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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
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Articles 58 Documents
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Search results for , issue "Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)" : 58 Documents clear
Optimization of Water-Ethanol Solvent Composition of Red Betel Leaf Extraction (Piper crocatum Ruiz & Pav) Using Simplex Latice Design Method on Antioxidant Activity Mulyaningsih, Sri; Ria Indah Pratami; Ichwan Ridwan Rais
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/5d1c7339

Abstract

Background: Free radicals cause oxidative stress that contributes to degenerative diseases and premature aging. Red betel leaves (Piper crocatum Ruiz & Pav) contain phenolic and flavonoid compounds with high antioxidant potential. Objective: This study aimed to determine the optimal water-ethanol solvent composition for red betel leaf extraction based on total phenol content and antioxidant activity. Method: Red betel leaf extraction was carried out by ultrasonication using several ratios of water and 96% ethanol solvents, then optimized using Simplex Lattice Design. Antioxidant activity was evaluated using the 2,2-azinobis(3-ethyl-benzothiazoline-6 ​​sulfonic acid (ABTS) method, which was measured using a microplate reader. Total phenol content was determined using a spectrophotometric method. Results: Red betel leaves extracted with water-ethanol solvent (0:100) showed the highest total phenol content of 152.23 ± 0.2 mg GAE/g with an IC50 of 74.18 ppm, which is categorized as strong. ANOVA analysis showed a significant model (p < 0.05) with R² > 0.90, confirming a strong correlation between phenolic content and antioxidant activity. SLD optimization produced a desirability value close to 1.0, indicating that ethanol is the most optimal solvent. Conclusion: Red betel leaves have strong potential as a source of natural antioxidants with ethanol as the optimal solvent for the extraction of bioactive compounds.
Synergistic Impact of The Combination of Moringa Leaves and Butterfly Pea Flowers Infusion on Cognitive Enhancement Annie Rahmatillah; Anna Fitriawati; Anisa Fadilah Kumala Putri
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/n9214f64

Abstract

Oxidative stress can induce memory loss, which may be mitigated by antioxidants. Moringa leaves (Moringa oleifera) and butterfly pea flowers (Clitoria ternatea) possess flavonoid chemicals that function as natural antioxidants. This study seeks to evaluate the impact of combined Moringa leaf and butterfly pea flower infusions on enhancing the memory of mice and to identify the optimal dosage. The research utilized male white mice (Mus musculus), categorized into six groups: a normal group, a negative control (aquadest), a positive control (Ginkgo biloba), and three treatment groups receiving various infusion doses. The procedure had three phases: acclimatization (T0), intraperitoneal administration of hyoscine butylbromide (T1), and therapy (T2). The manufacture of INDUK BUNTEL (an infusion of moringa leaves and butterfly pea flowers) was conducted using an infusion extraction method. Testing on test subjects was conducted utilizing the Radial Arm Maze methodology. The findings indicated that the infusion combination at dose III (100 mg/KgBW: 100 mg/KgBW) was the most efficacious in enhancing the memory of mice. The mean mistake rate in mice was 16.44%, representing the lowest score among the treatment groups. The one-way ANOVA test indicated no significant difference across treatment groups with three distinct dose combinations (p > 0.05).
Testing the Activity of Chitosan Nanohydrogel from Belut Sawah (Monopterus albus) Extract as a Future Anti-Aging Candidate anggraeni, Ratih; Romauli Anna Teresia Marbun
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/x4nw7q34

Abstract

Background: Premature aging has become a serious concern, especially among women. The aging process can occur at any time and progress rapidly. This condition may be caused by exposure to sunlight, which induces the formation of Reactive Oxygen Species (ROS) in the skin. When the amount of ROS exceeds the antioxidant defense capacity of skin cells, it can lead to dryness, thinning, loss of elasticity, wrinkles, and even skin cancer. The swamp eel (Monopterus albus) is commonly used as food by the community. Previous studies have shown that eel extract has been used to treat incision wounds, gastric ulcers, and anemia. It contains vitamin A, vitamin B, and selenium. This species is abundantly found in rice fields and muddy ponds in the Lubuk Pakam area. The formulation of the extract into nan chitosan derived from shrimp shells has been reported to improve the delivery of antioxidant effects into the skin layers. Objective: This study aimed to analyze the activity of a hydrogel combining swamp eel extract with nanochitosan, evaluate its antioxidant activity, and assess the physical stability of the hydrogel formulation as an anti-aging preparation. Methods: Extraction was carried out using the maceration method. The nanochitosan-based hydrogel formulation was designed to enhance the delivery of the eel’s active compounds. Antioxidant activity was tested using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method, and the physical stability of the hydrogel was evaluated. Results: The physical evaluation showed that the nanochitosan hydrogel containing swamp eel extract maintained good stability during storage. Organoleptic tests indicated a consistent yellowish-white color, characteristic aroma, and uniform texture (homogeneity) from day 0 to day 4. The pH value remained stable at 5.2 throughout weeks 0 to 4, within the physiological range of skin pH. Viscosity measurements were 10,350 cps for F1, 11,750 cps for F2, and 23,650 cps for F3. These findings suggest that the formulation possessed good physical stability and an appropriate consistency for topical application. Conclusion: Skin elasticity and biological activity tests showed an increase in skin firmness, likely due to the collagen, flavonoid, and antioxidant content in the swamp eel extract. Irritation and panelist preference tests confirmed its safety and user acceptability. Therefore, this hydrogel shows potential to be developed as a natural, safe, and consumer-friendly anti-aging formulation.
Formulation and Physical Stability Test of Aloe vera  Hydrogel Eye Mask (Aloe vera  (L.) Burm.f.) as Brightening Using Skin Analyzer Kanne Dachi; Linda Margata; Cut Faranisyah; Dini Pitriyani; Putri Maria Waruwu
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/pkv5ch12

