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INDONESIA
Journal of Health Sciences and Medicine
Published by Universitas Udayana
ISSN : 25497561     EISSN : 26220555     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Health Sciences and Medicine is an Indexed peer-reviewed open access journal which publishes original scientific articles, reviews and short communications that are not under consideration for publication elsewhere. The journal publishes papers based on original research that are judged by critical reviews, to make a substantial contribution in the field. It aims at rapid publication of high quality research results while maintaining rigorous review process. The Journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers are published approximately one month after acceptance.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 25 Documents
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NUTRITIONAL INTERVENTION TRIALS MODEL IN POOR AREAS OF BALI PROVINCE Kadek Tresna Adhi; Ni Wayan Arya Utami; I Made Suka Adnyana
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (65.346 KB) | DOI: 10.24843/JHSM.2017.v01.i01.p02

Abstract

Abstract The result from food utilization analysis in 2015 showed that a needed for a community based nutrition intervention model to decrease malnutrition cases among under five years children. This was non experimental study using pre-post test approached, conducted in Karangasem and Bangli regency. Samples were selected by purposive sampling method. Data were collected by questionnaire and observation. Nutrition intervention model was arranged in the form of training module given to society’s figure and integrated post service’s cadres. Result from trial of training module I showed no significant difference between means of knowledge before and after training with p-value (1,00) > ? (0,05), meanwhile in the trial of training module II showed significant difference between means of knowledge before and after training with p-value (0,048) < ? (0,05). Needed a model for socialization the nutrition intervention’s module which actively involved society’s figures and integrated post service’s cadre and ad vocation to policy maker thereby it can support the success of community nutrition improving program.
In Vitro Evaluation Of Antioxidant Activity Of Flavonoid Compounds From Terong Belanda Ida Ayu Raka Astiti Asih; Ni Made Puspawati; Wiwik Susanah Rita
Journal of Health Sciences and Medicine Vol 1 No 2 (2017): JHSM (September 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.18 KB)

Abstract

Terong belanda (Solanum betaceum, cav), is a fruit that has nutrients and vitamins which are essential for health of human body and it is believed to have a potent antioxidant activity. This research aimed to evaluate in vitro antioxidant activity of flavonoid compounds isolated from Terong belanda. In vitro antioxidant activity was evaluated using DPPH method. Identification of flavonoids was done using Infrared and UV–Vis Spectrophotometers. Extraction of ten (10) kg terong belanda fruits with ethanol gave of 126.17 g peels extract, 178.44 g flesh, and 253.11 g seed extracts respectively. Phytochemical test showed both peels, flesh, and seed extracts of Terong belanda contained flavonoids. Antioxidant activity test showed peels, flesh, and seeds extracts exhibited antioxidant activity with IC50 of 68,14 ppm, 621.45 ppm, and 1162.608 ppm respectively. Separation and purification of these three active extracts using column chromatography gave each one isolate which positive flavonoid on phytochemical test. Infrared spectra of each isolate from peels, flesh, and seed were similar and each revelaed to contain the same functional groups (OH alcohol, CH aromatic, C=O, C=C, and CH aliphatic). Analysis of UV-Vis spectra and its spectra with shifting reagents of the peels isolates gave absorption at the wavelength range of 310-330 nm (Bans I ) and 245-275 nm (bands II) due to isoflavones group with a hydroxy group at C6, C7 or C7, C8 and C3', C 4 ' while flesh and seed gave absorption at 300-330 nm (bands I) and 275-295 nm (bands II) that indicated the class of flavanones with hydroxyl groups at C-2', C-5', C-6' and Oglycoside at C7 for flessh and hydroxyl group at C6, C7 or C7, C8 for the seed.
DEVELOPMENT OF GEL DOSAGE FORM OF ETHYL ACETATE EXTRACT OF MANGOSTEEN RIND Ketut Widyani Astuti; Ni Putu Ayu Dewi Wijayanti; I Gusti Ngurah Jemmy Anton Prasetia
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.215 KB) | DOI: 10.24843/JHSM.2017.v01.i01.p08

Abstract

Abstract Alpha-mangostin is a xanthonoid compound contained in mangosteen rind (Garcinia mangostana L.) and has an antibacterial effect against Staphylococcus aureus, the bacterium that causes acne. In this study, mangosteen rind extract is formulated in a gel dosage form. This study aimed to determine the optimum formula, the physical and chemical properties as well as the optimum formula release profile of the gel dosage form of mangosteen rind extract. The mangosteen rind extract gel formula consists of viscolam, propylene glycol, glycerin, microcare®, ethyl acetate extract of mangosteen rind, and distilled water. The formula was optimized by varying the concentrations of viscolam (2% and 5%), propylene glycol (5% and 20%) and glycerin (2% and 15%) using a factorial experimental design program called Design Expert 7.0.0. The 8 formulas were developed into gel dosage form and the physical and chemical properties were then evaluated. The evaluation tests include viscosity, dispersive power, and pH tests. The evaluation results were processed using the Design Expert 7.0.0 program to determine the optimum formula. The results of the analysis showed the optimum formula of gel dosage form of mangosteen rind extract with viscolam percentage of 4.97%, propylene glycol of 9.91%, glycerin of 12.23%, microcare® of 0.3%, TEA (q.s), ethyl acetate extract of mangosteen rind of 1%, and distilled water of 45%. The evaluation results of the physical and chemical properties of the gel optimum formula revealed the viscosity of 2,345 cps, dispersive power of 6.59 cm, and pH of 6.74. Alpha-mangostin release test on the optimum formula revealed a flux value of 41.327 ?g/cm2/t1/2. From these results, it is concluded that the optimum formula has met the physical and chemical characteristics of a good gel.
Identification of Active Antioxidant Compounds from Ungu Leaf Ethanol Extract (Graptophyllum pictum L. Griff) Ni Luh Rustini
Journal of Health Sciences and Medicine Vol 2 No 1 (2018): JHSM (February 2018)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1292.552 KB)

