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Journal of Holistics and Health Sciences (JHHS)
Published by Universitas Ngudi Waluyo
ISSN : -     EISSN : 26863812     DOI : https://doi.org/10.35473/jhhs.v2i1
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Menerima hasil penelitian dalam bidang kesehatan, keperawatan, kebidanan, dan farmasi. Jurnal ini diterbitkan pada bulan Maret dan September
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 258 Documents
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Pengaruh Hiperoksigenisasi Terhadap Saturasi Oksigen Saat Suction Pra-Ekstubasi Pasien Laparoskopi: The Effect Of Hyperoxygenation On Changes In Oxygen Saturation During Suction Before Extubation In Laparascopy Patients Fauzan Ramadhan; Sapta Rahayu Noamperani; Rosa Delima Ekwantini; Maryana
Journal of Holistics and Health Sciences Vol. 8 No. 2 (2026): Journal of Holistics and Health Sciences (JHHS), September
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v8i2.759

Abstract

Endotracheal tube (ETT) suctioning prior to extubation in laparoscopic patients poses a risk of decreasing oxygen saturation due to temporary ventilation interruption and a reduction in alveolar oxygen reserves, which is compounded by pneumoperitoneum effects. This study aimed to analyze the effect of hyperoxygenation on oxygen saturation () changes during pre-extubation suctioning in laparoscopic patients. A quasi-experimental design with a pre-post test control group approach was employed. A total of 60 adult respondents (aged 18–59 years, ASA physical status I–II, predominantly female, and mostly undergoing laparoscopic cholecystectomy) were selected via consecutive sampling using a time-based cluster allocation method (odd weeks for intervention, even weeks for control) and equally divided into two groups. The intervention group () received hyperoxygenation with 100%  for 1 minute continuously via manual bagging prior to suctioning, while the control group () received standard hospital oxygenation. The  parameter was measured using a pulse oximeter integrated into the anesthesia monitor. Data were analyzed using Wilcoxon and Mann-Whitney tests. The results showed that the control group experienced a significant decrease in mean  from  to , with a mean delta decrease () of  (). Conversely, the intervention group demonstrated an increase in mean  from  to , with a mean delta increase () of  (). The Mann-Whitney test revealed a highly significant difference in  values between the two groups (). In conclusion, hyperoxygenation prior to pre-extubation suctioning is highly effective in maintaining oxygen saturation stability and preventing desaturation in post-laparoscopic patients.   ABSTRAK Tindakan suction endotracheal tube (ETT) sebelum ekstubasi pada pasien laparoskopi berisiko menurunkan saturasi oksigen akibat interupsi ventilasi sementara dan penurunan cadangan oksigen alveolar serta diperberat oleh efek pneumoperitoneum. Hiperoksigenisasi dengan pemberian FiO2 tinggi sebelum suction merupakan strategi preventif untuk mempertahankan stabilitas oksigenasi. Penelitian ini bertujuan untuk mengetahui pengaruh hiperoksigenisasi terhadap perubahan saturasi oksigen (SpO2) saat suction pra-ekstubasi pada pasien laparoskopi. Desain penelitian menggunakan quasi-experimental dengan pendekatan pre-post test dengan control group. Sampel berjumlah 60 responden dewasa (18–59 tahun, status fisik ASA I–II, mayoritas perempuan dan didominasi bedah laparoskopi kolelitiasis) dipilih menggunakan teknik consecutive sampling metode alokasi cluster berdasarkan waktu (minggu ganjil intervensi, minggu genap kontrol) dibagi secara rata: kelompok intervensi () mendapatkan hiperoksigenisasi  100% selama 1 menit kontinu melalui manual bagging sebelum suction, dan kelompok kontrol  mendapatkan oksigenisasi standar rumah sakit. Parameter  diukur menggunakan pulse oximeter terintegrasi pada monitor anestesi. Analisis data menggunakan uji Wilcoxon dan Mann-Whitney. Hasil penelitian menunjukkan kelompok kontrol mengalami penurunan rerata  dari  menjadi  dengan selisih penurunan rerata  sebesar  . Sebaliknya, kelompok intervensi mengalami peningkatan rerata  dari  menjadi  dengan selisih kenaikan rerata  sebesar  . Uji Mann-Whitney mendeteksi perbedaan perubahan nilai  yang sangat signifikan antar kedua kelompok . Pemberian hiperoksigenisasi sebelum tindakan suction pra-ekstubasi terbukti efektif secara signifikan dalam mempertahankan stabilitas dan mencegah desaturasi oksigen pada pasien pasca-laparoskopi.
Fraktur Nasal sebagai Faktor Prediktor Terjadinya Lesi Intrakranial dan Derajat Keparahan Cedera Kepala di RSUP Prof. Ngoerah Denpasar: Nasal Fracture as a Predictor of Intracranial Lesions and Head Injury Severity Salomo Mahaputra Messakh; I Wayan Periadijaya; I Made Mulyawan
Journal of Holistics and Health Sciences Vol. 8 No. 2 (2026): Journal of Holistics and Health Sciences (JHHS), September
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v8i2.766

