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Majalah Kesehatan Pharmamedika
Published by Universitas Yarsi
ISSN : 20855648     EISSN : 26552396     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Majalah Kesehatan Pharmamedika / Pharmamedika Health Magazine is a source of scientific information about medicine, pharmacy and sciences related to health aspects. This magazine is published every 6 months (2 times in a year) and each publication can contain the results of research, literature reviews, actual case reports.
Arjuna Subject : -
Articles 83 Documents
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Kuliah Kerja Nyata (KKN ) sebagai Metode Pembelajaran di Fakultas Kedokteran Universitas YARSI Pusparini, Miranti
Majalah Kesehatan Pharmamedika Vol 9, No 1 (2017): JUNI 2017
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5844.272 KB) | DOI: 10.33476/mkp.v9i1.672

Abstract

Sehubungan dengan adanya peraturan SNPT no 44 tahun 2015,bentuk pembelajaranpendidikan diploma empat, program sarjana, program profesi, dan program spesialis wajib ditambah pembelajaran berupa pengabdian kepada masyarakat. Dalam rangka mencoba menerapkan bentuk pembelajaran pengabdian masyarakat, Universitas YARSI bekerjasama dengan Dinas Perlindungan Anak dan Pemberdayaan Perempuan (DPPAPP) melaksanakan kegiatan Kuliah Kerja Nyata (KKN) Program Kependudukan dan Keluarga Berencana serta Pembangunan Keluarga (KKBPK). KKN dilaksanakan pada proses pembelajaran di Fakultas Kedokteran Universitas YARSI semester 7 (tujuh) tahun ajaran 2017 – 2018 dalam Blok Elektif dengan peminatan Kekerasan Dalam Rumah Tangga (KDRT), dilakukan oleh 1 kelompok yang terdiri dari 5 (lima) orang mahasiswa sebagai pemateri. Bentuk kegiatan berupa penyuluhan dengan pretest dan posttest serta diskusi. Pretes dan postes diberikan sebagai tolok ukur penyampaian materi. Hasil pretes menunjukan nilai yang baik (80-90) sebanyak 7 orang atau sekitar 29,17%, nilai cukup (antara 60-70) sebanyak 10 orang atau sekitar 41,67%, dan nilai kurang (≤ 50) sebanyak 7 orang atau sekitar 29,17%. Hasil post tes menunjukan nilai yang baik  (antara 80-100) sebanyak 12 orang atau sekitar 48%, nilai cukup (antara 60-70) sebanyak 9 orang atau sekitar 36%, dan nilai yang kurang sebanyak 4 orang atau sekitar 16%. Kuesioner penilaian pelaksanaan kegiatan penyuluhan juga disebarkan, dengan hasil pemateri 58,14% dinilai sangat baik, dan untuk materi penyuluhan 48,84% dinilai baik.Terlihat peningkatan rerata nilai secara umum sebanyak 12,38 poin yang semula 60,42 saat pretes menjadi 72,80 saat postes. Hal ini menunjukan bahwa materi penyuluhan dapat tersampaikan dengan baik oleh seluruh mahasiswa.
Pemberian Krim Ekstrak Daun Sukun (Artocarpus altilis )Mencegah Peningkatan Jumlah Melanin Kulit Marmut (Cavia porcellus )yang Dipapar Sinar Ultraviolet B (UVB ) Riliani, Marisa; Pangkahila, Wimpie; AAGP, Wiraguna
Majalah Kesehatan Pharmamedika Vol 9, No 2 (2017): DESEMBER 2017
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1531.869 KB) | DOI: 10.33476/mkp.v9i2.678

Abstract

Skin is the main target of ultraviolet (UV) ray that result the abnormality of hiperpigmentation. In pathology, hyperpigmentation is caused by an increasing in the amount of melanin. The purpose of this research was to prove the effect of administration of breadfruit leaves extract (Artocarpus altilis) cream prevented the increase of skin melanin in guinea pig (Cavia procellus) exposed to ultraviolet B and to prove the administration of breadfruit leaves extract (Artocarpus altilis) cream have the same effectiveness with 4% hydroquinone cream in preventing the increase of skin melanin in guinea pig (Cavia procellus) exposed to ultraviolet B. This study was a true experimental research using post test only control group design. The subjects were devided into three groups. Group 1 as a control group was treated by UVB exposure and basic cream. Group 2 was treated by UVB and 4% hydroquinone cream. Group 3 was treated by UVB and 3% breadfruit leaves extract cream. There was significant difference within control group compared with group 2 and 3 (p0,05). There was no significant difference within group 2 compared with group 3 (p0,05).The administration of 3% breadfruit leaves extract (Artocarpus altilis) cream prevented the increase of skin melanin in guinea pig (Cavia procellus) exposed to ultraviolet B. The administration of 3% breadfruit leaves extract (Artocarpus altilis) cream had the same effectiveness with 4% hydroquinone cream.
Clinical Picture and Microbiological Pattern in 3rd and 4th Degrees of the Pedis Classification of Diabetic Foot Infection Sumarjo, Kusmardi; Waspadji, Sarwono; Sosrosumihardjo, Rustadi; Suhendro, Suhendro
Majalah Kesehatan Pharmamedika Vol 10, No 1 (2018): JUNI 2018
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v10i1.683

