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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 174 Documents
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Pengetahuan Remaja dan Peran Teman Sebaya dengan Pencegahan Infeksi Menular Seksual Kartini Massa; Stendy Ali
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3530

Abstract

Lack of adolescent knowledge about sexually transmitted diseases and their dangers, especially to health and the role of peers, which contributes badly to the increase in sexually transmitted diseases, especially among adolescents. This study aims to determine the relationship between adolescent knowledge and the role of peers with the prevention of sexually transmitted infections at SMA Negeri 1 Tomohon. The research design uses an analytic survey with a cross sectional approach. The sampling technique with probability sampling is simple random sampling on a sample of 92 teenagers. Data analysis used the Chi Square statistical test. The results showed that most adolescent knowledge was in the good knowledge category with a percentage of 57.6%, the role of peers was mostly in the good role category with a percentage of 63% and the prevention of sexually transmitted infections was mostly in the good prevention category with a percentage of 52.2 %. The conclusion is that there is a relationship between adolescent knowledge and the prevention of sexually transmitted infections at SMA Negeri 1 Tomohon. There is a relationship between the role of peers and the prevention of sexually transmitted infections at SMA Negeri 1 Tomohon. It is recommended to increase the role of counseling guidance through health education to add insight into knowledge so as to change the behavior of adolescents in preventing sexually transmitted infections and for adolescents to seek information about infectious diseases from various information media sources, to be active in various positive activities such as extracurricular activities held at school or other activities. other social activities and hang out with friends who have good behavior.
Uji Efektivitas Antidiare Obat Herbal X pada Mencit (Mus musculus) galur Swiss Webster yang diinduksi Minyak Jarak (Oleum ricini) Nita Salsa Nuraprilia; Baiq Rilda Erliana Zahara; Putri Oktaviati Riadi; Tity Afriliani; Kerthika Ayu Wandeni; Muhamad Zainul Fajri Awwalin; Siti Rahmatul Aini
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3547

Abstract

Drug X is one of the herbal medicines used as anti-diarrhea that is known to have been circulating in the community. This medicine contains extracts of pomegranate peel, areca nut seeds, gambir leaves, and guava leaves. Its use is only based on empirical data, so further studies are still needed to prove its effectiveness as an antidiarrheal. The purpose of this study was to determine the effectiveness of herbal medicine X as an anti-diarrhea agent in male mice (Mus musculus) induced by castor oil (Oleum ricini). Testing the anti-diarrhea effect was carried out using the method of protection against diarrhea induced by castor oil. Mice were randomly divided into five groups (n = 15). Mice in the normal group were only given the preparation carrier, namely Na-CMC suspension, and were not induced by castor oil. Mice in the positive control group were given Diapet® suspension at a dose of 156 mg/kg BW, while the negative control mice were given Na-CMC suspension, and then both groups were induced with castor oil. Mice in both treatment groups were given X herbal medicine with different doses (128.7 mg/kg BW and 386.1 mg/kg BW) and then induced by castor oil. Diarrhea parameters, including the frequency of defecation and stool consistency, were observed and then statistically analyzed using the ANOVA test, Kruskal-Wallis, and Mann-Whitney. The results showed that the treatment dose of 128.7 mg/kg had comparable antidiarrheal effectiveness with the positive control (p≤0.05) and was significantly different from the negative control (p≤0.05). The dose of 386.1 mg/kg showed no significant difference with the negative control (p≤0.05) and showed a significant difference with the dose of 128.7 mg/kg and the positive control. From this study, it can be concluded that herbal medicine X has an anti-diarrheal effect and that a dose of 128.7 mg/kg BW shows the best anti-diarrheal effect.
Formulasi Sediaan Masker Peel Off dari Ekstrak Buah Alpukat (Persea Americana Mill.) dengan Variasi Konsentrasi Polivinil Alkohol (PVA) Ririn Ririn; Vina Purnamasari M; Nurfajeriani Ulfah
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3605

