Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Bioscientia Medicina : Journal of Biomedicine and Translational Research

bsm
Website

Published by HM Publisher

ISSN : - EISSN : 25980580 DOI : https://doi.org/10.37275/bsm

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to : 1.Rhemumatology 2.Molecular aspect of Indonesia Traditional Herb 3.Cardiology and Cardiovascular diseases 4.Genetics 5.Immunology 6.Environmental health 7.Toxicology 8. Neurology 9. Pharmacology 10. Oncology 11. Other multidisciplinary studies related medicine. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 1,249 Documents

1 2 3 4 5

Soil Transmitted Helminths (STH) Infection Relatedâ€¨Body Mass Index in Elementary School Students, Sukawinatan Landfill, Palembang City Indri Ramayanti; Asmarani Makmun
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 3 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i3.54

ABSTRACT Introduction The age of Primary School Children are the group most often affected by worm infections with a prevalence of more than 60%. Worm infection can cause a decrease in health conditions, Body Mass Index (BMI), intelligence and productivity of sufferers so that economically causes a lot of losses and decreases in the quality of human resources. Aims of Study The purpose of this study was to determine the relationship of infection with Soil Transmitted Helminths (STH) with the Body Mass Index (BMI) in the children of Elementary School ( SDN 188), Sukawinatan Landfill, Sukarame District, Palembang City. Methods This research is an analytic observational study with a cross-sectional approach. The population consisted of all children of SDN 188 Sukarame Subdistrict, Palembang City, 109 people who were selected by consecutive sampling. Examination of helminthiasis infection was obtained by taking faecal samples on the subject and then examined by laboratory with Kato-Katz method and Body Mass Index (BMI) through anthropomometric measurements of height and weight. The analysis carried out was univariate descriptively and bivariately by Chi-square test. Results There were found 27 (24.8%) children who were positive for helminthiasis and from the results of the bivariate test there was no correlation between STH infection and BMI (p> 0.05). Conclusion there was no significant relationship between infection with Soil Transmitted Helminths (STH) and the Body Mass Index (BMI) of primary school age children around the Sukawinatan landfill in Palembang. Keywords: STH Infection, Body Mass Indeks, Landfiil Area

N-Acetyl-Glucosamidase as Biomarker for Acute Kidney Injury Aulia Annisa Rizki; Zulkifli Zulkifli; Agustina Br Haloho; Zen Hafy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.56

Background : The estimated inciÂdence of Acute Kidney Injury (AKI) is two to three cases per 1,000 patients. Seven percent of hospitalized patients and about two-thirds of patients in intensive care units develop acute kidney injury and the mortalÂity rates range between 25 and 80 percent. Disruption in epithelial brush border of proximal tubular cell causes N-Acetyl-Î²-D-Glucosaminidase (NAG) to be released to the urine and the amount of enzyme could be directly correlated with tubular disruption. Objective : The aims of this research is to determine the sensitivity and specificity of NAG urine examination as an early biomarker for acute kidney injury. Methods : Thereâ€™s 66 subjects who met the inclusion criteria. All the subject were checked for the NAG urine level with Cloud Clone kit and creatinine serum were also checked 48 hours after admission. Results : The results showed in the cut-off point of 7.98 Ng/mL, urine NAG has a sensitivity of 68.6% and specificity 77.4%, positive predictive value 77.42%, negative predictive value 68.57 % and accuracy of 72.73% Conclusions : The result shows that urine NAG examination is more sensitive and specific as an early biomarker for Acute Kidney Injury compared to creatinine serum. Key words : Acute Kidney Injury, N-Acetyl-Î²-D-Glucosaminidase , sensitivity, spesificity

The Recommended Aerobic Gymnastics Has Better Effects on Improving Cognitive and Motoric Ability in Children Irfannuddin; Yunita Fediani; Budi Santoso; Minerva Riani Kadir; Masayu Rita Dewi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 3 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i3.57

