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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 174 Documents
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Hubungan Sikap Ibu dan Dukungan Suami dengan Kejadian Hiperemesis Gravidarum Grade II-III Limra Limra; Andi Parellangi; Elisa Goretti
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.4373

Abstract

Hyperemesis gravidarum, which often occurs in the early stages of pregnancy, can be quite disruptive. However, the majority of pregnancy-related nausea and vomiting can be managed with outpatient care and the use of antiemetic medications. In this context, social support, especially from spouses, and the mother's attitude toward hyperemesis gravidarum symptoms can play a role in preventing further development of this condition. This research was conducted to examine the relationship between the mother's attitude and spousal support with the occurrence of Grade II-III hyperemesis gravidarum at the Kaubun Health Center in 2023. The research method used was a correlation study with a cross-sectional approach. The study population involved 32 first-trimester pregnant women who visited the Kaubun Health Center in January 2023, and the entire population was sampled. The results of the statistical analysis using the chi-square test indicated a significant relationship between the mother's attitude (p-value = 0.000) and spousal support (p-value = 0.006) with the occurrence of hyperemesis gravidarum. Therefore, the conclusion of this research is that the mother's attitude and spousal support are associated with the occurrence of Grade II-III hyperemesis gravidarum at the Kaubun Health Center in 2023. Husbands play a crucial role in providing support, understanding, and positive feelings to wives experiencing hyperemesis gravidarum, helping wives feel comfortable and capable of managing these symptoms. A deeper understanding of this condition enables husbands to provide more effective support, contributing to the prevention and management of hyperemesis gravidarum during pregnancy.
Pengaruh Pemberian Aromaterapi Lemon dan Minuman Jahe Terhadap Pengurangan Emesis Gravidarum pada Ibu Hamil Trimester I Dian Laila Novianita; Inda Corniawati; Frana Andrianur
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.4375

Abstract

Emesis gravidarum, or excessive nausea and vomiting during early pregnancy, is a common issue frequently experienced by pregnant women. Most cases of pregnancy-related nausea and vomiting can be managed through outpatient care and the use of sedatives and anti-emetics. However, the treatment of hyperemesis gravidarum, a more severe form of pregnancy-related nausea and vomiting, can be approached both pharmacologically and non-pharmacologically. One non-pharmacological approach involves the use of aromatherapy with lemon essential oil and the consumption of ginger-infused beverages. This study aims to analyze the effects of lemon aromatherapy and ginger beverage consumption on reducing emesis gravidarum symptoms in first-trimester pregnant women at the Kaubun Health Center. The research employs a Pretest-Posttest without Control Group design, with a sample of 30 first-trimester pregnant respondents. Statistical analysis using the Wilcoxon test reveals a significant difference in the reduction of emesis gravidarum symptoms between the group receiving lemon aromatherapy and the group consuming ginger beverages, with a p-value of 0.001. Based on these findings, it can be concluded that the administration of lemon aromatherapy and ginger beverage consumption has a positive impact on reducing emesis gravidarum symptoms in first-trimester pregnant women. This non-pharmacological approach can be an effective alternative for managing emesis gravidarum during early pregnancy.
The Influence of Maternal Empowerment Through Maternal Class on Maternal Knowledge about Pregnancy Danger Signs Rahmawati Rahmawati; Dwi Prihatin Era; Ega Ersya Urnia
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.4382

