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Cervical Cancer Awareness and Its Association with VIA (Visual Inspection with Acetic Acid) Screening Behaviors Among Women of Reproductive Age: A Cross-Sectional Study at Simpang Limun Primary Health Center Khosasi, Felix; Elbert Elbert; Ginting, Anastasia Grace Milenia; Matondang, Halisa Tiara Ariani; Batubara, Riska Primayanti; Rina Amelia
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.21104

Background: Cervical cancer is a malignant disease that affects the cervix and ranks as the fourth most common cause of cancer globally, according to the World Health Organization. Women over the age of 15 are at high risk, with the most affected age group being 25–64 years. Early detection through screening, such as viasual examintation tests, plays a crucial role in reducing cervical cancer morbidity and mortality. Objectives: This study aims to determine the relationship between the knowledge of women of childbearing age about cervical cancer and VIA tests, and their behavior (attitudes and actions) regarding VIA examination as a screening method for cervical cancer. Methods: This analytical descriptive study used a cross-sectional design. Data were collected through questionnaires distributed to women of childbearing age who visited the Simpang Limun Primary Health Center. The study population included women of childbearing age in the health center's working area. A total of 100 participants were selected using the one-population hypothesis sampling formula. Data were analyzed using the Chi-square test in SPSS. Results: The findings indicate a significant relationship between knowledge about cervical cancer and VIA tests and the behavior (attitudes and actions) of women of childbearing age towards undergoing VIA examinations. Conclusion: Enhancing knowledge about cervical cancer and tests can positively influence the behavior of women of childbearing age, leading to increased participation in cervical cancer screening. Keyword: Cervical cancer, Screening, VIA test, Knowledge, Behavior Latar Belakang: Kanker serviks merupakan penyakit ganas yang menyerang leher rahim dan menempati peringkat keempat sebagai penyebab kanker tersering di dunia menurut World Health Organization. Wanita berusia di atas 15 tahun berisiko tinggi, dengan kelompok usia yang paling banyak terkena adalah 25–64 tahun. Deteksi dini melalui skrining, seperti pemeriksaan IVA, berperan penting dalam menurunkan angka kesakitan dan kematian akibat kanker serviks. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan wanita usia subur tentang kanker serviks dan tes IVA dengan perilaku (sikap dan tindakan) mereka terhadap pemeriksaan IVA sebagai metode skrining untuk kanker serviks. Metode: Penelitian deskriptif analitik ini menggunakan desain cross-sectional. Data dikumpulkan melalui kuesioner yang dibagikan kepada wanita usia subur yang berkunjung ke Puskesmas Simpang Limun. Populasi penelitian mencakup wanita usia subur di wilayah kerja puskesmas tersebut. Sebanyak 100 partisipan dipilih menggunakan rumus one-population hypothesis sampling formula. Data dianalisis menggunakan uji Chi-square dengan bantuan program SPSS. Hasil: Hasil penelitian menunjukkan adanya hubungan yang signifikan antara pengetahuan tentang kanker serviks dan pemeriksaan IVA dengan perilaku (sikap dan tindakan) wanita usia subur terhadap pemeriksaan IVA. Kesimpulan: Peningkatan pengetahuan tentang kanker serviks dan tes IVA dapat berpengaruh positif terhadap perilaku wanita usia subur, sehingga meningkatkan partisipasi dalam melakukan skrining kanker serviks. Kata Kunci: Cervical cancer, Screening, VIA test, Pengetahuan, Sikap

Are Your Painkillers Putting Your Kidneys at Risk? A Meta-Analysis of Non-Aspirin NSAIDs and Kidney Cancer Elbert, Elbert; Khosasi, Felix
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.21145

