Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Jurnal Riset Sains dan Kimia Terapan

jrskt
Website

Published by Universitas Negeri Jakarta

ISSN : 23028467 EISSN : 23030720 DOI : https://doi.org/10.21009/JRSKT.

Core Subject : Science,

Chemistry

Jurnal Riset Sains dan Kimia Terapan (JRSKT) is the journal for the publication of original studies and occational reviews in the field of science and applied chemistry. It is published electronically two times a year

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 99 Documents

6 7 8 9 10

The Potential of Activated Carbon from Durian (Durio Zibenthius) Peel Waste As An Adsorbent Of Oil Spill Yulyani Nur Azizah; Nur Azizah Dwi Ningrum; Nurhasni
Jurnal Riset Sains dan Kimia Terapan Vol. 11 No. 2 (2025): Jurnal Riset Sains dan Kimia Terapan, Volume 11 Nomor 2, Desember 2025
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.112.01

Oil exploration activities, such as ship loading and unloading, can lead to oil spills at sea, as can oil spills and tanker collisions. An affordable method for dealing with these spills is adsorption using activated carbon derived from bio-waste, such as durian peel. This study aims to evaluate the adsorption efficiency of durian peel-activated carbon on oil spills. The carbonization of durian peel was carried out at 300 °C and activated with KOH at 5, 20, 35, and 50% (w/v). Durian peel activated carbon with 35% KOH showed the best results for moisture content (5.442%), ash content (4.457%), bound carbon content (72.050%), and iodine adsorption (896.033 mg/g), according to SNI 06-3730-1995. FTIR measurements revealed that KOH activation did not induce significant changes in the wavenumbers of functional groups, but did increase the pore diameter, as confirmed by SEM. Its adsorption efficiency with a batch system on crude oil in simulated and real seawater reached 90.182% and 90.091%, respectively. These results suggest that activated carbon from durian peel has excellent potential as an oil adsorbent. This would increase its utility value and reduce the accumulation of biomass waste.

Screening of Bioactive Compounds of Spirulina platensis as Potential Antioxidants: An In-silico Approach Himawan Prasetiyo; Fitri Novita Nanda; Mad Rudi; Nurul Azila Razak
Jurnal Riset Sains dan Kimia Terapan Vol. 11 No. 2 (2025): Jurnal Riset Sains dan Kimia Terapan, Volume 11 Nomor 2, Desember 2025
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.112.05

Oxidative stress is a significant trigger of degenerative diseases, caused by an imbalance between free radicals and the body's antioxidant defenses. This study aims to identify bioactive compounds from Spirulina platensis and to evaluate their antioxidant potential using an in-silico approach. Candidate screening was conducted using Gas Chromatography-Mass Spectrometry (GC-MS) analysis, antioxidant activity prediction, pharmacokinetic evaluation (Lipinski's Rule of Five), and ligand–receptor interaction analysis (molecular docking). GC-MS analysis identified 30 bioactive compounds across various classes, including hydrocarbons, alcohols, phenols, aldehydes, and steroids. Activity prediction showed that all compounds exhibited antioxidant potential with Pa > 0.7 and Pi > 0.3, meeting both Lipinski's criteria and drug-likeness requirements. Among them, phytol and ethyl iso-allochol were demonstrated binding energies (∆G) of –5.0 and –7.3 kcal/mol, respectively, which were lower than the natural ligand 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl) ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl) pyridin-2-amine with –8.3 kcal/mol, suggesting their potential as free radical inhibitors. The microalga S. platensis thus contains antioxidant-active compounds with promising potential for further development. However, additional evaluations through active compound isolation as well as in vitro and in vivo studies are required.

