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Jurnal Medika Hutama
Published by Yayasan MEDIKA Indonesia
ISSN : 27158039     EISSN : 27159728     DOI : https://doi.org/10.66940
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Nursing Public Health Veterinary
Jurnal Medika Hutama adalah jurnal hasil penelitian, studi kasus, dan tinjauan pustaka di bidang Kesehatan dan Kedokteran
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 557 Documents
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Potensi Penggunaan Ekstrak Daun Kayu Manis (Cinnamomum Burmannii) Sebagai Antibiotik Alternatif Berbasis Herbal Satrya Jati Jayachrisna
Jurnal Medika Hutama Vol. 7 No. 1 Oktober (2025): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i1 Oktober.756

Abstract

Infections caused by bacteria continue to pose a significant public health challenge, especially in developing nations. The excessive and improper use of synthetic antibiotics has greatly contributed to the rise of antibiotic-resistant bacteria, which is currently responsible for around 1.27 million deaths each year. This situation highlights the urgent need for safer and more sustainable alternative therapies, including the use of plant-based antimicrobials. One promising option is the leaf of Cinnamomum burmannii, which is packed with various bioactive compounds like flavonoids, alkaloids, saponins, tannins, and phenols. These compounds demonstrate multiple antibacterial mechanisms, such as disrupting bacterial cell membranes, inhibiting the synthesis of nucleic acids and proteins, inactivating enzymes, and interfering with energy metabolism. Several in vitro studies have demonstrated that extracts of Cinnamomum burmannii leaves possess moderate to strong antibacterial activity against pathogens such as Staphylococcus aureus, Escherichia coli, and Salmonella Typhi. Besides its efficacy, the use of Cinnamomum burmannii leaf extract is considered safer, more economical, and less likely to induce resistance. However, the application of this extract in clinical settings remains limited due to the lack of in vivo and clinical studies addressing its safety, toxicity, pharmacokinetics, and pharmacodynamics. Additional research is essential to fully investigate the therapeutic potential of Cinnamomum burmannii leaf extract as an evidence-based alternative antibacterial agent.
Revolusi Terapi MDR-TB: Kolaborasi Liquid Biopsy CFDNA, Pemetaan Genetik, dan CRISPR-RNAI Untuk Deteksi Dini dan Penanganan Presisi: A Literature Review Rizka Fauziah
Jurnal Medika Hutama Vol. 7 No. 1 Oktober (2025): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i1 Oktober.757

Abstract

Multidrug-Resistant Tuberculosis (MDR-TB) is a global health issue with a high disease burden and limited therapeutic success rates. Limitations of conventional methods, such as bacterial culture and rapid molecular tests, include long examination duration, low sensitivity, and failure to detect minor infections that cause resistance. A literature review discusses a precision biomolecular approach through the integration of circulating free DNA (cfDNA)-based liquid biopsy, genetic mapping, and CRISPR-RNAi technology. Liquid biopsy may be able to detect Mycobacterium tuberculosis and resistance noninvasively, rapidly, and can be used for real-time therapy monitoring. Genetic mapping analysis is enhanced by the identification of specific mutations, which can then be targeted by the CRISPR-RNAi system. CRISPR-RNAi technology plays a role not only in highly sensitive diagnosis but also as a therapeutic strategy that inactivates resistance genes without disrupting the normal microbiota. The integration of these three approaches offers a new paradigm in MDR-TB management that is precise, personalized, and efficient, with the potential to shorten treatment duration, increase therapy effectiveness, and reduce the risk of further resistance.
Faktor-faktor yang Berhubungan dengan Intensi Pencarian Bantuan Kesehatan Mental pada Mahasiswa Sarjana FKM UI Muhammad Ma'shum; Caroline Endah Wuryaningsih; Dien Anshari
Jurnal Medika Hutama Vol. 7 No. 1 Oktober (2025): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i1 Oktober.762