Abstract Background Cognitive and motoric ability has important role in childrenâ€™s development, whereas exercise has benefit effects on those abilities. Knowledge materials mostly have dominant role in primary school curriculum. Physical exercise lesson is only complementary lesson without a target to improve childrenâ€™s cognitive ability. We conducted a study to give evidence that 3x/week structured exercise program has better effect compared to 1 x/week exercise on cognitive and motoric skill ability in children. Materials and methods Children aged 6-8 years old were divided into treatment (n=34) and control group (n=33). Treatment group were performing fun aerobic gymnastics guided by trained instructor, 45 minutes each, 3 times a week for 8 weeks with intensity target. Control group were also performing the same gymnastic activity for only once a week with no target. Cognitive and motoric ability were assessed before and after intervention. Results A recommended regular exercise has better effect on executive function, reaction speed, coordination, flexibility and agility, compared to control. There were no differences on memory and balance ability. Both groups have shown better result for all indicators after exercise. Exercise in both groups has positive effect on cognitive and motoric ability, but a recommended 3 x/week regular exercise has better effects compared to 1 x/week exercise. Conclusions School program should give more portions for exercise activity in their curriculum. Keywords: Gymnastics exercise, cognitive ability, motoric ability

Sensitivity and Spesificity of Interleukin 18 as Biomarker for Acute Kidney Injury Febri Jaya Gunawan; F Heru Irwanto; Andi Miarta; Theodorus Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.58

Background : Incidence of AKI in intensive care unit patients reach 60-70%, and the mortality rate is about 60%. IL-18 is a pro-inflammatory cytokine which increased in endogenous inflammation process. Studies in human showed that IL-18 concentration increased prior to AKI. Objective : The aims of this research is to determine the sensitivity and specificity of Interleukin-18 urine examination as an early biomarker for acute kidney injury. Methods : Thereâ€™re total of 66 subjects who met the inclusion criteria. All the subject were checked for the IL-18 urine level with Cloud Clone kit and creatinine serum were also checked 48 hours after admission. Results :The results showed in the cut-off point of 411.25 Pg/mL , urine IL-18 has a sensitivity of 54.3 % and specificity 83.9%, positive predictive value 79.17%, negative predictive value 61.9% and accuracy of 68.18% Conclusions : Our result suggest that IL-18 urine holds a promise as an early biomarker of AKI and more sensitive and specific as an early biomarker for AKI compared to creatinine serum. Key words : Acute Kidney Injury, Interleukin-18, sensitivity, spesificity

The Risk Factors of Anorectal Malformation Patients Mortality in Palembang Muhammad Bima; Shalita Dastamuar; Rachmat Hidayat
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 3 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i3.59

Anorectal malformations are serious anal and rectal disorders ranging from stenosis to anorectal agenesis. The incidence of mortality in cases of anorectal malformations is influenced by many factors, including the type of anorectal malformation, associated congenital anomalies, sepsis, and prematurity as investigated in this study. The aim of this study was to identify the risk factor of mortality on anorectal malformation patients. This study is an observational analytic study with cross sectional study design. Secondary data collection was obtained from eighty-two medical records of anorectal malformation patients in Dr. Mohammad Hoesin Hospital Palembang from January 2015 to June 2017 that meets the inclusion criteria. From eighty-two cases of anorectal malformations found nineteen cases of mortality (23.2%). There were four risk factors identified, anorectal malformation type, associated congenital anomalies, sepsis, and prematurity. Two risk factors found significantly affect the mortality on anorectal malformation patients, anorectal malformation type (p value = 0.036) and sepsis (p value = 0.049) from four risk factors studied. Type of anorectal malformation and sepsis have a significant effect on the mortality of patients with anorectal malformations, but there is no effect on the mortality of the patients with assciated congenital anomalies and prematurity. Keywords: Anorectal malformation, congenital abnormalities, sepsis, prematurity

Identification of IL-10 Gene Polymorphisms in Leprosy Desi Oktariana; Susilawati Susilawati; Gita Dwi Prasasti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.60