Abstract

This study was conducted to determine the chemical compounds contained in ungu leaf ethanol extract that has antioxidant properties. Ungu leaf powder (2000 g) was extracted with 10,000 mL of 96% ethanol yielding 51.77 g thick purple-green viscous extract. The result of phytochemical test on ungu leaf ethanol extract showed that the extract contained flavonoid, saponin, phenolic and steroid, with the highest content being steroid. The separation of the ethanol extract was carried out by column chromatography using silica gel as a stationary phase and a mixture of n-hexane: dichloromethane: ethyl acetate (2: 1: 1) as the mobile phase, yielding 10 fraction groups. Fraction F1 is relatively pure, then identified with UV-Vis, IR, and GCMS spectrophotometers. The results of identification with UV-Vis, IR, and GC-MS spectrophotometers showed that ungu leaf ethanol extract containing antioxidant activity contained stigmasterol compounds, namely: stigmasta-5,22-dien-3-ol and stigmast acid-5-en-3-ol.
The Extraction and Phytochemical Test of Toxic Extract of Xestospongia testudinaria Sponge I Made Diraswantara; Wiwik Susanah Rita
Journal of Health Sciences and Medicine Vol 2 No 1 (2018): JHSM (February 2018)
Publisher : Institute for Research and Community Services Udayana University

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Abstract

This research aims toextraction and phytochemical test of the toxic extract of the Xestospongia testudinaria sponge collected from Sanur beach, Bali, Indonesia. Extraction of the sponges was carried out by methanol at room temperature. Toxicity screening test was done based on Bhrine Shrimp Lethality Test (BSLT). The compounds of the toxic extract were performed by phytochemical test. Based on the results, it was found that the methanol extract of X. testudinaria sponges has toxic activity with LC50 of 31.62 ppm. The toxic extract contained alkaloid, steroid, polyphenol, and saponin compounds.
Optimization Of Isolation Method Of Carrageenan From Kappaphycuss Alvarezii Doty Using Factorial Experimental Design Ketut Widyani Astuti; Ni Putu Ayu Dewi Wijayanti; I Gusti Ngurah Agung Dewantara Putra; Ni Putu Linda Laksmiani
Journal of Health Sciences and Medicine Vol 1 No 2 (2017): JHSM (September 2017)
Publisher : Institute for Research and Community Services Udayana University

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Abstract

Kappaphycus alvarezii Doty is a species of red algae ( Rhodophyceae) producing kappa carrageenan. The value of carrageenan will increase if it is able to form thermoreversible gels. The quality of carrageenan is determined by the isolation method which includes several stages, namely soaking, extraction, purification, and drying. This study aims to obtain an optimum isolation method of carrageenan from seaweed Kappaphycus alvarezii Doty using the factorial experimental design software, Design Expert Version.7.0.0. with the characteristics that meet the standards set by FAO. The seaweed was collected from the sea in Nusa Lembongan, Bali Province. The carrageenan isolation method was optimized by varying three factors, namely the concentration of NaOH (4% and 8%), extraction time (0.5 hour and 3 hours), and precipitation time (0.25 hour and 0.5 hour) in order to obtain 8 formulae which then went through an evaluation of the physical and chemical characteristics of the carrageenan. The physical and chemical characteristics include the yield, viscosity, sulfate content, and ash content, analyzed using Design Expert Version 7.0.0 program to determine the optimum method of isolation. The analysis showed that the optimum method of carrageenan isolation was using NaOH with a concentration of 4.40%, the extraction time of 2.16 hours and the precipitation time of 0.29 hour. The physical and chemical characteristics of carrageenan with the optimum isolation method include the yield of 25.73%, the viscosity of 11.92 cPs, sulfate content of 31.95% and the ash content of 26.16% which have met the standards set by FAO.
ANTIOXIDANT ACTIVITY TEST OF ANDROGRAPHOLIDE IN BITTER HERBS USING DPPH SCAVENGING Ni Made Pitri Susanti; Ni Kadek Warditian; I Made Agus Gelgel Wirasuta
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.435 KB) | DOI: 10.24843/JHSM.2017.v01.i01.p03