Background: Kidney cancer cases are rising globally, with over 400,000 new cases reported annually. Nonsteroidal anti-inflammatory drugs (NSAIDs), widely used for pain relief, have been linked to an increased risk of kidney cancer, particularly renal cell carcinoma, with long-term use of non-aspirin NSAIDs. This association may be due to chronic kidney damage and prostaglandin-mediated DNA alterations, though the evidence remains inconsistent. Objectives: This meta-analysis reviews recent studies (2014–2024) to reassess the relationship between non-aspirin NSAIDs and kidney cancer Methods: This meta-analysis followed PRISMA 2020 guidelines, reviewing case-control and cohort studies (2014–2024) on non-aspirin NSAIDs and kidney cancer risk from PubMed, Scopus, Web of Science, and Cochrane. Data extraction, bias assessment (ROBINS-E), and quantitative analysis (Review Manager 5.4) were conducted, with significance set at p<0.05 and heterogeneity assessed via I². Results: Out of 190 studies, three met inclusion criteria (two case-control, one cohort). The risk of bias was low in two studies, and there were some concerns in one. Meta-analysis revealed an OR of 2.08 [95% CI: 0.77–5.65], indicating no significant association (p=0.15). High heterogeneity (I²=95%) suggests substantial variability due to differences in study populations, methodologies, or therapies. These findings highlight the need for further research to better understand the relationship between non-aspirin NSAID use and kidney cancer risk and to address the observed inconsistencies. Conclusion: This meta-analysis suggests a potential link between non-aspirin NSAIDs and kidney cancer, though results lacked statistical significance. Future research should address limitations and include larger, more homogeneous datasets for clearer conclusions. Keyword: Cancer risk, Kidney cancer, Non-aspirin NSAIDs, Renal cell carcinoma Latar Belakang : Kasus kanker ginjal meningkat secara global, dengan lebih dari 400.000 kasus baru dilaporkan setiap tahun. Obat nonsteroidal anti-inflammatory (NSAIDs), yang banyak digunakan untuk meredakan nyeri, telah dikaitkan dengan peningkatan risiko kanker ginjal, khususnya karsinoma sel ginjal, terutama pada penggunaan jangka panjang NSAID non-aspirin. Asosiasi ini mungkin disebabkan oleh kerusakan ginjal kronis dan perubahan DNA yang dimediasi prostaglandin, meskipun buktinya masih tidak konsisten. Namun, bukti yang ada masih tidak konsisten, dan klarifikasi hubungan ini penting secara klinis mengingat penggunaan NSAID non-aspirin yang luas dan sering kali berlangsung dalam jangka panjang. Objectives: Meta-analisis ini meninjau studi-studi terbaru (2014–2024) untuk menilai hubungan antara NSAID non-aspirin dan kanker ginjal. Methods: Meta-analisis ini mengikuti pedoman PRISMA 2020, meninjau studi case-control (2014–2024) mengenai risiko kanker ginjal terkait NSAID non-aspirin dari PubMed, Scopus, Web of Science, dan Cochrane. Ekstraksi data, penilaian bias (ROBINS-E), dan analisis kuantitatif (Review Manager 5.4) dilakukan, dengan batas signifikansi p<0.05 dan heterogenitas dinilai menggunakan I². Results: Dari 190 studi, dua studi memenuhi kriteria inklusi. Risiko bias rendah pada kedua studi. Meta-analisis menunjukkan OR 2.08 [95% CI: 0.77–5.65], yang mengindikasikan tidak ada asosiasi yang signifikan (p=0.15). Heterogenitas yang tinggi ditemukan (I² = 95%), yang kemungkinan mencerminkan perbedaan ukuran sampel yang mencolok antar studi case-control yang disertakan. Temuan ini menekankan perlunya penelitian lebih lanjut untuk memahami hubungan antara penggunaan NSAID non-aspirin dan risiko kanker ginjal serta untuk mengatasi inkonsistensi yang terlihat. Conclusion: Meta-analisis ini menunjukkan adanya potensi hubungan antara NSAID non-aspirin dan kanker ginjal, meskipun hasilnya tidak mencapai signifikansi statistik. Penelitian selanjutnya sebaiknya berfokus pada populasi yang lebih besar dan lebih homogen, dengan definisi durasi paparan NSAID non-aspirin yang terstandarisasi serta periode laten yang didefinisikan secara jelas antara penggunaan NSAID non-aspirin dan terjadinya kanker ginjal. Kata Kunci : Kanker ginjal, Karsinoma sel ginjal, Non-aspirin NSAIDs, Risiko kanker

Behavior of Generation Z, Obesity, and Chronic Kidney Disease among Children and Adolescents: A Literature Review Furqon, Al; Ridha, Rasyid
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.22594

Background: Generation Z is defined as individuals born between 1995 and 2010. Being raised in digital era, some lifestyle of Generation Z in nutritional fullfillment and physical activity raises concern about obesity and chronic kidney disease (CKD). Objectives: This review looked into role of behavior in obesity and chronic kidney disease in Generation Z. Methods: Search strategy was done using keywords, such as “obesity”, “chronic kidney disease”, “children”, “adolescent”, and “generation Z” in several search engines, including Pubmed, ScienceDirect, and Google Scholar. Discussion: Ease of digital access, including instant meal order, makes Generation Z tend to have high calorie food intake, but with minimal physical activity. The imbalance of daily energy expenditure contributes to obesity. Obesity consequently triggers neurohormonal pathways leading to chronic kidney damage. Conclusion: Preventive measures should be taken, including healthy eating habits, daily water intake, and engaging in more physical activity. Keyword: adolescent, children, chronic kidney disease, generation Z, obesity Background: Generasi Z adalah individu yang lahir antara tahun 1995 hingga 2010. Hidup berkembang dalam era perkembangan digital, gaya hidup Generasi Z terutama yang berkaitan dengan asupan nutrisi dan aktivitas fisik meningkatkan risiko terjadinya obesitas dan penyakit ginjal kronik. Objectives: Tinjauan pustaka ini menelaah peran gaya hidup dan perilaku terhadap terjadinya obesitas dan penyakit ginjal kronik pada Generasi Z. Methods: Telaah literatur dilakukan menggunakan kata kunci, “obesitas”, “penyakit ginjal kronik”, “anak”, “remaja”, dan “generasi Z” melalui mesin pencari, seperti Pubmed, ScienceDirect, dan Google Scholar. Discussion: Generasi Z cenderung memanfaatkan kemudahan akses digital, termasuk dalam mendapatkan makanan sehari-hari. Hal ini umumnya menyebabkan asupan kalori berlebih dengan aktivitas fisik yang minimal. Ketidakseimbangan tersebut menjadi penyebab utama obesitas, yang kemudian dapat merangsang mekanisme neurohormal tubuh yang berakhir pada kerusakan ginjal kronik. Conclusion: Pencegahan obesitas dan penyakit ginjal kronik, seharusnya dapat dilakukan dengan melaksanakan pola makan yang sehat, asupan air yang cukup, dan meningkatkan aktivitas fisik. Keyword: anak, generasi Z, obesitas, penyakit ginjal kronik, remaja