Background: Leprosy is a chronic disease caused by an infection of Mycobacterium leprae, which affects skin and nerve lesions, which can result in disability. The prevalence of leprosy continues to increase, especially in Indonesia, which is one of the endemic areas of leprosy. The unique immune response of each individual not only determines the susceptibility of individuals to leprosy, but also determines the type of leprosy that will manifest. One of the immune responses that plays an important role in the pathogenesis of leprosy is interleukin-10 (IL-10). Increased regulation of IL-10 can have an effect on decreasing macrophage activity in killing bacteria. Production of IL-10 is regulated by genes that encode the cytokine. Gen IL-10 is located on chromosome 1q32. Polymorphism in this gene can cause variations in the function of IL-10 protein, which can then influence the process of microbial elimination in the development of leprosy.Objective: This study aimed to identify IL-10 -819 C / T gene polymorphisms which were cut with the MslI enzyme in lepers.Method: This study is a laboratory study, which is also an observational descriptive study with a cross sectional study approach to 40 subjects with leprosy. Identification of IL-10 -819 C / T gene polymorphism was carried out by PCR amplification and RFLP (restriction fragment length polymorphism) technique using the MslI enzyme. Results: Distribution of TT, CT, and CC genotypes in the study subjects were 0 (0%), 14 (35%), and 26 (65%). Based on age, the distribution was 0 (0%), 6 (15%), 19 (47.5%) for those under 50 years old, and 0 (0%), 8 (20%), 7 (17.5 %) for those over 50 years old. Based on gender, the distribution is 0 (0%), 5 (12.5%), 16 (40%) in men, and 0 (0%), 9 (22.5%), 10 (25%) in women. Based on the classification of diseases, the distribution was 0 (0%), 3 (7.5%), 7 (17.5%) for papalacillary, and 0 (0%), 11 (27.5%), 19 (47.5 %) for multibasilers. Conclusion: More wild type genotypes are found in lepers (65%). Keywords: leprosy, polymorphism, IL-10 gene

The Efficacy of Sauropus androgynus Leaves Extract To Improve Cognitive Function in Wistar Rats Induced Alzheimerâ€™s Rachmat Hidayat; Raden Ayu Adelia Safitri; Tungki Pratama Umar; Arindi Maretzka
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 3 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i3.61

Background Sauropus androgynus leaves is the substance which has the potency to prevent degenerative processes. Sauropus androgynus leaves has flavonoid as the main component. Flavonoid has antioxidant and anti neuro-inflammation that can be used to prevent Alzheimer dementia. Research purpose is knowing the effect of Sauropus androgynus leaves for the cognitive function and Î²-amyloid expression in the hippocampus of wistar rats. Methods Reseacrh was done by in vivo method, where male wistar rats (n=24) were distributed to six groups which consisting of four rats. Group 1: Normal control, group 2: positive control, group 3: standard treatment (B12 vitamin), group 4, 5 and 6 were give Sauropus androgynus leaves extract with the dose of 75 mg/kgBB, 150 mg/kgBB and 300 mg/kgBB, respectively for 28 days. Cognitive function was evaluated by t-maze test, where hippocampal Î²-amyloid expression was tested by immunohistochemistry. Results Time differences (day 0-28), alternation ratio distinction (day 0-28) and Î²-amiloid expression were: group 1 (1,84 second; 0,23 unit; 0,518%), group 2 (56,78 second; -0,42 unit; 40,036%), group 3 (34,46 second; -0,25 unit; 33,08%), group 4 (32,83 second; -0,09 unit; 28,88%), group 5 (-3,91 second; 0,42 unit; 14,728%), group 6 (24,25 second; 0,42 unit; 9,4%). Conclusion Sauropus androgynus leaves extract at the dose of 150 mg/kgBB and 300 mg/kgBB can maintain cognitive function by decreasing hippocampal Î²-amyloid formation.

The Efficacy of Cinnamomum burmanii Extract on the Protection of Neuronal Cell Death in Haloperidol Induced Male Wistar Rats Nita Parisa; MT Kamaluddin; Theodorus Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.62

Background Haloperidol is categorized as the first class antipsychotic drug. Long-term use of haloperidol may convey to increased Reactive Oxygen Species (ROS) that will yield oxidative damage which further leads to cell death. Several studies had identified the effects of cinnamon extract on cell death. This study aimed to determine the efficacy of cinnamon extract (Cinnamomum burmanii) on the protection of neuronal cell death in haloperidol-induced male Wistar white rats. Methods This study was experimental with pre and post-test design. Thirty male Wistar rats were divided into 5 groups, induced with haloperidol and followed by treatment. Caspase-3 and dopamine were assayed by ELISA sandwich method using ELISA kit. Mean difference of caspase expression and dopamine levels before and after induction were shown (p<0.05). Results There were mean differences of caspase-3 expression level in the positive control group, cinnamon extract of 100 and 200mg/kgBW before and after treatment (p<0.05). Whereas for dopamine levels, there were mean differences in positive control group, cinnamon extract of 50, 100 and 200mg/kgBW before and after treatment (p<0.05). With Post Hoc test, it was found that there were no mean differences of caspase-3 expression level between positive group with cinnamon extract group of 100 and 200mg/kgBW (p>0,05) and there were also no mean differences of positive group dopamine level with group of cinnamon extract of 100 and 200mg/kgBW (p>0.05). Conclussion Cinnamomum burmanii extract at dose of 100 and 200mg/kgBW were effective in the protection against neuronal cell death in haloperidol induced male Wistar white rats.

