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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 174 Documents
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Analisis Faktor Risiko TB paru Anak yang Tinggal Serumah dengan Penderita TB paru Dewasa Yumi Abimulyani; Yuliana Yacinta Kainde; Tri Novianty Mansyur; Neny San Agustina Siregar
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3671

Abstract

Pulmonary tuberculosis (TB) is still a major public health problem in Indonesia. Based on the Household Health Survey (SKRT) results tuberculosis is the number one respiratory disease and infectious disease. Tuberculosis in children causes growth disorders and even death. If pulmonary tuberculosis in a child is not treated immediately, it can quickly develop into parenchymal or tubercular pneumonia, milliary tuberculosis, bone tuberculosis (scrofuloderma), joint tuberculosis, abdominal tuberculosis, and even meningitis. This study used a case-control design with analytical observation. Children who were exposed to and lived in the same household with adult pulmonary tuberculosis patients as many as 90 adults participated in the study. The case sample consisted of children aged 0-15 years who were diagnosed with Pulmonary TB by doctors at the Wania Health Center, Mimika Regency. The case sample size was 30 respondents and the control sample was 30 respondents. The free variables in this study were parental knowledge, BCG vaccination history, child nutritional status, occupancy density, the behavior of TB sufferers at home, and length of contact. Data were analyzed using univariate analysis, bivariate analysis, and multivariate analysis (multiple logistic regression). The results of the study analysis showed that the factors that influence the incidence of tuberculosis in children are parental knowledge (p = 0.001), BCG vaccination history (p = 0.001), and the behavior of adult tuberculosis sufferers in the household (p = 0.000) The conclusion of the study was that the behavior of adult pulmonary tuberculosis patients who lived in the same house with children was most influential in the transmission of pulmonary tuberculosis in children who lived in the same household as adult pulmonary tuberculosis patients at the Health Centre of Wania, Mimika District.
Analisis Perbedaan Skor Plak Gigi Sebelum dan Sesudah Berkumur Air Garam Hangat Rezki Dirman; Arsad Arsad; Utari Zulkaidah; Yulistina Yulistina; Marwa H Guricci
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3675

Abstract

- Dental and oral health is one of the problems in the health sector which is a concern for health workers. Dental and oral health is a part of body health that cannot be separated from one another because dental and oral health will affect holistic body health. Disorders related to dental and oral health are a conflict experienced by most countries in the world. The group of school-aged children is a group that is vulnerable to dental and oral diseases as a result of which it needs to be properly and properly prevented. This study aims to determine differences in dental plaque scores before and after gargling with warm salt water in grades 4, 5 and 6 at UPT SD Negeri 7 Arawa Sidrap Regency in 2023. The type of research used was experimental research with pre-test & post-test methods. . Sampling in this study using stratified random sampling. This sampling technique is carried out by determining the research sample by determining the grouping of members of the population in a group division with a certain level. The results showed that the average score before gargling with salt water was 24.7 and after gargling salt water was 11.8 and the decrease in dental plaque scores before and after gargling with warm salt water was 12.9.
Narrative Review: Terapi Kortikosteroid Pada Pasien COVID-19 dengan Komorbiditas Diabetes Melitus Novia Ariani Dewi; Tri Murti Andayani; Ika Trisnawati
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3713