Abstract

Face mask peel off is a skin care product that when applied to the skin will dry out which can be peeled off from the skin of the face. Avocado Flesh (Persea americana Mill.) has powerful antioxidants that can be used in moisturizing and anti-aging products. This study aims to produce mask preparations to peel off gel from avocado fruit extract (Persea americana Mill.) to moisturize facial skin. This study used the maceration method to obtain a thick extract from avocado fruit. Mask formulation peel off made in a variety of polyvinyl alcohol (PVA) bases, namely 10% (F1), 12% (F2) and 14% (F3) as a film-forming agent. The evaluation is based on physical parameters including organoleptic, homogeneity, spreadability, pH, viscosity, flow properties, drying time and measurement of facial skin moisture levels. The evaluation results on the pH test, homogeneity and drying time showed that all formulas met the standard parameters, namely the PVA pH test 10% = 6.46; PVA 12% = 6.4; PVA 14% = 6.35, in the long test the drying time of 10% PVA = 18.97 minutes; PVA 12% = 20.82 minutes; and 14% PVA = 24.66 minutes. Meanwhile, in the organoleptic test,viscosity, the three formulas were pharmaceutically unstable, namely in the organoleptic test the three formulas experienced a change in consistency, in the spreadability test the spreadability value of PVA 10% = 5.41; PVA 12% = 4.75; PVA 14% = 4.03, in the viscosity test of the three formulas after forced conditions = E (error: the viscosity value exceeds the maximum limit of the viscometer). Based on the results of the facial skin moisture test, it shows that Avocado fruit extract with a concentration of 0.6% can provide effectiveness as a moisturizer for facial skin.
Hubungan Tingkat Pengetahuan Ibu Tentang Perawatan Gigi Dengan Karies Gigi Anak Usia Pra Sekolah 4-5 Tahun Arsad Arsad; Yulistina Yulistina; Sulastri S; Sultan Amin Yasin; Utari Zulkaidah
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3641

Abstract

Pre-school age children are a period of child growth. Caries is a case experienced by pre-school age children. The 2018 Basic Health Research, the prevalence of dental caries in children aged 3-4 years in Indonesia is 36.4%, the prevalence of dental caries in pre-school children in South Sulawesi is 73.6%, the prevalence of dental caries in East Luwu is 82.8%, and the prevalence of dental caries at the age of pre-children as in Nuha District 89.2%. This condition is very concerning considering that pre-school children still need the role of parents in caring for their health, especially dental health. In this case, parental knowledge is needed in guiding and giving more attention so that children do not experience caries. This study aims to determine the relationship between the level of knowledge of mothers about dental care and dental caries in pre-school aged children 4-5 years at Al-Ikhwan Kindergarten. The research method used is analytic observational with a retrospective approach. This research was conducted in May 2023 with the subjects of this study being parents, especially mothers whose children attended TK Al-Ikhwan as many as 89 people. Collecting data using a questionnaire sheet. Analysis of research data using Univariate and Bivariate Test analysis. The level of parents' knowledge about dental health is mostly in the sufficient category (47, 21%). The majority of respondents experienced media caries (61.79%). Ha is accepted with ƿ Value – 0.006, correlation coefficient -0.946. There is a relationship between the level of parental knowledge about dental health and the occurrence of caries in preschool children aged 4-5 years at TK-Al Ikhwan, East Luwu Regency.
Pembuatan dan Karaterisasi Tablet NPN Lepas Lambat Berlapis Polikaprolakton Sebagai Suplement Ruminansia Edtyva Monicha; Akmal Djamaan; Rini Agustin; Rusmana Wijaya Setia Ningrat
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3642