Identification and Assay of Isoniazid and Pyrazinamide in Fixed-Dose Dispersible Tablets Containing Rifampicin Using High-Performance Liquid Chromatography Citra Santikasari; Meyliana Wulandari; Shofi Nafisa Ulfa; Mirawati Siregar; Syed Azhar Syed Sulaiman
Jurnal Riset Sains dan Kimia Terapan Vol. 11 No. 2 (2025): Jurnal Riset Sains dan Kimia Terapan, Volume 11 Nomor 2, Desember 2025
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.112.04

Tuberculosis (TB) remains a major global health challenge, particularly in Indonesia, which ranks among the countries withthe highest TB burden. Fixed-dose dispersible anti-tuberculosis formulations containing rifampicin, isoniazid, and pyrazinamide are widely recommended to enhance patient adherence and minimize the risk of drug resistance. Ensuring the quality and appropriate dosage of active pharmaceutical ingredients is essential for achieving therapeutic effectiveness and maintaining TB control. This study aimed to perform routine quality assessment and regulatory compliance assays on commercialanti-TB fixed-dose combination (FDC) dispersible tablets using a reversed-phase high-performance liquid chromatography (HPLC) method as specified in the International Pharmacopoeia 2025. The HPLC system was equipped with a C18 column and used a mobile phase consisting of acetate buffer (pH 5) and methanol (94:6 v/v). System suitability testing was conducted before analysis, with %RSD values below 2%, resolution greaterthan 2.0, and tailing factors ≤ 2.0, indicating acceptable precision, selectivity, and chromatographic performance. The retention times of isoniazid and pyrazinamide were consistent with those of the reference standards, confirming identity. The assay results showed that pyrazinamide (100.3%) and isoniazid (99.9%) were within the specification limits set by the International Pharmacopoeia. These findings demonstrate that the official monograph method is suitable for regulatory-grade quality control testing of dispersible anti-tuberculosis fixed-dose combination tablets, and that the tested product met pharmacopeial quality requirements.

Molecular Docking Insights into EDTA and Tween-20-Induced Inhibition of Lysozyme in Bacterial DNA Isolation Buffers Ika Keumala Fitri; Meredith Jannaatu 'Adn; Tegar Cahya Widodo; Muktiningsih Nurjayadi; Futi Kusuma Hati
Jurnal Riset Sains dan Kimia Terapan Vol. 12 No. 1 (2026): Jurnal Riset Sains dan Kimia Terapan, Volume 12 Nomor 1, Juni 2026
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.121.03

The efficiency of bacterial deoxyribonucleic acid (DNA) isolation is a critical bottleneck in Polymerase Chain Reaction (PCR) based pathogen detection. This study investigates the potential inhibitory effects of standard lysis buffer components, including ethylenediaminetetraacetic acid (EDTA), Tris base, and Tween-20, on Hen Egg White Lysozyme (HEWL) to address the low DNA yields observed in a locally developed isolation kit. Molecular docking simulations were performed using AutoDock 4.2.6. The protocol was validated by redocking the native ligand, which established the suitability of a 60x60x60 Å grid box. The results revealed that EDTA binds with high affinity, with an intermolecular energy of -6.44 kcal/mol, and interacts with crucial anchoring residues Trp62 and Asp101. Notably, the hydrophobic tail of Tween-20 exhibited the strongest binding (-7.12 kcal/mol), penetrating the active cleft and blocking the catalytic residue Glu35. Conversely, Tris base and the hydrophilic head of Tween-20 showed weaker, less stable interactions. These findings suggest a dual-inhibition mechanism in which EDTA blocks substrate access, while Tween-20 hinders the catalytic center. This study provides a molecular explanation for the kit's reduced performance and highlights the need for buffer optimization.

Analytical Investigation of Oleic Acid Double Bond Cleavage Using Cu-BiVO4 Photocatalyst in Water/Ethanol System Using GC-MS Analysis Annisa Aulia Rahmah; Bambang Prijamboedi; Fainan Failamani
Jurnal Riset Sains dan Kimia Terapan Vol. 12 No. 1 (2026): Jurnal Riset Sains dan Kimia Terapan, Volume 12 Nomor 1, Juni 2026
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.121.02

