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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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TOTAL IGG AND IG ANTI PGL-I WITH DURATION OF THE THERAPY AND REACTIONS IN MULTIBACILLER LEPROSY (Jumlah Keseluruhan IgG dan IgG Anti PGL-I Mycobacterium leprae dengan Lama Pengobatan dan Reaksi Kusta Multibasiler) Endang Retnowati; Halik Wijaya; Indropo Agusni
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 3 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i3.1244

Abstract

Penyakit kusta masih menjadi masalah kesehatan utama. Penyakit kusta ditandai dengan berbagai spektrum manifestasi klinis danragam perbedaan antar spektrum yang ditentukan oleh respons imun dari host. Respons imun humoral di pasien kusta telah dilakukandengan penelitian mengukur kadar imunoglobulin (Ig). Tujuan penelitian ini adalah untuk mengetahui kenasaban jumlah keseluruhanIgG dan IgG anti PGL-I M.leprae dengan lama pengobatan dan reaksi kusta di pasien kusta tipe MB dengan mempelajarinya. Penelitiandilakukan dari bulan Juni sampai dengan Desember 2013 dengan sampel dari pasien kusta tipe MB di Kabupaten Sampang-Mandura.Serum pasien yang diperiksa adalah jumlah keseluruhan IgG dengan metode Radial Immunodiffusion (RID) dan IgG anti PGL-I M. lepraedengan Enzyme Linked Immunosorbent Assay (ELISA). Data dikumpulkan dan diuji kenasabannya. Median jumlah keseluruhan IgGyaitu 172IU/mL dan median IgG anti PGL-I yaitu 574,33U/mL. Median jumlah keseluruhan IgG di pasien yang menerima pengobatankurang dari tiga bulan lebih rendah dibandingkan dengan yang lebih dari atau sama dengan tiga bulan. Median jumlah keseluruhanIgG di pasien yang mengalami reaksi lebih tinggi dibandingkan dengan yang tidak mengalami reaksi. Median IgG anti PGL-I di pasienyang sudah diobati kurang dari 3 bulan lebih tinggi dibandingkan dengan yang lebih dari atau sama dengan tiga bulan. Median IgGanti PGL-I di pasien yang mengalami reaksi lebih tinggi dibandingkan dengan yang tidak. Tidak terdapat kenasaban yang bermaknajumlah keseluruhan IgG dan IgG anti PGL-I dengan lama pengobatan dan reaksi kusta pada penelitian ini. Tidak terdapat kenasabanbermakna jumlah keseluruhan IgG dan IgG anti PGL-I dengan lama pengobatan dan reaksi kusta.
MENAHAN ATAU MENEKAN KEKEBALAN (IMUNOSUPRESI) UNTUK PENCANGKOKAN GINJAL (Bagian II) Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 3 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i3.936

Abstract

Renal transplantation is the treatment of choice for most patients with end stage renal disease. Most of the time, transplantationrejection is immunological mediated. Both T cells and circulating antibodies are induced against allograft. Successful organtransplantation requires the use of immunosuppressive drugs to prevent the host’s immune system from rejecting the transplanted organ.The development of immunosuppressive drugs is the key to successful allograft function Immunosuppressive agents are used for induction(intense immunosuppressant in the initial days after transplantation), maintenance and reversal of established rejection. This reviewfocuses on agents that are either approved or in phase 2 or phase 3 trials in kidney transplantation.
LIMFOSIT T CD4+SEBAGAI PERAMAL PERJALANAN PENYAKIT PASIEN YANG MENGALAMI SEPSIS Lestari Ekowati; Aryati Aryati; Hardiono Hardiono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 3 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i3.418

