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INDONESIA
Jurnal Insan Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 26213184     EISSN : 26214032     DOI : https://doi.org/10.36387/jifi
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics
Focus and Scope Jurnal Insan Farmasi Indonesia (JIFI) is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIFI is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 314 Documents
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UJI AKTIVITAS ENZIM SUPEROKSIDA DISMUTASE (SOD) EKSTRAK DAUN SALAM (Syzygium polyanthum) DENGAN METODE WATER SOLUBLE TETRAZOLIUM SALT-1 (WST-1) Fitriana Novita Sari; Ana Indrayanti; Pudiastuti Rahayu Sawarno Putri
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1270

Abstract

Free radicals can cause various kinds of degenerative diseases and skin aging. Free radicals can be neutralized with an enzymatic antioxidant, namely superoxide dismutase (SOD). One of the plants that has high SOD activity is salam (Syzygium polyanthum). The aim of this study was to determine the activity of the crude SOD extract of bay leaves precipitated with ammonium sulfate salt at various concentrations of 25, 50, 75%. The study began with plant determination, enzyme extraction, precipitation of enzyme extracts with ammonium sulfate concentrations of 25, 50, 75%, measurement of total protein content and SOD activity test using the WST-1 method to calculate the percent inhibition. The results were statistically analyzed using one way ANOVA. The results showed that the total protein content of the crude extract of SOD and the results of precipitation with ammonium sulfate 25, 50, and 75% respectively were 9.38; 6.36; 8.50; and 11.6 mg/mL. Meanwhile, the percentage inhibition values were 73.13; 34.33; 65.67; and 80.59%. The highest SOD activity was obtained in the crude extract of the enzyme precipitated with 75% ammonium sulfate salt, which was 80.59%.
HUBUNGAN SIKLUS MENSTRUASI DENGAN GANGGUAN TIDUR PADA MAHASISWI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS AIRLANGGA ANGKATAN 2019 Dhawam Decandra Putra; Bambang Purwanto; Jimmy Yanuar Annas
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1274

Abstract

Factors that affect the menstrual cycle are hormones, enzymes, vascularization, prostaglandins, psychological factors, chronic disease, malnutrition, physical activity, and drugs. The prevalenceof menstrual cycle abnormalities in Indonesian adolescents is quite high, around 31.6%. Normal sleep disorders in women have risks to health, namely in mood disorders and cognitive function. This study aims to analyze the relationship between menstrual cycle length and sleep disturbances in female medical students. This research is an observational analytic research with cross sectional design. This research was conducted at the Faculty of Medicine, Airlangga University from September 2021 to November 2022. The subjects of this study were 60 female medical students from the Faculty of Medicine, Airlangga University, class of 2019. The independent variable in this study was the menstrual cycle, while the dependent variable in this study was sleep disturbances. Data analysis used in this study was bivariate analysis using fisher's exact test to test the menstrual cycle and sleep disturbances. The conclusion in this study is that there is no relationship between menstrual cycle length and sleep disturbances in female medical students at the Faculty of Medicine, Airlangga University class of 2019 with a value of (p> 0.05)
UJI AKTIVITAS ANTIDEPRESAN ISOMIRISTISIN TERHADAP IMMOBILITY TIME MENCIT PUTIH JANTAN (MUS MUSCULUS) Sasqia Indri Maharani; Hery Muhamad Ansory; Inaratul Rizkhy Hanifah
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1279

Abstract

Isomyristicin results from myristicin isomerization and is reported to have the same biological activity as myristicin, an antidepressant. Myristicin at a specific dose causes toxicity, so it is necessary to study isomyristicin, which is estimated to have the same biological activity as myristicin. However, there has been no test related to isomyristicin having antidepressant activity. Therefore, this study aimed to determine the antidepressant activity and the optimum dose of isomyristicin to decrease the immobility time of male white mice (Mus musculus). This study used 30 male white mice divided into six groups: positive control, negative control, normal control, and isomyristicin dose 1.5 mg/Kg BW, 3 mg/Kg BW, and 6 mg/Kg BW mice. The method to measure the immobility time of male white mice is the Forced Swimming Test (FST) and Tail Suspension Test (TST) to induce depression. To analyze the normality data using a Shapiro Wilk and a one-way ANOVA to analyze the significant difference in the data. The result showed all doses of isomyristicin have the ability to antidepressant, and the optimal dose was 1,5 mg/kg BW mice with 82 % as the decrease percentage and proved by post hoc with sig. p (<0,05).
THE ISOLATION OF α-CELLULOSE & THE PREPARATION OF MICROCRYSTALLINE CELLULOSE FROM SOURSOP LEAVES (Annona muricata L.) Yulianita Pratiwi Indah Lestari; Mi'rajunnisa; Raudatul Patimah
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1298