Abstract

Diabetic foot infection (DFI) is one complication of diabetes mellitus that has high morbidityand mortality. The success of management of DFI is influenced by many factor. This study aimed to recognize clinical picture and microbiological pattern in 3rd and 4th degrees of the PEDIS classification. The design was a prospective cross-sectional study conducted in RSCM at March until May 2005. The clinical pictures in 52 DFI’pateints were included to the PEDIS classification with the wound’s odour and crepitation. Microbiological examination was done culture for microorganisms and the antibiotiks sensitivity test. The female were greate (55,8%) than male the greatest age group were at 51-60 years old (44,2%). Poorly controlled blood glucose was found in 88%, duration of wound 2 weeks in 56%, wound without critical-limb ischaemia in 81% with wound size 25 cm2 in 58%, with bottom of wound had reached tendons in 75%. Most of the patiens undergroune sepsis (65%), diabetic neouropathy (77%), with odour distance of ≥1 m (65%), and crepitation/gas (63%). We found 96 types of microorganism, of which the greatest number was: E.coli 17,7% with highest sensitivity towards cefepime; S.aureus 15,6% towards co-amoxyclav; Bacteroides spp 4,2% towards co-amoxyclav, sultamicillin and metronidazole.
Efektivitas Etelcalcitide terhadap Hiperparatiroidisme Sekunder Pada Pasien Gagal Ginjal Kronik Muhammad Tola, Sakura
Majalah Kesehatan Pharmamedika Vol 10, No 1 (2018): JUNI 2018
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v10i1.688

Abstract

Secondary hyperparathyroidism (sHPT) is a frequently occurring severe complication ofadvanced kidney disease. Its clinical consequences include extraskeletal vascular and valvular calcifications, changes in bone metabolism resulting in renal osteodystrophy, and an increased risk of cardiovascular morbidity and mortality. Calcimimetics are a cornerstone of parathyroid hormone (PTH)-lowering therapy, as confirmed by the recently updated 2017 Kidney Disease: Improving Global Outcomes chronic kidney disease – mineral and bone disorder clinical practice guidelines. Contrary to calcitriol or other vitamin D-receptor activators, calcimimetics reduce PTH without increasing serumcalcium, phosphorus,or FGF23 levels. Etelcalcetide is a new second-generation calcimimetic that has been approved for the treatment of sHPT in adult hemodialysis patients. Where as the first-generation calcimimetic cinacalcet is taken orally once daily, etelcalcetide is given intravenously thrice weekly at the end of the hemodialysis session. Apart from improving drug adherence, etelcalcetide has proven to be more effective in lowering PTH when compared to cinacalcet, with an acceptable and comparable safety profile. The hope for better gastrointestinal tolerance with intravenous administration is no true, as etelcalcetide isn’t significantly mitigate the adverse gastrointestinal effects associated with cinacalcet. Enhanced adherence and strong reductions in PTH, phosphorus, and FGF23 can set the stage for a future large randomized controlled trial to demonstrate that improve biochemical control of mineral metabolism with etelcalcetide in hemodialysis patients translates into cardiovascular and survival benefits and better health-related quality of life.
Perilaku Suami dalam Pengambilan Keputusan pada Ibu Bersalin ada Kasus Kegawat Daruratan Maternal di RSUD Koja Tahun 2018 Arihta T, Dina; Kristina, Rahayu
Majalah Kesehatan Pharmamedika Vol 10, No 2 (2018): DESEMBER 2018
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (78.331 KB) | DOI: 10.33476/mkp.v10i2.728