Abstract

Nasal fracture is the third most common facial fracture globally and carries a risk of head injury and intracranial lesions, yet incidence data in Bali remain limited. To assess nasal fracture as a predictor of intracranial lesions and head injury severity at Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar. A retrospective cross-sectional study reviewed medical records of adult patients (>18 years) treated from January 2021 to December 2023. Seventy-one patients were selected by consecutive sampling based on completeness of CT-scan and initial GCS data; associations were analyzed using bivariate and multivariate tests (SPSS v.25; α=0.05). Nasal fracture was found in 42 patients (59.2%); intracranial lesions in 35 patients (49.3%) and moderate-severe injury (GCS ≤12) in 41 patients (57.7%). Multivariate analysis identified age >40 years (aOR 5.18; 95%CI 1.35–19.77; p=0.016) and nasal fracture (aOR 7.12; 95%CI 2.22–22.81; p=0.001) as independent predictors of intracranial lesions; nasal fracture also independently predicted moderate-severe injury (aOR 6.01; 95%CI 2.03–17.78; p=0.001).: Nasal fracture is an independent predictor of intracranial lesions and moderate-severe head injury, and may serve as an early clinical marker in craniofacial trauma triage.   ABSTRAK Fraktur nasal merupakan fraktur tulang wajah paling umum ketiga secara global dan berisiko menimbulkan cedera kepala serta lesi intrakranial, namun data insidennya di Bali masih terbatas. Menilai fraktur nasal sebagai prediktor lesi intrakranial dan derajat keparahan cedera kepala di RSUP Prof. Dr. I.G.N.G. Ngoerah, Denpasar. Studi potong lintang retrospektif dilaksanakan melalui penelusuran rekam medis pasien dewasa (>18 tahun) yang dirawat pada Januari 2021–Desember 2023. Sebanyak 71 pasien dipilih secara consecutive sampling berdasarkan kelengkapan data CT-scan dan skor GCS awal; hubungan fraktur nasal dengan lesi intrakranial dan keparahan cedera dianalisis menggunakan uji Chi-Square dan regresi logistik biner (SPSS v.25; α=0,05). Fraktur nasal ditemukan pada 42 pasien (59,2%); lesi intrakranial pada 35 pasien (49,3%) dan cedera sedang-berat (GCS ≤12) pada 41 pasien (57,7%). Analisis multivariat menunjukkan usia >40 tahun (aOR 5,18; 95%CI 1,35–19,77; p=0,016) dan fraktur nasal (aOR 7,12; 95%CI 2,22–22,81; p=0,001) sebagai prediktor independen lesi intrakranial; fraktur nasal juga menjadi prediktor independen cedera sedang-berat (aOR 6,01; 95%CI 2,03–17,78; p=0,001). Fraktur nasal merupakan prediktor independen lesi intrakranial dan keparahan cedera kepala sedang-berat, sehingga dapat dipertimbangkan sebagai penanda klinis awal dalam triase pasien trauma kraniofasial.
Efektivitas Ekstrak Buah Senggani (Melastoma malabathricum L.) sebagai Pewarna Inti Sel Alternatif Hematoksilin pada Preparat Histologi Hepar Mencit (Mus musculus): Effectiveness of Senggani (Melastoma malabathricum L.) Fruit Extract as an Alternative Hematoxylin Nuclear Stain for Mouse (Mus musculus) Liver Histological Preparations Candra Widyasmara; Yuyun Nailufar; Yeni Rahmawati
Journal of Holistics and Health Sciences Vol. 8 No. 2 (2026): Journal of Holistics and Health Sciences (JHHS), September
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v8i2.774