Abstract

Powder characteristics are very important to consider in the tablet manufacturing process because they can affect the characteristics of the resulting tablets. This study aims to determine the characteristics of microcrystalline cellulose powder isolated from soursop leaves. This research method includes preparation of soursop leaves raw material, isolation of α-cellulose using 17.5% NaOH solution with 3.5% nitric acid (containing 20 mg sodium nitrite), manufacture of microcrystalline cellulose using 1 M HCl solution, and characterization of microcrystalline cellulose including quality checks. powder (organoleptic, identification, solubility), and pH testing. The results showed that the yield of microcrystalline cellulose (MCCDSr) was 96.59% against α-cellulose. The results of the characterization of microcrystalline cellulose powder including organoleptic, identification, solubility, melting point, and pH showed similar characteristics with Avicel® PH 101 as a comparison. Based on the research that has been done, the characteristics of microcrystalline cellulose powder from soursop leaves are similar to Avicel® PH 101.
PEMBUATAN APLIKASI PENYIMPANAN OBAT (APO) DALAM PENGONTROLAN MASA KADALUARSA OBAT DI APOTEK BERBASIS WEB Fitrah Shafran Ilahi; Abdul Mahmud Yumassik; Mochammad Maulidie Alfiannor Saputera
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1301

Abstract

Digital pharmacy has been growing in the current era, so the need for an application to help the performance of a pharmacist is indispensable. Pharmacy management information system applications that have been circulating are known to have not used a drug expiration date notification system to email. The purpose of this study was to find out whether the drug storage application design can control drug expiration in a website-based pharmacy. The research method is carried out by making website-based software by applying data flow diagrams (DFD). The research procedure is to first design a data flow diagram consisting of drug data input, purchase transaction data input, sales transaction data input, drug storage data input and transaction report input. After that, create a use case design consisting of two, namely admin and cashier. The last step is to create a block diagram flow with notifications of drugs approaching expiration in the form of incoming e-mails to users. The results showed that the design of the drug storage application system that was made could operate properly and had been tested independently. The drug storage application has not yet been tested by the public, so further testing is needed.
GAMBARAN PENGELOLAAN PERSEDIAAN PERBEKALAN FARMASI DAN BAHAN MEDIS HABIS PAKAI DI APOTEK HALIM MEDIKA BANJARBARU Amaliyah Wahyuni; Abdul Mahmud Yumassik; Isninoriyah Isninoriyah
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1302

Abstract

Inventory management of pharmaceutical supplies and medical consumables at pharmacies is very important to be considered, because management that is not according to procedures will result in inappropriate use, there will be many expired drugs and budget overlaps. The purpose of this study was to describe the management of pharmaceutical supplies and medical consumables at the Halim Medika Pharmacy Banjarbaru which includes planning, procurement, receipt, storage, expiration checks, control, destruction and withdrawal, recording and reporting. This research was a non-experimental. Data were collected using observation sheets based on the SOP of the Halim Medika Pharmacy and the Minister of Health Regulation No. 73, 2016. The sample in this study were all inventory management of pharmaceutical supplies and medical consumables at the Halim Medika Pharmacy Banjarbaru in February-March 2022. Data analysis was carried out by calculating the percentage of conformity. The results showed that 91% of the activities were appropriate, namely planning, procurement, and receiving activities, 9% were not appropriate, including storage and inspection activities for expiration and based on Permenkes No. 73/2016, 100% activities were in accordance with all, namely control activities, destruction and withdrawal, recording and reporting.
OPTIMASI WAKTU FERMENTASI JAMUR SIMBION DARI SPONGE Rhabdastrella SP. DAN UJI AKTIVITAS ANTIBAKTERINYA Mahfur Mahfur; Khafidz Mahbub; Nada Safira Salsabila; Maulida Nur Istiqomah
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1333