Abstract

Angka kematian ibu (AKI) merupakan salah salah satu indikator untuk melihat derajat kesehatan perempuan. Di indonesia penyebab kematian obstetri umumnya terkait dengan permasalahan gawat darurat obstetri,  selain itu dapat disebabkan oleh keterlambatan suami dalam pengambilan keputusan sehingga berdampak pada kematian ibu. Tujuan penelitian ini untuk mengetahui cepat atau tidak suami dalam pengambilan keputusan pada kegawatdaruratan maternal.Penelitian ini menggunakan metode deskriptif dengan desain cross sectional. Jumlah populasi  dalam  penelitian  ini  yaitu  110  orang.  Sampel  pre  eklamsi  berat  (PEB)  sebanyak  52 responden diambil dengan teknik accidental sampling. Alat pengumpulan data yang digunakan adalah kuesioner. Analisis data menggunakan distribusi frekuensi dari cross table. Perilaku suami dalam pengambilan  keputusan  ibu  bersalin  dengan  kasus  kegawatdaruratan  maternal  menunjukkan sebagian besar responden lambat dalam pengambilan keputusan sebanyak 47 (90,4%)  orang  dan sebagian kecil responden berperilaku cepat dalam pengambilan keputusan sebanyak 5 (9,6%) orang . Perilaku suami dalam pengambilan keputusan kegawatdaruratan maternal dalam kategori lambat.
Aktivitas Antiproliferasi Ekstrak Etanolik Herba Ciplukan (Physalis angulata L.) Terhadap Sel Hepar Tikus Betina Galur Sprague Dawley Terinduksi 7,12-Dimetilbenz[a]antrasena Agusta Fauzi, Ilham; Amalia, Fikri; Sabila, Nurma; Hermawan, Adam; Ikawati, Muthi; Meiyanto, Edy
Majalah Kesehatan Pharmamedika Vol 3, No 1 (2011): JANUARI - JUNI 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v3i1.434

Abstract

One of the natural materials as potentially efficacious chemopreventive agents are Ciplukan (Physalis angulata L.). Several previous studies reported that Physalis angulata L. herbs ethanolic extract (PEE) has cytotoxic activity and induction of apoptosis in breast cancer cells MCF-7 and HeLa cervical cancer cells. This study aims to determine the effects of  PEE as an chemopreventive agent on rat liver cells induced 7,12-dimetilbenz[a]anthracene (DMBA). This study used Sprague Dawley strain female rats aged 40-50 days were divided into 5 groups : (1) DMBA control group, mice were induced with DMBA in per oral dose of 20 mg/kg; (2) DMBA + PEE dose 750 mg/kgBW group ; (3) DMBA + PEE dose 1500 mg/kgBW group ; (4) solvent control group of CMC-Na 0,5%; (5) PEE dose 1500 mg/kgBW control group. PEE was dissolved in CMC-Na 0,5% and administered daily, starting the seventh week after administration of DMBA. At the beginning of  the tenth week of the study, rats were necropted and liver organs were isolated and stored in buffered formalin 4%. Qualitative analysis to determine the histopathology of liver cells through staining method of Hematoxyllin Eosin (HE), while quantitative analysis to determine the level of liver cell proliferation by AgNOR staining method. The results showed in the DMBA control group that liver cell morphology changes that hiperproliferation leading to carcinogenesis. In DMBA + PEE dose of  1500 mg/kgBW group improved the situation of DMBA-induced liver cells histopathology and antiproliferation activity better than DMBA + PEE dose of 750 mg/kgBW on DMBA-induced rat liver cells. The results showed that Physalis angulata L. herbs ethanolic extract can inhibit cell proliferation in rat liver caused by DMBA administration through antiproliferation mechanism and have potential for the development as chemoprevention material on liver cancer
Aktivitas Sitotoksik Ekstrak Etanolik Rimpang Temu Kunci (Boesenbergia pandurata) Terhadap Sel Kanker Serviks HeLa dan Sel Kanker Kolon WiDr Feby Handoko, Fransiscus; Ayu Maruti, Astrid; Rivanti, Erlina; Dewi Pamungkas Putri, Dyaningtyas; Meiyanto, Edy
Majalah Kesehatan Pharmamedika Vol 3, No 1 (2011): JANUARI - JUNI 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v3i1.439

Abstract

Temu kunci (Boesenbergia pandurata) rhizome showed cytotoxic effect against T47D breast cancer cell line. It contains Panduratin, a chalcone compund, that has been investigated as chemopreventive agent. The exploration of extract of temu kuci as chemopreventive agent was expected to be an alternative for cancer therapy. The aim of this research was to determine the cytotoxic activities of ethanolic extract of temu kunci against HeLa cervix cancer and WiDr colon cancer cell line. The cytotoxic activities of ethanolic extract of temu kunci were tested using MTT assay against HeLa and WiDr cells. The IC50 values were obtained using linier regression equation. The ethanolic extract of temu kunci showed cytotoxic activities on HeLa cervix cancer and WiDr colon cancer cell lines with IC50 at 87 µg/mL and 76 µg/mL, respectively. Low IC50 values (100 µg/mL) showed that ethanolic extract of temu kunci is potential to be developed as chemoprevention agent on cervix cancer and colon cancer. However, its molecular mecahanism need to be explored.
Perbedaan Titer Imunoglobulin G Anti Campak Bayi Baru lahir Aterm dengan Preterm di RSUD Dr.Moewardi Surakarta Wahyu Herlinawati, Sri; Subagyo, Bambang; Hafidh, Yulidar
Majalah Kesehatan Pharmamedika Vol 3, No 2 (2011): JULI - DESEMBER 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (83.749 KB) | DOI: 10.33476/mkp.v3i2.444

