cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Juliandi Harahap
Contact Email
juliandiharahap@yahoo.com
Phone
+6285358792636
Journal Mail Official
scripta@usu.ac.id
Editorial Address
Faculty of Medicine Universitas Sumatera Utara, Jalan dr. T. Mansur No. 5, Kampus USU, Medan 20155, Indonesia
Location
Kota medan,
Sumatera utara
INDONESIA
SCRIPTA SCORE Scientific Medical Journal
Published by Universitas Sumatera Utara
ISSN : 20888686     EISSN : 26860864     DOI : https://doi.org/10.32734/scripta.v1i2
Core Subject : Health,
Medicine & Pharmacology
SCRIPTA SCORE Scientific Medical Journal is a journal aimed to provide a forum for publishing scientific articles in the field of medical or health science. The main focus of SCRIPTA SCORE Scientific Medical Journal is tropical medicine and oncology medicine also the rest of medical fields as the additional focus. To achieve its aim, SCRIPTA SCORE Scientific Medical Journal publishes research articles, review articles, and case reports especially manuscript with a regional or national data to raise the interest of the reader in tropical medicine or oncology medicine as the main focus and the rest of medical fields as the addition focus.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 148 Documents
 11   12   13   14   15 
Probiotic Supplementation’s Efficacy and Safety in Preventing Healthcare-Associated Infections: A Systematic Review and Meta-Analysis Satria, Fauzi; Widyawati, Tri; Dwi Jalma, Monica
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.15897

Abstract

Background: Infections that people may get while seeking treatment in health facilities are known as healthcare-associated infections (HAIs). The application of probiotics represents a forefront approach in ongoing research and development for the prevention of HAIs. Probiotics' effectiveness has been the subject of several prior research, although the findings have not always been consistent. Objectives: This research aims to determine the efficacy and safety of probiotic supplementation in lowering HAIs when compared to a placebo. Methods: The PRISMA 2020 guidelines were followed in this investigation. Using the keywords "Healthcare-Associated Infections", "Nosocomial Infection, and "Probiotic", a search of the literature was done in July 2023 on the Cochrane Library, Google Scholar, PubMed, Proquest, Science Direct, Springer Link, and the ClinicalTrial.gov registry, with a focus on Randomized Clinical Trials from the previous ten years that compared the efficacy and safety of probiotics and placebos in preventing HAIs. The University of Oxford CEBM sheet, the Cochrane Risk of Bias Tools and Modified Jadad Score were used to evaluate the RCTs included. Meta analysis is carried through using RevMan Software 5.4. Results: Three RCTs that included 542 adult patients were qualified. The patient’s ages varied from 18 to 80, with 304 men (67.26%) and 148 women (32.74%) present. Probiotics significantly reduced HAIs compared to placebo (OR 1.92; 95% CI 1.10-3.35; p=0.02). Probiotics were administered to patients without causing any significant negative effects. Conclusion: In comparison to a placebo, probiotics are effective and safe in lowering the frequency of HAIs. Latar Belakang: Infeksi yang diperoleh pasien saat berobat ke fasilitas pelayanan kesehatan dikenal sebagai healthcare-associated infections (HAIs). Penggunaan probiotik merupakan pendekatan terdepan dalam penelitian dan pengembangan saat ini untuk upaya pencegahan HAIs. Efektivitas probiotik telah menjadi subjek beberapa penelitian sebelumnya, meskipun temuan yang diperoleh tidak selalu konsisten. Tujuan: Penelitian ini bertujuan untuk mengetahui efikasi dan keamanan suplementasi probiotik dalam menurunkan HAIs jika dibandingkan dengan plasebo. Metode:Penelitian ini mengikuti pedoman PRISMA 2020. Penelusuran literatur dilakukan menggunakan kata kunci “Healthcare-Associated Infections”,“Nosocomial Infection”, dan “Probiotic” pada bulan Juli 2023 di database Cochrane Library, Google Scholar, PubMed, Proquest, Science Direct, Springer Link, dan ClinicalTrial registri.gov, dengan fokus artikel Randomized Clinical Trials (RCT) terpublikasi sepuluh tahun terakhir yang membandingkan efikasi serta keamanan probiotik dan plasebo dalam mencegah HAIs. Lembar The University of Oxford CEBM, instrumen deteksi risiko bias Cochrane, dan skor Jadad yang dimodifikasi digunakan untuk mengevaluasi artikel RCT terpilih. Meta Analisis dilakukan dengan menggunakan Software RevMan versi 5.4. Hasil: Tiga artikel RCT yang mencakup sebanyak 542 pasien dewasa memenuhi syarat untuk disertakan dalam penelitian. Usia pasien bervariasi dari 18 hingga 80 tahun, terdiri dari 304 pria (67,26%) dan 148 wanita (32,74%). Probiotik secara signifikan mengurangi HAIs dibandingkan dengan plasebo (OR 1.92; 95% CI 1.10-3.35; p=0.02). Probiotik diberikan kepada pasien tanpa menimbulkan efek negatif yang signifikan Kesimpulan: Dibandingkan dengan plasebo, probiotik efektif dan aman dalam menurunkan frekuensi HAIs.
Relationship between Elementary Students’ Activity Patterns and the Occurrence of Refractive Disorder Sitorus, Francisca Teratai Anindithya; Aldy, Fithria; Amra, Aryani Atiyatul; Nasution, Malayana Rahmita
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.16055