Abstract

University students are vulnerable to mental health problems such as anxiety and depression. However, there is still limited research examining factors associated with mental health help-seeking among educated populations. This study aims to identify factors associated with the intention to seek mental health help among undergraduate students at the Faculty of Public Health, Universitas Indonesia (FKM UI). This quantitative study employed a cross-sectional design with quota sampling (n=108). The dependent variable was intention to seek help from mental health professionals, while the independent variables were attitudes toward help-seeking, subjective norms, and perceived behavioral control. Univariate analysis showed the mean score for intention was 2.64 (SD=0.53). The mean scores for attitudes toward behavior, subjective norms, and perceived behavioral control were 3.22 (SD = 0.47), 2.91 (SD = 0.4), and 2.88 (SD = 0.41), respectively. Spearman’s correlation test results showed that only perceived behavioral control was positively associated with help-seeking intention (p < 0.001), while attitudes and subjective norms were not associated with intention (p = 0.094 and p = 0.284). Based on these findings, health promotion efforts to improve mental health help-seeking among FKM UI undergraduate students should place greater emphasis on strengthening perceived behavioral control.
THE CORRELATION BETWEEN THE LEVEL OF KNOWLEDGE ABOUT CERVICAL CANCER PREVENTION AND IVA EXAMINATION RESULTS IN THE COASTAL COMMUNITY OF WAAI, CENTRAL MALUKU REGENCY, MALUKU PROVINCE Debora Hetharia
Jurnal Medika Hutama Vol. 7 No. 2 Januari (2026): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i2 Januari.761

Abstract

Cervical cancer remains one of the leading causes of death among women, especially in developing countries such as Indonesia. Visual Inspection with Acetic Acid (VIA) is an effective, simple, and appropriate method of early detection for regions with limited resources. The level of public knowledge about cervical cancer prevention greatly influences the success of IVA screening programs. Coastal communities, including those in Negeri Waai, Central Maluku Regency, face geographical, social, and cultural barriers that can reduce participation in screening. This study aims to determine the relationship between the level of knowledge about cervical cancer prevention and IVA screening results in coastal communities in Negeri Waai, Maluku Province. This study used a quantitative approach with a cross-sectional correlational design. The sample consisted of 40 women who were married or sexually active. Knowledge levels were measured using a standardized questionnaire, while IVA results were obtained from examinations by trained health workers. Data analysis was performed using Pearson's correlation test. The results showed a significant negative correlation between knowledge level and IVA examination results (r = –0.501; p = 0.001). This means that the higher the respondents' knowledge level, the less likely the IVA examination results would indicate precancerous abnormalities. These findings emphasize the importance of increasing community knowledge as an effort to prevent and detect cervical cancer early in coastal areas.
RUPTURED ECTOPIC PREGNANCY PRESENTING AS ACUTE APPENDICITIS WITH A FALSE NEGATIVE URINE PREGNANCY TEST IN A LIMITED RESOURCE SETTING: A CASE REPORT Nooryanto Mukhamad; Rony Sibuea
Jurnal Medika Hutama Vol. 7 No. 2 Januari (2026): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i2 Januari.763

Abstract

Preterm Premature Rupture of Membranes (PPROM), defined as the rupture of membranes before 37 weeks of gestation, can lead to serious complications such as infection. Vaginal probiotics have the potential to serve as a solution by restoring a healthy microbiome balance while reducing the risk of antibiotic resistance when used as adjunctive therapy. This study aims to investigate the effects of vaginal probiotics in normalizing the vaginal microbiota of pregnant women as prophylaxis for PPROM. A review of four Randomized Controlled Trial (RCT) articles from databases such as Google Scholar, PubMed, and ScienceDirect up to January 2025 evaluated the effectiveness of probiotics. The quality of the studies was assessed using the Joanna Briggs Institute (JBI) checklist. Three studies showed that probiotics were effective in improving pregnancy outcomes. One study reported that oral probiotics in healthy pregnant women may reduce the incidence of PPROM. Consistently, probiotic administration was associated with significant improvements, including an increase in gestational age at delivery (ranging from 30.18±2.49 to 34.0±2.0 weeks) and an increase in infant birth weight (from 1,562±450 g to 2,800±440 g). The length of stay in the neonatal intensive care unit (NICU) was also shorter in the probiotic group. It can be concluded that vaginal probiotics, especially when used in conjunction with antibiotics, provide significant benefits as prophylaxis for PPROM and contribute to improved maternal and neonatal health.
PERBANDINGAN HASIL LAJU ENDAP DARAH (LED) SEDIPLAST ESR SYSTEM DENGAN METODE OTOMATIS PADA PASIEN TUBERKULOSIS Inggit Ismayanti; Enny Khotimah; Dian Rachma Wijayanti
Jurnal Medika Hutama Vol. 7 No. 2 Januari (2026): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i2 Januari.764

