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Medicra (Journal of Medical Laboratory Science/Technology)
Published by Universitas Muhammadiyah Sidoarjo
ISSN : 25807730     EISSN : 25807730     DOI : https://doi.org/10.21070/medicra
Core Subject : Health,
Health Professions Public Health
Focus : to facilitate scholar, researchers, and lecturers for publishing the original articles of review articles. Scope : Medicra publishes research articles in the field of “medical laboratory (science/technology)” with the following scope: Clinic Chemical Hematology Microbiology Parasitology Immunology Food and beverage analysis Chemical Molecular Diagnostics Toxicology Cytology Histology Epidemiology Laboratory Management Laboratory Quality Control
Arjuna Subject : Profesi Kesehatan - Teknologi Laboratorium Medis
Articles 129 Documents
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The Relationship between HbA1c and Glucosuria in Diabetes Mellitus (DM) Patients: Hubungan HbA1c dengan glukosuria Pada Penderita Diabetes Mellitus (DM) Nurjanah, Mutia Hariani; Wijaya, Anas Fadli; Meri, Meri; Tilarso, Dara Pranidya; Siswidiani, Maya Diva
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 6 No. 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v6i2.1727

Abstract

Diabetes mellitus is a condition of abnormalities in blood glucose metabolism that can cause various macroangiopathy complications such as disorders of the peripheral blood vessels, heart blood vessels, cerebral blood vessels as well as microangipathic complications such as diabetic retinopathy disorders, nephropathy and neuropathy. HbA1c describes the level of sugar in the blood for the last 3 months. Glucose is not found in normal urine because it is reabsorbed back into the blood vessels by renal filtration. The aim of this study was to determine the relationship between HbA1c levels and glucosuria in people with diabetes mellitus. The design of this study is a cross-sectional approach to DM patients. The sampling technique used was purposive sampling. Data analysis was carried out by means of Spearman's rank correlation test. Results Correlation analysis showed that there was a significant relationship between HbA1c levels and glucosuria in DM patients p-value 0.005 with a coefficient value of 0.597. The conclusion from this study is that there is a significant relationship with a strong correlation strength and a positive correlation direction for DM sufferers.
The Formulation, Evaluation and Physical Stability Test of Aloe Vera (Aloe vera L.) Extract Gel Preparations with the Addition of Sodium Metabisulfite: Formulasi, Evaluasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Lidah Buaya (Aloe vera L.) dengan Penambahan Sodium Meta Wiji Purnamasari, Yulia; Juniarti; Rahmah, Nunung Ainur
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 1 (2024): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i1.1737

Abstract

Aloe vera (Aloe vera L.) is a plant that has many benefits, such as anti-inflammatory, anti-fungal, antibacterial, and moisturizing the skin. Gel preparations are easily contaminated by bacteria and fungi, so it is necessary to consider adding sodium metabisulfite as a preservative. The aim of this research is to prove the effectiveness of using sodium metabisulfite as a preservative for aloe vera extract gel preparations. The aloe vera plant (Aloe vera L.) was extracted using the maceration method for 3x24 hours using methanol solvent. This research used 5% aloe vera (Aloe vera L.) extract, and in the evaluation and stability test used 4 variation formulations using a carbomer base, only gel base (F1), gel base with the addition of sodium metabisulfite (F2), gel base with 5% aloe vera extract (F3), and gel base with 5% aloe vera extract and sodium metabisulfite (F4). The evaluations carried out were organoleptic tests, pH tests, viscosity tests, and ALT (Total Plate Number) tests and AKK (Yeast Mold Number) tests. The physical stability test is carried out for 3-14 days. The extract yield test results obtained were 4.892%. Organoleptic tests on F1, F2, F3 and F4 did not show changes in color, odor and texture, whereas on day 14 changes in color, odor and texture began to occur in the F3 preparation. The pH test showed pH results of 4.67 (F1), 4.9 (F2), 5 (F3) and 5.1 (F4). The viscosity test shows the gel has a viscosity of 2760 cps (F1), 2650 cps (F2), 2590 cps (F3), and 2575 cps (F4). The ALT and AKK tests showed that there was an increase in the value of the F3 preparation. So based on these results it can be concluded that the best gel preparation is F4
Biochemical and Hematological Assessment in Patients With Thyroid Dysfunction Kadhum, Nadia. H.
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 1 (2024): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i1.1740