Abstract

Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR) remain serious issues related to pregnancy and childbirth. To address this problem and enhance maternal knowledge about pregnancy danger signs, innovative efforts through maternal classes are necessary. The objective of this study is to examine the influence of maternal empowerment through maternal classes on maternal knowledge about pregnancy danger signs in UPT Karangan Primary Health Center, Kutai Timur Regency. This study utilized a pre-experimental design with one-group pretest and posttest. The purpose was to assess the influence of maternal empowerment through maternal classes on maternal knowledge in UPT Karangan Primary Health Center, Kutai Timur Regency. The population consisted of 54 pregnant women who attended maternal classes in UPT Karangan Primary Health Center during the period of July 2022 to November 2022. Nonprobability sampling technique was used to select a sample of 22 pregnant women. The test statistic showed that the Sig (2-tailed) value was 0.008, which is less than α (α=0.05). Based on the analysis using the Mc Nemar test, it can be concluded that there is a significant influence between pretest and posttest scores in the first and second meetings. Maternal empowerment through maternal classes significantly enhances knowledge about pregnancy danger signs. Expert teaching and class evaluation contribute to the effectiveness of this program in reducing maternal and infant mortality rates.
Uji Aktivitas Penyembuhan Luka Sayat Gel Ekstrak Etanol Lidah Buaya (Aloe Vera L.) pada Mencit Putih Jantan (Mus Musculus) Yulia Asmindra Milasanti; Ratih Tyas Widara; Aldesra Fitri
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.4415

Abstract

Aloe vera (Aloe vera L.) is an herbal plant that contains phytochemicals such as tannins, saponins, flavonoids, and polyphenols, which are useful in healing cut wounds. The phytochemical content has antimicrobial, antibacterial, and antiseptic properties. Several research findings show wound healing activity in experimental animals that have been treated with aloe vera plant extract. This research aimed to make ethanol extract gel from aloe vera leaves and test cuts on male white mice (Mus musculus). The type of research used is true experimental design research. An incision wound was made on the back of the mouse with a length of 1 cm and a depth of 2 mm. The test animals used were 24 animals which were divided into 6 experimental groups, namely Positive Control (Bioplacenton), Negative Control (Without extract content), Base (Without aloe vera extract and preservatives), F1 (Aloe vera extract content 2.5%), F2 (Aloe vera extract content 5%), and F3 (Aloe vera extract content 7.5%). Statistical analysis of wound healing data was carried out using the One way ANOVA (Analysis of Variants) method, while the physical examination of the gel formulation was described descriptively. The statistical test results significantly affected wound healing in male white mice (p<0.05). There is a significant difference between the negative control and F3, p-value = 0.027. The best activity in the wound healing process is F3, with an average percentage of wound healing on the 7th day, F2 on the 8th day, and F1 on the 9th day.
Analisis Kuantitatif Hidrokuinon pada Krim Pemutih di Kota X Menggunakan Spektrofotometri UV–Vis Maria Istiqomah; Ratih Tyas Widara; Agung Permata; Marshela Anjani
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.4417

Abstract

Whitening cream is a cosmetic product containing organic chemicals or other substances which are used to whiten the face or remove black spots on the skin. Whitening cream has many benefits for sufferers of skin disorders, namely being able to whiten and remove black marks. Meanwhile, the concept of beauty circulating in society is having white skin. This stigma makes people, especially teenagers, justify any means to get white skin. One way to beautify your skin is to use skin whitening and lightening products. The aim of this research was to determine hydroquinone levels in whitening cream in X City using UV–vis spectrophotometry. The method used in this research is quantitative using the UV–vis spectrophotometric method. The research results showed that all of the 15 samples tested were positive for containing hydroquinone with the highest percentage of hydroquinone found in S1, S5, and S10 with a percentage of 0.0581%; 0.062%; and 0.0501%. Meanwhile, samples with low percentages were in S4, S6, S7, and S12 with a percentage gain of 0.011%; 0.0134; 0.0103%; and 0.0105%. It can be concluded that the hydroquinone levels of the 15 whitening cream samples do not meet the requirements permitted by BPOM No. 23 of 2019, namely 0%.
Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Etanol Daun Rambutan (Nephelium Lappaceum L.) Astriani, Andi Dian; Fitriani, Ana; Pakki, Ermina
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.3412