Abstract

Nuclear staining is an important step in histological examination to clarify cell and tissue structure. Hematoxylin is a widely used nuclear stain, but its use still has several limitations, including dependence on imported materials and the use of synthetic chemicals. Therefore, it is necessary to develop more environmentally friendly natural dyes as an alternative histological stain. This study aims to evaluate the potential of senggani fruit extract (Melastoma malabathricum L.) as an alternative nuclear stain compared to hematoxylin in liver histology preparations of mice (Mus musculus). This study is an experimental laboratory study using two groups, namely the control group (hematoxylin) and the treatment group (senggani fruit extract). The study sample consisted of 32 liver histology preparations of mice divided into 16 control preparations and 16 treatment preparations. Assessment of staining quality was carried out based on the intensity and sharpness of the nuclear color, then analyzed descriptively and using the Mann–Whitney test. The results showed that all preparations in the control group obtained a higher staining quality score (mean = 6), while all preparations in the treatment group obtained a mean score of 2, indicating a lower quality of cell nucleus staining compared to the control group. The results of the Mann–Whitney test showed a significant difference between the two groups (p < 0.001). Based on these results, it can be concluded that senggani fruit extract has not been able to produce a quality of cell nucleus staining that is equivalent to hematoxylin under the conditions of this study. However, senggani fruit extract still has the potential to be developed as a natural histological dye through optimization of concentration, extraction method, use of mordant, and staining conditions.   ABSTRAK Pewarnaan inti sel merupakan tahapan penting dalam pemeriksaan histologi untuk memperjelas struktur sel dan jaringan. Hematoksilin merupakan pewarna inti sel yang digunakan secara luas, namun penggunaannya masih memiliki beberapa keterbatasan, antara lain ketergantungan terhadap bahan impor serta penggunaan bahan kimia sintetis. Oleh karena itu, diperlukan pengembangan pewarna alami yang lebih ramah lingkungan sebagai alternatif pewarna histologi. Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak buah senggani (Melastoma malabathricum L.) sebagai alternatif pewarna inti sel dibandingkan hematoksilin pada preparat histologi hepar mencit (Mus musculus). Penelitian ini merupakan penelitian laboratorium eksperimental (experimental laboratory study) yang menggunakan dua kelompok, yaitu kelompok kontrol (hematoksilin) dan kelompok perlakuan (ekstrak buah senggani). Sampel penelitian terdiri atas 32 preparat histologi hepar mencit yang dibagi menjadi 16 preparat kontrol dan 16 preparat perlakuan. Penilaian kualitas pewarnaan dilakukan berdasarkan intensitas dan ketajaman warna inti sel, kemudian dianalisis secara deskriptif dan menggunakan uji Mann–Whitney. Hasil penelitian menunjukkan bahwa seluruh preparat pada kelompok kontrol memperoleh skor kualitas pewarnaan yang lebih tinggi (rerata = 6), sedangkan seluruh preparat pada kelompok perlakuan memperoleh rerata skor 2, yang menunjukkan kualitas pewarnaan inti sel lebih rendah dibandingkan kelompok kontrol. Hasil uji Mann–Whitney menunjukkan terdapat perbedaan yang signifikan antara kedua kelompok (p < 0,001). Berdasarkan hasil tersebut, dapat disimpulkan bahwa ekstrak buah senggani belum mampu menghasilkan kualitas pewarnaan inti sel yang setara dengan hematoksilin pada kondisi penelitian ini. Meskipun demikian, ekstrak buah senggani masih berpotensi untuk dikembangkan sebagai pewarna alami histologi melalui optimasi konsentrasi, metode ekstraksi, penggunaan mordant, dan kondisi pewarnaan. 
Aggressive Manifestation of Cerebral Venous Sinus Thrombosis: Rapid Progression from Hemiparesthesia to Spastic Tetraparesis Within 24 Hours in a Young Male – A Case Report Janaari Pramana Putri Gelgel; Ni Made Yuli Artini; I Putu Dhidhi Pradnya Suryadiarsa
Journal of Holistics and Health Sciences Vol. 8 No. 2 (2026): Journal of Holistics and Health Sciences (JHHS), September
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v8i2.779