Abstract

This investigation conducted for biochemical and hematological assessment in patients with thyroid dysfunction. The research was carried out at a laboratory in Baghdad, Iraq, and it is a case-control study. The sample was gathered from February 2023 through the years 2021 and 2022. About 250 individuals were a part of this study; 100 were hypothyroid, 100 were hyperthyroid, and 50 had normal thyroid function and complete blood counts. A total of three millilitres of whole blood and two millilitres of EDTA were obtained from each subject in an aseptic manner for the CBC. Also, 2 ml of blood was drawn for serum separation, these sera were used for evaluation T3, T4, TSH, AST, ALT, Urea and Creatinine by using kits purchased from Linear company, the procedures for all were done according to manufacturer instructions. The control group had considerably greater mean RBC, Hb, HCT, and MCH concentrations, while the hypothyroid group had significantly lower values. The hyperthyroid group showed no significant difference between MCV and MCH. There were no statistically significant MCHC results in either the hypothyroid or hyperthyroid groups compared to the control group. There was little difference in total lymphocyte and platelet counts between the control, hyperthyroid, and hypothyroid groups. Differential leukocyte count showed statistically significant differences between the hypothyroid and hyperthyroid groups. As seen in Table 2, the hypothyroid group had higher serum TSH levels (p<0.05), in contrast to the hyperthyroid group which exhibited lower levels (p<0.05). Alternatively, when contrasted with the control group, the hypothyroid group had lower T3 and T4 levels (p<0.05), whereas the hyperthyroid group had higher levels (p<0.05). Improvements in hepatic and kidney functions were seen in patients with hypo or hyperthyroidism as compared to the control group in this investigation. In conclusion, both hypothyroidism as well as hyperthyroidism affects on hematological and biomarkers for thyroid, liver and kidney
Role of House Fly, Musca domestica (Diptera: Muscidae) as a Mechanical Vector of pathogenic Bacteria in Thi Qar Province Lhoak, Hussein Anad; Al-Awadi, Alaa Hussein
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 1 (2024): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i1.1741

Abstract

The common house fly, known as Musca domestica, has been acknowledged to carry and spread numerous contagious illnesses. The purpose of this investigation is to uncover the extent of the house fly's involvement as a carrier of harmful bacteria that can lead to diseases in both humans and animals. To accomplish this goal, a collection process was conducted using manual traps from March 2023 until July 2023. I collected house flies from various locations in Thi Qar province. A total of 370 samples were gathered, out of which 270 flies were utilized to isolate bacteria from both the outer and inner surfaces. To identify the house flies, I sent 100 of them to the Natural History Museum at the University of Basra. The current study recorded among 270 flies 104 (38.52%) have not bacteria, while 166 (61.48%) have bacteria. The results were recorded the highest isolated bacteria from outer surface 94 (34.81%) and 72 (26.67%) from inner surface, in contrast the lowest negative bacteria were from outer surface 41 (15.19%), and 63 (23.33%) inner surfaces. The study recorded the highest number of isolated bacteria were from Arido 23 (8.52%), followed in both Al-Sharqiyah and Altathhia 22 (8.15%), followed by Shuhadda, Ur and Summer 21 (7.78%), while the lowest isolated bacteria were in Shmoukh 4 (1.48%), followed in both Aledara almahaleia 14 (5.19%). The current study recorded the most isolated bacteria was P. Vulgaris 21 (20.19%), followed by P. mirabilis 18 (17.31%), followed by S. aureus 11 (10.58%), in contrast the lowest isolated bacteria were P. stuartii 1 (0.96%), followed by both S. paucimobilis and S. maltophilia 2 (1.92%).
Extraction and identification of certain bioactive compounds with antibacterial activity from the green algae Cladophora glomerate Mohammed, Ali Hussein; Lhwak, Nasser Salh; Jabbar, Ahmed Abdulhadi
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 1 (2024): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i1.1742