Pengaruh Faktor Pelayanan Farmasi terhadap Kualitas Pelayanan yang Dimediasi oleh Waktu Tunggu Resep di Apotek Rumah Sakit Aulia Jakarta Selatan Lestari, Vania Puji; Andarusito, Nurcahyo; Nurminingsih
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.23063

Background: Pharmaceutical services in hospitals play a crucial role in determining the overall quality of healthcare services, particularly regarding efficient prescription waiting times. Objectives: This study aims to analyze the influence of factors such as Human Resources (HR), drug availability, facilities and infrastructure, and prescription types on service quality, with waiting time as a mediating variable at Aulia Hospital Pharmacy, South Jakarta. Methods: This research employed a quantitative approach with a cross-sectional design involving 90 respondents selected through purposive sampling. Data were collected using a validated and reliable questionnaire, and analyzed using univariate, bivariate (chi-square), and multivariate multinomial logistic regression tests. Results: The findings indicate that waiting time significantly affects service quality, where shorter waiting times lead to better perceptions of pharmaceutical service quality. Facilities and infrastructure were also found to have a significant effect on service quality. However, HR, drug availability, and prescription types did not show a significant effect in the multivariate model. Conclusion: The efficiency of waiting time and the comfort of facilities and infrastructure are the main determinants influencing the perceived quality of pharmaceutical services at Aulia Hospital, South Jakarta. Keyword: HR, drug availability, facilities and infrastructure, prescription types, waiting time, service quality, hospital Latar Belakang: Pelayanan farmasi di rumah sakit memiliki peran penting dalam peningkatan kualitas pelayanan kesehatan, khususnya dalam efisiensi waktu tunggu resep. Tujuan: Penelitian ini bertujuan untuk menganalisis pengaruh faktor-faktor seperti Sumber Daya Manusia (SDM), ketersediaan obat, sarana dan prasarana, serta jenis resep terhadap kualitas pelayanan, dengan waktu tunggu sebagai variabel mediasi di Apotek RS Aulia Jakarta Selatan. Metode: Penelitian ini menggunakan desain kuantitatif dengan pendekatan cross-sectional yang melibatkan 90 responden yang dipilih melalui purposive sampling. Data dikumpulkan menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya. Analisis data dilakukan dengan uji univariat, bivariat menggunakan chi-square, dan multivariat menggunakan regresi logistik multinomial. Hasil: Hasil penelitian menunjukkan bahwa waktu tunggu berpengaruh signifikan terhadap kualitas pelayanan; waktu tunggu yang lebih singkat menghasilkan penilaian yang lebih baik terhadap kualitas pelayanan. Sarana dan prasarana juga memiliki pengaruh signifikan terhadap kualitas pelayanan. Namun, SDM, ketersediaan obat, dan jenis resep tidak menunjukkan pengaruh signifikan terhadap kualitas pelayanan dalam model multivariat. Kesimpulan: Efisiensi waktu tunggu dan kenyamanan sarana prasarana merupakan faktor utama yang memengaruhi persepsi kualitas pelayanan farmasi di RS Aulia Jakarta Selatan. Kata Kunci: jenis resep, ketersediaan obat, kualitas pelayanan, rumah sakit, sarana prasarana, SDM, waktu tunggu.

Implementation of Enhanced Recovery After Surgery (ERAS) Protocols in Pediatric Cardiac Surgery: A Comprehensive Review Nugroho, Edwin Rasendriya; Heroe Soebroto; Ketut Alit Utamayasa
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.23099