Abstract

The ethanol extract of rambutan leaves has anti-Staphylococcus aureus properties. The purpose of this investigation is to formulate the ethanol extract of rambutan leaves (Nephelium lappaceum L.) in order to determine the stable concentration of carbopol 940 for gel preparations. The extraction technique utilised was maceration with 96% ethanol. Formula 1 (0.7% carbopol 940), Formula 2 (0.9% carbopol 940), and Formula 3 (1.1% carbopol 940) were developed for the gel preparation formulation. Organoleptic assays, homogeneity, spreadability, pH, and adhesion were conducted before and after accelerated storage at 400°C and 75% relative humidity. The results of the organoleptic test revealed that preparations F1, F2, and F3 had a semi-solid consistency, a dark brown hue, and a distinct extract odour, and that they were homogeneous. Before accelerated conditions, the spreadability test yielded Farmula 1 (6,3 cm), Farmula 2 (5,96 cm), and Farmula 3 (5.3 cm). After accelerated conditions, the results were F1 (5.86cm), F2 (5.43cm), and F3 (5.16cm). Before the accelerated condition, the pH test results were F1 (5.54), F2 (5.91), and F3 (6.00). After the accelerated condition, the results were F1 (6.43), F2 (6.08), and F3 (5.76). The adhesion test before the accelerated condition yielded F1 (4.37 seconds), F2 (4.28 seconds), and F3 (4.45 seconds), and after the accelerated condition yielded F1 (4.57 seconds), F2 (4.38 seconds), and F3 (4.66 seconds of data, it can be concluded that the gel formulation of rambutan leaf extract from various concentrations of 0.7%, 0.9%, and 1.1% carbopol 940 is physically stable.
Korelasi Efek Samping Obat Anti Tuberkulosis dengan Kepatuhan Pengobatan Pasien TB Paru Ruben, Sethiana Dewi; Tondok, Santalia Banne; Suprayitno, Guruh
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.3670

Abstract

Pulmonary TB is an infectious disease which is a major problem for health in communities, especially in developing countries. The incidence of TB in Indonesia in 2020 is 301 per 100,000 population, the death rate is 34 per 100,000 population. Pulmonary TB patients who do not comply with taking medication can cause a decrease in the cure rate and an increase in the death rate. OAT side effects are one of the causes of non-compliance. This study aims to determine the correlation of OAT side effects with adherence in pulmonary TB patients. The research design was an analytic observational cross sectional study approach and was carried out at the Asolokobal Health Center with a total sample of 30 respondents. Respondents filled out a questionnaire and gave a checklist on the perceived side effects of OAT, compliance was measured with the Guttman scale, the answers "Yes" or "No". The statistical test used is Chi Square with the alternative Fisher's Exact Test. The results of the study showed that 20 respondents (66.7%) adhered to the level of compliance with mild drug side effects. The level of compliance of respondents with symptoms of severe side effects who adhered to it was 6 respondents (20.0%), the level of compliance of respondents with symptoms of severe side effects who did not comply was 4 respondents (13.3%). Fisher's Exact Test, obtained p value = 0.008. It was concluded that there is a correlation between the side effects of anti-tuberculosis drugs and adherence to treatment of pulmonary TB patients.
Uji Aktivitas Antioksidan Fraksi Ekstrak Kulit Bawang Putih (Allium Sativum L.) dengan Metode FRAP (Ferri Reducing Antioxid Power) Pratiwi, Rizky Indah; Kalsum, Ummu; Suleman, Abdul Wahid
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.4166

Abstract

Garlic is used by some people to treat itching on the skin which is often known as tinea versicolor. These materials are used by rubbing the itchy skin area. Garlic produces waste in the form of skin, garlic bulb skin contains flavonoids, phenols, alkaloids, tannins and saponins, which have antioxidant activity. This study aims to determine the antioxidant activity of the garlic skin extract fraction (Allium Sativum L.) using the FRAP (Ferric Reducing Antioxidant Power) method and to determine the IC50 value of the garlic skin extract fraction using the FRAP method. The type of research used was experimentation with garlic skin samples extracted using the maceration method with 70% ethanol solvent, then fractions were carried out with polar (ethanol:water) and non-polar (n-hexane) solvents. Antioxidant activity testing using uv-vis spectrophotometry. Based on the results of the descriptive analysis, it showed that the garlic extract and skin fraction samples had antioxidant activity. The results obtained were the ethanol:water fraction was 1.52 ppm and the n-hexane fraction was 2.75. conclution is the polar fraction (ethanol:water) and the non-polar fraction (n-hexane) have strong antioxidant activity.
Formulasi dan Stabilitas Mutu Fisik Sediaan Lulur Serbuk dari Ampas Kopi Arabika (Coffea arabica) Gayo, Ubi Jalar Ungu (Ipomea batatas L) dan Rimpang Jahe (Zingiber officinale) Elfariyanti, Elfariyanti; Zarwinda, Irma; Zakaria, Nurmalia
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4383