Abstract

Infection and inflammation in tuberculosis patients are caused by the bacterium Mycobacterium tuberculosis. Increased fibrinogen levels cause erythrocytes to stick together and accelerate the formation of rouleaux, thereby increasing the Erythrocyte Sedimentation Rate (ESR). The Westergren method is recommended by the International Council for Standardization in Haematology (ICSH) for ESR testing. With the advancement of technology, ESR testing can now be performed using modified Westergren methods such as the Sediplast ESR System and automated methods to avoid and reduce the risk of laboratory personnel exposure to infectious agents.The aim of this study was to determine whether there was a difference in ESR results on the Sediplast Esr System using EDTA + 3.8% sodium citrate blood and the automatic method using EDTA blood in patients with active tuberculosis at the Tambora Community Health Center. This study used an analytical observational research design with a cross-sectional approach. The sample in this study consisted of 35 patients with active tuberculosis who were treated at the Tambora Community Health Center pulmonary clinic. The results of the ESR test using the Sediplast Esr System method obtained an average of 57.86 mm/hour, while the automatic method obtained an average of 52.51 mm/hour, with an average difference of 5.34 mm/hour. Statistical analysis using the Paired T Test yielded a sig value (2-tailed) of 0.025. This study shows that there is a difference in the results of the Sediplast Esr System method and the automatic method for measuring erythrocyte sedimentation rate (ESR).
MANAGEMENT OF MULTIPLE FRACTURES IN OSTEOGENESIS IMPERFECTA PATIENTS IN REGIONAL HOSPITAL OF RURAL AREAS: WHAT AN ORTHOPEDIC SURGEON CAN DO? zukhruful muzakkie; Doli Mauliate Sitompul
Jurnal Medika Hutama Vol. 7 No. 2 Januari (2026): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i2 Januari.766

Abstract

ABSTRACT Background: Osteogenesis Imperfecta (OI) is a connective tissue disorder characterized by bone fragility and recurrent fractures. Managing fractures in OI patients in rural regions poses challenges due to limited resources and high treatment costs. Objective: To describe the management of pathologic fractures in a pediatric patient with OI who resides in a remote area. Case Summary: An 8-year-old girl with known OI presented with pain and deformity of the right lower leg after falling from a stroller. Radiographs confirmed closed fractures of the tibia and fibula. The ideal management is Fassier-Duval intramedullary rodding; however, due to socioeconomic limitations and lack of facility availability, closed reduction and immobilization were performed. Conclusion: Management of fractures in OI should be individualized. In resource-limited settings, closed reduction and immobilization may be an acceptable alternative. Keywords: Osteogenesis imperfecta, pediatric fracture, rural hospital, closed reduction, pathologic fracture.
HUBUNGAN PARITAS DAN JARAK KEHAMILAN DENGAN BERAT BADAN LAHIR BAYI DI PUSKESMAS MAMBORO Eunike Syerin Glori Baan
Jurnal Medika Hutama Vol. 7 No. 2 Januari (2026): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i2 Januari.767