Abstract

COVID-19 is a respiratory disease caused by SARS-CoV-2, a corona virus that was discovered at the end of 2019. Diabetes mellitus (DM) is the second highest comorbidities in Indonesia of COVID-19 patients. One of the treatments for COVID-19 patients is corticosteroids. Commonly used corticosteroids are dexamethasone, methylprednisolone, and hydrocortisone. This study aims to determine the effect of corticosteroid therapy in COVID-19 patients with DM comorbidities so that it can be a source of information and a reference in the management of therapy in patients. This research is a narrative review using literature from the science databases Cochrane, PubMed and Science Direct. Literature search used the keywords COVID-19, diabetes, and corticosteroids. The results of the literature screening obtained 16 study articles that met the inclusion criteria. The conclusion of this narrative review study is that the recommended corticosteroid therapy for COVID-19 patients is dexamethasone. Administering corticosteroids to COVID-19 patients with comorbid DM can increase the incidence of hyperglycemia, especially at high doses and in the long term, thereby worsening the patient's prognosis, causing new onset diabetes, and increasing the need for insulin doses.
Uji Efektivitas Antidiabetes Rebusan Daun Belimbing Wuluh (Averrhoa bilimbi L.) pada Mencit (Mus musculus) Washliaty Sirajuddin; Shabran Hadiq; Rahmatullah Rahmatullah
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3315

Abstract

Diabetes mellitus is a condition where blood glucose levels increase due to the body's metaboIism of protein, fat, and carbohydrates. The purpose of this study was to determine the antidiabetic effectiveness of star fruit leaf decoction (Averrhoa bilimbi L.) on mice (Mus musculus). This type of research is a laboratory experimental study using 15 male mice divided into 5 groups of mice, each of which is fed for ± 8 hours. Then, the blood glucose level of mice was measured after being fed. Then, a glucose solution of 0.195 mg/0.2 ml was given. Next, blood glucose was measured, if each group of mice had experienced an increase in blood glucose levels, then given a negative control solution, positive control, and 10%, 15% and 20% decoction of starfruit leaves. Then measured the glucose levels of mice using a glucometer at 30, 60, and 90 minutes. The results showed that giving a 20% concentration of star fruit leaf (Averrhoa bilimbi L) decoction was effective as an antidiabetic with a percentage reduction of 42% in mice (Mus musculus).
Uji Antidiare Ekstrak Etanol Daun Matoa (Pometia pinnata) Terhadap Mencit Jantan Diinduksi Oleum Ricini Fenny Hasanah; Muharni Saputri; Desi Natalia Siahaan; Putri Arya Kusuma; Sri Rezki Rudhoh Matondang
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3620

Abstract

Matoa leaf is a plant that is used as traditional medicine. Matoa leaves contain tannins, alkaloids, flavonoids, steroids, and glycosideswhich acts as an antidiarrheal. Oleum riciniis a triglyceride that is efficacious as a laxative. The purpose of this study was to prove that matoa leaves can be efficacious as an antidiarrheal. This study used an experimental method, using matoa leaf assay (Pometia pinnata J. R Forst & G. Forst.) with oleum ricini induction. This research includes the collection, processing, phytochemical screening, preparation of suspension of ethanol extract of matoa leaves, and testing the effectiveness antidiarrheal of suspension of ethanolic extract of matoa leaves (Pometia pinnata J.R. Forst& G. Forst.). The results of phytochemical screening on matoa leaf simplicia powder (Pometia pinnata J. R. Forst& G. Forst.) and ethanol extract of matoa leaf (Pometia pinnata J. R. Forst & G. Forst.) which has tannins, alkaloids, saponins, flavonoids, and triterpenoids. The results showed that EEDM at a dose of 300 mg/kg bw had an antidiarrheal effect comparable to EEDM at a dose of 150 mg/kg bw and had a stronger antidiarrheal effect than EEDM 75 mg/kg bw. The results also showed that the EEDM dose of 300 mg/kgbw was not significantly different from that of Loperamide HCl.
Hubungan Kelahiran Prematur dengan Kejadian Ikterus Neonatorum pada Bayi Baru Lahir di RSUD Baiq Disnalia Siswari; Eka Mustika Yanti; Baiq Eva Priyatna
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3667