Abstract

Cladophora glomerata algae extract was used to inhibit the growth of five bacterial species: Escherichia coli, Staphylococcus aureus, Proteus mirabilis, Citrobacter, and Klebsiella pneumoniae. Algae samples were collected from the river Euphrates in Al-Fadhiliya/Thi-Qar governorate and extracted into alcohol. The concentrations of the extracts were compared with five antibiotics. The 200% concentration showed the highest effectiveness against bacteria, with an inhibition zone of 28mm. The antibiotics Imipenem and Meropenem had an inhibition zone of 28mm, while Amikacin, Norfloxacin, and Piperacillin had an inhibition area of 12-21mm. The 20% concentration was least effective against E. coli, with an inhibition diameter of 2mm. The alcoholic extract of C. glomerata alga had the highest inhibition region of 28 against K. pneumonia and 13mm against P. mirabilis. The chemical algal contents were identified using mass GC technology, revealing compounds like 10-Undecyn-1-ol, n-hexadecanoic acid, 4,4-dimethyl-1-hex, and isoamyl nitrite, which were found to have the major function of inhibiting bacterial growth
The Protective Role of Nigela Sativa Volatile Oil on Antioxidant and Oxidative Stress Enzymes Ahmed, Ahmed Tawfeeq; Hameed, Inas Hazim; Hameed, Walaa Hazim
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 1 (2024): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i1.1743

Abstract

Hepatotoxicity is the outcome of a paracetamol overdose.In this study, 40 adult male rats, weighing 180–260 gm and aged between 9 and 13 weeks, were given doses of Nigela sativa oil and their liver enzymes were examined to see how paracetamol affected them. The rats were kept in an environment at a temperature of 25 Co in an animal house. ,There were four groups of rats, and food was provided for them. (G). (G1) The only injections given to the control group are food and regular saline (0.9% of the time). (G2) 200 mg/kg of N. sativa and (G3) 400 mg/kg of paracetamol Addition of 400 mg/kg body weight of paracetamol. supplying 300 mg/kg B.W. of N. sativa to (G4)400 milligrams/kg B.W. of aspirin. Rat G2, GPT 87.80 IUL, and GOT hepatic enzyme concentration (129.32 IUL) all exhibit significant increases in comparison to the control. Furthermore, the levels of the liver GSH enzyme in rats (G2 )1.24 IUL shown a substantial increase, whereas G3 ( GOT ) 91.9 IUL, (GPT )76.70 IUL, and group (G4) GOT 109.88 IUL and enzyme (GPT ) 55.66 IUL exhibited significant declines as compared with control. While MDA enzyme in rats G2 (0.259 IUL) shows a major increase in comparison to the control, rats G3 (0.139 IUL) and G4 (0.112) show a noticeable decrease in comparison to G2. While body weight indicates that G2's outcomes are significantly lower than those of the other three groups. Groups G3 (2.55 gm) and G4 (2.7 gm) demonstrated a significant rise in liver weight compared to controls and G2, whereas groups G2 (24.23 gm) demonstrated a significant increase in liver weight compared to controls and group G2. Male rats in groups G2 (1.7 gm) demonstrated a significant drop in liver weight compared to controls.
A Comparative Study of Biomarker Levels for Iraqi Individuals’ Smokers and Non-Smokers Depending on the Duration of Smoking Abbood, Shaymaa Saadi; Ibraheem, Aseel Khalil; Hashim, Heyam A; Challoob, Muntadher Hussein
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i2.1750

Abstract

Smoking is a widespread public health challenge globally, impacting societal health and economy while elevating the risk of cardiovascular and peripheral vascular diseases. This study aims to examine hematological parameters (HB, PCV%, WBC, RBC, PLT, ESR), liver and kidney function, lipid profile, and electrolytes (K+, Na+, Ca++) in male smokers aged 20-55 from Baghdad City, subdivided by smoking duration (≥5 years and <5 years), compared to non-smoking controls. A total of sixty participants were recruited across three areas (Diyala Bridge, Mada'in, Talbieh), with each group comprising thirty individuals. Venipuncture was performed for blood sample collection. Results revealed statistically significant elevations in total WBC and RBC counts, hematocrit, hemoglobin, total cholesterol, and liver enzymes (GOT, GPT, ALP) among smokers compared to non-smokers (p<0.05 or p<0.001). Serum uric acid, urea, and creatinine levels were significantly higher in smokers (p<0.001), while triglyceride levels showed no significant difference (p>0.05) between groups. Smokers with longer duration (>5 years) exhibited higher HB, triglyceride, and Na+ levels compared to shorter-term smokers. Sensitivity analysis indicated Na+ as a potentially effective biomarker for smoking-related health impacts, complementing PCV% and urea sensitivity. The study underscores the association between smoking and oxidative stress, notably reflected in elevated GOT and GPT levels, suggesting implications for antioxidant therapies in managing smoking-induced oxidative damage. These findings contribute novel insights into biomarker responses influenced by smoking duration and advocate for targeted public health strategies and further research into antioxidant interventions to mitigate smoking-associated health risks effectively.
Evaluation of Tumor necrosis factor (TNF-α) Concentration and Renal Function in the Sera of Patients with Type 2 Diabetes in Erbil City Abdulrazaaq, Zina Abdulmunem
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i2.1751