Abstract

Sepsis is the most common cause of ICU mortality in USA. Mortality of sepsis in developing countries is still very high, about 50- 70% and has became a 80% incidence in septic shock. There was a decrease of CD4+ T lymphocyte count in patients with sepsis caused by apoptosis indicating septic patients suffered from immune functional impairment. CD4+ T lymphocyte count can reflect the severity of sepsis and predict the prognosis of the patients with sepsis effectively. Eighty eight (88) patients who met sepsis criteria were studied. The researchers collected clinical variables of all patients within 24 hours diagnosis of sepsis, and calculated APACHE II score. At the same time, blood sample were taken to measure the CD4+ T lymphocyte count. The data were analyzed using independent Student-T-test and ROC curve was used for prognosis. There is a significant difference in CD4+ T lymphocyte count between non survival and survival group (non survival group 203±178 cells/μL, survival group 442±303 cells/μL, p<0.001), and the percentage of CD4+ T lymphocyte (non survival group 25.05±11.55%, survival group 34.38±9.15%, p<0.001). There is an under ROC curve for CD4+ T lymphocyte count was 0.81, and for the percentage of CD4+ T lymphocyte was 0.748. Cut off value for CD4+ T lymphocyte count was 204 cells/μL, and the percentage of CD4+ T lymphocytes was 25.23%. Based on this study, the CD4+ T lymphocyte count can be used as a predictor of prognosis in sepsis patients.
A THIRTY-ONE-YEARS-OLD FEMALE WITH SLE AND SYSTEMIC SCLERODERMA Rahardjo Rahardjo; Rachmawati Rachmawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1210

Abstract

Systemic Lupus Erythematosus (SLE) adalah penyakit rematik autoimun yang ditandai adanya inflamasi luas, yang mempengaruhisetiap organ atau sistem dalam tubuh. Sklerosis sistemik (skleroderma) adalah penyakit multisistem kronis yang tidak diketahuipenyebabnya, ditandai dengan penebalan kulit akibat penumpukan jaringan ikat disertai kelainan fungsi dan bentuk organ visceral.Seorang perempuan 31 tahun mengalami nyeri jari-jari dan sendi. Lima tahun lalu didiagnosis kusta serta diobati selama satu tahun.Pemeriksaan fisik didapatkan mouse face appearance, teleangiektasis, salt and pepper appearance, sclerodactili, artritis, serta calcinosis.Peregangan dan pengerasan kulit simetris. Hemoglobin menurun, sediaan darah tepi terdapat sebaran roleaux, neutrofilia dan limfositteraktivasi. Indirect Coomb Test (ICT) inkompatibel. SGOT, total protein, globulin meningkat. Anti Ds-DNA meningkat lima kali dan ANAmeningkat dua puluh kali lipat dari batas normal. Diagnosis SLE didasarkan pada peningkatan kadar ANA dan Ds-DNA. Sklerodermadidasarkan pada pemeriksaan fisik, pemeriksaan hematologi dan anti Scl-70 (anti tropoisomerase I)
KEUNTUNGAN DAN KERUGIAN PENJAMINAN MUTU BERDASARKAN UJI MEMASTIKAN KECERMATAN (POCT) Hartono Kahar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.898

Abstract

Laboratory examination especially for critical care such as emergency care, intensive care has been developed near the site of patientcare which is referred to point-of-care testing (POCT). As to the definition of POCT, there are many synonyms such as ancillary testing,satellite testing, and bedside testing, near patient testing, home testing, self-management, patient self-management, remote testing andphysician’s office laboratories. Based on evidence-based POCT, the National Academy of Clinical Biochemistry (NACB) has recommendedsome POCT such as coagulation tests, transcutan bilirubin testing, marker for acute coronary syndromes, diabetes mellitus, drugsand ethanol, Infectious disease testing, occult blood test, pH testing, renal function test, intraoperative PTH, renal function test andreproduction test. Some researchers conclude that performing POCT for critical care is efficient, while others found it not efficient,therefore, careful assessment of the advantages and disadvantages is important when implementing POCT. Nurses are the personnelin the acute care unit who often perform POCT; however they desire that laboratory personnel take the responsibility, therefore it isimportant to discuss which personnel are appropriate to conduct quality control of POCT.
RAPID PROGRESSION OF CLAVICULAR SOLITARY PLASMACYTOMA TO MULTIPLE MYELOMA Hantoro Gunawan; Paulus Budiono Notopuro
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1398