Abstract

Cerebral venous thrombosis (CVST) is an uncommon cause of stroke, accounting for less than 1% of cerebrovascular events worldwide, and predominantly affects young adults with highly variable and nonspecific neurological manifestations. Delayed recognition may lead to significant neurological deterioration due to venous congestion, cerebral edema, and venous infarction. We report a 33-year-old male who presented with acute right-sided hemiparesthesia upon awakening, preceded by five days of persistent occipital headache. Within hours of admission, he developed right-sided hemiparesis, dysarthria, supranuclear cranial nerve VII and XII palsy, and recurrent generalized seizures. Non-contrast computed tomography revealed a hypodense lesion in the left parietal lobe with hemorrhagic components consistent with venous infarction, along with hyperdensity in the superior sagittal sinus suggestive of cerebral venous sinus thrombosis. The patient was managed with antiepileptic therapy and close supportive care. Within 24 hours, he experienced rapid neurological deterioration progressing to spastic tetraparesis. This case highlights an aggressive clinical course of cerebral venous sinus thrombosis and underscores the importance of early recognition in young patients presenting with acute neurological deficits, particularly when preceded by persistent headache or accompanied by seizures, to prevent delayed diagnosis and severe neurological complications.
Peran Potensial N-Asetilsistein dalam Penatalaksanaan Stroke Iskemik Akut: Sebuah Tinjauan Sistematis: The Potential Role of N-Acetylcysteine in Treatment of Acute Ischemic Stroke: A Systematic Review Janaari Pramana Putri Gelgel; Luh Kadek Trisna Lestari; I Putu Dhidhi Pradnya Suryadiarsa
Journal of Holistics and Health Sciences Vol. 8 No. 2 (2026): Journal of Holistics and Health Sciences (JHHS), September
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v8i2.780

Abstract

Stroke is the second leading cause of death and a major cause of disability worldwide; oxidative stress and inflammation are key pathophysiological mechanisms in acute ischemic stroke that worsen neuronal injury and clinical outcomes. N-acetylcysteine (NAC), a glutathione precursor with antioxidant, anti-inflammatory, and thrombolytic properties, is considered a promising adjuvant therapy. This review aimed to summarize evidence on NAC’s efficacy and safety in acute ischemic stroke, following PRISMA 2020 and searching PubMed/MEDLINE, Cochrane Library, ScienceDirect, and ProQuest up to September 2025, supplemented by Google Scholar; eligible studies involved adult patients receiving NAC, alone or combined, with reported clinical outcomes or oxidative biomarkers. Of 618 articles identified, four studies (194 patients) met the inclusion criteria. NAC consistently improved NIHSS scores and 90-day modified Rankin Scale outcomes (p<0.05), while reducing oxidative biomarkers such as MDA, neopterin, and total oxidant status (p<0.05), alongside increases in total antioxidant capacity, SOD, and GPx (p<0.001); one study reported an 82% reduction in von Willebrand Factor multimers (p<0.001), although one trial found no significant difference in long-term mRS outcomes (p=0.85). NAC was generally well tolerated, though two fatal intracerebral hemorrhages occurred in patients with prior antiplatelet use. Current evidence remains limited, warranting large multicenter randomized trials.   ABSTRAK Stroke merupakan penyebab kematian kedua dan penyebab utama disabilitas secara global; stres oksidatif dan inflamasi menjadi mekanisme patofisiologis kunci pada stroke iskemik akut yang memperberat kerusakan neuron dan memperburuk luaran klinis. N-asetilsistein (NAC), sebagai prekursor glutation, memiliki aktivitas antioksidan, antiinflamasi, dan potensi trombolitik sehingga dipertimbangkan sebagai terapi adjuvan yang menjanjikan.  Tinjauan sistematis ini bertujuan merangkum bukti efektivitas dan keamanan NAC pada stroke iskemik akut, mengikuti pedoman PRISMA 2020 dengan penelusuran PubMed/MEDLINE, Cochrane Library, ScienceDirect, dan ProQuest hingga September 2025 serta pencarian manual via Google Scholar; studi diinklusi bila melibatkan pasien dewasa penerima NAC (monoterapi/kombinasi) dengan laporan luaran klinis atau biomarker oksidatif. Dari 618 artikel yang teridentifikasi, empat studi dengan 194 pasien memenuhi kriteria inklusi. NAC secara konsisten memperbaiki skor NIHSS dan modified Rankin Scale hari ke-90 (p<0,05), serta menurunkan biomarker oksidatif MDA, neopterin, dan total oxidant status (p<0,05) disertai peningkatan kapasitas antioksidan total, SOD, dan GPx (p<0,001); satu studi melaporkan penurunan multimer von Willebrand Factor 82% (p<0,001), meski satu uji klinis tidak menemukan perbedaan mRS jangka panjang (p=0,85). NAC umumnya ditoleransi baik, meski dua kasus perdarahan intraserebral fatal tercatat pada pasien dengan riwayat antiplatelet. Bukti yang tersedia masih terbatas sehingga diperlukan uji klinis acak terkontrol multisenter berskala besar.
Hubungan Efikasi Diri Keluarga dengan Tingkat Kekambuhan Pasien Skizofrenia di RSJ Amino Gondohutomo Semarang: The Relationship Between Family Self-Efficacy and the Relapse Rate of Schizophrenia Patients at Amino Gondohutomo Psychiatric Hospital, Semarang Liyanovitasari; Zumrotul Chairiyyah; Puji Lestari
Journal of Holistics and Health Sciences Vol. 8 No. 2 (2026): Journal of Holistics and Health Sciences (JHHS), September
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v8i2.748

