as 98%, 99.6%, 98.3%, and 98.3% for malignant tumors, respectively. The reassessment of the inappropriate slide preparations obtained a weighted kappa value of 0.586, signifying moderate agreement. Diagnostic discordance is caused by the experience of pathologists, freezing artifacts, and challenges in obtaining precise samples under a limited timeframe. Conclusion This study provided valuable insights into the effectiveness of VC procedure in intraoperative tissue diagnosis, showing the need for collaborative efforts and experienced pathologists to achieve improved accuracy.

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