Abstract

Background: Hydrogel mask is a type of preventive cosmetic, to prevent skin problems, protect and maintain the skin. Hydrogel eye mask is a type of eye mask with easy to stick and remove use, providing a cooling sensation around the skin around the eye area. Aloe vera  gel (Aloe vera  (L.) Burm.f.) can moisturize and brighten the skin, and contains secondary metabolite compounds that inhibit the tyrosinase enzyme. Objective: This study aims to formulate Aloe vera  gel (Aloe vera  (L.) Burm.f.) in the form of a hydrogel eye mask as a brightening using a skin analyzer. Method: This study used an experimental method with concentrations of 0% (blank), 0,5% (F1), 1% (F2), and, 1,5% (F3). Result: Phytochemical screening of Aloe vera  gel (Aloe vera  (L.) Burm.f), irritation test, physical evaluation of the preparation before the cycling test, namely homogeneity, elasticity, adhesiveness, and after the cycling test, namely organoleptic and pH, as well as effectiveness as a brightening using a skin analyzer. The results of 200 mL of Aloe vera  gel extract (Aloe vera  (L.) Burm.f.) contain alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The preparation does not cause irritation, and is homogeneous. Blank elasticity:30,11%, F1:31,58%, F2:32,99%, and F3:33,67% with the condition 30-115%. Blank adhesion:6,13 seconds, F1:7,19 seconds, F2:9,18 seconds, and F3:12,11 seconds with the condition >4 seconds. After the cycling test there was no change in color, odor, and shape. pH Blank:6,43, F1:6,41, F2:6,14, and F3:6,10 with the requirement of 4,5-6,5 and the brightening effectiveness test on the skin analyzer experienced an increase in recovery of 32,59% in water content, elasticity of 36,81%, and a decrease in melanin of 29,87% for 4 weeks and the best formula is F3.  Conclusion: Aloe vera  gel extract (Aloe vera  (L.) Burm.f.) can be formulated into a hydrogel eye mask preparation with good physical quality and does not cause irritation.
Antiinflamation Activity Assay of Ethanol Extract of Rhabdastrella sp Sponge Using Denaturation of Chicken Egg Albumin Protein Method Mahfur, Mahfur; Mahbub, Khafid; Achada, Dina; Dika, Ika Vina
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3jvv5b49

Abstract

Inflammation is a body defense mechanism by the presence of cell damage against harmful stimuli caused by pathogens, toxic compounds, or irradiation. Drugs that have been used have adverse side effects for the body. The use of natural ingredients is an alternative, one of which is natural ingredients from the sea, namely Rhabdastrella sp. The sponge genus Rhabdastrella has various bioactivities such as anticancer, antimalarial, antibacterial, chemopreventive, anti-inflammatory, antioxidant, cardioprotective, insecticidal, antidiabetic, cytotoxic. Other species of the Genus Rhabdastrella, such as the sponge Rhabdastrella sp. has never been studied. The purpose of this study was to determine the antiinflamation activity of the ethanol extract of the sponge Rhabdastrella sp. The research method was carried out using the method of denaturation of chicken egg protein. The sponge Rhabdastrella sp. was extracted with 96% ethanol. The anti-inflammatory test with protein denaturation used spectrophotometry at a wavelength of 660 nm. concentrations of sample are 50 ppm, 100 ppm, 150 ppm, 200 ppm, and 250 ppm. The positive control comparison used sodium diclofenac with concentrations are 3.12 ppm; 6.25 ppm; 12.5 ppm; 25 ppm; and 50 ppm. The results showed that the ability to inhibit protein denaturation of 20% ethanol extract of Rhabdastrella sp. was obtained at 70.29 ppm, while the IC50 of the ethanol extract obtained was 280.33 ppm. These results were significantly different from the positive control of sodium diclofenac, which was 36.51 ppm. The anti-inflammatory activity of the sample sponge extract was very small because the content of compounds that have anti-inflammatory abilities, including flavonoids, was only about 2%. Based on this, the sponge extract of Rhabdastrella sp. is not potential as an anti-inflammatory.
Formulation and Evaluation of the Physical Properties of Anti-Acne Serum Based on Ethanol Extract of Passiflora foetida L. Leaves Elianasari, Elianasari; Kiki Yuli Handayani; Agita Casanova Cava; Corona Mentari; Wanda Nurbaiti
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/h92bfr53