Abstract

According to data from the World Health Organization (WHO), the infant mortality rate (IMR) in the world in 2012 was 49 per 1000 live births, high risk infant or infant factors that increase the risk of perinatal or neonatal death is one of them is jaundice neonatorum or jaundice. neonatorum is the cause of neonatal death about 20-40% of all deliveries. Based on the results of a preliminary study conducted at the hospital, from 120 cases of premature birth there were 32 cases of neonatal jaundice. This study was to determine the relationship between premature birth and the incidence of neonatal jaundice in newborns. This type of research is correlational analytic with a case control design. The number of samples used in this study is 55 people in the case group and 55 people in the control group. The analysis used is univariate analysis and bivariate analysis. based on the results of statistical test analysis, it was found that in the case group or mothers who experienced premature birth, there were 32 babies (58.2%) who had neonatal jaundice and in the control group or the group of mothers who did not experience premature birth, they got 14.infants or (25.5%) who had neonatal jaundice. the results of the chi square test obtained a p-value of 0.001, it can be concluded that there is a significant relationship between premature birth and the incidence of neonatal jaundice. it is hoped that pregnant women will continue to routinely carry out antenatal care to prevent premature birth, for further researchers to be able to look for other variables related to the incidence of neonatal jaundice.
Profil Noda Ekstrak Kloroform : Metanol (2:1) dan Aktivitas Bslt Kulit Batang Nyirih (Xylocarpus Granatum) Surmadi Sumardi; Nilsya Febrika Zebua; Vriezka Mierza; Reihan Maurani Arafah; Qhairunnisa Qhairunnisa; Riska Amalia
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3678

Abstract

Nyirih plants (Xylocarpus granatum) grows along the edge of the sea, and in other salty environments. Chemical compounds contained in the bark of the betel nut (Xylocarpus granatum) include alkaloids, triterpenoids, steroids, saponins, and flavonoids. The content of lipid compounds in the bark of betel nut (Xylocarpus granatum) has not been widely studied, including toxicity to cells. This study aims to determine the profile of stains on the bark extract of nyirih (Xylocarpus granatum) and to determine the toxicity of the bark extract of nyirih (Xylocarpus granatum). This research method is experimental which includes the manufacture of betel nut bark extract (Xylocarpus granatum) using maceration method with Chloroform:Methanol (2:1) solvent. The stain profile of Nyirih Stem Bark (Xylocarpus granatum) extract was characterized by Thin Layer Chromatography with n-Hexana:Ethyl Acetate as eluent (7:3). Nyirih Bark Extract (Xylocarpus granatum) was tested for toxicity by the Brine Shrimp Lethality Test (BSLT) method. Nyirih Stem Bark Simplisia (Xylocarpus granatum) 630 grams yielded 90 grams thick extract with a yield percentage of 14,28%. The results of the thin layer chromatography test showed that the stain profile visually produced 3 spots, UV 254 nm light had 5 spots, and UV 366 nm light had 4 spots. The LC50 value of coroform:methanol extract of betel nut bark (Xylocarpus granatum) using probit analysis was 130,7 µg/ml so it was classified as toxic and has the potential to be developed as cytotoxic.
Formulasi Sediaan Ekstrak Etanol Daging Buah Pare (Momordica charantia L.) Sebagai Krim Alas Bedak Nilya Febrika Zebua; Sudewi Sudewi; Vriezka Mierza; Salman Salman; Lisda Wardani; Rama Mulya Dwi Safita; Silvia Primastuti Daeli; Nurfazila Nurfazila
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3700