Background: Enhanced Recovery After Surgery (ERAS) represents an evidence-based, multidisciplinary approach that optimizes perioperative care, reduces surgical stress, and accelerates postoperative recovery. While ERAS protocols have been widely implemented in adult cardiac surgery, their adaptation to pediatric congenital heart disease (CHD) remains emerging and underexplored. Pediatric populations pose unique challenges due to differences in physiology, surgical complexity, and developmental status. Objectives: This review aims to provide a comprehensive overview of ERAS implementation in pediatric cardiac surgery, focusing on its key components, outcomes, and research gaps to guide future practice and investigation. Methods: A narrative literature review was conducted using PubMed and Google Scholar, targeting publications from 2010 to 2025. The search utilized the keywords “Enhanced Recovery After Surgery,” “ERAS,” “Pediatric Cardiac Surgery,” and “Congenital Heart Disease.” Relevant randomized controlled trials, cohort studies, reviews, and clinical guidelines were critically analyzed to identify core ERAS elements, perioperative strategies, and reported outcomes. Discussion: The reviewed evidence supports that ERAS protocols in pediatric cardiac surgery are feasible and associated with reduced mechanical ventilation duration, ICU stay, and hospital length of stay, without increasing complications or readmissions. However, most available studies are observational, highlighting the scarcity of randomized controlled trials specifically addressing pediatric CHD. Conclusion: ERAS offers a promising framework to enhance recovery and safety in pediatric cardiac surgery. Standardized, multicenter trials are required to establish evidence-based pediatric ERAS models and determine their long-term impact on recovery and quality of life. Keyword: cardiac surgery, congenital heart disease, ERAS, pediatric, recovery Latar Belakang: Enhanced Recovery After Surgery (ERAS) merupakan pendekatan multidisiplin berbasis bukti yang bertujuan mengoptimalkan perawatan perioperatif, mengurangi stres pembedahan, dan mempercepat pemulihan pascaoperasi. Meskipun protokol ERAS telah banyak diterapkan pada pembedahan jantung dewasa, adaptasinya pada kasus Congenital Heart Disease (CHD) pediatrik masih tergolong baru dan belum banyak diteliti. Populasi pediatrik memiliki tantangan tersendiri karena perbedaan fisiologi, kompleksitas pembedahan, serta status perkembangan. Tujuan: Tinjauan ini bertujuan untuk memberikan gambaran komprehensif mengenai penerapan ERAS pada pembedahan jantung pediatrik, dengan menyoroti komponen utama, luaran klinis, serta kesenjangan penelitian untuk panduan praktik dan penelitian selanjutnya. Metode: Tinjauan literatur naratif dilakukan dengan menggunakan basis data PubMed dan Google Scholar untuk publikasi tahun 2010 hingga 2025. Pencarian dilakukan dengan kata kunci “Enhanced Recovery After Surgery,” “ERAS,” “Pediatric Cardiac Surgery,” dan “Congenital Heart Disease.” Artikel yang relevan, termasuk randomized controlled trials, studi kohort, tinjauan pustaka, dan pedoman klinis dianalisis secara kritis untuk mengidentifikasi elemen utama ERAS, strategi perioperatif, serta luaran yang dilaporkan. Pembahasan: Bukti yang ditinjau menunjukkan bahwa penerapan protokol ERAS pada pembedahan jantung pediatrik bersifat layak dan berhubungan dengan penurunan durasi ventilasi mekanik, lama perawatan di ICU, serta lama rawat inap, tanpa meningkatkan komplikasi maupun angka readmisi. Namun, sebagian besar studi yang tersedia bersifat observasional, menyoroti keterbatasan uji acak terkontrol yang secara khusus meneliti CHD pediatrik. Kesimpulan: ERAS menawarkan kerangka kerja yang menjanjikan untuk meningkatkan pemulihan dan keamanan pada pembedahan jantung pediatrik. Diperlukan uji multicenter terstandar untuk membangun model ERAS berbasis bukti pada populasi pediatrik serta menilai dampak jangka panjangnya terhadap pemulihan dan kualitas hidup. Keyword: bedah jantung, ERAS, pediatrik, pemulihan, penyakit jantung bawaan

Effectiveness of Robot-Assisted Gait Training on Gait and Gross Motor Function in Children with Cerebral Palsy : A Literature Review Mahendika, Devin
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.23159

