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Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 174 Documents
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Potensi Antibakteri Ekstrak Etanol Batang Balakka (Phyllanthus emblica L.) terhadap Staphylococcus epidermidis serta Evaluasi Mutu Fisik Krim Nasuha, Nabila; Saputri, Muharni; Tambunan, Ika Julianti; Julianty, Siti Muliani; Br Sitepu, Ulva Wirdana; Syahputri, Nabila; Sinaga, Manuella; Syahputri, Devi Yanti
Journal of Pharmaceutical and Health Research Vol 6 No 3 (2025): October 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i3.8525

Abstract

Balakka (Phyllanthus emblica L) is a wild plant, commonly used as a cooking spice called holat. The stem of balakka is believed to contain alkaloids, flavonoids, and tannins that have antibacterial properties. Most previous studies have focused on the fruit and leaves of balakka. On the other hand, Staphylococcus epidermidis bacteria are normal flora on human skin that cause infections. The increasing resistance of these bacteria to antibiotics makes it important to find alternative natural antibacterial agents. The purpose of this study was to examine the antibacterial activity of balakka stem extract and cream against Staphylococcus epidermidis bacteria and to evaluate the physical quality of the cream. This study used experimental methodology. The maceration method used ethanol p.a. on 100 g of balakka stem simplisia. The stages included phytochemical screening, cream formulation with concentrations of 1%, 2%, and 3%, and physical quality tests (organoleptic, homogeneity, emulsion type, pH, viscosity, stability, and irritation). Antibacterial tests were carried out using the agar well diffusion method on extracts and cream preparations. The results showed that 19.30 g of thick extract was obtained, which was positive for alkaloids, flavonoids, and tannins. The resulting cream met physical quality standards, was homogeneous, had an oil-in-water (O/W) emulsion type, a pH of 5.3–6.2, was stable, and did not cause irritation. The antibacterial activity of the extract showed inhibition zones of 14.5 mm (100 mg/ml), 11.5 mm (75 mg/ml), and 8.5 mm (50 mg/ml), while the cream showed 5.5 mm (1%), 7.5 mm (2%), and 9.5 mm (3%). Thus, ethanol extract of balakka stems has potential as an antibacterial agent and can be formulated into a safe cream that meets physical quality standards.
Sinergi Ekstrak Buah Cengkeh (Syzygium Aromaticum) Dengan Amoksisilin dan Siprofloksasin Terhadap Bakteri Resisten Patandung, Rosliana; Ariastuti, Reni; Subiyanto, Abyasa Fajari; Ilmi, Ibnul
Journal of Pharmaceutical and Health Research Vol 6 No 3 (2025): October 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i3.8614

Abstract

Antibiotic resistance is a serious global health threat, leading to increased morbidity, mortality, and economic burden due to the reduced effectiveness of infection therapy. One promising strategy to overcome this problem is the combination of antibiotics with natural phytochemical compounds that can enhance antibacterial activity. This study aimed to evaluate the synergistic potential between the ethanol extract of clove fruits (Syzygium aromaticum) and the antibiotics amoxicillin and ciprofloxacin against resistant Staphylococcus aureus and Escherichia coli. The study was conducted in vitro, including clove fruit extraction using 70% ethanol, determination of the minimum inhibitory concentration (MIC) by microdilution, and combination testing using the checkerboard assay to calculate the Fractional Inhibitory Concentration (FIC) index. The results showed that clove extract exhibited antibacterial activity with MIC values of 2000 µg/mL against S. aureus and 4000 µg/mL against E. coli. The combination of clove extract with amoxicillin produced a ΣFIC value of 0.25 (strong synergy), while the combination with ciprofloxacin yielded a ΣFIC of 0.50 (additive effect). These findings indicate that phytochemical constituents in clove, particularly eugenol, may enhance bacterial membrane permeability, thereby strengthening antibiotic activity. This study demonstrates the potential of clove extract as a natural adjuvant to improve the efficacy of antibiotics against resistant bacteria. The practical implication of this result is the opportunity to develop phytochemical–antibiotic combination formulations in pharmaceutical dosage forms that are more efficient and sustainable.
Formulation of VCO (Virgin Coconut Oil) Massage Oil with Red Ginger (Zingiber Officinale Var Rubrum) Combination as A Muscle Pain Relief Hakim, Reny Anggriany; Rahmasiah, Rahmasiah; Sulaiman, Sulaiman; Sabil, Sabil
Journal of Pharmaceutical and Health Research Vol 6 No 2 (2025): June 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i2.6295

