cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Dr. dr. Puspa Wardhani, SpPK
Contact Email
admin@indonesianjournalofclinicalpathology.org
Phone
+6285733220600
Journal Mail Official
majalah.jicp@yahoo.com
Editorial Address
Laboratorium Patologi Klinik RSUD Dr. Soetomo Jl. Mayjend. Prof. Dr. Moestopo 6-8 Surabaya
Location
Kota adm. jakarta selatan,
Dki jakarta
INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
 20   21   22   23   24 
EFEK SINERGIS KLOROKUIN DAN N-ACETYL CYSTEINE TERHADAP PENURUNAN PARASITEMIA DAN PENURUNAN KADAR MALONDYALDEHYDE ERITROSIT MENCIT YANG DIINFEKSI PLASMODIUM BERGHEI Iskandar, Agustin; Sudjari, Sudjari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.439

Abstract

Malaria is still a global health problem around the world particularly in Indonesia. Chloroquine is one of the anti-malarial drugs which is still used in Indonesia. The aim of this research is to know the synergic effect of Chloroquine and N-Acetyl Cysteine towards parasitemia and erythrocyte malondyaldehyde levels in mice infected with Plasmodium berghei. This was an experimental research using Plasmodium berghei and BALB/c strain mice, 6−8 weeks old, with body weight 20−30 grams. After infected with Plasmodium berghei, the mice were divided into eight (8) groups: control, chloroquine, NAC 0.25 mg/gBb; NAC 0.5 mg/gBb; NAC 1 mg/gBb and combined drugs of chloroquine and NAC 0.25 mg/gBb; NAC 0.5 mg/gBb; NAC 1 mg/gBb. On the 3rd, 5th, and 7th day after treatment, the mice were killed and their parasitemia and Malondialdehyde (MDA) levels were measured. By using MANOVA and Tukey HSD test, a signifi cant difference in parasitemia level was found between the control and chloroquine group, as well as the control and combined drug groups. In the NAC groups, there was no decrease. The decrease of MDA level began on the 7th day. It can be concluded that there was a synergic effect between the chloroquine and N-Acetyl Cysteine in decreasing parasitemia and malondyaldehyde levels in mice BALB/c infected with Plasmodium berghei.
FCγII (CD32) MONOSIT DI INFEKSI DENGUE PRIMER DAN SEKUNDER {FcγRII (CD32) Monocytes in Primary and Secondary Dengue Infection} Umi S. Intansari; Usi Sukorini; Shanti Ika Sari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1221

Abstract

Dengue infection is a major health problem in the world, including Indonesia. Clinical manifestations of dengue infection varywidely, from asymptomatic until dengue shock syndrome (DSS). Antibody Dependent Enhancement (ADE) hypothesis that states thatnon-neutralizing antibodies in secondary dengue infection may enhance dengue infection via Fcγ receptors is still controversial. Clinicalresearch shows that not all secondary infections manifest as DHF/DSS, but nearly all DHF/DSS cases are caused by secondary infection.Allegedly, the expression of Fcγ has an effect on this incident. This study is an observational analytical study with a cross sectional designto determine the expression of FcγRII (CD32) monocytes in patients with primary and secondary dengue infection. CD32 of monocyteswas measured using FACS Calibur with lyse no wash technique. Primary and secondary dengue infection were determined by IgM/IgGoptical density ratio using ELISA capture method. The ratio of IgM/IgG ≥1.2 was considered as primary infection, while the ratio <1.2was considered as secondary infection. Twenty primary and 32 secondary dengue infection patients in acute phase of dengue infectionpartisipated in this study. Expressions of Fcγ RII (CD32) monocytes were significantly lower in primary than secondary dengue infection(187.825±31.584 vs 218.598±43.414 MFI; p=0.008). CD32 expressions were higher in day 3 compared to day 4 of fever.
HUBUNGAN ANTARA KADAR HEMOGLOBIN DENGAN KADAR KREATININ SERUM PENDERITA PENYAKIT GINJAL MENAHUN (KRONIS) Rosnety, .; M Arif; Hardjoeno .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.908