Background: Cerebral palsy (CP) causes motor impairments in children, including abnormal gait, muscle weakness, spasticity, and poor balance. Robot-assisted gait training (RAGT) provides intensive, repetitive gait practice using wearable exoskeletons or treadmill-based systems to promote neuroplasticity, but its effectiveness remains debated. Objectives: To review recent evidence on RAGT effectiveness in children with CP, comparing wearable and tethered systems and their effects on gait, balance, and gross motor function. Methods: A literature search was conducted in PubMed and Scopus (last 5 years). Experimental studies (including RCTs), observational studies, and reviews on RAGT in pediatric CP were selected and narratively synthesized. Results: Recent trials report that wearable RAGT improves Gross Motor Function Measure (GMFM) scores and balance compared to conventional therapy. In contrast, meta-analyses indicate that tethered treadmill-based RAGT does not significantly improve walking speed or distance over standard therapy. Wearable systems using assist-as-needed control allow adaptive overground gait training with more natural sensory feedback, whereas trajectory-controlled devices impose fixed gait patterns. Conclusion: Wearable RAGT with adaptive assistance appears effective in enhancing walking ability, balance, and gross motor function in children with CP, while tethered systems show limited additional benefit. RAGT should be applied as a complementary intervention with individualized protocols. Further research is needed to evaluate long-term outcomes. Keyword: Assist-as-needed, Cerebral Palsy, Exoskeleton, Robot-Assisted Gait Training, Wearable Exoskeleton Latar Belakang: Menelaah bukti terkini efektivitas RAGT pada anak CP, termasuk perbandingan sistem wearable vs tethered, dampaknya pada pola berjalan, keseimbangan, dan motorik kasar, serta mode kendali (assist-as-needed vs trajectory-controlled) dan intensitas latihan. Tujuan: Menelaah bukti terkini efektivitas RAGT pada anak CP, termasuk perbandingan sistem wearable vs tethered, dampaknya pada pola berjalan, keseimbangan, dan motorik kasar, serta mode kendali (assist-as-needed vs trajectory-controlled) dan intensitas latihan. Metode: Pencarian literatur dilakukan di PubMed dan Scopus (5 tahun terakhir) menggunakan kata kunci RAGT dan CP anak. Studi eksperimental, observasional, dan ulasan yang relevan dipilih dan disintesis secara naratif. Hasil: Studi terbaru menunjukkan RAGT wearable meningkatkan skor GMFM (berdiri/jalan/berlari) dan keseimbangan anak CP lebih signifikan dibanding terapi konvensional. Sebaliknya, meta-analisis RAGT tethered di treadmill menunjukkan tidak ada peningkatan signifikan pada kecepatan atau jarak berjalan dibanding kontrol. Eksoskeleton wearable assist-as-needed memberikan latihan berjalan adaptif dengan umpan balik sensorik fisiologis, sedangkan sistem trajectory-controlled memaksakan pola berjalan kaku. Simpulan: Bukti mendukung bahwa RAGT wearable efektif meningkatkan fungsi berjalan, keseimbangan, dan motorik kasar anak CP, dengan kontrol assist-as-needed sebagai faktor kunci. RAGT tethered belum terbukti lebih unggul dari terapi konvensional. Penggunaan RAGT direkomendasikan sebagai pelengkap terapi konvensional dengan protokol latihan terpersonalisasi. Penelitian lanjutan diperlukan untuk mengevaluasi efek jangka panjang dan optimasi desain eksoskeleton bagi anak CP. Keyword: Anak Cerebral Palsy, Eksoskeleton, Intensitas Latihan, Latihan Berjalan, Rehabilitasi Robotik

Premedication Before Contrast-Enhanced Computed Tomography Scans: A Systematic Review Maulana Muhtadin; Ihsan Fahmi Rofananda
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.23171

Background: The use of iodinated contrast media (ICM) in Computed tomography (CT) scan improves visualization but carries a risk of hypersensitivity and other adverse reactions. Premedication with corticosteroids and antihistamines is often recommended, though its effectiveness remains debated. Objective: This systematic review aimed to evaluate the efficacy of premedication in reducing adverse reactions to ICM in patients undergoing contrast-enhanced CT. Methods: Following PRISMA 2020 guidelines, a systematic search was conducted in PubMed, ProQuest, and ScienceDirect. Eligible studies included randomized controlled trials, cohort, and case-control studies involving premedication and reporting adverse outcomes after ICM administration. Risk of bias was assessed using the Cochrane RoB tool and Newcastle-Ottawa Scale. Results: Of 2675 records screened, five studies (one RCT and four cohorts; >8,000 exposures) were included. All reported a reduction in adverse reactions with premedication, though protective effects varied. Antihistamines consistently reduced recurrence of mild and late hypersensitivity reactions. Corticosteroids modestly lowered overall reaction rates but were less effective in high-risk patients compared with contrast substitution. One study showed diazepam reduced seizure incidence in glioma patients. Conclusion: In conclusion, Premedication reduces ICM-related adverse reactions, but its benefit depends on patient risk, prior reaction severity, and regimen used. Antihistamines are particularly effective for mild and late reactions, while contrast substitution may outperform corticosteroids in high-risk patients. Keyword: Adverse reactions, Computed tomography, Contrast media, Hypersensitivity, Premedication Latar Belakang: Penggunaan media kontras beryodium (ICM) dalam pemindaian tomografi terkomputasi (CT scan) meningkatkan visualisasi tetapi berisiko menyebabkan hipersensitivitas dan reaksi merugikan lainnya. Premedikasi dengan kortikosteroid dan antihistamin sering direkomendasikan, meskipun efektivitasnya masih diperdebatkan. Tujuan: Tinjauan sistematis ini bertujuan untuk mengevaluasi efikasi premedikasi dalam mengurangi reaksi merugikan terhadap ICM pada pasien yang menjalani CT scan dengan kontras. Metode: Mengikuti pedoman PRISMA 2020, pencarian sistematis dilakukan di PubMed, ProQuest, dan ScienceDirect. Studi yang memenuhi syarat meliputi uji coba terkontrol acak, studi kohort, dan studi kasus-kontrol yang melibatkan premedikasi dan pelaporan hasil yang merugikan setelah pemberian ICM. Risiko bias dinilai menggunakan alat Cochrane RoB dan Skala Newcastle-Ottawa. Hasil: Dari 2675 jurnal yang disaring, lima studi (satu RCT dan empat kohort; >8.000 paparan) diikutsertakan. Semua studi melaporkan penurunan reaksi merugikan dengan premedikasi, meskipun efek perlindungannya bervariasi. Antihistamin secara konsisten mengurangi kekambuhan reaksi hipersensitivitas ringan dan lanjut. Kortikosteroid sedikit menurunkan laju reaksi keseluruhan tetapi kurang efektif pada pasien berisiko tinggi dibandingkan dengan substitusi kontras. Satu studi menunjukkan diazepam mengurangi insiden kejang pada pasien glioma. Kesimpulan: Sebagai kesimpulan, premedikasi mengurangi reaksi merugikan terkait ICM, tetapi manfaatnya bergantung pada risiko pasien, tingkat keparahan reaksi sebelumnya, dan rejimen yang digunakan. Antihistamin khususnya efektif untuk reaksi ringan dan lanjut, sementara substitusi kontras dapat mengungguli kortikosteroid pada pasien berisiko tinggi. Kata Kunci: Hipersensitivitas, Media kontras, Premedikasi, Reaksi yang tidak diinginkan, Tomografi terkomputasi