Abstract

Introduction: Solitary plasmacytoma is a monoclonal plasma cell malignancy restricted to one tumor. Fifty percents of cases can progress to multiple myeloma (MM). Median time to progression is 19 months. A case about plasmacytoma progressing rapidly to MM within 2 months from initial diagnosis is hereby described. Case:  A 45-year-old male, attended the Surgery clinic with the chief complaint of progressive swelling on the left neck for two months. Physical examination revealed a fixed, solid, 8x8 cm mass on the left supraclavicular. FNAB showed plasmacytoma. Surgical biopsy and immunohistochemistry confirmed the diagnosis of plasmacytoma. Ki67 index was 80%. There was no abnormality in laboratory examination. Two months later he was admitted to the Internal ward with anemia and kidney disorder. Serum protein electrophoresis revealed M-spike. BMA showed plasma cell proliferation with 78% proportion, which confirmed the diagnosis of MM. Discussion: Solitary plasmacytoma can occur on any bone, mostly on axial bones. Solitary plasmacytoma on clavicle is very rare, with prevalence 0.45% of all primary bone tumors. Diagnosis of solitary plasmacytoma relies on tissue biopsy, laboratory, radiology and bone marrow aspiration. Progression of plasmacytoma to MM can be detected from CBC and clinical chemistry results. Serum protein electrophoresis and bone marrow aspiration results confirmed the diagnosis of MM. High proliferation index (Ki67>8%) and tumor size(>5cm) were the risk factors for rapid progression of plasmacytoma. Conclusion: Early detection of systemic symptoms is very important in the management of solitary plasmacytoma. Keywords: solitary plasmacytoma, multiple myeloma
UJI DIAGNOSTIK NT pro NATRIURETIC PEPTIDE (NTpro BNP) GAGAL JANTUNG KONGESTIF Dewi Indah Noviana Pratiwi; Suwarso Suwarso; Osman Sianipar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 1 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i1.360

Abstract

Congestive Heart Failure (CHF) is a syndrome associated with disturbances of heart structure and function, as a result of various cardiovascular diseases. These disturbances decrease ventricle ability to pump or fill blood in physiological pressure, which causes limitation on the ability to excercise or daily activities without dyspnea and fatigue.Early diagnosis is important to initiate prompt treatment that can prevent further disease development. To measure heart hormone in this case, NT pro Natriuretic Peptide (NT pro BNP) can be use as a more ideal examination for early detection of CHF. The aim of this study is to investigate the clinical performance of NT pro BNP and assess the cut-off point 125 pg/mL compared to clinic (Framingham criteria) and or echocardiogram in the diagnosis CHF.The diagnostic test was carried out using clinical (Framingham criteria) and or echocardiography as reference methods. The subject of this research was patients with cardiac and blood vessel disorders complaints at risk of developing congestive heart failure, who came to the Emergency Department at Dr. Sardjito Hospital Yogyakarta, supported by clinical data, radiology, other laboratory test, electrocardiography and echocardiography. The diagnosis of CHF was obtained by conducting investigation toward echocardiography examination reading in patient’s medical record. Receiver Operating Characteristics (ROC) curve analysis was conducted using SPSS 13.0 program. Sensitivity, specificity, positive and negative predictive value, accuracy and likelihood ratios were measured with 2x2 table by CAT marker program. Forty-six of fifty-seven specimens were from congestive heart failure (CHF). At 125 pg/mL as a cut-off point, regardless the interval between the onset of the symptoms and taking of blood samples, the sensitivity, specificity, positive and negative predictive value and diagnostic accuracy are 96%, 36%, 86%, 67%, 84% respectively. Likelihood ratios for positive and negative results are 1.50 and 0.12. NT pro BNP measuring is expected to give more benefit than the conventional signal, so that an early diagnosis can be achieved accurately in a timely manner.
PENGUMPULAN DAN BATAS PEMAKAIAN SAMPEL POPOK PADA PERBENIHAN URIN Rini Riyanti; Prihatini Prihatini; M.Y Probohoesodo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 2 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i2.847

