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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 58 Documents
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Search results for , issue "Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)" : 58 Documents clear
Evaluation and Characterization of Caryophyllene Nanoemulsion Preparations from Clove Oil (Syzigium aromaticum) Eriska Agustin; Martavinus, Whilly
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/zz7g4329

Abstract

The clove plant (Syzygium aromaticum) is a plant from the Myrtaceae family. Clove plants can be found in various countries, including Indonesia. The contents of the clove plant have been studied to have beneficial pharmacological effects, one of which is the caryophyllene content in the clove plant which has antioxidant, antibacterial, etc. activities. This research aims to create a formula and evaluate the physical characteristics of a karyophyllene nanoemulsion preparation from clove oil. The method for making nanoemulsion preparations is made into three formulas with varying concentrations of karyophyllene compounds as active substances, namely F0 (0%), F1 (0.5%), and F2 (1%). Evaluation of the preparation includes organoleptic tests, pH tests, particle morphology tests, stability tests, and nanoemulsion globule size tests. The results showed that the nanoemulsion preparations of caryophyllene compounds F0, F1, and F2 had globule sizes of 82 ± 1.45 nm, 95 ± 2.67 nm, 89 ± 1.46 nm on day 1, while on day 28 the globule sizes were 99±2.87 nm, 116±2.56 nm, and 121±1.56 nm. The nanoemulsion preparation is clear white, semi-thick, and has a distinctive aroma. The morphology of the nanoemulsion globules is spherical and homogeneous. All three nanoemulsion formulations demonstrated good physical stability, as indicated by the absence of precipitation, phase separation, and turbidity, as well as pH values within the acceptable range for nanoemulsion systems, despite a slight increase in globule size observed over the 28-day storage period.
From Laboratory to Algorithm: The Role of Computational Methods in New Drug Design Discovery in the Digital Era Fajarini, Syifa Rizkia; Amin, Saeful; Ansyirohanisa; Beni Maulana Habib; Muhammad Rahmat Darmawan
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8f4xh746

Abstract

In the digital era, the integration of computational methods in drug discovery has revolutionized laboratory practices, enhancing efficiency and accuracy in drug development. This article provides a comprehensive review of the crucial role of computational technology in accelerating the discovery of new drug compounds, highlighting its impact on the effectiveness and success of pharmaceutical development. Traditional drug discovery methods often require extensive time and high costs, with relatively low success rates in clinical trials. To address these challenges, various computational approaches, such as Molecular Docking, Quantitative Structure-Activity Relationship (QSAR), and machine learning, have been widely adopted in the pharmaceutical industry. This study employs a systematic approach to explore different computational techniques and their applications in identifying potential drug candidates. Findings indicate that computational tools significantly expedite the drug development process, reduce costs, and improve the success rates of clinical trials. The conclusion emphasizes the importance of leveraging computational technology as an innovative strategy in pharmaceutical research and development, ultimately accelerating the discovery of safer and more effective therapies. Keywords: Computation, Drug Discovery, Digital Era, QSAR, Molecular Docking.
Antibiotic Use in Digestive Surgery Patients with the Anatomical Therapeutic Chemical-Defined Daily Dose Method Saragi, Sahat; Martirini, Agnes Stefania
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/0fpekm65