Abstract

Productivity of ruminant cattle can be increased by providing non-protein nitrogen, especially urea. Urea not only has benefits as a plant fertilizer, but is also used as a substitute for nitrogen sources for ruminants. The purpose of this research is to use urea more efficiently because urea in the rumen is degraded more quickly to form ammonia so that urea excretion becomes faster in the urine. In this study it was designed so that urea is released in a slow release, its use is more practical and the dosage is correct. The method used is to make urea tablets and then coat them with a coating, characterize the tablets including their shape and urea content, then test the release of the tablets in vitro in rumen fluid. Based on this, the characteristics of the tablets are using Scanning electron microscopy (SEM), Differential Scanning Calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) methods. From the results of the study showed that urea tablets fulfilled the tablet evaluation including tests for uniformity in size, weight variation, tablet hardness and friability. Meanwhile, for testing the release of urea tablets in the rumen fluid, it can be seen from testing that 70% of the urea tablets without coating were released, while for the coated urea tablets, only 15% were released in the first minute. Sequentially the release of urea tablets from the first minute with three successive repetitions of the test was 14.641; 15.323 and 14.798 %. Meanwhile, tablets that were not coated in the first minute released as much as 71.257%. For this reason, the manufacture of polycaprolactone-coated slow release urea tablets makes urea more beneficial for ruminants without rapid excretion and lasts longer in the rumen so that rumen microbes take advantage of this nitrogen source to form microbial protein.
Formulasi dan Evaluasi Masker Hyrogel Ekstrak Etanol Pegagan (Centella Asiatica (L). Urb) Sebagai Antiaging dengan Variasi Basis Carbopol dan HPMC Vina Purnamasari M; Nurlina Nurlina; Anita Sari Anwar
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3644

Abstract

Gotu kola ethanol extract (Centella asiaticaI (L)urb.) has very strong antioxidant activity with an IC50 value of 20.43 μg/ml which can be utilized in the development of pharmaceutical or cosmetic preparations. The purpose of this study was to formulate and evaluate a pharmacologically stable preparation of hydrogel antiaging mask of gotu kola ethanol extract (Centella asiaticaI (L)urb.). The research design used by varying the concentration of carbopol and HPMC was then carried out physical evaluations such as organoleptis, homogeneity, ph measurement, viscosity and flow type tests, adhesion tests, dispersion tests, weight and size tests of hydrogel masks, inflating power tests and shrinkage tests and stability tests. The evaluation results showed that gotu kola ethanol extract (Centella asiaticaI (L)urb.) that met the pharmaceutical stability test was formula 2 with a carbopol concentration of 1.25% and HPMC 2.25%.
Formulasi dan Evaluasi Tablet Urea Lepas Lambat Berlapis Biopolimer Poliasam Laktat Sebagai Suplemen Ruminansia Bilqis Nurganiyu; Akmal Djamaan; Rini Agustin; Rusmana Wijaya Setia Ningrat
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3651

Abstract

Urea is a source of non-protein nitrogen (NPN) which can be used to replace pure protein in ruminants. Urea is easily soluble and is degraded to ammonia by rumen bacteria, thus affecting the quality of ruminants. To increase the utilization of urea as a supplement is to try to slow its release into ammonia in the rumen so that it can be used efficiently by rumen microbes to form microbial protein. Slow release urea tablets as an alternative can control the rate of urea degradation and release of ammonia into the rumen and increase rumen efficiency. This study aims to determine the rate and pattern of release of urea tablets in the rumen so that their use is more practical and the dosage is correct. To maintain ammonia levels in the rumen, an alternative polymer-coated urea slow release tablet was designed. Based on this, it was carried out to manufacture slow release urea tablets with biopolymer polylactic acid (PLA) coating in the rumen fluid of ruminants. Furthermore, an in vitro evaluation was carried out by measuring pH into rumen fluid and measuring NH3 by UV-Vis spectro analysis at a wavelength of 630 nm. The results of the test for urea release in the rumen in formulas 1, 2 and 3 were 75.133%, 76.076% and 74.051% respectively, while the release of urea in uncoated urea tablets was 96.384%, these results indicate that tablets with lactic acid coated polyacid last longer. release compared to urea tablets without biopolymer coating.
Hubungan Tingkat Pengetahuan Pasien dengan Minat Perawatan Saluran Akar Gigi di Poli Gigi RS Daerah Beriman Balikpapan 2023 Yulistina Yulistina; Sultan Amin Yasin; Arsad Arsad; Rezki Dirman; Rahmah Rahmah
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3655