Abstract

Background: Refractive disorder is circumstance in which the eye fails to focus the light coming from an object onto the retina resulting in blurred shadows. One of the risk factors that cause or increase the progressivity of refractive disorder is environmental factors. Environmental factors are avoidable factors and are related to the social aspects of a child, such as a child's habitual patterns in carrying close range activities (reading, using a computer, playing video games, and watching television), and also outdoor activities. Objective: To examine the correlation between student activity patterns and the occurrence of refractive disorder. Methods: This study used an analytical method with a cross sectional design. The data used are primary data obtained directly through visus examination with the Snellen Chart and filling out questionnaires by elementary school students. Results: Based on the results of the Chi-square test, it was found that there was a significant relationship (p < 0,05) between the duration, distance and position of the body when reading books with the occurrence of refractive disorder. There was also a significant relationship (p < 0,05) between duration, distance and body position when using gadgets with the occurrence of refractive disorder. Conclusion: There is a significant relationship between the activity patterns of the students when reading books and when using gadgets with the occurrence of the refractive disorder.   Latar Belakang: Kelainan refraksi adalah keadaan di mana mata gagal untuk memfokuskan cahaya yang berasal dari suatu objek ke retina sehingga dihasilkan bayangan yang kabur. Salah satu faktor yang berisiko menyebabkan maupun meningkatkan progresivitas kelainan refraksi adalah faktor lingkungan. Faktor lingkungan merupakan faktor yang dapat dihindari dan berkaitan dengan aspek sosial seorang anak, seperti pola kebiasaan seseorang dalam melakukan aktivitas jarak dekat (membaca, menggunakan komputer, bermain video games, dan menonton televisi), dan juga aktivitas di luar ruangan. Tujuan: Untuk mengetahui hubungan antara pola aktivitas siswa dengan terjadinya kelainan refraksi. Metode: Penelitian ini menggunakan metode analitik dengan desain cross sectional. Data yang digunakan adalah data primer yang diperoleh secara langsung melalui pemeriksaan visus dengan Snellen Chart serta pengisian kuesioner oleh siswa/i sekolah dasar. Hasil: Berdasarkan hasil uji Chi-square didapati adanya hubungan yang signifikan (p < 0,05) antara durasi, jarak dan posisi tubuh ketika membaca buku dengan terjadinya kelainan refraksi. Didapati juga adanya hubungan yang signifikan (p < 0,05) antara durasi, jarak dan posisi tubuh ketika menggunakan gawai dengan terjadinya kelainan refraksi. Kesimpulan: Terdapat hubungan yang signifikan antara pola aktivitas para siswa  pada saat membaca buku ataupun pada saat menggunakan gawai dengan terjadinya kelainan refraksi.
Low Oxalate Diet for Prevention of Kidney Stone Disease: A Literature Review Alhamdi, Mochammad Haikal; Alimah, Ghina Jilan
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.16080

