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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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FUNGSI DAN PEMERIKSAAN LIMFOSIT γδT (Functions and Examination of γδT lymphocytes) Yulia Nadar Indrasari; Jusak Nugraha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1230

Abstract

T lymphocytes most have TCR α and β chains. However, TCR formed from γ and δ chains determine a new subset of T lymphocytes. γδTCR specific to different types of ligands, including bacterial phosphoantigen, nonclassical MHC-I molecules and unprocessed protein. γδT lymphocytes have several innate cell-like features that allow their early activation following the recognition of conserved stress-inducedligands. γδ T lymphocytes able to rapidly produce cytokines that regulate pathogen clearance, inflammation and tissue homeostasisin response to tissue stress. They are capable of generating more unique antigen receptors than γδ T lymphocytes and B lymphocytescombined, yet their repertoire of antigen receptors is dominated by specific subsets that recognize a limited number of antigens. A varietyof sometimes conflicting effectors functions have been ascribed to them, yet their biological functions remain unclear. Innate featuresof γδ T lymphocytes underlie their non-redundant role in several physiopathological contexts and are therefore being exploited in thedesign of new immunotherapeutic approaches. The purpose of writing is giving an overview in mainly functions of γδ T lymphocytes inthe immune system and laboratory tests that expand knowledge about the introduction of γδ T lymphocytes.
PERALIHAN (KONVERSI) SPUTUM BTA ANTARA PEMBERIAN DOSIS BAKU (STANDAR) DAN TINGGI RIFAMPICIN PADA PENGOBATAN (TERAPI) ANTI TUBERKULOSIS KELOMPOK (KATEGORI) I Yani Triyani; Ida Parwati; I. Sjahid; J. E. Gunawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.917

Abstract

Acid fast bacilli (AFB) sputum microscopy is used as a diagnostic tool of pulmonary tuberculosis (TB) in TB eradication program with directly observed treatment short course (DOTS) strategy. The AFB sputum microscopy should be performed before treatment,two months after intensive phase and four months after advance phase treatment. This study is a part of a research to compare thestandard (450 mg) and high (600 mg) rifampicin dose in patients with pulmonary tuberculosis in Indonesia. The aim of this studywas to detect the sputum conversion time of AFB in pulmonary TB patients who obtained category I antituberculous treatment with standard dose compared to one who received high dose of rifampicin at the beginning and at the end of the intensive phase. This AFB sputum microscopy have been performed from September 2003 until August 2005 from 85 pulmonary TB patients every two weeksusing Ziehl Neelsen and read by means of International Union Against Tuberculosis and Lung Diseases (IUATLD) scale, in PoliklinikParu Balai Pengobatan Penyakit Paru-paru and Department of Internal Medicine RS. Dr. Hasan Sadikin. Patients with pulmonary TBwho obtained category I antituberculous treatment of the intensive phase were divided randomly double blind into two groups, usingstatistical analysis by Page test for order alternative and Mann Whitney test. After randomization, there were 52 patients who receivedstandard dose and 33 patients who had high dose of rifampicin. Sputum conversions of AFB on week 2, 4, 6, and 8 were 36.1%, 63.9%,75%, and 91.7% for standard dose group. Sputum conversions of AFB on week 2, 4, 6, and 8 were 46.2%, 80.8%, 80.8%, and 84.6%for high dose group. Sputum conversion of AFB for high dose group were faster than standard dose group (p=0.030). Dropout (DO)patients were 5.9% (5/85) and no sputum conversion of AFB on week 8 was 8.3% and 15.4% for standard dose group and high dosegroup of rifampicin, respectively. Sputum conversions of AFB for high dose group were found significant more quickly than standarddose group of rifampicin statistically.
TENSILE STRENGTH AND FIBRINOGEN YIELD IN FIBRIN GLUE PREPARATIVES WITH AND WITHOUT FREEZE-DRYING METHOD Brilliant Margalin; S. P. Edijanto; Paulus B. Notopuro
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1460