Comparison of Success Rates between Buccal Mucosal Graft and Penile Skin Graft in Anterior Urethral Stricture Repair: A Systematic Review Alhamdi, Mochammad Haikal
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.23471

Background: Anterior urethral stricture is a common urologic condition that may require substitution urethroplasty when endoscopic treatment fails. Buccal mucosal graft (BMG) and penile skin graft/flap (PSG/PSF) are established options, but their comparative success remains debated. Objective: To compare the success and safety outcomes of BMG and PSG/PSF urethroplasty in adult males with anterior urethral stricture. Methods: A systematic review was conducted following PRISMA 2020 guidelines. Databases searched included PubMed, Embase, Scopus, Web of Science, and Cochrane Library for studies published between 2015 and 2025. Randomized controlled trials, comparative cohorts, and meta-analyses evaluating BMG versus PSG/PSF urethroplasty were included. Twelve studies met inclusion criteria and were analyzed narratively. Results: Both graft types showed comparable success and stricture-free rates (85–94%) with no significant difference in recurrence or urinary flow improvement. BMG was favored in patients with lichen sclerosus due to resistance to dermal inflammation, whereas PSG/PSF was suitable when oral harvest was contraindicated. Donor-site morbidity was mild and self-limiting in both groups. Conclusion: Buccal mucosal and penile skin graft urethroplasty yield equivalent outcomes in anterior urethral stricture repair. Graft selection should be individualized based on patient condition and surgeon expertise. Further multicentre randomized studies with standardized outcome definitions are required to confirm long-term differences. Keywords: anterior urethral stricture, buccal mucosal graft, penile skin graft, urethroplasty, reconstruction surgery. Latar Belakang: Striktur uretra anterior merupakan kelainan urologis yang memerlukan urethroplasty substitusi bila terapi endoskopi gagal. Cangkok mukosa bukal (BMG) dan cangkok kulit penis (PSG/PSF) merupakan pilihan utama, namun perbandingan keberhasilannya masih diperdebatkan. Tujuan: Membandingkan keberhasilan dan keamanan urethroplasty menggunakan BMG dan PSG/PSF pada pria dewasa dengan striktur uretra anterior. Metode: Tinjauan sistematik dilakukan berdasarkan pedoman PRISMA 2020. Basis data PubMed, Embase, Scopus, Web of Science, dan Cochrane Library ditelusuri untuk publikasi tahun 2015–2025. Studi acak terkontrol, kohort komparatif, dan meta-analisis yang menilai BMG versus PSG/PSF disertakan. Sebanyak dua belas studi memenuhi kriteria inklusi dan dianalisis secara naratif. Hasil: Kedua jenis cangkok menunjukkan tingkat keberhasilan dan bebas striktur serupa (85–94%) tanpa perbedaan bermakna pada angka kekambuhan atau peningkatan aliran urin. BMG lebih unggul pada kasus dengan lichen sclerosus, sedangkan PSG/PSF sesuai untuk pasien yang tidak dapat dilakukan pengambilan mukosa oral. Morbiditas donor ringan dan bersifat sementara. Kesimpulan: Cangkok mukosa bukal dan kulit penis memberikan hasil yang sebanding pada rekonstruksi striktur uretra anterior. Pemilihan cangkok sebaiknya disesuaikan dengan kondisi pasien dan pengalaman operator. Diperlukan penelitian acak multisenter dengan definisi hasil yang terstandar untuk evaluasi jangka panjang. Kata Kunci: bedah rekonstruksi, cangkok mukosa bukal, cangkok kulit penis, striktur uretra anterior, urethroplasty.