Abstract

Background: Nephrolithiasis is the most common illness affecting the urinary system. It affects 600,000 Americans annually and about 12% of the world's population. It caused by a concentration of crystals that exits the kidney and genitourinary system. Calcium stones, primarily composed of calcium phosphate or oxalate, are present in about 80% of patients with nephrolithiasis. Kidney stones can be avoided by controlling the production of oxalate stones through the low oxalate dietary sources and regulating other factors that affect oxalate absorption. Objectives: The purpose of this literature review is to explain how to maintain a low-oxalate diet and other factors, such as enzymes, oxalate precursors, and bacteria in the colon, affect urine oxalate excretion and help prevent the formation of kidney stones. Methods: A summary of this literature was compiled using data from numerous internet resources. Ten earlier research RCTs or observational studies with statistical analysis—that met a number of inclusion criteria were used to support the goals of this work. The journal is available for open access, its publication year is at least 2014. Discussion: Consuming more water, DASH, low calcium and salt diet, and a low-oxalate diet can all considerably reduce the excretion of oxalate. Conversely, a poor dietary pattern has been associated with an increased risk of kidney stones. Oral formulations ALLN-177, Oxabact, and OxDC are helpful in lowering urinary oxalate levels. Conclusion: Kidney stone disease may be avoided by adopting a low-oxalate and low-precursor diet. Latar Belakang: Nefrolitiasis merupakan penyakit yang banyak terjadi pada sistem saluran kemih. Penyakit ini mempengaruhi 600.000 orang Amerika setiap tahunnya dan sekitar 12% populasi dunia. Hal ini disebabkan oleh peningkatan konsentrasi kristal di sistem genitourinari.  Pada pasien nefrolitiasis, 80% diantaranya disebabkan oleh pembentukan batu kalsium, terutama fosfat atau oksalat. Nefrolitiasis dapat dihindari dengan mengendalikan produksi batu oksalat melalui sumber makanan rendah oksalat dan mengatur faktor lain yang mempengaruhi penyerapan oksalat.Tujuan: Penulisan literatur ditujukan untuk mengetahui pengaturan pola makan rendah oksalat dan faktor lain seperti enzim, prekursor oksalat dan bakteri di usus sebagai pencegahan pembentukan batu oksalat di ginjal dengan menurunkan eksresi oksalat dalam urin. Metode: Literature review dilakukan dengan mengumpulkan berbagai literatur bersumber dari Internet. Digunakan 10 penelitian yang sesuai dengan kriteria inklusi, penelitian RCT ataupun studi observasional, artikel memiliki akses gratis, tahun terbit minimal 2014 Diskusi: Peningkatan konsumsi air, DASH, diet rendah kalsium dan rendah garam dapat menurunkan eksresi oksalat. Pola diet yang buruk dapat meningkatkan risiko pembentukan batu ginjal. Konsumsi ALLN-177, Oxabact dan OxDC membantu menurunkan oksalat urin. Kesimpulan: Pembentukan batu ginjal dapat dihindari dengan menerapkan pola makan rendah oksalat dan rendah prekursor oksalat.
Sigmoid Volvulus in An Adolescent Female With Colitis: A Rare Case Report Jaya Putra, Edwin Satya; Setiawati, Rosy
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.16466