Abstract

Fibrin glue is a useful biological product to stop bleeding, adhesive tissue and accelerate wound healing. Preparation of Fibrin Glue requires fibrinogen and thrombin components. The routine cryoprecipitation method performed at the Blood Bank can be used to improve the quality of the fibrinogen component. The Freeze Drying process can increase the retention time of plasma products at room temperature. Yield Fibrinogen and Tensile Strength is a quantitative and qualitative parameter of preparation quality of fibrin glue. This study focused on finding differences between Tensile Strength and Yield Fibrinogen on fibrin glue preparative by cryoprecipitate with and without freeze drying methods.This study is in vitro laboratory experiments design by comparing the Yield Fibrinogen and Tensile Strength of fibrin glue preparation from cryoprecipitic plasma with and without freeze dried process. The results were analyzed comparatively using paired T test.The plasma fibrinogen content of the sample was 237.66 ± 67.10 mg / dL. The fibrinogen content of the cryoprecipitate component without freeze drying process was 327.74 ± 103.42 mg / dL with a yield fibrinogen of 1.38 ± 0.25. The fibrinogen content of the cryoprecipitate component with freeze drying process was 251.20 ± 103.91 mg / dL with yield fibrinogen 1.04 ± 0.25. Tensile strength of fibrin glue from cryoprecipitate without freeze drying process was found to average 0.52 ± 0.18. Tensile strength of fibrin glue from cryoprecipitate with freeze drying process was found to average 0.33 ± 0.12. There was a significant difference between yield fibrinogen and tensile strength of fibrin glue preparation of cryoprecipitation method with and without freeze dried process.There is a significant difference on yields fibrinogen and tensile strength in the preparation of fibrin glue by the freeze drying process which is probably due to changes in the structure and function of fibrinogen proteins.
MEAN PLATELET VOLUME DI STROK Besse Rosmiati; Sulina Y Wibawa; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.392

Abstract

Ischemic stroke is the cause of most cases which occur due to obstruction, this pathogenesis can be caused by the formation of thrombus in the cerebrum blood vessels. Platelet aggregation plays a role in the pathogenesis of thromboembolic cerebrovascular disease. Platelets size, measured as Mean Platelet Volume (MPV) is a marker of platelet function and is associated with the indicator of platelet activity. Several studies have found that there was an increased of MPV in acute ischemic stroke while the correlation with the severity and outcome of stroke was still controversial. The aim of study is to determine the MPV and their association with outcomes in acute ischemic stroke patients. A cohort study during May up to July 2010 was carried out, the researchers measured MPV and analyze their correlation with its outcome using modified Rankin scale score 10 days after the onset in 33 acute ischemic stroke patients. The mean of MPV for the first three days of the onset was 8.9 fl, on the 5th day was increased up to 9.4 but at the 10th day of onset the MPV remains the same value as the 5th day. The MPV of first three days and 5th day have a positive correlation, but insignificant with their outcome, with p values 0.158 and 0.06, respectively. From this study can be concluded that the increased of MPV on the fifth day onset did not have any significant correlation with the outcome of acute ischemic stroke illness.
AGREGASI TROMBOSIT DAN MEAN PLATELET VOLUME DENGAN SINDROM METABOLIK TERKAIT KEGEMUKAN Nindia Sugih Arto; Adi Koesoema Aman; Dharma Lindarto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1095

Abstract

The hyperactivity of platelet had been seen in patients with metabolic syndrome which can be caused by several factors, such as:insulin resistance, obesity, dyslipidemia and hypertension. The hyperactivity of platelet leads to its aggregation that can be increased therisk of cardiovascular disease. This study is aimed to know the platelet aggregation and mean platelet volume in patients with metabolicsyndrome and obesity by determination 30 patients were choosen for this cross sectional study, those whom attended to the laboratoryand policlinic at H. Adam Malik Medan Hospital, between May 2013 until August 2013. The diagnosis used of metabolic syndromecriteria established by the International Diabetic Federation 2005. From the 30 patients with 15 metabolic syndrome and 15 obesity,four patients were excluded because of their tryglyceride were more than 200 mg/dL. There is no significant differences between theplatelet aggregation with the agonist adenosin difosfat (ADP) in patient with metabolic syndrome and obesity. And there is no significantdifferences of the mean platelet volume values between the metabolic syndrome (9.6±0.93) and the obesity group (9.73±0.74), with pvalue 0.846. Based on this study there is no significant differences between the platelet aggregation and the Mean Platelet Volume values(MPV) in the metabolic syndrome and the obese group
COAGULATION ACTIVITY AND D-DIMER IN SEPSIS PATIENTS Anggraini D; Maani H; Rofinda Z D
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 2 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i2.1315