Abstract

Background: The use of antibiotics serves as therapy for various types of infections caused by pathogens or for other preventive measures, such as major surgeries. Evaluating antibiotic use is necessary to ensure effectiveness, accuracy, and safety in rational usage. Purpose: The aim of this study was to evaluate the use of antibiotics at dr. T.C. Hillers Maumere General Hospital in 2019 among inpatients undergoing digestive surgery. Method: This research is a descriptive, non-experimental study with a cross-sectional design. A quantitative and qualitative approach was used, employing the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) method and the Gyssens flowchart based on retrospective data. The study involved reviewing medical records from January to December 2019. A total of 338 data samples were collected, including 9 types of oral antibiotics and 8 types of parenteral antibiotics according to the ATC classification. Results: The results showed that among oral antibiotics, Cefadroxil 500 mg had the highest DDD value at 9.51 DDD/100, while among parenteral antibiotics, Cefotaxime 1 g injection had the highest DDD value at 10.74 DDD/100. Conclution: The evaluation using the Gyssens flowchart indicated that 68.34% of antibiotic use was appropriate, while 31.66% was inappropriate. In conclusion, the use of antibiotics for digestive surgery inpatients was generally appropriate, but further evaluation is needed regarding antibiotic use that does not comply with clinical guidelines.
Hepatoprotective Activity of the Combined Leaf Extracts of Syzygium Polyanthum and Moringa oleifera Against AntituberculosisDrug-Induced Hepatotoxicity in Rats SUNDHANI, ELZA; Sigit Prasuma, Galar; Firda Ramadhani, Reninta
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/rezxt096

Abstract

Oral antituberculosis drugs (OAT) used repeatedly can negatively impact the liver. Natural compounds with high antioxidant potential could be used as hepatoprotective agents. This study aims to determine the hepatoprotective activity of the combination ethanolic leaf extract of Syzygium polyanthum (SPEE) and Moringa oleifera (MOEE) in rats administered with OAT. The hepatoprotective activity of the combination of SPE and MOE was determined by calculating the SGOT and SGPT levels of rats administered rifampicin (RMP), pyrazinamide (PZA), and isoniazid (INH) for 14 days. An experimental study using eight groups: standard control (CMCM-Na), negative control treatment with OAT (RMP 100 mg/kg BW; PZA: 252 mg/kg BW INH 50 mg/kg BW), positive control (OAT + Curcumin 100 mg/kg BW), OAT+SPEE 150 mg/kg BW group, OAT+MOEE 400 mg/kg BW group, and 3 group OAT + combination SPEE and MOEE (25%: 75%; 50%:50%; 75%:25%). SGPT & SGOT levels were determined using spectrophotometry with analytical methods using specific SGPT & SGOT reagent kits at 340 nm. After 14 days of OAT administration, SGOT levels increased by 1.3-fold, and SGPT levels increased by 1.8-fold compared to baseline levels. This considerable increase is still considered mild hepatotoxicity. The combination of SPEE: MOEE (25%:75%) was most effective in decreasing SGOT levels by 23.5%, or 1.3-fold, whereas the combination treatment of SPEE: MOEE (75%; 25%) was most effective in reducing SGPT levels by 51.56%, or 2-fold. The ratio value of the decrease in SGOT and SGPT levels from single SPEE and MOEE and the combination of both (p>0.05). The combination treatment of SPEE and MOEE in rats administered OAT showed an additive effect and could evolve as a hepatoprotective substance.
Rationality Analysis of Antibiotic Use in Chronic Kidney Disease Patients at Dr. R. Sosodoro Djatikoesoemo Regional HospitalUsing the Gyssens Method Dian Aisyah Aprilina; Titi Agni Hutahaen; Ainu Zuhriyah; Sabilah Sebil Noer
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6xrbg306

Abstract

Chronic kidney disease (CKD) requires special attention in antibiotic therapy due to pharmacokinetic changes that can affect drug concentration and efficacy. Inappropriate antibiotic selection or dosing may increase toxicity risk and further impair renal function. This study aimed to analyze the rationality of antibiotic use in CKD patients in the internal medicine ward of Dr. R. Sosodoro Djatikoesoemo Regional Hospital, Bojonegoro. A retrospective design was used, analyzing patient medical records from July to December 2024. The rationality of antibiotic use was assessed using the Gyssens method, which evaluates the appropriateness of indication, dosage, interval, duration, and antibiotic selection. Among 91 patients, the largest age group was 45–55 years (26.37%), with a hospital stay of 1–3 days (51.65%). The most frequently used antibiotics were ceftriaxone (43.96%) and cefepime (32.97%). The Gyssens analysis showed that 63.74% of antibiotic use was rational (category 0), while 36.26% was irrational, with the most common issue being category IVd (availability of a narrower-spectrum alternative) at 37.36%. Although most antibiotic use complied with clinical guidelines, there remains a need for improvement in selecting antibiotics with a more appropriate spectrum. Strengthening antibiotic stewardship programs is expected to improve therapeutic outcomes, minimize toxicity risks, and prevent antimicrobial resistance in hospital settings. 
Identification, Characterization and Antifungal Activity Test of Chemical Compounds from Methanol Extract of Macroalgae Padina australis Against Dandruff Fungus Malassezia globosa Djohansah, Violetta; Panjaitan, Riong Seulina; Zuraida Sagala
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3mat6358