Abstract

Schizophrenia is a global health issue that requires the active involvement of families in home-based care, particularly regarding medication adherence and the implementation of nursing interventions. Family self-efficacy plays a crucial role in the ability to face and overcome various care-related challenges. Therefore, research on family self-efficacy is essential to support the continuity of care and improve the quality of life for patients with schizophrenia. This study aims to determine the relationship between self-efficacy and the relapse rate among patients with schizophrenia. This study used a quantitative design with a cross-sectional approach. The population in this study was all families caring for schizophrenia patients at the Amino Gondohutomo Mental Hospital in Semarang in March 2025, totaling 520 patients. The sampling technique used in this study was accidental sampling. The sample size was 105 families. The stages of this research included the first stage of preparation, data collection by distributing three questionnaires to patients' families, and data processing and report preparation. Self-efficacy was measured using the Caregiver Self-Efficacy Scale for Serious Mental Illnesses questionnaire, consisting of 20 statements. Relapse in schizophrenia patients was assessed using the Relapse Assessment for Schizophrenia Patients (RASP) questionnaire. Bivariate testing used the Kendall's tau test. The study showed that most respondents had moderate family self-efficacy (88 respondents (83.8%), and moderate relapse rates (64 respondents (61%). Bivariate analysis showed a significant relationship between family self-efficacy and relapse rates in schizophrenia patients at Amino Gondohutomo Mental Hospital in Semarang, with a p-value of 0.001 with a correlation coefficient of -0.512, indicating a negative relationship of moderate strength Families are expected to improve their self-efficacy in caring for ill family members by improving their knowledge, caregiving skills, and active involvement in the treatment process. Strong self-efficacy can help families feel more confident in supporting therapy adherence and preventing relapse.   ABSTRAK Skizofrenia merupakan masalah kesehatan global yang memerlukan peran aktif keluarga dalam perawatan di rumah, terutama dalam kepatuhan pengobatan dan pelaksanaan intervensi keperawatan. Self-efficacy keluarga berperan penting dalam kemampuan menghadapi dan mengatasi berbagai kendala perawatan. Oleh karena itu, penelitian mengenai self-efficacy keluarga diperlukan untuk mendukung keberlangsungan perawatan dan meningkatkan kualitas hidup pasien skizofrenia. Penelitian ini bertujuan untuk mengetahui hubungan efikasi diri dengan tingkat kekambuhan pasien skizofrenia. Desain penelitian ini menggunakan metode Kuantitatif dengan pendekatan Cross Sectional. Populasi dalam penelitian ini adalah seluruh keluarga yang merawat pasien skizofrenia di Poli RSJ Amino Gondohutomo Semarang, pada bulan Maret 2025 sejumlah 520 pasien. Teknik yang digunakan untuk pengambilan sampel dalam penelitian ini adalah Accidental Sampling. Adapun sampel dalam penelitian ini adalah 105 keluarga. Tahapan Penelitian ini mencakup tahap pertama adalah persiapan, tahap melakukan pengambilan data dengan membagikan ketiga kuesioner untuk diisi oleh keluarga pasien, dan tahap pengolahan data dan penyusunan laporan. Efikasi diri menggunakan kuesioner Caregiver Self‑Efficacy Scale for Serious Mental Illnesses terdiri 20 pernyataan. Dan kekambuhan pasien skizofrenia menggunakan kuesioner Relapse Assessment for Schizophrenia Patients (RASP). Adapun uji bivariat menggunakan uji Kendall tau. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki efikasi diri keluarga dalam kategori sedang sebanyak 88 responden (83,8%) dan tingkat kekambuhan sedang sebanyak 64 responden (61%). Analisis bivariat menunjukkan terdapat hubungan yang signifikan antara efikasi diri keluarga dengan tingkat kekambuhan pasien skizofrenia di RSJ Amino Gondohutomo Semarang dengan nilai p < 0,001 dengan nilai koefisien korelasi -0,512 hubungan negatif dan kekuatan sedang. Keluarga diharapkan dapat meningkatkan efikasi diri dalam merawat anggota keluarga yang sakit melalui peningkatan pengetahuan, keterampilan perawatan, serta keterlibatan aktif dalam proses pengobatan. Efikasi diri yang baik dapat membantu keluarga lebih percaya diri dalam mendukung kepatuhan terapi dan mencegah terjadinya kekambuhan.
Analisis Obat Fast Moving pada 4 PBF di Jawa Tengah Periode September 2025: Analysis of Fast-Moving Pharmaceuticals at 4 Pharmaceutical Wholesalers (PBF) in Central Java for the Period of September 2025 Muhammad Chabib; Ekky Kusumawardani; Dani Wisma Wardana; Afifta Yogi Anajwaa; Melati Aprilliana Ramadhani
Journal of Holistics and Health Sciences Vol. 8 No. 2 (2026): Journal of Holistics and Health Sciences (JHHS), September
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v8i2.769