Abstract

Abstract Bitter herbs (Sambiloto) have many pharmacological activities including antioxidant, antidiabetic, anticancer, antihyperlipidemic and anti-inflammation. Andrographolide is a diterpene compounds contained in bitter herbs. It is known that andrographolide compound responsible for the pharmacological activity of the bitter herbs. This study investigated DPPH free radical scavenging activity from andrographolide diterpene lactone. This study was initiated with the isolation of andrographolide compound from bitter herbs and then testing their DPPH free radical scavenging. The results suggested that andrographolide had IC50 value of 5.45 mg. This means andrographolide has 50% DPPH inhibition effect, i.e 5.45 mg.
Perception Of Contraception Access And Utilization In Teenagers In Senior High School No 8 Denpasar, Bali R. Listyowati; N. M. S. Nopiyani; P. A. Indrayathi
Journal of Health Sciences and Medicine Vol 1 No 2 (2017): JHSM (September 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.188 KB)

Abstract

The images of teenagers in the world, especially in South Asia and Southeast Asia have less information about reproductive and sexual health because of the assumption that it is unnecessary even considered harmful if they knew it. It’s not surprise that the teen birth rate is still quite high. previous research in Indonesia on adolescent premarital sexual behavior, obtain a yield of about 25% - 51% of teens have sex before marriage. (Utomo ID 2009; 40 (2) :. 133-46.). Studies in Bali obtain the results of teenage boys in high school (SMA) and junior high school (SMP) more premarital sex (40.3% and 29.4%) than girls (3.6% and 12.5%). Teenage boys in Bali more permissive toward premarital sexual behavior than girls and about 5% of teens have sex before marriage (Faturochman 1992; 1 :. 12-7) Adolescents have a right to a healthy life. They need to have access of the tools that can protect their health, such as condoms, contraception and youth-friendly health services are comprehensive. Governed by Law no. 36/2009 Article 4 and 5, which states that everyone has the same right to gain access of health and this rule does not see marital status. The purpose of this study was to describe the general perception of access and use of contraception among adolescents in the city of Denpasar.
THE ESSENTIAL OIL CONTENTS OF JERINGAU (Acorus calamus L.) RHIZOMES AND THEIR ANTIFUNGAL ACTIVITY AGAINST Candida albicans Wiwik Susanah Rita; Retno Kawuri; I Made Dira Swantara
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.011 KB) | DOI: 10.24843/JHSM.2017.v01.i01.p09

Abstract

Acorus calamus L. rhizome was trusted having antibacterial activity. This study aimed to identify the compounds in the Acorus Calamus L. rhizomes essential oils and to recognize the antifungal activity of the oils against Candida albicans. The extraction of essential oils from rhizome was carried out by steam distillation technique. Identification of compounds in the oils was conducted by Gas Chromatography- Mass Spectroscopy (GCMS), while the antifungal test against Candida albicans was done by well diffusion method. Extraction of 10 kg of rhizomes produced 16.53 mL essential oil with a yield of 0.1653% (? = 1.066), the oil was brownish yellow and very flavorful. GC-MS analysis showed that the essential oil contained 11 compounds, they are (E)-3,7 dimethyl-1,3,6-Octatriene (trans-?-Ocimene) (3,73%), linalool (1,07%), ?-elemene (1,15%), trans methyl isoeugenol (7,68%), shyobunon (15,74%), bicyclogermakren (0,93%), dehidroxy-isocalamendiol (2,61%), ?-calacorene (3,34%), euasarone (26,84), cis-asarone (18,62%); dan trans- asarone (18,29%). Antifungal activity test showed that the growth and biomass inhibition of C. albicans increased with the increase of the oil concentration. Minimum Inhibitory Concentration (MIC) of essential oil toward C. albicans was 1% with the inhibition of 7.83 mm.
DETECTING TRANSOVARIAL INFECTION IN AEDES AEGYPTI BASED ON IMMUNOCYTOCHEMICAL STREPTAVIDIN BIOTIN PEROXIDASE COMPLEX ASSAY (ISBPC) IN BALI Sang Gede Purnama
Journal of Health Sciences and Medicine Vol 2 No 1 (2018): JHSM (February 2018)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (477.892 KB)

Abstract

Immunocytochemical method is one of dengue virus examination alternative with affordable cost. Through immunocytochemical methods it will be proven that transovarial transmission of dengue virus from mosquitoes to their eggs and its relationship with the incidence of DHF in Bali. This study is done by the installationovitrap indoor and outdoor as much as 1200 points. The mosquito will be cultured for dengue virus examination using the Immunocytochemical-Immunomodoxidase streptavidin biotin complex (IISBC) method of head squash. The results of examination of larvae density were known to the ovitrap index in Denpasar (4.4), Tabanan (6.6), Gianyar (8.9). There is evidence of transovarial transmission from female mosquitoes to eggs using Immunocytochemical Technique known to its transovarial index of each city ie Denpasar (11%), Gianyar (7.14%) and Tabanan (7.14%). Key words: transovarial, immunocytochemical, Bali

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