The oxidative cleavage of unsaturated fatty acids is a promising pathway for producing value-added chemicals; however, its photocatalytic conversion remains limited by catalyst efficiency. This study investigates the performance of BiVO₄ and Cu-modified BiVO₄ (Cu–BiVO₄) in promoting the photocatalytic cleavage of oleic acid in a water–ethanol system under visible light irradiation. The catalysts were synthesized via hydrothermal and impregnation methods, followed by photocatalytic reactions for 24 h. Product distribution and transformation pathways were analyzed using GC–MS. The results show that pristine BiVO₄ exhibits limited catalytic activity, while Cu–BiVO₄ significantly enhances the formation of C14 and C16 saturated fatty acids along with various oxidative cleavage products. This improvement is attributed to enhanced charge separation and increased generation of reactive oxygen species. These findings demonstrate that Cu–BiVO₄ is a more effective photocatalyst for the oxidative transformation of unsaturated fatty acids.

Coupled Raman and FTIR Analysis of Biomass-Derived Carbon Prepared at Low Carbonization Temperature Gugus Handika; Fairuz Gianirfan Nugroho; Afina Faza Hafiyyan; Feber Valentin Br Sembiring; Neysa Azzahra; Abu Saad Ansari; Nurul Taufiqu Rochman
Jurnal Riset Sains dan Kimia Terapan Vol. 12 No. 1 (2026): Jurnal Riset Sains dan Kimia Terapan, Volume 12 Nomor 1, Juni 2026
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.121.04

Biomass-derived carbon is commonly produced at high temperatures to promote graphitization; however, understanding carbon formation at lower temperatures remains critical for applications that rely on surface reactivity rather than crystallinity. In this work, carbon obtained from oil palm empty fruit bunch (EFB) through pyrolysis at 500 °C was systematically investigated using coupled Fourier transform infrared (FTIR) and Raman spectroscopy, supported by density functional theory (DFT)-based structural interpretation. FTIR analysis reveals extensive dehydration, cleavage of aliphatic C–H bonds, and progressive loss of oxygenated functional groups, accompanied by the emergence of aromatic C=C and C–O–C linkages. Raman spectra, resolved through pseudo-Voigt deconvolution, are dominated by defect-related bands (D, D2, D3, and D4) with a broadened G band, indicating the formation of small, disordered sp2 carbon domains rather than extended graphitic lattices. DFT-assisted analysis suggests that the carbon framework is composed of interconnected polyaromatic hydrocarbon clusters incorporating residual heteroatoms and mixed sp2–sp3bonding. These results demonstrate that low-temperature pyrolysis of EFB produces a defect-rich aromatic carbon structure strongly governed by precursor chemistry, offering a viable route for tailoring functional carbon materials with abundant active sites, making it highly suitable for applications in adsorption, catalysis, and environmental remediation technologies.

Revealing the Role of Mobile Phase Composition and pH in Benzoic Acid Analysis of Beverages and Processed Foods: Implications for SDG 3 Vida Zenitha Sudariasri; Meyliana Wulandari; Galuh Fathin Aulia; Susy Affrini Hutapea; Mardiana Saaid
Jurnal Riset Sains dan Kimia Terapan Vol. 12 No. 1 (2026): Jurnal Riset Sains dan Kimia Terapan, Volume 12 Nomor 1, Juni 2026
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.121.01

To prevent health risks in excessive consumption, monitoring benzoic acid as a food additive is necessary in line with SDG 3 principles. Conventional methods for determining benzoic acid levels have limitations in selectivity and sensitivity due to matrix interference contained in food products. This study aims to determine benzoic acid levels in support of food safety monitoring in Jakarta by optimizing the mobile phase in a reversed-phase HPLC system (RP-HPLC. Reverse-phase high-performance liquid chromatography with a UV detector, investigated in this research, operated at 225 nm. A C-18 or octadecyl silica (ODS) column stationary phase (250 mm x 4,6 mm, 5 µm particle size) was used, which is classified as nonpolar. The mobile phase used is a polar methanol-phosphate buffer with a ratio 4:96 at pH 6.8. Optimization of mobile phase composition and pH was necessary to control the ionization degree of benzoic acid, improve analyte‒stationary phase interactions, and produce optimal retention time, peak shape, and resolution. The test results for benzoic acid levels in carbonated drinks, jelly drinks, and mayonnaise were 140.973 mg/kg, 232.294 mg/kg, and 710.695 mg/kg, respectively. It can be concluded that the benzoic acid levels in the sample remain below the maximum limit set by BPOM RI.