Abstract

Sponges are known have many metabolites compounds and potential to be used as raw materials for medicines. spongesare have the ability to form symbiosis with microorganisms. Rhabdastrela sp is have to contain various secondary metabolites, especially the Triterpenes group. The fermentation process is a method to produce abundant secondary metabolite from microorganisms such as symbiont fungi. This study aims to determine the optimal fermentation time for the symbiont fungus Rhabdastrella sp. by looking at the secondary metabolites produced and their antibacterial activity. This research is included of experimental research. Cultivation of the sponge Rhabdastrella sp. for the growth of symbiont fungi. Followed by a fermentation process with variations in time with 2,4,6,8,10,12, and 14 days to get the secondary metabolites produced. Liquid liquid extraction was carried out to obtain secondary metabolites. The final stage is TLC profile and test the antibacterial activity of extract using the well-diffusion method. The results showed that the long fermentation time affected the secondary metabolites obtained, and their antibacterial activity. The profile of secondary metabolites showed that the 12th day of fermentation had the most complex secondary metabolites and the highest yield and had a clear zone of 12.5 ± 0.26 mm.
Uji Aktivitas Antelmintik Ekstrak Etanol Kulit Batang Sengkuang Dracontomelon dao (Blume) Merr. & Rofle Terhadap Cacing Gelang Ayam (Ascaridia gallu) Secara In Vitro Inderiyani Inderiyani; Heny Puspasari; Risma Wahyu Architasari
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1357

Abstract

Worms are diseases caused by worms that need serious treatment. Sengkuang Dracontomelon dao (Blume) Merr & Rofle has the potential as an alternative worm treatment because it contains secondary metabolites i.e. alkaloids, saponins, tannins, flavonoids and triterpenoids which have activity as anthelmintics. This study aims to determine the activity, LC50 and LT50 values ​​of sengkuang stem bark as an anthelmintic against Ascaridia galli in vitro. Sengkuang bark is processed into simplicia and then macerated using 96% ethanol as a solvent. Then the extract was used to test the anthelmintic activity by incorporating 5 chicken roundworms into each test solution, 0,9% NaCl (negative control), 0,5% mebendazole (positive control), ethanol extract of sengkuang stem bark 0,2%; 0,4%, and 0,6%. Incubated at 37°C and observed the time of paralysis, the time and number of worm deaths every 1 hour for 24 hours. The results showed that the ethanol extract of sengkuang bark at concentrations of 0,2%; 0,4% and 0,6% had anthelmintic activity with a mortality rate of 100%, an LC50 value is 0,13% and an LT50 value respectively is 15,67 hours; 10,83 hours and 7,85 hours.
FORMULASI SEDIAAN MASKER CLAY DARI EKSTRAK DAUN PIDADA MERAH (Sonneratia caseolaris) SEBAGAI ANTIOKSIDAN Eka Kumalasari; Regita Ayu Wulandari; Noor Aisyah; Dwi Rizki Febrianti; Rakhmadhan Niah
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1363

Abstract

One of the causes of skin damage is free radicals, to counteract free radicals it can be inhibited using antioxidants. The use of natural antioxidants is considered safer because they are obtained from plant extracts. Red pidada leaf extract has a very strong antioxidant activity with an IC₅₀ value of 24.22 ppm. This plant contains compounds of alkaloids, flavonoids, tannins, saponins, and phenols. This study aims to determine the results of the physical properties test and then determine the formula that better meets the requirements of a good clay mask. The preparation of red pidada leaf extract was carried out using the maceration method with 96% ethanol as solvent. In formula 1 and formula 2 there are variations in the concentration of kaolin clay base and bentonite. The tests carried out were physical properties test of the preparation which included organoleptic test, homogeneity test, pH test, dispersion test, and dry time test . The results showed that all clay mask formulations were declared to meet the physical properties test requirements. In formula 2, the clay mask preparation is a better formulation than formula 1, because in formula 2 it produces greater dispersion, and the dry time is faster.
EFEK SITOTOKSISITAS SENYAWA BIOAKTIF TUMBUHAN TERHADAP SEL KANKER PAYUDARA -SKBR3 CELL LINE : A SYSTEMATIC REVIEW Rita Maliza; Azizah Amatu zikrah; Chairunnisa Azzahra Azzahra H; Hylda; Aprilia Cassa Nova
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1367

Abstract

SKBR3 cancer cells are cell cultures isolated from pleural effusion of a 43-year-old Caucasian woman with metastatic breast cancer. Many plant species are used in alternative medicine which has increased in recent decades for purposes related to breast cancer. The purpose of this systematic review is to make it easier to study the potential of bioactive compounds of medicinal plants and to analyze the effects of medicinal plants on cancer cells. This study uses a search strategy to retrieve articles, including the following items: related scientific questions, database to be used, selection of keywords, inclusion and exclusion criteria, definition of results and conclusions regarding the selected articles. Eight articles that met the inclusion criteria and had compounds derived from plants were tested in vitro on the SKBR3 cell line to see their toxicity. These plant bioactive compounds play an important role in the proliferative phase, cell cycle, fatty acid synthesis and apoptosis of cancer cells.

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