Abstract

Chronically Kidney Disease (CKD) is the health problem of society worldwide, included Indonesia which its amount will increase.Clinical manifestation often following CKD is anaemia which will be severe with the increasing of serum creatinine values. To determinefrequent distribution of anaemia degree and assessing relationship between haemoglobin (Hb) and creatinine concentration in CKDpatients. Retrospective Descriptive Study in CKD patients with anaemia. In the period of May-September 2006, from 50 CKD patientsat the Department of Internal Medicine, Dr.Wahidin Sudirohusodo Hospital Makassar, 38 patients (76%) suffered severe anaemia(Hb < 8 g/dl). Mean value of Hb was 6,85 g/dl and serum creatinine concentration was 11.89 mg/dl. There was a significantrelationship between increasing of serum creatinine and decreasing of Hb (p = 0,013). Majority of CKD patients suffered from severeanaemia, there was relationship between increasing of serum creatinine and decreasing of Hb. To make routine blood tests and bloodsmears in CKD patients is needed, with large of samples to assess the relationship between Hb and serum creatinine.
THE RELATIONSHIP BETWEEN THE LEVEL OF INTERLEUKIN-6 AND PROCALCITONIN IN SEVERE SEPSIS PATIENTS AT THE ADAM MALIK HOSPITAL Sesily C Nainggolan; Adi Koesoema Aman; Achsanudin Hanafie
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1488

Abstract

Severe sepsis is defined as sepsis that is accompanied by one or more organ dysfunctions, hypotension or hypoperfusion (decreased renal function, hypoxemia, lactic acidosis, oliguria, mental status changes). Macrophages and monocytes produced Procalcitonin (PCT) in serious bacterial infections and sepsis. Interleukin-6 (IL-6) is an interleukin that acts as proinflammatory cytokines. The high IL-6 level is due to chronic inflammation and sepsis. IL-6 is found increased more rapidly in the acute phase, so it can be used to evaluate early phase infection and sepsis. The purpose of this study was to find out IL-6 and PCT levels in severe sepsis patients. This study was a cross-sectional observational study. The subjects were sepsis patients treated in Adam Malik Hospital on Jan-Mar 2016. Statistical data was analyzed using SPSS and the Spearman rank correlation, with significant p-value < 0.05. IL-6 was tested using Chem Well 9210 series. Procalcitonin examination was done by mini VIDAS BRAHMS PCT. There were 40 people observed as subjects in this study, 26 males (65%) and 14 females (35%). The average age of male was 49.42 ± 18.19 years old, the youngest 18 years old, and the oldest 79 years old. The average age of females 57.35 ± 20.73, the youngest 18 years old, and the oldest 87 years old. The average of IL-6  was 10862.12 ± 25489.16 and PCT was 9666.73 ± 10540.13. Spearman rank test was also used, the value of r = 0.176 and p = 0.277. The conclusion is there is no significant correlation between IL-6 and PCT. There is no significant correlation between IL-6 and PCT levels in severe sepsis patients.
PEMERIKSAAN PROTHROMBIN TIME DAN ACTIVATED PARTIAL THROMBOPLASTIN TIME DENGAN HUMACLOT VA SERTA SYSMEX CA 500 Misnah Misnah; Agus Alim Abdullah; Mansyur Arif; Burhanuddin Bahar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 3 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i3.382

