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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 23 Documents
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Search results for , issue "Vol. 31 No. 3 (2025)" : 23 Documents clear
Hydatidiform Mole Pregnancy with Hyperthyroidism: A Case Report Dewi, Ni Made Ratih Purnama; Gotera, Wira; Lestari, Anak Agung Wiradewi; Herawati, Sianny; Wande, I Nyoman; Mulyantari, Ni Kadek; Sudana, I Nyoman Gde; Prabawa, I Putu Yuda
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2243

Abstract

Hyperthyroidism is a condition with excess biosynthesis and hormone secretion by the thyroid gland. One of the secondary causes of hyperthyroidism is hydatidiform mole pregnancy, which is included in Gestational Trophoblastic Disease (GTD). Hyperthyroidism in hydatidiform mole pregnancies occurs due to increased beta-Human Chorionic Gonadotropin (beta-hCG).  Increasing beta-hCG level affects stimulation of the thyroid gland, increasing thyroid hormone levels in the serum, which causes thyrotoxicosis. This case is such a rare case. A 22-years-old female, G1P0A0, came complaining of amenorrhea accompanied by vaginal bleeding with abdominal pain, nausea, vomiting and palpitations.accompanied by vaginal bleeding with abdominal pain, nausea, vomiting and palpitations. Physical examination showed tachycardia with a pulse rate of 120 beats per minute. Ultrasound examination of the abdomen showed an anteflexed uterus with a honeycomb appearance. Based on a series of tests, the patient has a hydatidiform mole pregnancy with a risk of impending thyroid storm, indicated by TSH suppression with increased fT4. Beta-hCG can cause hyperthyroidism through cross-reaction with TSH receptors. In patients with hyperthyroidism due to GTD, it is not characterized by the characteristic features often found in Graves' disease. Evacuation with curettage and medication was performed to reduce thyroid hormone and serum beta-hCG levels. Hyperthyroidism is an abnormality that can be found in hydatidiform mole pregnancies. It is important to carry out early detection by examining thyroid function in GTD, proper management, and regular monitoring of thyroid function and beta-hCG in pregnant female to provide comprehensive management and prevent complications that can be caused by hyperthyroidism.      
Analysis of Urine Synaptopodin Levels in Non-Diabetic Adults with Obesity and without Obesity Sheridan, Sabilla; Samad , Raehana; Kurniawan, Liong Boy
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2293

Abstract

Obesity correlates strongly with insulin resistance and diabetes mellitus and ultimately becomes a major risk factor for kidney disease. Podocytes play a crucial role in maintaining glomerular filtration balance. Synaptopodin is a proline-rich protein closely associated with the actin microfilaments in podocyte foot processes. This study aims to compare urinary synaptopodin levels in non-diabetic obese subjects with non-obese subjects. A cross-sectional study was conducted on males and females without diabetes mellitus who met inclusion and exclusion criteria. Urinary synaptopodin levels were assessed using an ELISA method. The study included 70 participants, comprising 35 males and 35 females. There were 36 obese subjects and 34 non-obese subjects. No significant difference was found in urinary synaptopodin levels between non-obese and obese subjects (0.51±0.43 vs. 0.49±0.37 ng/dL, p=0.672). No correlation was found between urinary synaptopodin levels and body mass index (r = -0.060, p=0.623). Urinary synaptopodin levels did not differ significantly between non-obese and obese subjects.
Correlation between Serum Visfatin Level with Glycemic Control in Type 2 Diabetes Mellitus Subjects Fadillah, Ismirayanti; Nurahmi, Nurahmi; Kurniawan, Liong Boy
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2304