Abstract

Passiflora foetida L. (rambusa) leaves contain bioactive compounds with potential antibacterial activity against acne-causing bacteria. This study aimed to evaluate the antibacterial effect of ethanolic extracts of P. foetida L. leaves against Propionibacterium acnes and Staphylococcus epidermidis, and to formulate and assess the physical properties of serum preparations containing the extract. Ethanolic extracts at concentrations of 5%, 10%, and 15% were tested using the well diffusion method on Mueller Hinton Agar (MHA), with positive and negative controls. Serum formulations containing 0% (F0), 5% (FI), 10% (FII), and 15% (FIII) extract concentrations were prepared and evaluated for organoleptic characteristics, homogeneity, spreadability, adhesion, pH, and viscosity. The extract demonstrated antibacterial activity against both bacteria, producing inhibition zones at 15% concentration of 5.83 mm for P. acnes and 3.69 mm for S. epidermidis. The inhibition zone diameter increased with extract concentration. All formulations showed good homogeneity, stable pH (approximately 6.0), and acceptable organoleptic characteristics. Spreadability ranged from 9.0–10.0 cm, adhesion time from 8–17 seconds, and viscosity values were 300 mPa·s (F0), 165 mPa·s (FI), 189 mPa·s (FII), and 198 mPa·s (FIII). In conclusion, the 96% ethanolic extract of P. foetida L. leaves possesses antibacterial potential against acne-causing bacteria, while the formulated serum exhibits favorable physical characteristics for topical application and potential as a functional anti-acne cosmetic product.
Anti-Inflammatory Activity of Ethanol Extract of Turmeric Rhizome (Curcuma Longa Linn) Male White Mice Pepper Induced Caragenan Turnip, Nur Ulina M. Br.; Sefrini Ois Lasmaria Pasaribu
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3n8wb204

Abstract

Background: Inflammation is the body's natural response to tissue injury caused by internal or external stimuli, with the aim of neutralizing the agent causing damage and repairing injured tissue. Initial treatment of inflammation is generally done by eliminating local triggering factors, such as pain relievers through the use of chemical drugs. However, this therapy often causes unwanted side effects. The use of natural ingredients that have anti-inflammatory activity is a safer alternative than modern drugs. Objective: to determine the anti-inflammatory effect of ethanol extract of turmeric rhizome (Curcuma longa L.). Method: using a model of edema on the soles of the feet of male white mice induced by 1% carrageenan. A total of 24 mice were divided into 6 treatment groups, one group was not given treatment as a comparison, three groups received doses of ethanol extract of turmeric rhizome (100, 200, and 300 mg/kgBW), one negative control (Na CMC 0.5%), and one positive control (6.5 mg/kgBW Na diclofenac). Results: showed that after carrageenan induction, all test groups experienced a progressive decrease in inflammation levels from the 60th to the 360th minute. After the extract dose groups of 100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, and Na diclofenac, the Na CMC group had the highest percentage of inflammation at the 120th minute. The Na diclofenac group showed the highest percentage of inflammation inhibition, followed by extract doses of 300, 200, and 100 mg/kgBW. In contrast to the Na CMC group which did not show anti-inflammatory activity, these data indicate that the ethanol extract of turmeric rhizome at a dose of 300 mg/kgBW has the highest anti-inflammatory efficacy after Na diclofenac, followed by doses of 200 mg/kgBW and 100 mg/kgBW. Conclusion: turmeric rhizome extract has the potential to reduce inflammation in the soles of mice's feet.
Physical Stability Test of Anti-Acne Cream from Ethanol Extract of Seruni Leaves (Spaghneticola trilobata) on Different Bases Sari Wijayanti; Faizal Mustamin; Muhammad Luthfi
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8zkc4p63