Abstract

Traditional medicine used by people today, sometimes uses synthetic materials to make preparations, one of which is massage oil. This has long been an inseparable part of the Indonesian nation which is believed to provide benefits for health and beauty. For centuries in Indonesia, the term massage or urut has long been known. So that massage oil made from natural ingredients is widely in demand by the Indonesian people as a traditional medicine used for relaxation, relieving muscle pain, and relaxing muscles. Purpose of the study To find out how to make a VCO (Virgin Coconut Oil) massage oil formulation combined with red ginger (Zingiber Officinale Var Rubrum) as a muscle pain reliever. The research method is experimental by testing each formula with organoleptic, pH, homogeneity, and stability tests. The results of organoleptic testing of each Formula: f1 bright yellow color, has VCO and a little ginger, runny texture, f2 golden yellow color, has VCO and red ginger, runny texture, f3 golden yellow color, has VCO and red ginger odor, slippery texture. The pH value of f1 does not meet the pH standard while f2 and f3 meet the pH standard. Homogeneity testing of all formulas meets the standard. Stability testing of all formulas meets the stability standard.
Comparative Pharmacoeconomic Study of Proton Pump Inhibitors in Gastritis Treatment Using Cost Minimization Approach Hakim, Reny Anggriany; Hadiq, Shabran; Jannah, Raudhatul; Umi, Sri
Journal of Pharmaceutical and Health Research Vol 6 No 3 (2025): October 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i3.7012

Abstract

Gastritis is an inflammatory condition of the gastric mucosa with varying degrees of severity, ranging from mild asymptomatic cases to more severe forms associated with significant morbidity. The condition may be influenced by multiple factors, including dietary habits that stimulate gastric acid secretion, irregular eating patterns, infections, psychological stress, alcohol consumption, and the use of certain medications such as nonsteroidal anti-inflammatory drugs and corticosteroids. Cost Minimization Analysis (CMA) is a pharmacoeconomic approach applied to compare therapeutic alternatives that have equivalent clinical effectiveness by identifying the option with the lowest direct medical cost. Meanwhile, studies examining real-world cost efficiency at the level of primary care services or private community pharmacies remain relatively limited and underreported. Therefore, this study aims to analyze the cost of PPI use in gastritis patients at Fella Farma Pharmacy in 2023 using the Cost Minimization Analysis (CMA) approach. The results of this study are expected to determine PPI alternatives with the lowest therapy costs as a basis for decision-making in more efficient and rational pharmaceutical services. This study conceptualizes that the use of proton pump inhibitors, specifically omeprazole and lansoprazole, influences the total therapy costs incurred by patients. The choice of PPI is assumed to affect overall treatment expenses as reflected in retrospective medical record data from Fella Farma Pharmacy in 2023. This study used a quantitative research design with retrospective data collection using medical records obtained from Fella Farma Pharmacy for the year 2023.A sample of 52 patients who met the inclusion and exclusion criteria at the Fella Farma Clinical Pharmacy in 2023. The data obtained were then analyzed for minimum costs to determine the lowest cost of treatment between Omeprazole (patent brand x) and Lansoprazole (patent brand y). The results of the study showed that the use of Proton Pump Inhibitor (PPI) drugs that had the lowest cost was omeprazole with an average total cost of IDR 351,000/patient compared to lansoprazole with an average total cost of IDR 514,000/patient.

Page 18 of 18 | Total Record : 174

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