Abstract

Sepsis is a systemic inflammatory response with the presence of suspected or proven infection. The inflammation will increase the production of proinflammatory cytokines that will activate coagulation and suppress fibrinolytic system. An imbalance of hemostasis mechanism and inflammation in sepsis can progress into Disseminated Intravascular Coagulation (DIC). The objective of this study was to determine the coagulation activity (platelet count, Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT)), and D-dimer in sepsis patients. A descriptive study was conducted at the Dr. M. Djamil Hospital on December 2012-July 2013. Subjects were adult patients with two or more of four criteria for Systemic Inflammatory Response Syndrome (SIRS) and presence of suspected or proven infection admitted to the Department of Internal Medicine. Laboratory examination was conducted in the Clinical Pathology Laboratory Dr. M. Djamil Hospital including the coagulation activity and D-dimer level. Data were processed manually and presented in distribution tables, and diagrams. Subjects of this study were 54 sepsis patients, consisting of 57% males and 43% females with a median age of 53.5 year-old, platelet count 188.5 x 103/µL, PT 13.7 seconds, aPTT 39.3 seconds, and D-dimer level 1.15 μg/mL. Based on this research it can be concluded that coagulation activity in sepsis patients showed that platelets count were still in the normal range while PT and aPTT were prolonged and D-dimer levels were increased. 
ANALYSIS OF DECREASED GLUCOSE LEVEL IN STORED SAMPLES CORRELATED TO SERUM SEPARATION AND TEMPERATURE STORAGE Gustamin Gustamin; Liong Boy Kurniawan; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1157

Abstract

Glukosa darah merupakan uji yang rutin untuk menilai bahaya penyakit diabetes melitus. Masalah utama yang dihadapi rumahsakit di daerah adalah sering terjadinya penundaan terhadap pemeriksaan glukosa darah, sehingga terjadi penurunan kadar glukosaakibat glikolisis. Penelitian ini bertujuan untuk mengetahui penurunan kadar glukosa darah berdasarkan suhu penyimpanan danpemisahan serum. Penelitian ini merupakan penelitian observasional dengan pendekatan kohort kajian yang dilakukan di RS Dr. WahidinSudirohusodo masa waktu Agustus 2016. Kadar glukosa diukur dengan menggunakan ABX-Pentra 400. Data yang didapat dianalisismenggunakan uji statistik Shapiro wilk dan wilcoxon. Hasil penelitian didapat dari 22 sampel darah lengkap dengan perlakuan berbedaberdasarkan suhu penyimpanan dan pemisahan serum. Hasil menunjukkan perbedaan bermakna antara glukosa serum dengan bekuanyang disimpan selama 2 jam pada suhu ruang yang mengalami penurunan sebesar 9,32 mg/dL jika dibandingkan dengan penyimpananselama 2 jam pada suhu freezer yaitu sebesar 0,8 mg/dL (p=0,000) dan jika dibandingkan dengan serum pada suhu ruang selama 2jam sebesar 1,38 mg/dL (p=0,000). Sampel untuk pemeriksaan glukosa yang tertunda sebaiknya dilakukan pemisahan antara serumdan bekuan eritrosit agar tidak terjadi penurunan glukosa.
KATEKIN DAUN TEH HIJAU (Camelia sinensis) TERHADAP MALONDIALDEHYDE DAN SUPER OXIDE DISMUTASE Sukina B; Gwenny I.P; Suhartati Suhartati; Harianto N
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1063