Abstract

One of the formulations commonly used in treating acne is cream. However, most creams contain chemicals that can irritate the skin. Therefore, an alternative solution should be to use natural antibacterial ingredients. There is scientific evidence that chrysanthemum leaves (Spaghneticola Trilobata) have antimicrobial activity due to their secondary metabolite content consisting of terpenoids, flavonoids, steroids, tannins, saponins, and alkaloids. In this study, Chrysanthemum Leaf extract will be formulated into a physically stable anti-acne cream. To make chrysanthemum leaf ethanol extract cream, the concentration of stearic acid and TEA was varied. The amount of extract used to make the cream is 2.5%. Different concentrations of TEA:Stearic acid, namely F1 (0.2%:5%), F2 (0.4%:10%), and F3 (0.6%:15%). Type M/A cream that extracts ethanol from chrysanthemum leaves produces a semi-solid texture, olive green color, and characteristic odor of chrysanthemum leaves. After homogeneity test, the cream is said to be homogeneous because there are no coarse particles. The pH value of this cream is around 6-7, so it is safe to apply on the face. The spreadability test of Formula I, which reached 5.65 cm, met the standard for good cream spreadability, and the stickiness test, which lasted for 4.57 seconds, showed that this cream met the criteria for good stickiness. Formula I (F1) is the best formula that meets the criteria for a quality cream, according to the physical stability test results.
Anti-Inflammatory Effectiveness Test Of Ethanol Extract Of Ara Sungsang Leaf ((Asystasia gangetica) On Male White Mice (Mus musculus )Induced By 1% Carrageenan Cahya, Cucu Arum Dwi; Putri Alvanisia Saragih
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/brjms302

Abstract

Background: Leaf Ara Sungsang, also known as Asystasia gangetica, is a plant that has been used for a long time to treat different health issues, including inflammation. This plant has compounds called flavonoids and tannins, which are thought to help reduce inflammation by stopping certain chemicals that cause it. Objective: This study looked at how well the ethanol extract from Asystasia gangetica leaves works as an anti-inflammatory treatment in male white mice that had been given 1% carrageenan to induce inflammation. Methods: The study used 25 mice, which were split into five groups. One group received sodium diclofenac at 6.5 mg per kg of body weight as a positive control. Another group got 0.5% Na-CMC as a negative control. The other three groups received different doses of the ethanol extract: 100 mg/kg, 200 mg/kg, and 250 mg/kg. All the mice were given 1% carrageenan to create inflammation. Result: The highest level of inflammation was seen at 6 hours. The strongest anti-inflammatory effect was found in the group that received sodium diclofenac. The groups that received the ethanol extract also showed some anti-inflammatory effects, with the highest dose (250 mg/kg) being the most effective. The Na-CMC group did not show any significant anti-inflammatory effect. The data was analyzed using One Way ANOVA, and there were significant differences in the percentage of inflammation reduction between the different treatment groups (p < 0.05). Conclusion:  Based on the percentage of inhibition, it can be concluded that the ethanol extract of ara sungsang leaves at a dose of 250 mg/kgBB has the best anti-inflammatory effect after sodium diclofenac.
Antimicrobial Effectiveness Test of Ethanol Extract of Red Betel (Piper crocatum Ruiz And Pav) Rismahara Lubis; Dodoh Khodijah; Adhisty Nurpermatasari
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/22z4xd23

Abstract

Background: Red betel leaf (Piper crocatum Ruiz & Pav) is a traditional medicinal plant that contains active compounds such as flavonoids, alkaloids, tannins, saponins, and essential oils that have potential as antimicrobials. Objective: This study aims to determine the effectiveness of ethanol extract of red betel against microbial growth. Methods: The research was conducted experimentally using the disc diffusion method on agar media with concentrations of 80%, 90% and 100%. The dependent variable was microbial inhibition. Several antibiotics and antifungals were used as positive controls, while distilled water was used as negative control. Results: The results showed that the average inhibition zone against Staphylococcus aureus at concentrations of 80%, 90% and 100% were 26,96 mm, 28,69 mm and 30,1 mm respectively with a positive control of tetracycline of 28.1 mm. In Escherichia coli it was 12,66 mm, 14,13 mm and 15,17 mm respectively with positive control of amoxicillin of 22.16 mm. Pseudomonas aeruginosa produced inhibition zones of 12,7 mm, 14,5 mm and 15,78 mm respectively with a positive control of chloramphenicol of 6.95 mm. In Klebsiella pneumoniae it was 13,47 mm, 14,81 mm and 16,05 mm respectively with ampicillin positive control of 6,22 mm. On Candida albicans, the zones of inhibition were 9,77 mm, 11,26 mm and 12,32 mm, respectively, with a positive control of ketoconazole of 29.95 mm. The zones of inhibition of antibiotics and comparative antifungals varied, some producing larger diameters than the extract, while others were lower. The negative control showed no inhibitory activity. Conclusion: It was concluded that the ethanol extract of red betel was able to inhibit some microbial growth according to the Indonesian Pharmacopoeia VI Edition standard of 14-16 mm.

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