Rice Husk Silica-Based magMCM-41 Composites: Synthesis, Characterization, and Pb(II) Adsorption Performance Nita Trisnawati; Eti Rohaeti; Deden Saprudin; Sarah Yasir
Jurnal Riset Sains dan Kimia Terapan Vol. 12 No. 1 (2026): Jurnal Riset Sains dan Kimia Terapan, Volume 12 Nomor 1, Juni 2026
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.121.05

Lead (Pb) contamination in water poses serious environmental and health risks, necessitating the development of effective and sustainable adsorbents for its removal. This study aimed to synthesize and characterize magMCM-41 composites derived from rice husk silica, and evaluate their performance for Pb(II) ion removal in aqueous solutions. The magMCM-41 was prepared by integrating magnetite (Fe3O4) nanoparticles into a mesoporous silica framework via co-preparation and sol-gel methods using cetyltrimethylammonium bromide (CTAB) as a template. Characterization by XRD, FTIR, BET, and PSA confirmed successful composite formation, revealing a high specific surface area o f 476.744 m2/g, a mesoporous framework (pore diameter 3.83 nm), and an average particle size of 362.7 nm. Adsorption conditions were optimized using Response Surface Methodology (RSM); pH positively influenced capacity, whereas adsorbent dosage had a negative effect. The maximum adsorption capacity was 115.77 mg/g at pH 5 with 0.05 g of adsorbent. The Dubinin-Radushkevich model best described the adsorption equilibrium (R2=0.935), indicating physisorption on a heterogeneous surface. Thermodynamic analysis confirmed a spontaneous and exothermic process. These results demonstrate that rice husk-derived magMCM-41 is a sustainable and magnetically separable adsorbent with high potential for Pb(II) remediation.

Interaction of Bioactive Compounds from Mentha arvensis with HER2 Receptors as Anti-Breast Cancer Drugs Elsi Fauzani; Trisna Kumala Sari; Noor Hana Hanif Abu Bakar
Jurnal Riset Sains dan Kimia Terapan Vol. 12 No. 1 (2026): Jurnal Riset Sains dan Kimia Terapan, Volume 12 Nomor 1, Juni 2026
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.121.06

Mentha arvensis is a medicinal plant known to contain bioactive compounds such as flavonoids, terpenoids, and phenolic compounds with potential anticancer activity. This study aims to evaluate the potential of compounds from Mentha arvensis as HER2 inhibitors (PDB ID: 5TDN) using an in silico approach. The methods employed include drug-likeness evaluation based on Lipinski’s Rule and molecular docking simulations using PyRx software, with interaction visualization performed using Discovery Studio. The docking results showed that catechin and diosmetin exhibited the best affinity values, at –8.5 kcal/mol. These findings support the potential of compounds from Mentha arvensis as natural anticancer candidates, particularly for breast cancer therapy, although further experimental validation is still required.

Page 10 of 10 | Total Record : 99

6 7 8 9 10

Filter by Year

2011 2026

Filter By Issues

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Yussi Pratiwi

Contact Email
jrskt@unj.ac.id

Phone
-

Journal Mail Official
jrskt@unj.ac.id

Editorial Address
Universitas Negeri Jakarta

Location
Kota adm. jakarta timur,

Dki jakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Yussi Pratiwi

Contact Email jrskt@unj.ac.id

Phone -

Journal Mail Official jrskt@unj.ac.id

Editorial Address Universitas Negeri Jakarta

Location Kota adm. jakarta timur, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Yussi Pratiwi

Contact Email
jrskt@unj.ac.id

Phone
-

Journal Mail Official
jrskt@unj.ac.id

Editorial Address
Universitas Negeri Jakarta

Location
Kota adm. jakarta timur,

Dki jakarta

INDONESIA