Abstract

Introduction: Sigmoid volvulus among pediatric patients is a rare occurrence. Case: A 13-year-old pediatric female presented to hospital’s emergency department with abdominal pain, nausea, and inability to defecate for three days. No fever or vomiting was reported. She had a multiple episodes of constipation and was menstruating. Physical examination suggested bowel obstruction. Plain abdominal radiograph showed diffuse colon dilation with minimal small bowel and pelvic gas. Abdominal contrast CT revealed severe large bowel dilatation with redundancy from the cecum to the rectosigmoid area, along with a "whirl sign" as the diagnostic feature. Colon in-loop procedure revealed stenosis at the sigmoid-descending colonic junction due to volvulus with partial obstructive ileus. The diagnosis of sigmoid volvulus was confirmed and subsequently the patient underwent an endoscopic decompression procedure. Colitis was visualized during endoscopy. Symptoms completely resolved the following day and her parents requested discharge two days after the procedure.  Discussion: Sigmoid volvulus is a potential differential diagnosis in children with symptoms of bowel obstruction. Physicians and radiologists should remain vigilant to avoid morbidity and mortality resulting from delayed and untreated cases. Conclusion: Thorough clinical, radiological, and histopathologic investigations play a crucial role in preventing treatment delays. It is important to be aware of uncommon causes of abdominal pain in the pediatric age group. Keywords: decompression, pediatric, radiology, rare case, sigmoid volvulus Latar Belakang: Volvulus sigmoid pada pasien anak merupakan kasus yang jarang. Presentasi Kasus: Remaja perempuan berusia 13 tahun datang ke Instalasi Gawat Darurat rumah sakit dengan keluhan nyeri perut, mual, dan tidak dapat buang air besar sejak tiga hari yang lalu. Keluhan demam dan muntah disangkal. Terdapat riwayat konstipasi berulang serta pasien saat ini sedang menstruasi. Pemeriksaan fisik mengarah adanya obstruksi saluran cerna. Foto polos abdomen menunjukkan adanya dilatasi kolon difus dengan gas minimal di usus kecil dan area pelvis. CT-scan abdomen dengan kontras menunjukkan dilatasi kolon signifikan disertai adanya redundansi dari sekum hingga area rektosigmoid dan tampak “whirl sign” sebagai fitur diagnostik yang sensitif. Hasil colon-in-loop menunjukkan adanya stenosis pada area pertemuan antara kolon sigmoid dan kolon desenden akibat volvulus dengan ileus obstruksi parsial. Diagnosis volvulus sigmoid ditegakkan dan pasien menjalani prosedur dekompresi endoskopi setelahnya. Kolitis tervisualisasi saat prosedur. Keluhan membaik seluruhnya pada keesokan hari dan orang tua pasien meminta pasien dipulangkan dua hari post-prosedur. Diskusi: Volvulus sigmoid merupakan diagnosis diferensial yang potensial pada anak dengan gejala obstruksi saluran cerna. Klinisi dan radiolog harus selalu waspada demi menghindari morbiditas dan mortalitas akibat kasus yang lambat maupun tidak tertangani. Kesimpulan: Pemeriksaan fisik, radiologis, serta histopatologis yang menyeluruh memainkan peranan penting dalam mencegah keterlambatan penanganan. Kasus ini menekankan pentingnya kewaspadaan terhadap suatu penyebab tidak umum kasus nyeri perut pada populasi anak.  
Tuberkulosis Gumma pada Pasien Tuberkulosis Paru Donytasari, Fitri Meutia; Dalimunthe, Dina Arwina; Siregar, Remenda
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.16760