Abstract

Prothrombin Time (PT) and an activated Partial Thromboplastin Time (aPTT) are routine coagulation tests used for pre-operative screening. The analytical step as one of the laboratory test’s stage that plays the role in the determination of the test is influenced by several factors, one of them is choosing its proper devices. The aim of this study was to know the correlation of the PT and aPTT test’s result using Humaclot VA and Sysmex CA 500 devices. A cross sectional study has been done at the Clinical Pathology Laboratory of Wahidin Sudirohusodo Hospital Makassar started from May 2009 until June 2009. The data were analyzed with T and Pearson’s Correlation test. From the 50 samples were obtained the percentage of the corresponding frequency of the PT results between Humaclot VA and Sysmex CA 500 about 84%, whereas the frequency of the corresponding results aPPT between Humaclot VA and Sysmex CA 500 is 76%, the Pearson correlation test for PT=0.58, and aPTT=0.38. There were found the suitability of PT, aPTT of Humaclot VA with CA 500 and both tools have a positive correlation.
UJI DIAGNOSTIK PLASMODIUM MALARIA MENGGUNAKAN METODE IMUNOKROMATOGRAFI DIPERBANDINGKAN DENGAN PEMERIKSAAN MIKROSKOPIS Ima Arum L; Purwanto AP; Arfi S; Tetrawindu H; M Octora; Mulyanto Mulyanto; Surayah K; Amanukarti Amanukarti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 3 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i3.871

Abstract

Microscopic examination is still a gold standard for malaria diagnostic tests. Immunochromatographic (IC) technique can be usedas an alternative examination. The aim is to compare the identification value of immunochromatographic method diagnostic test tomicroscopic examination of malaria in laboratory examination. Cross sectional diagnostic study approach was applied to those withsymptoms of: (1) fever (temperature > 38°C) or intermittent fever lasting for two days or more (2) cephalgia/myalgia, 604 sampleswere taken consecutively in January to July 2005 from primary health centres of Sukaraja and Keruak, as well as Clinic Nugraha atLombok Timur district , province of Nusa Tenggara Barat . From these samples, there were 37 samples with P.vivax, 45 samples with P.falciparum, 5 samples with mixed infection and 517 samples without Plasmodium sp. From IC examination, results were reserved for 36samples with P. vivax, 69 samples with P. falciparum, 5 samples with mixed infection and 503 samples without Plasmodium sp. Diagnostictest data analysis showed that the immunochromatographic test revealed 100% sensitivity, 96.7% specificity, 83.2% positive predictivevalue and 100% negative predictive value. It can be concluded that malaria IC test is reliable to be used as a routine malaria test.
ANALYSIS OF HEMOGLOBIN LEVELS AND LEUKOCYTE COUNT IN NEONATES WITH HYPERBILIRUBINEMIA Dewi Suharti; Sulina Yanti Wibawa; Mutmainah Mutmainah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1373

Abstract

Hyperbilirubinemia is one of the most common clinical phenomena in neonatal patient. Etiology is generally physiological, only about 10% being pathological. It is important for clinicians to distinguish between physiological and pathological hyperbilirubinemia, because uncontrolled pathological conditions can cause severe complications of kern icterus, one ofthe causes of death in infants.This study was retrospective study by obtaining data of all neonatal patients with diagnosis of hyperbilirubinemia, who undergone hemoglobin and leukocyte count test. The data were classified into two groups: physiological and pathological hyperbilirubinemia. Statistical tests were performed to assess the association of hemoglobin levels and leukocytes count between the two groups. A total of 144 data were collected, 54 physiological and 90 pathological hyperbilirubinemia. In physiological hyperbilirubinemia, hemoglobin levels and leukocyte counts were found to be normal, whereas in pathological anemia and leukocytosis developed and the difference between the two groups was statistically significant (p<0,001). Anemia was found in neonates with pathological hyperbilirubinemia caused by RDN, LBW, sepsis, hemolytic, and hemorrhagic. Leukocytosis was found in pathological hyperbilirubinemia caused by sepsis.There was a significant difference between the incidence of anemia and leukocytosis in physiological and pathological hyperbilirubinemia. It can be concluded that routine blood tests can be used to distinguish whether hyperbilirubinemia experienced by neonatel patient is a physiological or pathological condition, so it can be one of the tests suggested when the neonate is hyperbilirubinemia.
LEUKOCYTE INTERFERENCE ON HEMOGLOBIN EXAMINATION IN HEMATOLOGY MALIGNANCY Trinil Sulamit; Fery H. Soedewo; Arifoel Hajat
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1193