Abstract

Padina australis is a species of brown macroalgae with potential as a natural source of bioactive compounds, including antifungal agents. This study aimed to identify the functional groups present in the methanolic extract of Padina australis using Fourier Transform Infrared (FTIR) spectroscopy and to evaluate its antifungal activity against Malassezia globosa through the disk diffusion method. FTIR analysis revealed the presence of hydroxyl (3433.41 cm⁻¹), aliphatic C–H (2916.47 cm⁻¹), carbonyl (1735.99 and 1643.41 cm⁻¹), amine (1573.97 and 1242.20 cm⁻¹), C–O, and carboxylate (COO⁻) groups, indicating key secondary metabolites such as flavonoids, phenols, esters, amines, and polysaccharides. Antifungal testing showed that the extract at a concentration of 100 ppm produced the largest inhibition zone (16.58 ± 4.71 mm), while the minimum inhibitory concentration (MIC) was determined at 12.5 ppm with an inhibition zone diameter ≥12 mm. These findings suggest that Padina australis holds promising potential as a natural source for developing antifungal therapies against Malassezia globosa.
Competitive Advantage Strategies to Improve the Business Performance of PT. XYZ's Cosmetic Products Permanakusumah, Oki; Faizatun; Deriawan
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/1dby8365

Abstract

This study aims to analyze and formulate a competitive business strategy for PT. XYZ to enhance its corporate performance. The research employs a qualitative descriptive method with a quantitative approach. Primary data were obtained through FGDs and in-depth interviews with ten informants, while secondary data were sourced from literature and company reports. Data processing involved four interrelated methods: the IFE and EFE matrices to analyze internal and external factors, the SWOT, IE, and Grand Strategy matrices to determine alternative business strategies, and the QSPM method to establish strategic priorities. The findings indicate that PT. XYZ's strategies include affordable pricing, product variations, branding, and extensive distribution. Internal and external factor analysis resulted in IFE and EFE scores of 2.60, placing the company in the "Hold and Maintain" quadrant, with a focus on product development and market penetration. The grand strategy matrix positions the company in Quadrant 1, highlighting its potential to capitalize on opportunities through an aggressive business strategy. Competitive analysis identifies PT. Mandom Indonesia as the strongest competitor, with a score of 3.3. The SWOT analysis produced seven key competitive strategies, including optimizing machinery for product innovation, external collaboration, sales system integration, internal coaching, strengthening digital media presence, utilizing locally sourced materials with international quality standards, and adaptive planning for regulatory changes. The highest QSPM score (5.40) was achieved by the strategy of optimizing custom machinery for innovative and hard-to-replicate products. It is recommended to maintain the existing strategy, monitor performance, and continuously innovate.
Pharmacists’ Role in Enhancing Community Awareness of Cancer Prevention and Early Detection Budiatin, Aniek S.; Ratri, Dinda MN; Rahmawati, Anik; Samirah; Aryani, Toetik
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mas24m38