Abstract

Infants are protected from infections due to maternal IgG which were taken intrauterine. Gestational age is predicted to have direct correlation with IgG titer in newborn. The aim of this study was to find out the mean difference of anti measles IgG titer between preterm and aterm newborn. Preterm newborns were taken consecutively and appropriated by gender to aterm groups. Laboratory examination and interview to the parents were performed. Paired t-test were used to compare anti measles IgG titer between two groups. Multivariate analysis were performed to factors contributed in anti measles IgG titer. The result showed the mean difference was significant, between anti measles IgG titer preterm and aterm newborn. The mean difference was 1417,05 mIU/ml (p0,05). The mean of anti measles IgG titer was lower in preterm newborn compared with aterm. Multivariat analysis showed prematurity is risk factor for a low level anti measles IgG titer in newborn. This study concluded that the mean of anti measles IgG titer in preterm newborn is lower than aterm. Prematurity is risk factor for a low level anti measles IgG titer in newborn. Maternal anti measles IgG and uteroplacenta circulation give contribution to anti measles IgG titer in newborn.
Melatonin dan Kanker Payudara Sandra, Yurika
Majalah Kesehatan Pharmamedika Vol 3, No 2 (2011): JULI - DESEMBER 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v3i2.450

Abstract

Melatonin adalah hormon peptida golongan indolamin yang disintesis pada kelenjar pineal. Berbagai studi secara in vitro dan in vivo telah membuktikan bahwa melatonin memiliki efek onkostatik pada kanker payudara. Kanker payudara merupakan salah satu kanker yang terinduksi pada paparan estrogen. Estrogen dapat menstimulasi proliferasi sel epitel payudara melewati  2 cara yaitu berikatan dengan reseptor α sehingga menyebabkan propagasi dan kemungkinan estrogen langsung bersifat genotoksik. Melatonin dapat menekan pertumbuhan kanker payudara karena  memiliki kemampuan untuk menghambat radikal bebas, imunomodulator, menekan aktivitas telomerase dan mempengaruhi sintesis serta transduksi sinyal hormon estrogen. Melalui studi epidemiologis juga membuktikan bahwa terdapat hubungan yang bermakna antara wanita yang bekerja malam hari  dengan peningkatan risiko terjadinya kanker payudara. Beberapa uji klinik juga membuktikan bahwa pemberian suplemen melatonin pada penderita kanker payudara dapat meningkatkan angka kesembuhan.
Perbandingan Pengaruh Indeks Massa Tubuh (IMT ) Perokok dengan Bukan Perokok Pasien Penyakit Jantung di Rumah Sakit Umum Daerah Kota Bekasi Tahun 2016 Dwi Rahmawati, Santi; Kenconoviyati, Kenconoviyati
Majalah Kesehatan Pharmamedika Vol 9, No 2 (2017): DESEMBER 2017
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v9i2.679

Abstract

Indeks massa tubuh (IMT²) adalah berat badan dalam kilogram (kg) dibagi tinggi badan dalam meter kuadrat (m²) Indeks massa tubuh merupakan suatu parameter obesitas yang dapat memperkirakan risiko seseorang dapat terkena penyakit penyerta obesitas atau tidak. Makin tinggi nilai IMT, makin tinggi pula risiko terkena penyakit penyerta obesitas. Indeks massa tubuh berlebih atau obesitas mengundang potensi terserang penyakit diabetes dan hipertensi yang nantinya juga akan berdampak pada jantung. Tujuan penelitian ini adalah mengetahui perbandingan pengaruh indeks massa tubuh perokok dengan bukan perokok pasien penyakit jantung di RSUD Kota Bekasi Penelitian ini menggunakan desain penelitian cross sectional dengan jenis data kuantitatif. Teknik penetapan besar sampel dilakukan dengan menggunakan rumus Slovin. Total responden penelitian sebanyak 160 responden, dengan kriteria yaitu pasien yang berkunjung dan berobat ke poli jantung RSUD Kota Bekasi pada tahun 2016. Pengambilan data menggunakan kuesioner dengan analisa statistika Chi-square. Hasil analisis uji statistik chi-square didapatkan indeks massa tubuh pasien perokok penyakit jantung memiliki p-value 0.03 yang dikatakan terdapat hubungan antara indeks masa tubuh perokok dengan penyakit jantung. Berbanding terbalik dengan pasien bukan perokok yang memiliki p-value 0,05 dikatakan tidak terdapat hubungan antara indeks massa tubuh dengan penyakit jantung. Indeks massa tubuh perokok pasien penyakit jantung lebih banyak memiliki indeks massa tubuh yang lebih. Sedangkan untuk bukan perokok lebih banyak memiliki indeks massa tubuh normal

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