Abstract

Healthcare development requires the support of Pharmaceutical Wholesalers (PBF) in safely distributing high-quality medications. Inventory control of fast-moving drugs is crucial to prevent stockouts that could disrupt the operations of healthcare facilities. This study aims to analyze fast-moving drug categories at four pharmaceutical wholesalers in Central Java. This study employs a quantitative descriptive design with a retrospective approach. The sample was selected using total sampling of September 2025 sales data from four pharmaceutical distributors: PBF A, PBF B, PBF C, and PBF D. The data were then processed and analyzed descriptively using Microsoft Excel. The results of the study indicate that each PBF has a varying profile of fast-moving medications due to differences in distribution focus and market segmentation. Cold and cough medications dominate the market at PBF A with 26,059 units due to seasonal changes. Anticonstipant medications were the top-selling category at PBF B with 435 units; at PBF C, eye drops accounted for 305 units; and at PBF D, analgesics and anti-inflammatories totaled 207 units. The analgesic-antipyretic class of drugs has consistently been a fast-moving product across all PBFs due to its essential nature for basic self-medication among the public. The conclusion of this study is that the drug distribution profile of the four PBFs shows a dominance of respiratory and digestive tract medications, as well as drugs in the.   ABSTRAK Pembangunan kesehatan memerlukan dukungan Pedagang Besar Farmasi (PBF) dalam menyalurkan obat berkualitas secara aman. Pengendalian persediaan obat kelompok fast-moving sangat krusial guna menghindari kekosongan stok yang dapat mengganggu operasional fasilitas pelayanan kesehatan. Penelitian ini bertujuan untuk menganalisis golongan obat fast-moving pada empat PBF di Jawa Tengah. Penelitian ini menggunakan desain kuantitatif deskriptif dengan pendekatan retrospektif. Sampel dipilih melalui metode total sampling terhadap data penjualan bulan September 2025 pada empat distributor farmasi, yaitu PBF A, PBF B, PBF C dan PBF D. Data kemudian diolah dan dianalisis secara deskriptif menggunakan perangkat lunak Microsoft Excel. Hasil penelitian menunjukkan bahwa setiap PBF memiliki profil obat fast-moving yang bervariasi akibat perbedaan fokus distribusi dan segmentasi pasar. Obat batuk pilek mendominasi pasar pada PBF A yaitu 26.059 unit karena faktor perubahan musim. Obat antikonstipasi menjadi obat dengan katagori penjualan terbanyak pada PBF B  sebanyak 435 unit, PBF C terdapat 305 unit pada obat tetes mata, dan PBF D pada analgetik-antiinflamasi sebanyak 207 unit. Golongan obat analgetik-antipiretik secara konsisten menjadi produk fast-moving di seluruh PBF karena sifatnya yang esensial untuk swamedikasi dasar masyarakat. Simpulan pada penelitian ini adalah profil distribusi obat dari keempat PBF menunjukkan dominasi obat saluran pernapasan dan pencernaan, serta obat golongan analgetik-antipiretik sebagai menunjukkan obat yang masuk dalam katagori fast moving pada keempat PBF yang dianalisis.
Validasi Metode Analisa Penetapan Kadar Amoksisilin dengan Kromatografi Cair Kinerja Tinggi dalam Sediaan Injeksi Kering : Validation of a Method for Determining the Amoxicillin Concentration in Dry Injection Preparations Using High-Performance Liquid Chromatography Fahrudin Arif; Muhamad Khudzaifi; Teguh Setiawan Wibowo
Journal of Holistics and Health Sciences Vol. 8 No. 2 (2026): Journal of Holistics and Health Sciences (JHHS), September
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jhhs.v8i2.783