Abstract

Background: Tuberculosis (TB) gumma (metastatic tuberculous abscess) is a rare form of cutaneous TB, generally occurring in malnourished and immunocompromised patient. Case: A 24 year old man with a chief complaint of ulcers accompanied by a thick pigmented crusts on the neck and left abdomen without pain since 3 months ago. Initially, 6 months ago a small skin coloured lump the size of a green bean seed arised on the stomach and neck, not itchy or painful. One month later, the mass got bigger, ulcerated, and pus drainage were seen. The patient was also currently diagnosed with pulmonary TB. Dermatological examination showed an ulcer with a diameter of 10 cm with crusts and pus with irregular edges and hyperpigmentation in the left colli region and an ulcer with a diameter of 15 cm with crusts and pus with irregular edges and hyperpigmentation in the left lumbar region. The results of histopathological examination of the dermis showed fibrocollagenous connective tissue with infiltration of inflammatory lymphocytes and PMN cells, localized clusters of epithelioid cells with central necrosis and Langhans multinucleated giant cells were found. Discussion: Gumma tuberculosis is a multibacillary variant of cutaneous TB with a focus on hematogenous spread. Antituberculosis drugs are given according to the phase and the dose is according to the patient's body weight. Conclusion: A case of gumma tuberculosis has been reported in an immunocompetent young adult patient with pulmonary tuberculosis. The prognosis in patients is generally good. Pendahuluan: Tuberkulosis (TB) gumma (abses tuberkulosis metastatik) adalah bentuk TB kutis yang jarang, umumnya terjadi pada keadaan malnutrisi dan imunokompromais. Kasus: Seorang laki-laki berusia 24 tahun dengan keluhan utama luka borok disertai dengan keropeng hitam yang tebal pada leher dan perut kiri yang tanpa rasa nyeri sejak 3 bulan lalu. Awalnya, 6 bulan yang lalu pasien merasakan adanya benjolan kecil seukuran biji kacang hijau pada perut dan leher yang sewarna kulit dan tidak terasa gatal maupun nyeri. Satu bulan setelahnya benjolan dirasakan semakin membesar kemudian pecah dan mengeluarkan nanah. Pasien saat ini juga didiagnosis dengan TB paru. Dari pemeriksaan dermatologis tampak ulkus dengan diameter 10 cm disertai krusta dan pus dengan tepi ireguler dan hiperpigmentasi pada regio colli sinistra dan ulkus dengan diameter 15 cm disertai krusta dan pus dengan tepi ireguler dan hiperpigmentasi pada regio lumbalis sinistra. Hasil histopatologis dari jaringan regio abdomen dekstra menunjukan bagian dermis terdiri dari jaringan ikat fibrokolageneus dengan infiltrasi sel-sel radang limfosit dan PMN, setempat tampak kelompokan sel-sel epiteloid dengan nekrosis sentral dan dijumpai Langhans multinucleated giant cell. Diskusi: Tuberkulosis gumma merupakan varian multibasiler dari TB kutis dengan fokus penyebaran secara hematogen. Obat antituberkulosis (OAT) diberiksan sesuai fase dan dosis disesuaikan dengan berat badan pasien. Kesimpulan: Telah dilaporkan satu kasus tuberkulosis gumma pada pasien dewasa muda imunokompeten yang mengalami tuberkulosis paru. Prognosis pada pasien umumnya baik.
Peran Suami dalam Mendukung ASI Ekslusif dan Kaitannya dalam Penurunan Angka Stres pada Ibu Menyusui: sebuah Literatur Review Samosir, Fauzan Azmi Hasti Habibi; Rabbaanee, Muhammad Afif; Siagian, Bertrand Matahari Pustahasakti; Sinaga, Alya Anazwa; Pasaribu, Nashwa Zahra Putri Adlind; Siagian, Bernard Bintang Pustahabima
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.16925

Abstract

Background: Exclusive breastfeeding provides many benefits for mothers and babies, including protecting the baby's digestive system and preventing diarrhea and infection. In everyday life, exclusive breastfeeding has an impact on a mother's psychological condition, as a result of which breastfeeding mothers cause stress. Family support, especially the husband, can provide motivation for breastfeeding activities. Objectives: To find out the role of husbands in supporting exclusive breastfeeding and its relationship to reducing stress in breastfeeding mothers. Methods: This research uses a literature review method with 5 related scientific articles. Husband's support consists of several forms, such as emotional, physical, planning and informational support. Discussion: A wife must have all this support so that she can maximize exclusive breastfeeding for her child, although several studies show that support from a man is not the only factor in the absence of breast milk, because there are other factors that can reduce it. Husband's support can provide a wife with a feeling of comfort, love and respect so that children's growth and development becomes optimal, stress is reduced or disappeared and household harmony is maintained. Conclusion: Husbands have an important role in supporting the process of exclusive breastfeeding, especially in reducing stress levels in breastfeeding mother. Latar Belakang: ASI Eksklusif adalah pemberian ASI saja kepada bayi tanpa makanan atau minuman lain, kecuali vitamin, mineral, obat-obatan, dan garam rehidrasi oral. Pemberian ASI eksklusif memberikan banyak manfaat bagi ibu dan bayi, termasuk melindungi sistem pencernaan bayi serta mencegah diare dan infeksi. Pemberian ASI ekslusif berdampak pada keadaan psikis seorang ibu akibatnya ibu menyusui menjadi stres. Pentingnya dukungan keluarga terhadap suami dapat memberikan motivasi terhadap kegiatan menyusui. Tujuan: untuk mengetahui peran suami dalam mendukung ASI ekslusif dan kaitannya terhadap penurunan stres pada ibu menyusui. Metode: Penelitian ini menggunakan metode literature review dengan 5 artikel ilmiah terkait. Dukungan suami terdiri dari beberapa bentuk, seperti dukungan emosional, fisik, perencanaan, dan informasional. Diskusi: Segala dukungan tersebut harus dimiliki oleh seorang istri agar dirinya dapat memaksimalkan pemberian ASI eksklusif kepada anaknya, meskipun beberapa penelitian menunjukkan bahwa dukungan dari seorang pria bukanlah satu-satunya faktor tidak adanya ASI, karena ada faktor lain yang dapat menurunkannya. Dukungan suami dapat memberikan rasa nyaman, dicintai, dan dihargai bagi istri sehingga tumbuh kembang anak menjadi optimal, stres menjadi berkurang ataumenghilang  dan terjaganya keharmonisan rumah tangga. Kesimpulan: Suami memiliki peran penting dalam mendukung proses pemberian ASI ekslusif terutama dalam menurunkan angka stres pada istri yang menyusui.    
Front & Back Matter
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.17897

