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E-Prodenta Journal of Dentistry
Published by Universitas Brawijaya
ISSN : -     EISSN : 25974912     DOI : -
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology
E-Prodenta Journal of Dentistry is a journal published by Faculty of Dentistry Universitas Brawijaya Malang. This journal is published periodically every six months. The E-Prodenta Journal of Dentistry presents the latest articles/manuscripts of knowledge, information and development on dental and oral health which are the results of research, review articles, and case reports to support the advancement of science, education, and practice of dentistry.
Arjuna Subject : -
Articles 137 Documents
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EFEKTIVITAS EKSTRAK AIR BATANG CIPLUKAN (Physalis minima L.) TERHADAP KADAR MALONDIALDEHID TULANG MANDIBULA TIKUS PUTIH (Rattus norvegicus) Strain Wistar Pasca Ovariectomy Fadhilah, Nadia; Permatasari, Nur; Widodorini, Trining
E-Prodenta Journal of Dentistry Vol 9 No 2 (2025)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2025.009.02.2

Abstract

Estrogen has function as an antioxidant that can reduce free radicals. Hipoestrogen condition will increase oxidative stress in the body. Periodontitis is one of the diseases associated with oxidative stress. Oxidative stress, characterized by increased levels of malondialdehid (MDA). Malondialdehid is usually used to assess the oxidative stress. Phytoestrogens are plant components that have biological activity of estrogen. Ciplukan is a natural ingredient or plant suspected to be a phytoestrogen compound. The theoretical study results showed that ciplukan stem contained physalin, which have a similar effect to estrogen. The purpose of this study is to determine the effectiveness of ciplukan stem extract on malondialdehyde levels in the rat mandibular bone post ovariectomy. Twenty four rats were randomly divided into 6 groups with each 4 rats, that are 3 control groups and 3 groups treated rats that were given the ciplukan stem extract at the end of the first 5 weeks ovariectomy with three different doses: 500 mg/kg BW (K4), 1.500 mg/kg BW (K5), and 2.500 mg/kg BW (K6) for 4 weeks. MDA levels calculated by thiobarbituric acid (TBA) test and read by a spectrophotometer and MDA standard curve created. The results showed the incease of MDA levels can be inhibited at the dose of 500 mg / kg, while at the dose of 1500 mg/kg BW and 2500 mg/kg BW can restore MDA levels similar to normal. There is a strong correlation between the negative direction doses of ciplukan stem extract with MDA levels in mandibular bone (r = -0.507). The conclusion of this study is the ciplukan stem extract can reduce MDA levels in mandibular bone strain of wistar rats after ovariectomy.
JARAK DAN VOLUME UPPER AIRWAY PADA PASIEN PASCA OPERASI PALATOPLASTY MENGGUNAKAN CONE BEAM COMPUTED TOMOGRAPHY (CBCT) Fitriana; Yulia, Dhafina Gita
E-Prodenta Journal of Dentistry Vol 9 No 2 (2025)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2025.009.02.1

Abstract

Introduction: Cleft lip and palate (CLP) is a congenital anomaly with a global incidence of 1/500–1/1000 births, reaching 7,500 cases per year in Indonesia (Riskesdas 2019). Palatoplasty, a reconstructive procedure of the palate to restore velopharyngeal and speech function, is typically performed at 1–1.5 years of age in Indonesia. This study uses CBCT a low-radiation 3D radiology tool to analyze changes in upper airway distance and volume post-palatoplasty, as no similar studies have been conducted in Indonesia (particularly in Malang) to evaluate the anatomical impact of the surgery on the airway, obstruction risk, and patient quality of life. Objective: To observe and measure the distance and volume of the upper airway in CLP and/or CP patients after palatoplasty using CBCT. Methods: A cross-sectional study to observe and measure the condition of the upper airway in patients who have undergone palatoplasty, measured using CBCT. Results: CLP patients after palatoplasty generally have a wider airway and larger volume compared to normal individuals. Widening of the airway generally improves respiratory function, reduces the risk of sleep apnea, and enhances airflow. However, if narrowing occurs at specific points (e.g.,low PASmin), the risk of respiratory disorders such as OSA remains. Conclusion: CBCT is highly accurate in measuring the distance and volume of the airway in three dimensions.
THE PENGARUH NANOLIPOSOME EKSTRAK KUNYIT DAN LADA HITAM TERHADAP JUMLAH SEL MAKROFAG PADA PENYEMBUHAN ULKUS TRAUMATIK MUKOSA LABIAL TIKUS WISTAR: PENGARUH NANOLIPOSOME EKSTRAK KUNYIT DAN LADA HITAM TERHADAP JUMLAH SEL MAKROFAG PADA PENYEMBUHAN ULKUS TRAUMATIK MUKOSA LABIAL TIKUS WISTAR Fuadiyah, Diena; Nafa, Achmad Zulhafidz
E-Prodenta Journal of Dentistry Vol 10 No 1 (2026):
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2026.009.01.1