The Efficacy of Combination Extract Andrographis peniculata and Syzygium polyanthum on Glucose Uptake in Skletal Muscle in Diabetic Rats Fatmawati Karim; Ester Gonzales Panserga; Mgs Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.63

Insulin resistance is impaired insulin signaling cascade in target cells to respond normal or elevated circulating insulin to the final cellular effect, such as translocation of vesicles containing GLUT4 glucose transporters, which is the major mediator of glucose removal from the circulation and a key regulator of whole-body glucose homeostasis. Among the several plants, Andrographis peniculata (sambiloto) and Syzygium polyanthum (Daun salam). In the present study, a combination was made, Andrographis peniculata (sambiloto) and Syzygium polyanthum (Daun salam), and to determine the effects of combination on tretament insulin resistance. Male Wistar rats (weight, 200-300 g) were randomized into five groups (6 rats/group). Group 1: negative group. Group 2: positive group (metformin 63 mg/kgBW ). Group 3,4 and 5: treatment with extract combination, each group 250 mg/kgBW, 500 mg/kgBW and 1000 mg/kgBW. Rats were induced by high fat diet-glucocorticoid for insulin resistance. Insulin and GLUT-4 were assayed by ELISA. Treatment with extract combination (250, 500 and 1000 mg/kgBW) and metformin for 2 weeks showed a sigificant decrease in fasting plasma insulin compare with the negative control rats with a reduction of 11,2%, 33,6%, 20% and 19,4%, respectively. Two weeks treatment either extract combination or metformin in diabetic rats, significantly increased GLUT 4 level (p<0,05) with a percentage increase of 6,68%, 15,21%, 12,76% and 1,77%.

Association of Sociodemographic, Knowledge, Attitude and Practice with Pediculosis Capitis Linda Amelia; Chairil Anwar; Wardiansah Wardiansah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 1 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i1.64

Introduction : Pediculosis capitis is an infection of scalp and hair in humans caused by infestation of Pediculus humanus capitis and usually extends rapidly in a dense environment such as boarding schools. Aim of study : The aim of this study was to determine the association of studentsâ€™ sociodemographic, knowledge, attitude and practice with pediculosis capitis in Pondok Pesantren Tahfidzil Qur'an Yayasan Tijarotal Lan Tabur Palembang. Methods : This research was an analytical observational study with a cross sectional design conducted on November 2018. There were 117 samples that had the inclusion criteria and hadnâ€™t exclusion criteria. Data collected from anamnesis, questionnaires and hair examinations of respondents. The results were analyzed using Chi-Square and Logistic Regression. Results : Out of 117 students, 57 students (48.7%) has been found positive pediculosis capitis. Statistical test showed that age (p<0.001), gender (p<0.001), education level (p<0.001), knowledge (p=0.035), attitude (p=0.003) and practice (p =0.043) have significant association to the prevalence of pediculosis capitis. However, there was no significant association between father's education (p=1.000), mother's education (p=0.743), father's job (p=0.314), mother's job (p=1.000) and parents' income (p=1.000) to the prevalence of pediculosis capitis. The results of Multiple Logistic Regression analysis showed that gender, knowledge and practice were the most influential factors to the prevalence of pediculosis capitis (p<0.05) with the probability of 96.7%. Conclusion : There was a significant association between age, gender, education level, knowledge, attitude and practice to the prevalence of pediculosis capitis, and the most dominant variables were gender, knowledge and practice.

Page 3 of 125 | Total Record : 1249

1 2 3 4 5

Filter by Year

2017 2026

Filter By Issues

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
+6281949581088

Journal Mail Official
editor.bioscmed@gmail.com

Editorial Address
Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location
Kota palembang,

Sumatera selatan

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Rachmat Hidayat

Contact Email dr.rachmat.hidayat@gmail.com

Phone +6281949581088

Journal Mail Official editor.bioscmed@gmail.com

Editorial Address Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location Kota palembang, Sumatera selatan INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
+6281949581088

Journal Mail Official
editor.bioscmed@gmail.com

Editorial Address
Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location
Kota palembang,

Sumatera selatan

INDONESIA