Abstract

Pasien keganasan hematologi sering menunjukkan gejala anemia dengan hasil laboratorium leukositosis. Tolok ukur penentu anemiasalah satunya hemoglobin, namun pemeriksaannya terganggu oleh jumlah leukosit tinggi yang menyebabkan hemoglobin tinggi palsu.Penelitian ini bertujuan mencari berapa jumlah leukosit minimal penyebab hemoglobin tinggi palsu pada keganasan hematologi. Sampeldarah EDTA pasien keganasan hematologi yang memeriksakan darah rutin di Laboratorium Patologi Klinik RSUD Dr. Soetomo bulanApril–Mei 2016. Penelitian analisis observasional dengan membandingkan hemoglobin tanpa pemusingan dengan hemoglobin setelahpemusingan serta dibuang buffy coat-nya. Terdapat 93 sampel dengan leukemia 43%, limfoma 16,12% dan terduga leukemia 38%.Rerata selisih hemoglobin yaitu 0,06±0,089; 0,025±0,05; 0,1±0,081; 0,15±0,07; 0,81±0,63; 0,94±1,13; 1,13±0,718; 1,6±0,818 g/dL pada peningkatan kelompok jumlah leukosit secara berurutan >11.000-20.000 sel/μL, >20.000-30.000 sel/μL, >30.000-40.000sel/μL, >40.000-50.000 sel/μL, >50.000-100.000 sel/μL, >100.000-200.000 sel/μL, >200.000-300.000 sel/μL, >400.000 sel/μL.Kenasaban rerata selisih hemoglobin dengan kelompok jumlah leukosit menunjukkan makin tinggi leukosit maka makin besar rerataselisih hemoglobin dengan kenasaban positif sedang. Semakin tinggi jumlah leukosit makin tinggi persentase hemoglobin tinggi palsudan rerata selisih hemoglobin makin besar. Leukosit minimal penyebab hemoglobin tinggi palsu pada keganasan hematologi yaitu 56.745sel/μL yang memiliki kepekaan 89,4% dan kekhasan 100%, dengan koefisien  0,592.
UJI KESAHIHAN (VALIDITAS) PEMERIKSAAN D-DIMER CARA MENYARING KEKEBALAN (METODE IMUNOFILTRASI) DAN CARA MENGUKUR IMUNOTURBIDIMETRI David Rustandi; Delita Prihatni; Tiene Rostini; Nina Tristina
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 1 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i1.1049

Abstract

D-Dimer parameter is the most usefull laboratory assay to detect the present of activated coagulation. The D-Dimer fragment directlyindicate the fibrinolitic proccess whereas the increasing mark of D-Dimer is the most hemostatic parameter that was used to detectthe early stage of Disseminated Intravascular Coagulation (DIC) and has a correlation with the patient prognosis. D-Dimer assay byimmunoturbidimetric method was used to detect antigen-antibody reaction automatically and it can detect D-Dimer concentration lessthan 0.5 μg/mL. The immunoturbidimetric method has a good correlation with the ELISA method, but the proccess is complicated, ishigh costed, and need the competence of practical human resource. D-Dimer assay with immunofiltration method has the same principleas immunoturbidimetric method, but it's work more simpler, low cost and does not need the competence of practical human resource.The aim of this study is to compare the D-Dimer assay concentration between immunofltration and immunoturbidimetric method. Therewere 30 plasma samples assayed with these two methods (immunoturbidimetric and immunofiltration), and then compared betweenthem. The samples were collected between November until December 2008 at Rumah Sakit dr. Hasan Sadikin Bandung. The validity ofD-Dimer using immunofiltration method showed sensitivity 74%, specificity 95%, predictive value of negative test (PV-) 22%, predictivevalue of positive test (PV+) 95% with likelihood ratio 5.2. The conclusion of this study so far that the immunofiltration method has agood validity for diagnosing. D-Dimer work rapidly with low cost laboratory assay than the immunoturbidimetric method.
PERUBAHAN BENTUK ERITROSIT DI GLOMERULONEFRITIS Yosepha Dwiyana; Dalima AW Astrawinata
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.479