Abstract

The Relationship Between Sufficient Knowledge and Behavior of Medical Students in Faculty of Medicine Universitas Sumatera Utara regarding Acne Vulgaris Sitepu, Josapat Bima Sakti; Hazlianda, Cut Putri
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 2 (2025): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i2.14600

Abstract

ABSTRACT Acne vulgaris is a chronic inflammation of pilosebaceous follicles caused by Propionibacterium acnes. The clinical symptoms are polymorphic skin eruption, especially blackheads, non-inflammatory papule, pustule, nodule, and cyst formation. Generally, patients tend to complain of the aesthetic disfigurement caused by acne vulgaris. Even though it is not life-threatening, acne vulgaris can seriously harm patients’ confidence and might cause depression. One of risk factors is lack of knowledge and bad behavior. This research aimed to study the knowledge and behavior of medical students in University of North Sumatra regarding acne vulgaris in 2018. The research was observational cross-sectional study. Eighty-eight medical students in University of North Sumatra that fulfilled the inclusion criteria in this study were recruited and were randomized using consecutive sampling. The data was obtained by filling in the questionnaire to evaluate their knowledge and behavior. The accumulated data were processed with computer. The level of knowledge of the medical students in University of North Sumatra is 43.2% (sufficient) and the behavior of the medical students in University of North Sumatra was 68.2% (sufficient). There was a significant relationship between knowledge and behavior of the medical students in University of North Sumatera and acne vulgaris. Keywords: Acne Vulgaris, Behavior, Knowledge, University Student   ABSTRAK Acne vulgaris merupakan inflamasi kronis folikel pilosebasea yang disebabkan oleh Propionibacterium acne. Gejala klinis yang muncul umumnya berupa erupsi kulit polimorfik dengan dominasi komedo hitam, papula non-inflamasi, pustula, nodus, dan kista. Secara umum, pasien sering mengeluhkan gangguan kosmetik yang ditimbulkan akibat acne vulgaris. Walaupun tidak mengancam jiwa, acne vulgaris dapat membahayakan pasien karena dapat menyebabkan krisis kepercayaan dan depresi. Salah satu faktor risiko adalah pengetahuan dan perilaku buruk. Penelitian ini bertujuan untuk menilai pengetahuan dan sikap mahasiswa kedokteran di Universitas Sumatera Utara (USU) tentang acne vulgaris pada 2018. Penelitian ini berupa penelitian observasional potong-lintang. Sampel penelitian adalah 88 mahasiswa kedokteran USU yang memenuhi kriteria inklusi yang kemudian diacak menggunakan metode consecutive sampling. Data berasal dari kuesioner yang maharsiswa dengan acne vulgaris untuk menilai pengetahuan dan sikap yang selanjutnya diolah menggunakan komputer. Pengetahuan sampel didapati 43,2% (cukup), sedangkan sikap 68,2% (cukup). Penelitian berkesimpulan terdapat hubungan signifikan antara pengetahuan dan sikap mahasiswa kedokteran USU terkait acne vulgaris. Kata Kunci: Acne vulgaris, mahasiswa kedokteran, pengetahuan, sikap
Efficacy of Nintedanib for Idiopathic Pulmonary Fibrosis and Its Safety for Breastfeeding and Pregnancy Santoso, Resyana; Yoki Citra Perwira; Stevia Ariella Pasande
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 2 (2025): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i2.16475