Abstract

Background : Ulkus is a common condition frequently encountered in daily life, particularly in the oral cavity, and often causes painful disruptions to daily activities. Traumatic ulcers appear as single, oval lesions that can heal within less than a week after the causative factor is removed. However, some cases of traumatic ulcers do not heal spontaneously and can lead to serious complications such as infection and further tissue damage. Objective : The purpose of this study is to investigate the effect of nanoliposome extracts of turmeric (Curcuma longa L.) and black pepper (Piper nigrum) on the number of macrophages during the healing process of traumatic ulcers in the labial mucosa of Wistar rats (Rattus norvegicus). Methods : The method used in this study is a true experimental design conducted in vivo, using a randomized post test only control group design. The research object is 45 male Wistar rats (Rattus norvegicus), divided into 15 groups: three control groups (K3, K5, and K7) and 12 treatment groups (P3A, P3B, P3C, P3D, P5A, P5B, P5C, P5D, P7A, P7B, P7C, and P7D). Result : The results show a significant increase in the number of macrophages at day 5 compared to the control groups (p < 0.05) between days 3 and 7.Conclusion : Nanoliposome extracts of turmeric and black pepper play a role in increasing the number of macrophages during the healing process of labial mucosa ulcers in Wistar rats on day 5 post-heat induction.
Potensi Mengembang Hidrogel Komposit Chitosan dengan Tulang Sapi Demineralisasi Beku Kering untuk Regenerasi Tulang Wardani, Sinta Candra; Pratiwi, Ariyati Retno; Istikharoh, Feni; Pramaiswari, Made Adelia; Margareta, Isti Tri Aulia
E-Prodenta Journal of Dentistry Vol 10 No 1 (2026):
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2026.009.01.2

Abstract

Backgrounds: Demineralized freeze-dried bovine bone synthesized in nanoparticle size is expected to improve the osteoinductive of chitosan hydrogel as bone regeneration material. Therefore, an evaluation was carried out on whether this material can affect swelling as one of the physical properties of the hydrogel. Objective: To determine the swelling potential test of the hydrogel composite with varying concentrations of Demineralized Freeze-Dried Bovine Bone Nanoparticle (DFDBB-Np). Methods: The chitosan hydrogels at DFDBB-Np concentrations of 0%, 0.5%, 1%, 1.5%, 2%, and 2.5% are incubated in sterile water at 37°C for varying durations (3, 6, 12, 24 hours) until swelling occurs. The equilibrium Swelling Ratio (SR) is calculated as the ratio of the swelling to the initial weight. Results: After 24 hours of incubation, a significant difference was observed between concentrations of 0% and 0.5%, 1%, 1.5%, 2%, and 2.5% (sig = 0.015, 0.004, 0.000, 0.001, 0.000). However, other concentrations and duration did not show any significant difference. Conclusion: DFDBB-Np retains its potential as a composite material with chitosan hydrogel for bone regeneration.
Potensi Senyawa Aktif Ekstrak Apel Manalagi (Malus Sylvestris) dalam penghambatan reseptor ACE2 pada proses inflamasi periodontitis (Studi In Silico) Hidayat, Lukman Hakim; Milla, Lalita El; vamzah, varhan hamzah
E-Prodenta Journal of Dentistry Vol 10 No 1 (2026):
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2026.010.01.3