Abstract

Visfatin is an endocrine, paracrine, and autocrine peptide that functions in cell proliferation and glucose metabolism. Visfatin has insulin-like characteristics. Serum visfatin level is increased in diabetes mellitus subjects despite other contradicting results. The study aimed to investigate the correlation between serum visfatin level and glycemic control in subjects with type 2 diabetes mellitus. The study was a cross-sectional involving all patients diagnosed with type 2 diabetes mellitus at Dr. Wahidin Sudirohusodo Hospital as the research population. The research sample was all patients with type 2 diabetes mellitus and had HbA1c examination results that met the inclusion criteria. The level of serum visfatin was measured using the ELISA technique from Biobase. Data were statistically analyzed using Kolmogorov-Smirnov test, Mann-Whitney test, and Spearman’s correlation test. The research sample consisted of 70 subjects who were grouped into good glycemic control and poor glycemic control based on HbA1c values. Serum level of visfatin did not significantly differ between those with good and poor glycemic control (0.54±0.58 vs. 0.51±0.45 ng/mL, p=0.990). The level of serum visfatin and HbA1c value did not significantly correlate (p=0.813).  
Female Toddler Presenting with Suspected Gaucher Disease: A Rare Case Report Yunanto, David; Prihatni, Delita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2323

Abstract

Gaucher disease is a rare metabolism disease caused by a mutation of the glucocerebrosidase (GBA1) gene. The mutation causes an accumulation of glucocerebroside lipids (glycolipid glucocerebroside), which are harmful to the body. The accumulation goes within all areas of the body especially within the marrow, liver, and spleen. In the non-Jewish population, Gaucher disease affects 1 out of every 100,000 people. This case report describes the laboratory approach and interpretation of Gaucher disease. A 20-month-old female toddler with an enlarged abdomen accompanied by a history of severe dehydration and seizure without evidence of vomiting and diarrhea came to the nutrition Outpatient Clinic. Physical examination found hepatomegaly of 10 cm under arcus costa and spleen Schuffner 3. Laboratory findings are as follows:  hemoglobin 10.2 g/dL (10.5-13.5 g/dL) and thrombocyte 73,000/mm3 (150,000-450,000/mm3), total bilirubin 1.289 mg/dL (0.100-1.000 mg/dL), direct bilirubin 0.567 mg/dL (0.100-0.300 mg/dL), ferritin 310.1 ng/mL (4.63-204 ng/mL), APTT 41.30 s (21-41 s), CMV IgG and IgM 747.4 AU/mL (<6.0 AU/mL) and 1.3 index (<0.85 index), respectively. Gaucher disease should be considered in patients with unexplained splenomegaly, thrombocytopenia, frequent nosebleeds, anemia, acute or chronic bone pain, and/or delayed development. Gaucher cells shown in bone marrow examination can help diagnose Gaucher disease although the gold standard is the glucocerebrosidase enzyme test. This case report highlights the examination flow until the patient can be diagnosed with LSD in this case Gaucher disease.
Calcium and CA 15-3 Level in Breast Cancer Patients Pre- and Post-Mastectomy Surgery Kirom, Umi Aminotul; Santosa, Budi; Limijadi, Edward Kurnia Setiawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2343

Abstract

Breast cancer has a potentially affect the calcium levels because of its role in regulating cell proliferation, differentiation, migration, invasion, metabolism, and apoptosis. Analysis related to changes in calcium levels in breast cancer patients can contribute to developing patient treatment plans. CA 15-3 is a protein made primarily by breast cancer cells and is an epitope of the transmembrane glycoprotein (MUC1). High concentrations of calcium and CA 15-3 levels are associated with tumor burden and prognostic factors for breast cancer. This study aims to prove that there are differences in the results of an examination of calcium levels and CA 15-3 in breast cancer patients before and after mastectomy surgery. In this study, 50 female patients who were diagnosed with stage I, II, and III breast cancer had their serum CA 15-3 levels and calcium levels checked before and 10 days after surgery. The research analysis used for this difference test is the paired T-test and the Wilcoxon test. In this study, it was found that CA 15-3 levels decreased after breast surgery. Mean calcium levels before surgery were (10.092+1.2762 mg/dL). Mean calcium levels after surgery were (8.489+1.0204 mg/dL). CA 15-3 levels before surgery were 26.895+18.4914 UI/mL and after surgery were 21.678+11.9711 UI/mL. It can be concluded that there was a decrease in calcium levels of 1.603 mg/dL, and CA 15-3 levels decreased by 5.217 UI/mL between before and after mastectomy surgery.
Correlation of High Fluorescence Lymphocyte Count and Thrombocytopenia in Dengue Fever Infection Ileandea, Brigita Vania; Nurhayati, Dewi; Sunardi, Agus; Hikam, Muhamad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2344