Abstract

The incidence of cancer continues to increase annually, yet public awareness of early symptoms remains relatively low. A previous study in one of the sub-districts in Kenjeran showed that around 40% of housewives had never performed BSE (Breast Self-Examination) as an early detection effort for breast cancer. This study aimed to determine the effect of pharmacist-led education and demonstration on improving community knowledge and quality of life in cancer prevention and awareness efforts. This study used a pre-post test group design experimental method and was conducted on October 7, 2020, at the Kejawan Lor Futsal Field. The intervention was carried out through education and demonstration methods in three stages: preparation, implementation, and evaluation. Measurements were taken using questionnaires assessing two variables knowledge and quality of life through pre-tests and post-tests. The results show that knowledge scores increased significantly, from an average of 44% to over 86% after the intervention. Similarly, quality of life scores improved from 33–55% to 83–88% in the post-test. These findings indicate that educational approaches accompanied by demonstrations are effective in raising public knowledge and awareness about cancer prevention. This intervention also has a positive impact on improving the respondents’ quality of life. Therefore, similar programs should be continuously implemented, especially in communities with limited access to health information, such as those in the Kenjeran District.
Comparison of Continuous Percolation and Ultrasound-Assisted Extraction (UAE) Methods on Total Phenolic Content of 70% Ethanol Extract of Purslane (Portulaca oleracea L.) Aditya Sindu Sakti; Fransisca Dita Mayangsari; Sri Bintang Sahara Mahaputra Kusuma Negara; Elasari Dwi Pratiwi; Sandrawati
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/dxzsgc71

Abstract

Background: Portulaca oleracea L., commonly known as Krokot, is rich in phenolic compounds with notable pharmacological benefits. Optimizing extraction methods is critical to maximize its bioactive potential. Objective: This study aimed to compare the efficiency of Continuous Percolation (CP) and Ultrasound-Assisted Extraction (UAE) in obtaining total phenolic content (TPC) from 70% ethanol extract of P. oleracea. Methods: Dried powdered P. oleracea was subjected to CP and UAE using a 1:10 (w/v) plant-to-solvent ratio. Qualitative screening with FeCl₃ confirmed the presence of phenolics. TPC was quantified using the Folin–Ciocalteu method, expressed as mg gallic acid equivalent (GAE)/g extract. Statistical analysis included normality testing, Levene’s test, and the Mann–Whitney U test. Results: UAE yielded significantly higher TPC (420.04 ± 0.40 mg GAE/g) compared to CP (354.30 ± 0.00 mg GAE/g; p = 0.034), although CP produced a higher extract mass. Statistical results confirmed the superiority of UAE in selectively extracting phenolic constituents. Conclusion: UAE is more effective than CP in extracting phenolic compounds from P. oleracea, likely due to enhanced cavitation-induced mass transfer. This method is recommended for maximizing phenolic recovery in plant-based extractions, especially for thermolabile compounds.
Formulation of Facial Wash Gel from Kalamansi Orange (Citrusn microcarpa) Peel Extract as an Antioxidant for Facial Skin Care rambu lika, liany carolina; Liandhajani
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cf4ejv16

Abstract

Cosmetics are preparations used on the outer layer of the human body to cleanse, perfume, beautify, and maintain the body in good condition. Free radicals are reactive oxygen species with unpaired electrons that are unstable and can cause cellular damage, leading to degenerative diseases. Antioxidants play an important role in preventing this damage by inhibiting oxidation processes and scavenging free radicals. This study aimed to develop a facial soap gel formulation using calamansi orange peel extract (Citrus microcarpa) as the active ingredient. The extract was obtained through maceration using 96% ethanol and concentrated with a rotary evaporator. The facial soap gel was formulated in three concentrations, namely 1%, 1.5%, and 2%, and its physical properties were evaluated through organoleptic, pH, homogeneity, foaming power, viscosity, spreadability, and hedonic tests. The findings indicate that the calamansi orange peel extract was successfully formulated into a facial soap gel that meets the physical evaluation requirements. Antioxidant activity testing using the DPPH method shows that Formula III exhibits the highest antioxidant activity with an inhibition percentage of 73.75% and an IC₅₀ value of 29.45 µg/mL. Formula III has the potential to be developed as a functional facial soap that not only cleanses but also provides protection against skin damage caused by free radicals.

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