Abstract

Root canal treatment is a treatment that cannot be completed in one visit. Therefore, it is very important for patients to comply in order to complete root canal treatment within a few visits. But the need for public knowledge about the importance of undergoing root canal treatment so that the tooth does not end with extraction. This study aims to determine the relationship between the level of patient knowledge and interest in root canal treatment at the dental clinic at the Beriman Balikpapan Hospital. The type of research used is analytic observational with a cross sectional design. The population in this study were all patients at the Dental Clinic at the Beriman Hospital, Balikpapan. The sampling technique uses Random Sampling in which a sample consists of a number of elements selected at random. Then analyze the dynamics of the correlation between patient knowledge and interest in root canal treatment at the dental polyclinic at the Beriman Hospital in Balikpapan in 2023. The results of this study showed that the majority of respondents were highly knowledgeable and very interested in performing root canal treatment at the Dental Clinic at the Beriman Balikpapan Hospital, namely as many as 52 people (65%). Data analysis was carried out using the Kendall's tau formula and obtained a significant value of 0.002 <0.05 so that it can be concluded that there is a relationship between the level of patient knowledge and interest in root canal treatment at the dental polyclinic at the Beriman Balikpapan Hospital 2023.
Efektivitas Mengunyah Permen Xyilitol Dapat Mengurangi Indeks Plak Siswa Kelas IV Utari Zulkaidah; Arsad Arsad; Nurna Mitra Putri; Rezki Dirman; Yulistina Yulistina
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3656

Abstract

Teeth and mouth are part of the early stages of the digestive process. Teeth are located in the oral cavity which have several functions.Dental and oral health requires attention and is kept clean, including mechanical and chemical control so that it can carry out its functions properly.Poor dental cleaning can lead to plaque buildup and lead to tooth decay or gingivitis.Plaque is a bacterial biofilm structure that is well placed and adheres to the tooth surface. Plaque control measures can be achieved by using anti-plaque chemicals, namely xyilitol candy.Xylitol gum can reduce Streptococcus mutans because bacteria cannot metabolize xylitol into energy.The purpose of this study was to determine the plaque index before and after chewing gum containing xylitol and the relationship between before and after chewing xylitol gum. This type of research is experimental with a pre-post test design with total sampling.The results of this research from 25 respondents obtained before chewing xylitol gum there were 2 respondents who had good plaque criteria, after chewing xylitol gum there were 23 respondents who had good plaque criteria, the mean value was obtained 15.00 to 8.36, which means there is a decrease in score plaque index with a p-value of 0.004 there is a significant difference between before and after chewing xylitol gum.The conclusion of this study is that there is a decrease in the Denris index score after chewing xylitol gum and there is a significant difference between before and after chewing xylitol gum.
Efektivitas Daya Simpan dan Uji Organoleptik Nugget Ikan Gabus Ester Rumaseb; Berliana Tampubolon; Guruh Suprayitno
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3668

Abstract

The problem of malnutrition in Papua is caused by economic factors and parents' limited knowledge about nutrition. The impact of malnutrition on children under five causes growth and development to be hampered and can interfere with productivity. Providing food with high protein is an alternative to improve the nutritional status of children under five with infectious disease problems. One of the foods that contains high protein and albumin which is a local food and is easy to obtain in the Papua region is snakehead fish. Objective: To determine the effectiveness of storage and organoleptic tests on snakehead fish nuggets. Methods The research design used in this study used the factorial analysis method. The research design used in this study used the factorial analysis method by comparing the four treatments with three repetitions for each treatment. The four treatments are looking for processing results without using preservatives stored in open spaces and in refrigerators and processing results using preservatives stored in open spaces and in refrigerators. In each treatment three repetitions were carried out to obtain valid conclusions, namely the 1st test (first day), 2nd test (third day) and 3rd test (fifth day). The data analysis used was the mean comparison between treatments without preservatives in the open space and in the refrigerator and using preservatives in the open space and in the refrigerator. The significance test used the Kruskall Wallis test followed by the Friedman test. Results: The difference test for snakehead fish nuggets without preservatives showed a significant difference compared to fish nuggets without preservatives with a p value <0.05. Conclusion: The most optimal storage time for cork fish nuggets without preservatives or with preservatives in an open space or normal temperature can last up to the 3rd day.

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