Abstract

Dengue fever is a disease with mosquitos as vectors that carry one of four types of viruses (DENV -1, -2, -3, and -4). Dengue infects almost 2.5 million people throughout the world. Based on the latest WHO classification, it carries an extensive range of symptoms and severity. High Fluorescence Lymphocyte Count (HFLC) is a simple hematological parameter that calculates the amount of nucleic acid in ribonucleic acid or RNA in reactive lymphocytes. Lymphocyte reactions in patients with dengue virus infection give rise to this study, suggesting that HFLC can predict the severity of thrombocytopenia. This research was an observational analytical study with a cross-sectional design. This study aims to look at HFLC as an indicator of the seriousness of platelet counts in dengue fever patients. There was no significant relationship between HFLC values and thrombocytopenia in the children with dengue infection (p=0.496). In the adult group, there was a significant relationship between HFLC and thrombocytopenia (p=0.002). The Receiver Operating Characteristic (ROC) curve for HFLC as a predictor of severe thrombocytopenia in an adult group showed an HFLC cut-off of 5.35, sensitivity of 56.8%, and specificity of 58.5%. In conclusion, a significant relationship was found between HFLC values and thrombocytopenia in the adult group with dengue fever.
Crossmatch Results After Repeated Transfusions Horian, Erinca; Lismayanti, Leni; Sugianli, Adhi Kristianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2349

Abstract

Patients with thalassemia, chronic kidney disease, hematologic and non-hematologic malignancies may require repeated transfusions. Repeated transfusions can have a detrimental effect, leading to the formation of alloantibodies and/or autoantibodies. These antibodies can cause incompatible crossmatch results. This study aims to identify the clinical characteristics of patients with incompatible crossmatch results after repeated transfusions, to ensure safe transfusions. This study is a cross-sectional, observational descriptive study conducted at Dr. Hasan Sadikin General Hospital from January to December 2022. Patients were included if they had received more than one transfusion within the past year, defined as 'repeated transfusions'. The following data were collected: age, gender, blood type, diagnosis, quantity of blood bags, total number of transfusions, interval between transfusions, history of incompatibility, and Coombs Test. The data were obtained through the laboratory information system and from blood request forms in the Blood Service Unit. Out of 2285 subjects receiving repeated transfusions, 38.1% experienced crossmatch incompatibility. The majority (91.2%) of these cases were minor. Crossmatch incompatibility occurred more frequently in subjects under the age of 15 (22.6-23.3%) and those with diagnosis of thalassemia (25.6-27.3%). Most subjects with minor crossmatch incompatibility had a history of receiving more than four blood bags (51.9-60%), an interval between transfusions of four weeks or less (92.2-92.8%), and a history of previous incompatibility (72.1-80.5%). The important clinical characteristics of patients with incompatible crossmatch results after repeated transfusions were age, underlying diagnosis, quantity of blood bags, interval between transfusions, and history of previous crossmatch incompatibility.
Mapping of Donor Blood Antigens and Development of Panel Cell Reagents in Bali Province Mulyantari, Ni Kadek; Lestari, Anak Agung Wiradewi; Herawati, Sianny
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2351