Hubungan Karakteristik Ibu Hamil dengan Kejadian Preeklampsia di Rumah Sakit Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara Tahun 2020-2024 Nainggolan, Brigita Julia; Letta Sari Lintang; Arya Tjipta Prananda; Sufitni
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.24083

Background. Preeclampsia is one of the complications of pregnancy that is the leading cause of morbidity and mortality in mothers and fetuses worldwide. Objective. To determine the relationship between the characteristics of pregnant women and the incidence of preeclampsia. Methods. This study was an analytical observational study with a cross-sectional design. Research data were obtained from medical records at Prof. dr. Chairuddin P. Lubis Universitas Sumatera Utara Hospital, Universitas Sumatera Utara, Medan, 20155, INDONESIA. The total sample consisted of 142 patients, comprising 71 mothers with preeclampsia and 71 normal pregnant women. The data were selected using a combination of total sampling for mothers with preeclampsia and simple random sampling for normal pregnant women. The data were analyzed using univariate and bivariate analysis with the Chi-square test using SPSS version 27 software. Results. The majority of patients in the preeclampsia group were in the low-risk age group (20–35 years) with 49 patients (34.50%), came from the Batak ethnic group with 34 patients (23.94%), were Muslim with 51 patients (35.92%), had a high level of education with 63 patients (44.37%), unemployed 44 patients (30.99%), nulliparous 30 patients (21.13%), gestational age ≥37 weeks 43 patients (30.28%), with the highest body mass index (BMI) in the obesity I category, 43 people (30.28%), 69 women (48.59%) did not experience multifetal pregnancy, 62 women (43.66%) had no history of preeclampsia, 35 women (24.65%) had a history of hypertension, and 64 women (45.07%) had no history of previous illness. Bivariate analysis showed that there was no significant relationship between age, education level, occupation, parity, gestational age, multifetal pregnancy, previous history of preeclampsia, and previous history of disease with the incidence of preeclampsia (p-value > 0.05). The results of the analysis showed a significant relationship between body mass index (BMI) and history of hypertension with the incidence of preeclampsia. The relationship between BMI was found to be significant in the normal category (p-value = 0.016) and overweight category (p-value = 0.035), while a history of hypertension showed a very significant relationship with a p-value < 0.001 in mothers with a history of hypertension and a p-value = 0.002 in mothers without a history of hypertension. Conclusion. The characteristics of pregnant women that are significantly associated with the occurrence of preeclampsia are body mass index (BMI) and a history of hypertension, while age, ethnicity, religion, education level, occupation, parity, gestational age, multifetal pregnancy, previous history of preeclampsia, and previous history of disease are not significantly associated with the occurrence of preeclampsia. Keyword: Characteristics of Pregnant Women, Preeclampsia Latar Belakang: Preeklampsia merupakan salah satu komplikasi kehamilan yang menjadi penyebab utama morbiditas dan mortalitas ibu serta janin di seluruh dunia. Tujuan: Untuk mengetahui hubungan karakteristik ibu hamil dengan kejadian preeklampsia. Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Data penelitian diperoleh dari rekam medis di Rumah Sakit Pendidikan Prof. dr. Chairuddin P. Lubis Universitas Sumatera Utara, Universitas Sumatera Utara, Medan, 20155, INDONESIA periode 2020—2024. Total sampel sebanyak 142 pasien yang terdiri atas 71 ibu preeklampsia dan 71 ibu hamil normal. Data tersebut dipilih menggunakan metode kombinasi total sampling pada ibu preeklampsia pada dan simple random sampling ibu hamil normal. Data dianalisis menggunakan analisis univariat dan analisis bivariat dengan uji Chi-square melalui software SPSS versi 27. Hasil: Mayoritas pasien pada kelompok ibu preeklampsia berada pada usia risiko rendah (20–35 tahun) sebanyak 49 pasien (34,50%), berasal dari suku Batak 34 pasien (23,94%), beragama Islam 51 pasien (35,92%), memiliki tingkat pendidikan tinggi 63 pasien (44,37%), tidak bekerja 44 pasien (30,99%), nulipara 30 pasien (21,13%), usia kehamilan ≥37 minggu 43 pasien (30,28%), dengan indeks massa tubuh (IMT) terbanyak pada kategori obesitas I sebanyak 43 pasien (30,28%), tidak mengalami kehamilan multifetal 69 pasien (48,59%), tidak memiliki riwayat preeklampsia sebelumnya 62 pasien (43,66%), memiliki riwayat hipertensi 35 pasien (24,65%), dan tidak memiliki riwayat penyakit terdahulu 64 pasien (45,07%). Analisis bivariat menunjukkan bahwa tidak terdapat hubungan signifikan antara usia, tingkat pendidikan, pekerjaan, paritas, usia kehamilan, kehamilan multifetal, riwayat preeklampsia sebelumnya, serta riwayat penyakit terdahulu dengan kejadian preeklampsia (p-value > 0.05). Adapun hasil analisis menunjukkan adanya hubungan yang bermakna antara indeks massa tubuh (IMT) dan riwayat hipertensi dengan kejadian preeklampsia. Hubungan IMT ditemukan signifikan pada kategori normal (p-value = 0.016) dan overweight (p-value = 0.035), sedangkan riwayat hipertensi menunjukkan hubungan yang sangat signifikan dengan nilai p-value < 0.001 pada ibu dengan riwayat hipertensi dan p-value = 0.002 pada ibu tanpa riwayat hipertensi. Kesimpulan: Karakteristik ibu hamil yang berhubungan secara bermakna dengan kejadian preeklampsia adalah indeks massa tubuh (IMT) dan riwayat hipertensi, sedangkan usia, suku, agama, tingkat pendidikan, pekerjaan, paritas, usia kehamilan, kehamilan multifetal, riwayat preeklampsia sebelumnya, dan riwayat penyakit terdahulu tidak memiliki hubungan yang signifikan terhadap kejadian preeklampsia. Kata Kunci: Karakteristik Ibu Hamil, Preeklampsia