Abstract

Amoxicillin is a β-lactam antibiotic commonly used in the treatment of bacterial infections and is available in parenteral dosage forms, including dry powder for injection. The conformity of active ingredient content in parenteral preparations is an important aspect of ensuring drug quality and dose accuracy. Therefore, an accurate and precise analytical method is required to ensure reliable assay results. High-Performance Liquid Chromatography (HPLC) is widely used for the analysis of amoxicillin because of its good separation and quantification capabilities. However, the analytical method must be validated to ensure its suitability for the intended analytical purpose and the characteristics of the dosage-form matrix. This study aimed to validate an HPLC method for the assay of amoxicillin in a 1 g/vial dry powder for injection manufactured by a private pharmaceutical company. The study was conducted experimentally using a Bondapak C18 column (4.6 × 150 mm), a mobile phase consisting of sodium dihydrogen phosphate buffer at pH 4.4 and methanol (93:7), a flow rate of 1.5 mL/min, and a maximum absorption wavelength of 230 nm. The validation parameters included linearity, limit of detection (LOD), limit of quantification (LOQ), precision, and accuracy. The results showed an r value of 0.9999, a limit of detection (LOD) of 7.733 µg/mL, a limit of quantification (LOQ) of 25.778 µg/mL, a precision of ≤2% RSD, and an accuracy of 98.58–101.61%. The mean amoxicillin content in the samples was 102.87%. The HPLC method met the validation criteria and can be used for the accurate and precise assay of amoxicillin in dry powder for injection.   ABSTRAK Amoksisilin merupakan antibiotik β-laktam yang sering digunakan dalam pengobatan infeksi bakteri dan tersedia dalam bentuk sediaan parenteral, termasuk injeksi kering. Kesesuaian kadar zat aktif pada sediaan parenteral merupakan aspek penting dalam menjamin mutu dan ketepatan dosis obat. Oleh karena itu, diperlukan metode analisis yang akurat dan presisi untuk memastikan hasil penetapan kadar dapat diandalkan. Kromatografi Cair Kinerja Tinggi (KCKT) banyak digunakan dalam analisis amoksisilin karena memiliki kemampuan pemisahan dan kuantifikasi yang baik. Namun, metode analisis perlu divalidasi untuk memastikan kesesuaiannya terhadap tujuan analisis dan karakteristik matriks sediaan. Penelitian ini bertujuan memvalidasi metode KCKT untuk penetapan kadar amoksisilin dalam sediaan injeksi kering 1 g/vial produksi industri farmasi swasta. Penelitian dilakukan secara eksperimental menggunakan kolom Bondapak C18 (4,6 × 150 mm), fase gerak buffer natrium dihidrogen fosfat pH 4,4 dan metanol (93:7), laju alir 1,5 mL/menit dengan panjang gelombang maksimal 230 nm. Parameter validasi meliputi linearitas, BD, BK, presisi, dan akurasi. Hasil menunjukkan nilai r sebesar 0,9999, BD 7,733 µg/mL, BK 25,778 µg/mL, %RSD presisi ≤2%, dan akurasi 98,58–101,61%. Kadar rata-rata sampel amoksisilin sebesar 102,87%. Metode KCKT memenuhi kriteria validasi dan dapat digunakan untuk penetapan kadar amoksisilin dalam sediaan injeksi kering secara akurat dan presisi.

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