Abstract

Examination of other blood groups' antigens, such as Rhesus (d, C, c, E, e), Kell, Duffy, Kidd, and others, is not routinely carried out in blood services. This study aimed to determine the type of blood group antigen and the composition of the antigens of panel cell reagents for antibody screening and identification in Bali. The subjects were 120 voluntary donors who regularly donate blood. Blood group antigen examination was carried out with a column agglutination test. The antigen mapping was analyzed to determine the possible development of panel cell reagents. Among 120 research subjects, 76.67% were male. Rhesus antigen mapping showed 73.3% DCe phenotype, 3.33% DcE, 3.33% Dce, 19.17% DCE. MNS system, 22.5% M-N+, 35.83% M+N+, 85% S-s+, 14.17% S+s+ and 0.83% S+s-. For the Kell system, no donor with phenotype K+k-, 5.83% K+k+, 94.17% K-k+. No donor with Kpa antigen and 100% with Kpb antigen. Based on Duffy system, 74.17% Fy (a+b), 23.33% Fy(a+b+), 1.7% Fy(a-b+), 0.8% Fy(a-b-). For Kidd system 36.67% Jk(a+b-), 45.83% Jk(a+b+), 17.5% (Jk(a-b+) and no donor with Jk(a-b-). The screening analysis of donor antigens allows the development of panel cell reagents using two types of panel cells. Most donors have a Rhesus DCe phenotype with other dominant antigens, M+N+, S-s+, K-k+, Kpb, Fy(a+b-), and Jk(a+b+). The development of panel cell reagents can be done with the antigen composition of R1R1 (D, C, e, M, S, k, Kpb, Fya, Jka) and R2R2 (D, c, E, M, N, s, K,k, Kpb, Fya, Fyb, Jka, Jkb).  
Mid Regional Pro-Adrenomedullin, Lactate, and Risk Factors as Predictors of Sepsis Severity Andi Widagdo, Heribertus; Kurniati, Amiroh; Pramudianti, Maria Immakulata Diah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2352

Abstract

Sepsis is a syndrome determined by pathogenic and host factors, including gender, age, comorbidities, and bacteremia. A high level of MR pro-ADM is associated with vascular relaxation, while a high lactate level indicates tissue hypoxia and anaerobic metabolism. This study aimed to assess MR pro-ADM and lactate as predictors of sepsis severity by considering age, gender, comorbidities, clinical screening, and bacterial culture result factors. This study used an observational analytic research design with a prospective cohort approach. Researchers consecutively collected a sample of 80 sepsis patients at Dr. Moewardi Regional General Hospital (RSDM) in February-March 2023. Clinical characteristics, demographics, physical examinations, and laboratory results were collected from medical records and the Hospital Information System (HIS) of RSDM. MR pro-ADM and lactate levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA) and enzymatic amperometric methods. There were significant differences in severity and mortality predictor variables (clinical screening, log_lactate >0.40, bacterial culture). The ranking of the strength of association of predictors of severity was clinical screening ((Odds Ratio (OR)=15.40), bacterial culture results (OR=3.7), log_lactate (OR=2.74). Clinical screening, lactate, and culture results were independent predictors of sepsis severity. Multi-center studies with more complete data, considering other factors that influence sepsis, and using more accurate methods of measuring ADM and lactate are recommended.
The Predominance of the Synthesis Phase in Cell Cycles in Childhood Acute Lymphoblastic Leukemia Hernaningsih, Yetti; Aryati, Aryati; Ugrasena, I Dewa Gede; Nunki, Nastasya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2360

Abstract

Uncontrolled proliferation and resistance to apoptosis should be controlled to kill the cancer cells, as the goal of treatment in acute leukemia. It is therefore important to know, which characteristic dominates the proliferative phase because, to be more effective, new drugs that will be developed should be targeted at that phase. This study aimed to find the dominant phase in the proliferative phase of the cell cycle in childhood Acute Lymphoblastic Leukemia (ALL). This study was conducted on 63 patients, comprising 33 patients with specimens of Bone Marrow Mononuclear Cells (BMMC), 30 patients with specimens of Peripheral Blood Mononuclear Cells (PBMC), and 10 children as controls with specimens of PBMC. Cell cycle examinations were performed with PI/RNase, run on BD FACS Calibur, and analyzed with modfit LT 4.1 software to determine the phases of G0/G1, synthesis (S), and mitosis (G2/M). Regarded the S and G2/M phases as the proliferation phase. Statistical analyses used one-way ANOVA and Kruskal-Wallis to compare S and G2/M phases within groups,and an Independent T-test and Mann-Whitney to compare the same phases between groups. Among the proliferation phases, the synthesis phase had significantly higher domination than the mitotic phase in both the BMMC (10.18±7.81% vs. 5.41±3.77%; p = 0.010) and PBMC (4.33±2.15% vs 2.30±1.56%; p=0.000) groups. A similar result was found in the control group (1.01±0.51% vs 0.36±0.38%; p=0.011). The synthesis phase in BMMC had significantly higher domination than PBMC groups (p=0.024) and control (p 0.002). The synthesis phase predominates among the proliferation phases of the cell cycle in childhood ALL.

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