Abstract

Latar Belakang: Periodontitis merupakan penyakit inflamasi kronis yang menyerang jaringan pendukung gigi, dengan ekspresi tinggi Angiotensin-Converting Enzyme 2 (ACE2) di rongga mulut yang berpotensi menjadi target infeksi SARS-CoV-2. Malus sylvestris (apel Manalagi) mengandung senyawa bioaktif yang berpotensi sebagai agen antiinflamasi, namun mekanismenya dalam inflamasi periodontitis dan interaksinya dengan ACE2 masih belum banyak diteliti. Tujuan: Mengetahui potensi ekstrak apel Manalagi dalam menghambat inflamasi periodontitis melalui studi in silico. Metode: Eksperimental laboratoris. Uji digunakan meliputi Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) untuk identifikasi senyawa aktif, serta molecular docking untuk mengevaluasi afinitas pengikatan senyawa terhadap ACE2. Hasil: Hasil penelitian menunjukkan bahwa kuersetin, katekin, dan asam klorogenat memiliki interaksi kuat dengan residu kunci ACE2 dengan masing-masing memiliki berat molekul 302,24 g/mol, 290,27 g/mol, dan 354,31 g/mol. Ketiga senyawa ini menunjukkan interaksi kuat dengan residu kunci pada ACE2, seperti LYS B:288, ASN B:432, dan ASP B:431, yang berperan dalam stabilitas kompleks protein-ligan, berpotensi menghambat inflamasi periodontitis, serta memenuhi kriteria farmakokinetik yang baik, menjadikannya alternatif terapeutik yang aman dan efektif. Kesimpulan: Ekstrak Apel Manalagi (Malus Sylvestris) efektif dalam menghambat proses inflamasi pada periodontitis
Analisa Bibliometrik Kejadian Maloklusi yang Berhubungan dengan Stunting Istikharoh, Feni; madani, insi
E-Prodenta Journal of Dentistry Vol 10 No 1 (2026):
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2026.010.01.4

Abstract

Introduction: Indonesia currently still has a high incidence of dental and oral health problems. Based on the 2018 National Basic Health Research (Riskesdas), it was stated that as many as 57.6% of Indonesians have dental and oral problems. Dental and oral problems that are often found include malocclusion. Malocclusion has two basic causes, namely intrinsic factors and extrinsic factors. One example of an intrinsic factor is nutritional status. Nutritional status generally affects the growth and development of the body and especially the growth and development of teeth and mouth. Stunting (poor nutritional status) can cause tooth malformation, high prevalence of caries, easy injury to soft tissue, malocclusion of teeth, inhibited development of facial and jaw bones, and the presence of crowded teeth. Objective: To analyze the development of malocclusion events related to stunting. Method: This study uses a bibliometric analysis method using R software, from 159 journals obtained from the Scopus database in the period 2004-2024. Results: This study found that stunting (short nutritional status) can cause malocclusion in children of growth age. It was also found that the most common malocclusion in children is crowded teeth. Conclusion: From the bibliometric analysis conducted, in-depth insights were found regarding topic trends in research on malocclusion events related to stunting, an increase in the number of publications and research trends from year to year continue to develop, with various new topics and approaches emerging.
Efek Pemberian Nanoemulgel Ekstrak Moringa oleifera terhadap Jumlah Sel Makrofag Rattus norvegicus Pratiwi, Ariyati Retno; Risnauli, Yanice Natalia Regar
E-Prodenta Journal of Dentistry Vol 10 No 1 (2026):
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2026.010.01.5

Abstract

Introduction: Inflammation is a complex response of the body's immune system that refers to pathological conditions against various harmful stimuli. One of the factors causing inflammation is the presence of ulcers. At the beginning of the inflammatory response, macrophages tend to be polarized into the M1 phenotype (pro-inflammatory) then switch to the M2 phenotype (anti-inflammatory). The balance between M1 and M2 macrophage activity is essential for proper inflammation and optimal tissue repair. In the context of macrophage modulation, nanoemulgel formulation has the potential to increase the delivery of bioactive compounds from Moringa oleifera extract to target tissues, facilitate interactions with tissue macrophages, and enhance anti-inflammatory and immunomodulatory effects. Objective: This study aims to determine the effect of administering Moringa oleifera extract nanoemulgel on the number of Rattus norvegicus macrophage cells. Method: This study used a true experimental in vivo with a Randomized Post Test Only Control Group design using 24 male Wistar rats divided into 4 groups, 2 control groups and 2 treatment groups. The variables studied were the number of macrophage cells observed on the 5th day. Results: The results showed that Moringa oleifera extract nanoemulgel had an effect on the number of M1 Rattus norvegicus macrophage cells. This was evidenced by a significant increase in the number of M1 macrophage cells in the 30% Moringa oleifera extract nanoemulgel treatment group on the 5th day. Conclusion: After administering Moringa oleifera extract nanoemulgel, there was a difference in the number of macrophage cells in the inflammatory process observed on the 5th day.

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