Abstract

The plant known as bitter melon (Momordica charantia L.) which thrives in the lowlands of the tropics contains alkaloids, saponins, triterpenoids, and flavonoids that are good for the skin. The purpose of this study was to determine whether foundation cream preparations that have humidity activity at certain doses and do not irritate facial skin can be made using ethanol extract of bitter melon fruit flesh. The test material of this study was bitter melon (Momordica charantia L.) flesh which was prepared into foundation cream formulations with concentrations of 1.5%, 2%, 2.5%, and blank using maceration process and 96% ethanol solvent. Physical quality examination of the preparation was conducted as part of the examination. The results showed that bitter melon (Momordica charantia L.) pulp can be quickly made into a homogeneous foundation cream with a stable oil-in-water (O/A) emulsion type and a pH range of 5.8. -6.3, 5.7-6.2, and none of the foundation cream products containing bitter melon pulp ethanol extract irritated the facial skin after the cycling test. The preparation with a concentration of 1.5% is the optimal preparation and preparation concentration of 2.5% is recommended.
Pembuatan Sediaan Gel Anti Acne dari Asap Cair Tempurung Kelapa Berbasis Galaktomanan dengan Bakteri Staphylococcus aureus Nilsya Febrika Zebua; Rahma Yulia; Nia Zulkarnain
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.4219

Abstract

Liquid smoke is a condensate liquid resulting from coconut shell pyrolysis which contains the main constituents of acids, phenols and carbonyls, so it is widely applied as a natural preservative in food and as an anti-bacterial. Gel preparations are preferred because when used they leave a translucent, elastic layer, good drug release and an attractive appearance. This study aims to determine whether liquid smoke can be formulated into an acne gel dosage form on a galactomannan basis which at certain concentrations has antimicrobial activity againstStaphylococcus aureus and does not cause skin irritation. This research was conducted using experimental and descriptive methods. Beginning with collecting literature information related to the content of liquid smoke from coconut shells, then making a galactomannan base, formulation of acne gel preparations from liquid smoke, making microbiological media, methods of testing antimicrobial activity, examining the physical quality of preparations including preparation homogeneity, testing the preparation's pH, testing preparation stability, and irritation test on volunteers. Based on the results of the study, it was shown that liquid smoke can be formulated into an acne gel dosage form based on galactomannan. Homogeneity test results on gel preparations remained homogeneous, the pH obtained remained stable, skin irritation test results did not cause irritation, preparation viscosity test results obtained between 4520-9990 mPas, gel preparation test on growthStaphylococcus aureus at a concentration of 5% gives an inhibition of 15.3 mm and the results of the antibacterial activity test on liquid smoke can inhibit growthStaphylococcus aureus in the minimum range of 12.5 mg/ml gives an inhibitory diameter of 7.0 mm which is included in the medium category.
The Effect of Classic Music Therapy and Lavender Aromatherapy Candles on Anxiety Levels of Trimester III Pregnant Women Siti Romlah; Joko Sapto Pramono; Heni Suryani
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.4372

Abstract

High levels of anxiety or depression during pregnancy can pose risks such as stunted fetal growth and premature birth. Music is believed to be used for relaxation, stress relief and anxiety reduction because music is an organized auditory stimulus consisting of melody, rhythm, harmony, shape and style. Aromatherapy is also a non-pharmacological treatment that uses essential oils and stimulates the olfactory system to reduce stress and create a sense of calm. The aim of this study was to determine the effect of classical music therapy and aromatherapy candles on the anxiety level of third trimester pregnant women. This research method is a pre-experimental quantitative type. The design used in this study was one group pretest posttest, the population in this study were third trimester pregnant women in the Karangan Health Center area. The sampling technique was simple random sampling of 44 third trimester pregnant women. Data were analyzed using the Wilcoxon test. The results showed that the level of anxiety before the intervention experienced by most of the respondents was moderate anxiety in the number of 21 respondents (47.7%) and the level of anxiety after the intervention was mostly with mild anxiety in the number of 20 respondents (45.5%). The results of the bivariate analysis showed that there was an effect of classical music therapy and lavender aromatherapy candles on reducing the anxiety level of third-trimester pregnant women with a result (p=0.000) smaller than (<0.05). The anxiety level score in the pre-test measurement is higher than the post-test measurement, indicated by the mean value in the pretest (23.57) higher than the posttest (19.16) which means there is a decrease in the anxiety level score in the respondents before and after intervention.

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