Abstract

Infant mortality rate (IMR) is a parameter used for measuring a country’s health status, with the majority of deaths occurring during the neonatal period. Low birth weight, which refers to infants weighing under 2500 grams at birth, accounts for approximately 34.5% of a factor contributing to neonatal mortality. Infant birth weight is influenced by maternal factors, including parity and birth spacing. Low birth weight cases at Mamboro Health Center remain a concern, with more than 20 cases in 2024, particularly because the area still includes a rural community. This research aims to analyze the relationship between parity and birth spacing with birth weight at Puskesmas Mamboro in 2024. This study used a quantitative analytical observational design, with 69 samples. The data were then analyzed using the Chi-square test. The result showed a relationship between parity and birth weight (p=0,003), with multiparous mothers having a lower risk of delivering low birth weight. Meanwhile, there was no significant relationship between pregnancy spacing and birth weight (p= 0,226). Although not statistically significant, the proportion of low birth weight cases was more common at too short and too long intervals compared with ideal intervals.
PEMODELAN STRUKTUR LOYALITAS PEL PEMODELAN STRUKTUR LOYALITAS PELANGGAN DI RSUD AWET MUDA NARMADA KABUPATEN LOMBOK BARAT Sarwan Payanadi
Jurnal Medika Hutama Vol. 7 No. 2 Januari (2026): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i2 Januari.768

Abstract

In 2023, Awet Muda Narmada Regional General Hospital experienced a significant increase in customer visits compared to 2022. Outpatient services increased by 68.59 percent, while inpatient visits increased by 76.92 percent. Based on this, the researcher aimed to examine the extent of service quality, hospital customer value, and customer loyalty at Awet Muda Narmada Regional General Hospital. The purpose of this study was to identify the modeling structure of customer loyalty at Awet Muda Narmada Regional General Hospital. The number of respondents was 150 people. The respondent criteria in this study included: (1) patients registered as inpatients with a minimum length of stay of three days at Awet Muda Narmada Regional General Hospital; (2) patients registered as outpatients who had visited the hospital at least three times previously; (3) male or female patients aged at least 17 years who were registered in either the inpatient or outpatient department; and (4) patients who were conscious and willing to answer the questions. This study used a quantitative approach with the Structural Equation Modeling method using Partial Least Squares analysis. The results of the study concluded that service quality has a significant positive effect on customer loyalty; service quality also has a significant positive effect on customer value; customer value has a significant positive effect on customer loyalty; and the effect of service quality on customer loyalty can be mediated by customer value. The findings of this study can serve as a reference for the hospital in improving its services, which in turn can increase patient loyalty to the hospital
HUBUNGAN ANTARA IMT DENGAN TEKANAN DARAH PADA PENDERITA HIPERTENSI DI WILAYAH KERJA PUSKESMAS SIKO Ayu Novira
Jurnal Medika Hutama Vol. 7 No. 2 Januari (2026): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66940/jmh.v7i2 Januari.772

Abstract

Peningkatan tekanan darah diastolik ≥90 mmHg atau tekanan darah sistolik ≥140 mmHg merupakan indikasi hipertensi. Hipertensi adalah penyebab paling sering dari kondisi kardiovaskular seperti gagal jantung, infark miokard, dan stroke. Penelitian ini bertujuan untuk mengetahui hubungan antara tekanan darah dan indeks massa tubuh (IMT) pada pasien hipertensi di wilayah kerja Puskesmas Siko. Metode pada penelitian ini adalah studi korelasional dengan pendekatan cross-sectional. Penelitian ini menggunakan pemilihan acak untuk memilih 85 partisipan hipertensi yang berada di wilayah kerja Puskesmas Siko. Analisis bivariat antara IMT dan tekanan darah sistolik menghasilkan p=0.122 (p>0.05) r=0.169 berdasarkan 85 subjek, sedangkan analisis antara IMT dan tekanan darah diastolik menghasilkan p=0.527 r=0.070. Kesimpulan yang didapat tidak ditemukan korelasi yang bermakna antara tekanan darah dan indeks massa tubuh pada pasien hipertensi di Puskesmas Siko.

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