Abstract

Recent studies have shown that Plumbum could disrupt tissue prooxidant/antioxidant balance. The green tea leaves (Camelliasinensis) is an antioxidant scavenger of free radicals and chelator of heavy metals. This study was designed to know and investigate theefficacy of Katekin from green tea leaves malondialdehid (MDA) and superoxide dismutase (SOD) activity in erythrocytes caused by oralPb administration in Wistar rats. Thirty adult male rats were divided into six (6) groups (each groups: 5 rats): K+ group (oral 33.75mg/bw Katekin), K group as a normal control, K- group (oral 15.82 mg/day lead acetate), P1 group (oral 22.5 mg/bw Katekin and 15.82mg/day lead acetate, P2 group (oral 33.75 mg/bw Katekin and 15.82 mg/day lead acetate for), and P3 group (oral 45 mg/bw/Katekinand 15.82 mg/day lead acetate) for 4 weeks. The results showed that Pb exposure induced the raised of MDA levels and decrease SODactivity in erythrocytes of rats. The administration of Katekin from green tea leaves significantly reduced MDA levels and increased SODactivity in Pb exposed erythrocytes of rats. The optimal dose of Katekin from green tea leaves as a scavenger of free radicals and chelatorof heavy metals was 22.5 mg/bw/day (P1). These results indicated that the administration of Katekin from green tea leaves may havean important role in modulating oxidative stress in Pb exposed erythrocytes, but at a higher concentration of Katekin from green tealeaves showed prooxidant activity.
KENASABAN FOSFAT SERUM, C-REAKTIF PROTEIN DAN FETUIN A DI PASIEN GINJAL TAHAP AKHIR DENGAN HEMODIALISIS KS, Indranila; Winarto, Heri; AP, Purwanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1125

Abstract

Patients with end-stage renal disease (ESRD) who undergo hemodialysis have chronic inflammation caused by several factors,including biocompatibility of dialyzer membran. Inflammation will decrease the fetuin A level in serum. The elevation of the markerinflammation (CRP), hyperphosphatemia and decrease of fetuin A level are the risk faktors for vascular calcification. The aim of thisstudy was to know the relationship between serum phosphate, CRP and fetuin A levels in ESRD patients who underwent hemodialysis. Theresearch was carried out by observational cross sectional analytical approach with consecutive sampling on 31 ESRD patients undergoingchronic hemodialysis in the Hemodialysis Unit of the Dr.Kariadi Hospital, by examining levels of CRP by ELISA, serum phosphate byPhosphomolibdate methods and fetuin A by ELISA. The relationships between phosphate serum and CRP, CRP and fetuin A, phosphateserum and fetuin A were analyzed using Spearman correlation test. In this study it was found that 100% of subjects had CRP levels >0.3mg/dL (reference range 0.1-0.3 mg/dL); 61.3% of subjects had serum phosphate >5.1 mg/dL (reference range 2.5-5.1 mg/dL) and allsubjects (100%) had fetuin A levels <0.5 ng/mL (reference range 0.5-1 ng/mL). There was a moderate positive significant correlationbetween serum phosphate and CRP (p=0.024 and r=0.404), there was a strong negative significant correlation between CRP and fetuinA (p=0.000 and r=-0.628). No significant correlation between the phosphate serum and fetuin A (p=0.365 and r=-0.168) was found.Based on this study, it was found that the higher serum phosphate level resulted in a higher CRP and lower fetuin A.
DARAH AMAN DAN PENDONOR DARAH SUKARELA (Safe Blood and Voluntary Non-Remunerated Blood Donors) Teguh Triyono; Veronica Fridawati; Usi Sukorini; Budi Mulyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1253

Abstract

Safe blood was collected from safe, low risk donors with a related absence of infectious disease screening as well. WHO has statedthat to guarantee its safety, blood should only be collected from voluntary non-remunerated blood donors (VNBD) coming from a lowriskpopulation. The aim of this study was to know the blood donors’ profile in Fatmawati Hospital (FH), Jakarta and Dr. SardjitoHospital (SH), Yogyakarta by comparison The research was carried out by cross sectional study and data were obtained from the donor’sinformation records 2011-2013. The data were further descriptively analyzed and presented in tables and graphs. The Student’s t-testwas used to analyze the difference of percentage mean for VNBD per-month between two hospitals with p<0.05. Based on the blooddonor types, it was shown that most of the blood donors consisted of replacement persons. The mean of monthly VNBD percentage wassignificantly higher in FH than in SH. There was an increased VNBD percentage i.e. 32, 35, 54 (FH) and 12, 18, 22 (SH) respectively,within the year 2011, 2012 and 2013.

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