Abstract

Scrub is a traditional cosmetic preparation that has been prescribed for generations and is used to remove dead skin cells, dirt, and open pores so that air exchange is free and the skin becomes brighter and whiter. Previous research reported that Gayo Arabica coffee grounds discarded as waste contain antibacterial and antioxidant compounds. Purple sweet potatoes are reported to contain natural antioxidants because they contain anthocyanins and beta-carotene, apart from that, ginger rhizomes are reported to be able to inhibit the growth of bacteria that cause body odor on human skin. Therefore, these three ingredients have the potential to be used as ingredients for making natural powder scrubs. This research aimed to determine the effect of the proportion of Gayo Arabica coffee grounds, purple sweet potato, and ginger rhizome on the finished product of powdered scrub preparations as seen from the stability of their physical quality. The research method used was experimental in the laboratory with a Completely Randomized Design (CRD). The powder scrub formulation is made in 3 formulas (F1, F2, and F3) by varying the ratio of the amount of Gayo Arabica coffee grounds, purple sweet potato, and ginger rhizome respectively, namely F1 (1:3:1), F2 (2:2: 1) and F3 (3:1:1). The weight of each formula is 100 g. The physical quality stability test of the powder scrub preparation was carried out on the 1st, 7th, and 14th days including organoleptics, water content, homogeneity, pH, drying time, and adhesion. The test results showed that during 2 weeks of storage, the body scrub preparations that were made had met the requirements for good physical quality. In the organoleptic test, the color, shape, and odor of the preparation did not change, the preparation was homogeneous, the pH was stable at 6.2, and the water content was stable at below 10% where the F3 formula showed the lowest water content. The results of the drying time test meet the requirements, namely a minimum of 15 minutes and the adhesion test meets the requirements, namely greater than 1 second.
Perbandingan Kadar Fenolik Total Air Rebusan dan Ekstrak Etanol Daun dan Batang Sawi Langit (Cyanthillium cinereum (L.) H.Rob) Saputri, Muharni; Yulia, Rahma; Febriani, Yessi; Ginting, Ernawaty; Amara, Saniatul; Zulkhaira, Zulkhaira; Utami, Intan Putri
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4578

Abstract

Sky mustard is one of the herbaceous plants used by the community to treat diseases such as inflammation, malaria and fever. This herbaceous plant is believed to have secondary metabolites such as phenolics which have many functions. The aim of this research was to determine the total content of phenolic compounds in leaves and stems of sky mustard greens (Cyanthillium cinereum (L.) H.Rob). This research is experimental in nature, including collecting plant material, identifying plants, cold extraction using the maceration method using ethanol and boiled water as a solvent, phytochemical screening, and determining the total phenolic content of boiled water and equivalent ethanol extract of leaves and stems (Gallic Acid Equivalent (GAE)) or gallic acid by colorimetric method using reagents Folin-ciocalteu a wavelength of 760 nm using UV-Visible spectrophotometry. The result of phytochemical screening of sky mustard leaves and stems contain alkaloids, steroids, saponins, flavonoids, tannin, glycosides and phenols. The result showed that phenol levels were greater in the leaves than in the stem the ethanol solvents attracted more phenolic compounds than boiling, and the phenol by boiling was higher at 5 minutes at 0,649 mg/g GAE. For phenolic compounds using ethanol solvent, there was a yield of 748,33 mg/g extract.

Page 13 of 18 | Total Record : 174

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