Abstract

Background : An interstitial lung disease called pulmonary fibrosis can cause breathing difficulties by leaving scars in the lungs. IPF is the most prevalent kind of PF. A multiple tyrosine kinase inhibitor called nintedanib received approval for use in antifibrotic treatment. There are two dosage forms for nintedanib: 100 mg and 150 mg for oral use. Two times a day, 150 mg should be taken with food. The FVC decrease was effectively reduced with nintedanib. In INPULSIS-1, INPULSIS-2, and a data set , the yearly rate of FVC decrease was considerably reduced in nintedanib users than in placebo users. The mortality rate from respiratory causes was 3.8% for patient received nintedanib as opposed to 5.0% for patient received placebo. In this review, we mainly reviewed reports on efficacy of nintedanib for IPF and its safety for breastfeeding and pregnancy. Method : This review extracted the resources from PubMed using the boolean method [”Efficacy of nintedanib” OR "nintedanib efficacy”] AND "pulmonary fibrosis”. Compared to people who used placebo in the INPULSIS-1 and INPULSIS-2 trials, nintedanib recipients showed significantly decreased annual rates of FVC. Before beginning nintedanib and as needed throughout treatment, confirm your pregnancy status. Women should be informed that breastfeeding is not advised due to the possibility of harmful side effects in nursing babies from nintedanib. Conclusion, patients treated with nintedanib observed a decreased rate of Interstitial Lung Disease development compared to who treated with placebo and it's not recommended for pregnant and breastfeeding women. latarbelakang: Penyakit paru interstisial yang disebut fibrosis paru dapat menyebabkan kesulitan bernapas dengan meninggalkan bekas luka di paru-paru. Fibrosis paru idiopatik merupakan jenis fibrosis paru yang paling banyak. Nintedanib merupakan inhibitor tirosin kinase yang digunakan dalam pengobatan antifibrotic. Ada dua bentuk sediaan nintedanib untuk dikonsumsi secara oral : 100 mg dan 150 mg. Dosis 150 mg dikonsumsi dua kali sehari bersama dengan makanan. Penggunaan nintedanib sangat efektif dalam penurunan Forced Vital Capacity(FVC) dalam INPULSIS-1, INPULSIS-2, dan kumpulan data, tingkat penurunan Forced Vital Capatcity(FVC) tahunan sangat berkurang pada pengguna nintedanib daripada pengguna plasebo. Tingkat kematian akibat penyebab pernapasan adalah 3,8% untuk pasien yang menerima nintedanib dibandingkan dengan 5,0% untuk pasien yang menerima plasebo. Dalam ulasan ini, kami meninjau laporan tentang kemanjuran nintedanib untuk fibrosis paru idiopatik  dan keamanannya untuk menyusui dan kehamilan. Metode: Ulasan ini mengambil sumber dari PubMed menggunakan metode boolean ["Efikasi nintedanib" ATAU "kemanjuran nintedanib"] DAN "fibrosis paru". Dibandingkan dengan orang yang menggunakan plasebo dalam uji coba INPULSIS-1 dan INPULSIS-2, penerima nintedanib menunjukkan tingkat Forced Vital Capacity (FVC) tahunan yang menurun secara signifikan. Sebelum memulai nintedanib dan sesuai kebutuhan selama perawatan, konfirmasikan status kehamilan Anda.
The Combination of Surgical Excision with Debulking Technique and Intralesional Triamcinolone Acetonide Injection in the Management of Keloid Riana Miranda Sinaga; Desy Sahara Putri S
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 2 (2025): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i2.17727