Abstract

In glomerulonephritis there are intraglomerular inflammation, cell proliferation, and hematuria. Hematuria is characterized by more than 3 (three) erythrocytes per high-power field in the urine, which indicates the pathological processes in kidney or urinary tract. The combination of mechanical damage of erythrocyte membrane through the damaged glomerular basement membrane followed by the osmotic damage when it passes through the tubular system in the hypotonic osmotic solutions causes dysmorphic morphology. Erythrocytes trapped in the Tamm-Horsfall protein will form erythrocyte casts. Dysmorphic erythrocytes and or erythrocyte casts in the urine indicate glomerular hematuria. Various forms of dysmorphic erythrocytes in the urine can be found. Acanthocytes (G1-cells) are specific for glomerular hematury. The examination of these urinary sediments can be done natively or by using automated urinalysis analyzers.

Page 22 of 133 | Total Record : 1328

 20   21   22   23   24 

Filter by Year

2005 2025


Reset
Filter By Issues
All Issue Vol. 32 No. 1 (2025) Vol. 31 No. 3 (2025) Vol. 31 No. 2 (2025) Vol. 31 No. 1 (2024) Vol. 30 No. 3 (2024) Vol. 30 No. 2 (2024) Vol. 30 No. 1 (2023) Vol. 29 No. 3 (2023) Vol. 29 No. 2 (2023) Vol. 29 No. 1 (2022) Vol 29, No 1 (2022) Vol 28, No 3 (2022) Vol. 28 No. 3 (2022) Vol. 28 No. 2 (2022) Vol 28, No 2 (2022) Vol. 28 No. 1 (2021) Vol 28, No 1 (2021) Vol 27, No 3 (2021) Vol. 27 No. 3 (2021) Vol. 27 No. 2 (2021) Vol 27, No 2 (2021) Vol. 27 No. 1 (2020) Vol 27, No 1 (2020) Vol 26, No 3 (2020) Vol. 26 No. 3 (2020) Vol. 26 No. 2 (2020) Vol 26, No 2 (2020) Vol. 26 No. 1 (2019) Vol 26, No 1 (2019) Vol. 25 No. 3 (2019) Vol 25, No 3 (2019) Vol. 25 No. 2 (2019) Vol 25, No 2 (2019) Vol 25, No 1 (2018) Vol. 25 No. 1 (2018) Vol. 24 No. 3 (2018) Vol 24, No 3 (2018) Vol. 24 No. 2 (2018) Vol 24, No 2 (2018) Vol. 24 No. 1 (2017) Vol 24, No 1 (2017) Vol 23, No 3 (2017) Vol. 23 No. 3 (2017) Vol 23, No 2 (2017) Vol. 23 No. 2 (2017) Vol 23, No 1 (2016) Vol 22, No 3 (2016) Vol 22, No 2 (2016) Vol 22, No 1 (2015) Vol 21, No 3 (2015) Vol 21, No 2 (2015) Vol 21, No 1 (2014) Vol 20, No 3 (2014) Vol 20, No 2 (2014) Vol 20, No 1 (2013) Vol 19, No 3 (2013) Vol 19, No 2 (2013) Vol 19, No 1 (2012) Vol. 19 No. 1 (2012) Vol 18, No 3 (2012) Vol. 18 No. 3 (2012) Vol 18, No 2 (2012) Vol 18, No 1 (2011) Vol. 18 No. 1 (2011) Vol 17, No 3 (2011) Vol 17, No 2 (2011) Vol 17, No 1 (2010) Vol 16, No 3 (2010) Vol 16, No 2 (2010) Vol 16, No 1 (2009) Vol 15, No 3 (2009) Vol 15, No 2 (2009) Vol 15, No 1 (2008) Vol 14, No 3 (2008) Vol 14, No 2 (2008) Vol 14, No 1 (2007) Vol 13, No 3 (2007) Vol 13, No 2 (2007) Vol 13, No 1 (2006) Vol 12, No 3 (2006) Vol 12, No 2 (2005) Vol 12, No 1 (2005) More Issue