Abstract

The research included a total of 70 samples, including 40 samples from patients diagnosed with type 2 diabetes and 30 samples from the control group. The participants' age ranged from 40 to 60 years. The samples were gathered during a one-year duration from the Chronic Diseases Unit / Diabetes Department in the city of Erbil. Later, blood samples were collected from both ill and healthy individuals, and then separated via the process of centrifugation. The variables that were evaluated include glucose, ferritin, Tumor necrosis factor-alpha (TNFα), CRP, urea, creatinine, and uric acid. The results of this research showed a significant rise in the concentrations of glucose, ferritin, TNF-alpha, CRP, urea, creatinine, and uric acid in persons with type II diabetes as compared to the control group.
Pap Smear Diagnostic Test Towards Gold Standard Histopathology In Cervic Cancer: Uji Diagnostik Pap Smear Terhadap Gold Standard Histopatologi Pada Kanker Serviks Anik Handayati; Putri, Tiara Dewanti; Sri Sulami Endah Astuti
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i2.1655

Abstract

Cervical cancer is the second most common cancer in the world. Screening examination plays an important role in early detection of cervical cancer so that it can reduce mortality. Pap smear is an initial examination to detect the presence of abnormal cells in the cervix. This study aims to determine the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of pap smear examination by comparing them to histopathological examination as the gold standard. The design of this study was an observational study with secondary data obtained from the medical records of cervical cancer patients who had performed pap smears as well as histopathological examinations at the Anatomical Pathology Laboratory Installation, RSPAL dr. Ramelan Surabaya for the period January 2020 to March 2022. The data will be sorted based on inclusion and exclusion criteria. Data that pass the inclusion criteria will be tested using crosstabulation and then proceed to the diagnostic test. The sensitivity value is 97%, specificity value is 88%, accuracy value is 96%, positive predictive value is 98%, and negative predictive value is 79%. Pap smears have a fairly good diagnostic value for diagnosing cervical cancer.
Comparison of Reticulocyte Examination Results of Supravital Staining Method with Sysmex Xn 1000 Automated Device: Perbandingan Hasil Pemeriksaan Retikulosit Metode Pewarnaan Supravital Dengan Alat Otomatik Sysmex Xn 1000 Miasari, Abrina Rindi Riovika; Prasetya, Didik; Arwidiana, Dewa Putu
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i2.1745

Abstract

Retikulosit mengindikasikan produksi sel darah merah oleh sumsum tulang yang dapat digunakan mendiagnosa serta memantau terapi anemia. Pemeriksaan hitung retikulosit dapat dilakukan menggunakan metode supravital dan metode flowcytometri. Tujuan penelitian ini untuk mengetahui perbedaan hasil pemeriksaan retikulosit menggunakan metode manual pewarnaan supravital dengan alat otomatik Sysmex XN 1000 metode flowcitometri. Penelitian ini dilakukan di Laboratorium Klinik Prodia Kelapa Gading Jakarta Utara. Metode penelitian menggunakan desain penelitian analitik observasional dengan pendekatan cross sectional. Penelitian ini menggunakan teknik pengambilan total sampling, dengan jumlah sampel 36 orang. Hasil hitung retikulosit pada kedua metode memiliki rerata yang tidak berbeda jauh. Hasil retikulosit yang ditemukan tinggi dengan metode manual supravital juga ditemukan tinggi dengan metode flowcitometri. Uji normalitas data pada kedua metode tidak berdistribusi normal. Hasil analisis uji beda Wilcoxon signed rank t didapatkan nilai signifikasi 0,277 > α (0,05) maka hipotesa nol diterima, artinya tidak adanya perbedaan yang bermakna dengan jumlah retikulosit metode pewarnaan supravital dengan alat otomatik Sysmex XN 1000. Berdasarkan penelitian, pemeriksaan hitung retikulosit dapat dilakukan dengan menggunakan kedua metode tersebut dengan lebih memperhatikan faktor-faktor yang dapat mempengaruhi hasil perhitungan retikulosit.

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