A Cross-Sectional Study on the Association between Acyanotic Congenital Heart Disease and Cognitive Function in Children at Adam Malik Hospital Medan (2022–2023) Subrata, Aqilah Halwa; Lumban Tobing, Tina Christina; Mahmud Amin, Mustafa; Dalimunthe, Dina Arwina
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.24154

Background. Congenital Heart Disease (CHD) has become the primary health issue for newborns. Children with CHD who experience the most complications are those with acyanotic CHD. Children with acyanotic CHD experience many clinical disturbances such as shortness of breath, recurrent respiratory infections, cyanosis, and inadequate nutrition intake. This makes children with acyanotic CHD have a higher risk of experiencing cognitive developmental disorders compared to other normal children. Objective. This study aims to examine the correlation between acyanotic CHD and cognitive function in children at Adam Malik Hospital in 2022–2023. Method. An observational analytic study with a cross-sectional design. The subjects of this study are pediatric patients with acyanotic CHD. Data were obtained from the Denver Developmental Screening Test II cognitive function medical records of 46 patients at Adam Malik Hospital in 2022–2023. Data analysis was conducted using the chi-square hypothesis test. Results. This study involved 46 patient samples with acyanotic CHD. The chi-square test results showed no significant correlation between acyanotic CHD and meaningful cognitive function (p-value = 0.462), where acyanotic CHD did not significantly affect gross motor, fine motor, language, and personal–social functions in children. Conclusion. There is no significant correlation between acyanotic CHD and cognitive function in children at Adam Malik Hospital Medan in 2022–2023. Keyword: Acyanotic, children, cognitive function, congenital heart disease, denver developmental screening test II Latar Belakang: Penyakit Jantung Bawaan (PJB) menjadi masalah kesehatan yang paling utama pada anak yang baru lahir. Anak dengan PJB yang paling banyak mengalami gangguan adalah anak dengan PJB asianotik. Anak dengan PJB asianotik mengalami banyak gangguan klinis seperti sesak napas, infeksi saluran napas berulang, sianosis, dan nutrisi yang tidak adekuat. Hal ini membuat anak dengan PJB asianotik memiliki risiko yang lebih tinggi untuk mengalami gangguan perkembangan kognitif dibandingkan dengan anak normal lainnya. Tujuan: Penelitian ini untuk mengetahui hubungan antara PJB asianotik dengan fungsi kognitif pada anak di Rumah Sakit Adam Malik Medan tahun 2022–2023. Metode: Penelitian ini menggunakan metode analitik observasional dengan desain studi cross sectional. Subjek pada penelitian ini adalah pasien anak dengan PJB asianotik. Data diperoleh dari rekam medis fungsi kognitif Denver Developmental Screening Test II sebanyak 46 pasien di Rumah Sakit Adam Malik Medan tahun 2022–2023. Analisis data dilakukan dengan uji hipotesis chi-square. Hasil: Penelitian ini melibatkan 46 sampel pasien dengan PJB asianotik. Hasil uji chi-square menunjukkan tidak ada hubungan signifikan antara PJB asianotik dengan fungsi kognitif yang bermakna (p-value = 0.462), dimana PJB asianotik tidak berpengaruh signifikan terhadap fungsi motorik kasar, motorik halus, bahasa, dan personal–sosial pada anak. Kesimpulan: Tidak terdapat hubungan yang signifikan antara PJB asianotik dengan fungsi kognitif pada anak di Rumah Sakit Adam Malik Medan tahun 2022–2023. Keyword: Anak, asianotik, denver developmental screening test II, fungsi kognitif, penyakit jantung bawaan

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Juliandi Harahap

Contact Email
juliandiharahap@yahoo.com

Phone
+6285358792636

Journal Mail Official
scripta@usu.ac.id

Editorial Address
Faculty of Medicine Universitas Sumatera Utara, Jalan dr. T. Mansur No. 5, Kampus USU, Medan 20155, Indonesia

Location
Kota medan,

Sumatera utara

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Juliandi Harahap

Contact Email juliandiharahap@yahoo.com

Phone +6285358792636

Journal Mail Official scripta@usu.ac.id

Editorial Address Faculty of Medicine Universitas Sumatera Utara, Jalan dr. T. Mansur No. 5, Kampus USU, Medan 20155, Indonesia

Location Kota medan, Sumatera utara INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Juliandi Harahap

Contact Email
juliandiharahap@yahoo.com

Phone
+6285358792636

Journal Mail Official
scripta@usu.ac.id

Editorial Address
Faculty of Medicine Universitas Sumatera Utara, Jalan dr. T. Mansur No. 5, Kampus USU, Medan 20155, Indonesia

Location
Kota medan,

Sumatera utara

INDONESIA