Abstract

Urinary tract infection diagnosis is based on urine culture, taken from a midstream collection in the morning. Obtaining samplesin this manner is difficult in children less than 3 years. In children less than 3 years, urine is obtained by urine collectors. Using urinecollectors may cause discomfort, and the possibility that the urine collectors may not adhere resulting in contamination. (1) Developinga practical method for urine sample collection. (2) Comparing culture from diapers and urine collectors samples. (3) Knowing the limittime for using diapers acceptable for urine culture. Urine samples were obtained from 20 children less than 3 years, using urine collectorsand diapers used for 1 hour, 2 hours and 3 hours and then cultured. Majority of the urine culture from diapers used for 1 hour and 2hours showed the same result with the urine culture from urine collectors. Contamination was found in the urine culture result fromdiapers used for 3 hours. Urine samples from diapers used for 1 hour and 2 hours can be used as samples for urine culture. The techniqueis easy and can be done in children less than 3 years.
COMPARISON OF GLYCATED HEMOGLOBIN AND GLYCATED ALBUMIN IN TYPE 2 DM PATIENTS WITH AND WITHOUT CAD Andini Triasti Siregar; Nizam Zikri Akbar; Burhanuddin Nasution
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 3 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i3.1397

Abstract

Diabetes has been associated with Coronary Artery Disease (CAD). The atherosclerosis, underlying the pathogenesis of CAD, has been activated since the early stages of hyperglycemia and accelerated with uncontrolled blood sugar level fluctuations. Therefore, sensitive glycemic markers are required to be used as a screening instrument such as a traditional glycated hemoglobin A1c (HbA1c) glycated hemoglobin marker and non-traditional Glycated Albumin (GA). This study was a cross-sectional conducted on May - July 2017 at the Adam Malik Hospital Medan. Subjects were patients with HbA1c> 7%, Hb> 10 g/dL and albumin> 3 g/dL, divided into DM+CAD and non-CAD DM groups. Sixty patients participated in this study consisting of 36 males (60%) and 24 females (40%), with a mean age of 56 years. There was a significant difference between HbA1c and GA between the non-CAD DM group and DM + CAD (p=0.001; 0.022.) Patient characteristics did not affect CAD complications in DM patients; a significant difference indicated that poor glycemic control increased the complication of CAD in patients with DM type 2. Glycated albumin examination is recommended for patients with type 2 diabetes with CAD. 
ERYTHROCYTE INDICES TO DIFFERENTIATE IRON DEFICIENCY ANEMIA FROM β TRAIT THALASSEMIA (Indeks Eritrosit untuk Membedakan Anemia Defisiensi Besi dengan Thalassemia β Trait) Yohanes Salim; Ninik Sukartini; Arini Setiawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1184

Abstract

Anemia defisiensi zat besi dan thalassemia β trait merupakan penyebab tersering anemia mikrositik hipokrom di Indonesia. Keduapenyakit tersebut sulit dibedakan hanya dengan pemeriksaan hematologi, oleh karena itu diperlukan pemeriksaan tambahan sepertiferitin dan analisis hemoglobin. Banyak penelitian yang membedakan kedua penyakit tersebut dengan indeks eritrosit. Berbagai indekseritrosit memiliki nilai diagnostik yang berbeda di setiap negara dan belum ada data di Indonesia. Penelitian ini melakukan uji diagnostikIndeks Mentzer, RDW, Green-King, Sirdah dan mencari nilai cut-off baru yang dapat memberikan nilai diagnostik lebih baik. Penelitianterdiri dari 98 subjek definitif anemia defisiensi besi dan 80 subjek thalassemia β trait. Indeks Mentzer didapatkan kepekaan 83,6%,kekhasan 66,2%, NPP 75,2%, NPN 76,8% dan Indeks RDW mempunyai kepekaan 91,8%, kekhasan 75%, NPP 81,8%, NPN 88,2%. Nilaidiagnostik Indeks Green-King didapat kepekaan 96,9%, kekhasan 67,5%, NPP 78,5%, NPN 94,7%, sedangkan Indeks Sirdah adalahkepekaan 92,8%, kekhasan 58,7%, NPP 73,3%, NPN 87,0%. Nilai cut-off baru Indeks Mentzer adalah 13,44, RDWI 233,4, Green-King75,06 dan Sirdah 32,52. Keempat Indeks eritrosit dapat diterapkan untuk orang Indonesia dengan Indeks Green-King sebagai indeksyang terbaik.

Page 23 of 133 | Total Record : 1328

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