Abstract

Abstract. Background: Keloid is a fibroproliferative disorder of the dermis resulting from abnormal wound healing, characterized by excessive collagen deposition, thickened and highly vascularized dermis, and abundant infiltration of inflammatory cells.The highest incidence of keloid occurs in individuals during their second decade of life. Case Ilustartion: A 16-year-old female presented to the Dermatology and Venereology Clinic at Prof. Chairuddin P. Lubis Hospital, Medan, with the chief complaint of a lump on the front and back of her left earlobe accompanied by itching for the past three years. Initially, 4 years ago, the patient complained of itching after ear piercing. Over time, a lump appeared at the site of the piercing. The lump was reported to have gradually increased in size over the past 2 years. Dermatological examination, there was a solitary erythema nodule with firm boundaries, with a spongy solid consistency, oval round shape and size 1.4x1.3x0.9 cm, regular edges, smooth surface in the region of the anterior auricularis lobule sinistra and posterior auricularis lobule sinistra. The patient was diagnosed with keloid. The patient was then planned for surgical excision with debulking technique and intralesional triamcinolone acetonide injection. Discussion: It is stated in the literature that combination treatment is the optimal strategy and from most studies it has been found that surgical excision combined with steroid injection shows a recurrence rate of less than 50%. Conclusion: Keloid treatment should be done in combination to reduce recurrence.     Abstrak Keloid merupakan kelainan fibroproliferatif pada dermis akibat penyembuhan luka yang tidak normal, ditandai dengan deposisi kolagen yang berlebihan, penebalan dan vaskularisasi dermis yang tinggi, serta infiltrasi sel inflamasi yang melimpah. Insidensi keloid tertinggi terjadi pada individu pada usia dekade kedua.  Ilustrasi Kasus: Seorang perempuan berusia 16 tahun datang ke Poliklinik Dermatologi dan Venereologi RS Prof. Chairuddin P. Lubis Medan dengan keluhan utama adanya benjolan di bagian depan dan belakang daun telinga kiri disertai rasa gatal sejak tiga tahun yang lalu. Awalnya, 4 tahun lalu, pasien mengeluh gatal setelah tindik telinga. Seiring waktu, benjolan muncul di lokasi penindikan. Benjolan tersebut dilaporkan bertambah besar secara bertahap selama 2 tahun terakhir. Pada pemeriksaan dermatologi terdapat bintil eritema soliter berbatas tegas, konsistensi padat seperti spons, bentuk bulat lonjong dan ukuran 1,4x1,3x0,9 cm, tepi teratur, permukaan licin pada daerah lobulus aurikularis anterior sinistra dan lobulus aurikularis posterior sinistra. Pasien didiagnosis dengan keloid. Pasien kemudian direncanakan untuk dilakukan eksisi bedah dengan teknik debulking dan injeksi triamcinolone acetonide intralesi. Pembahasan: Penatalaksanaan kombinasi merupakan strategi yang optimal dan sebagian besar penelitian ditemukan bahwa eksisi bedah yang dikombinasikan dengan injeksi steroid menunjukkan angka kekambuhan >50%. Kesimpulan: Pengobatan keloid sebaiknya dilakukan secara kombinasi untuk mengurangi kekambuhan.

Page 13 of 15 | Total Record : 148

 11   12   13   14   15 

Filter by Year

2019 2025


Reset
Filter By Issues
All Issue Vol. 7 No. 1 (2025): SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 2 (2025): SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal Vol. 5 No. 2 (2024): SCRIPTA SCORE Scientific Medical Journal Vol. 5 No. 1 (2023): SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 2 (2023): SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal Vol. 3 No. 2 (2022): SCRIPTA SCORE Scientific Medical Journal Vol. 3 No. 1 (2021): SCRIPTA SCORE Scientific Medical Journal Vol. 2 No. 2 (2021): SCRIPTA SCORE Scientific Medical Journal Vol. 2 No. 1 (2020): SCRIPTA SCORE Scientific Medical Journal Vol. 1 No. 2 (2020): SCRIPTA SCORE Scientific Medical Journal Vol. 1 No. 1 (2019): SCRIPTA SCORE Scientific Medical Journal More Issue