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Jurnal Riset Sains dan Kimia Terapan

jrskt
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Published by Universitas Negeri Jakarta

ISSN : 23028467 EISSN : 23030720 DOI : https://doi.org/10.21009/JRSKT.

Core Subject : Science,

Chemistry

Jurnal Riset Sains dan Kimia Terapan (JRSKT) is the journal for the publication of original studies and occational reviews in the field of science and applied chemistry. It is published electronically two times a year

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 93 Documents

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The Potential of Activated Carbon from Durian (Durio Zibenthius) Peel Waste As An Adsorbent Of Oil Spill Azizah, Yulyani Nur; Ningrum, Nur Azizah Dwi; Nurhasni
Jurnal Riset Sains dan Kimia Terapan Vol. 11 No. 2 (2025): Jurnal Riset Sains dan Kimia Terapan, Volume 11 Nomor 2, Desember 2025
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.112.01

Oil exploration activities, such as ship loading and unloading, can lead to oil spills at sea, as can oil spills and tanker collisions. An affordable method for dealing with these spills is adsorption using activated carbon derived from bio-waste, such as durian peel. This study aims to evaluate the adsorption efficiency of durian peel-activated carbon on oil spills. The carbonization of durian peel was carried out at 300 °C and activated with KOH at 5, 20, 35, and 50% (w/v). Durian peel activated carbon with 35% KOH showed the best results for moisture content (5.442%), ash content (4.457%), bound carbon content (72.050%), and iodine adsorption (896.033 mg/g), according to SNI 06-3730-1995. FTIR measurements revealed that KOH activation did not induce significant changes in the wavenumbers of functional groups, but did increase the pore diameter, as confirmed by SEM. Its adsorption efficiency with a batch system on crude oil in simulated and real seawater reached 90.182% and 90.091%, respectively. These results suggest that activated carbon from durian peel has excellent potential as an oil adsorbent. This would increase its utility value and reduce the accumulation of biomass waste.

Screening of Bioactive Compounds of Spirulina platensis as Potential Antioxidants: An In-silico Approach Prasetiyo, Himawan; Nanda, Fitri Novita; Rudi, Mad; Razak, Nurul Azila
Jurnal Riset Sains dan Kimia Terapan Vol. 11 No. 2 (2025): Jurnal Riset Sains dan Kimia Terapan, Volume 11 Nomor 2, Desember 2025
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.112.05

Oxidative stress is a significant trigger of degenerative diseases, caused by an imbalance between free radicals and the body's antioxidant defenses. This study aims to identify bioactive compounds from Spirulina platensis and to evaluate their antioxidant potential using an in-silico approach. Candidate screening was conducted using Gas Chromatography-Mass Spectrometry (GC-MS) analysis, antioxidant activity prediction, pharmacokinetic evaluation (Lipinski's Rule of Five), and ligand–receptor interaction analysis (molecular docking). GC-MS analysis identified 30 bioactive compounds across various classes, including hydrocarbons, alcohols, phenols, aldehydes, and steroids. Activity prediction showed that all compounds exhibited antioxidant potential with Pa > 0.7 and Pi > 0.3, meeting both Lipinski's criteria and drug-likeness requirements. Among them, phytol and ethyl iso-allochol were demonstrated binding energies (∆G) of –5.0 and –7.3 kcal/mol, respectively, which were lower than the natural ligand 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl) ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl) pyridin-2-amine with –8.3 kcal/mol, suggesting their potential as free radical inhibitors. The microalga S. platensis thus contains antioxidant-active compounds with promising potential for further development. However, additional evaluations through active compound isolation as well as in vitro and in vivo studies are required.

Identification and Assay of Isoniazid and Pyrazinamide in Fixed-Dose Dispersible Tablets Containing Rifampicin Using High-Performance Liquid Chromatography Santikasari, Citra; Wulandari, Meyliana; Nafisa Ulfa, Shofi; Siregar, Mirawati; Sulaiman, Syed Azhar Syed
Jurnal Riset Sains dan Kimia Terapan Vol. 11 No. 2 (2025): Jurnal Riset Sains dan Kimia Terapan, Volume 11 Nomor 2, Desember 2025
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.112.04

Tuberculosis (TB) remains a major global health challenge, particularly in Indonesia, which ranks among the countries withthe highest TB burden. Fixed-dose dispersible anti-tuberculosis formulations containing rifampicin, isoniazid, and pyrazinamide are widely recommended to enhance patient adherence and minimize the risk of drug resistance. Ensuring the quality and appropriate dosage of active pharmaceutical ingredients is essential for achieving therapeutic effectiveness and maintaining TB control. This study aimed to perform routine quality assessment and regulatory compliance assays on commercialanti-TB fixed-dose combination (FDC) dispersible tablets using a reversed-phase high-performance liquid chromatography (HPLC) method as specified in the International Pharmacopoeia 2025. The HPLC system was equipped with a C18 column and used a mobile phase consisting of acetate buffer (pH 5) and methanol (94:6 v/v). System suitability testing was conducted before analysis, with %RSD values below 2%, resolution greaterthan 2.0, and tailing factors ≤ 2.0, indicating acceptable precision, selectivity, and chromatographic performance. The retention times of isoniazid and pyrazinamide were consistent with those of the reference standards, confirming identity. The assay results showed that pyrazinamide (100.3%) and isoniazid (99.9%) were within the specification limits set by the International Pharmacopoeia. These findings demonstrate that the official monograph method is suitable for regulatory-grade quality control testing of dispersible anti-tuberculosis fixed-dose combination tablets, and that the tested product met pharmacopeial quality requirements.

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Yussi Pratiwi

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Home Page

OAI Link

Editorial Team

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Reviewer

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Contact Name Yussi Pratiwi

Contact Email jrskt@unj.ac.id

Phone -

Journal Mail Official jrskt@unj.ac.id

Editorial Address Universitas Negeri Jakarta

Location Kota adm. jakarta timur, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Contact Name
Yussi Pratiwi

Contact Email
jrskt@unj.ac.id

Phone
-

Journal Mail Official
jrskt@unj.ac.id

Editorial Address
Universitas Negeri Jakarta

Location
Kota adm. jakarta timur,

Dki jakarta

INDONESIA