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Zulfiayu Sapiun
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Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 91 Documents
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Antibacterial Activity of Hand Sanitizer Spray Containing Green Betel Leaf (Piper betle L.) Extract against Staphylococcus aureus and Pseudomonas aeruginosa Marwati Marwati; Siti Mujayana; Zahwa Adiyanti; Siti Nur Afni; Muhammad Sholeh; Ildah Amaliah; Muh Erwin; Nur Khairi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 2 (2026): August 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i2.1672

Abstract

Green betel (Piper betle L.) leaf has traditionally been used as a medicinal plant and is known to contain various bioactive compounds with antioxidant, anticancer, and antibacterial properties, including flavonoids, phenolics, tannins, essential oils, and terpenoids. This study aimed to formulate and evaluate the antibacterial effectiveness of a hand sanitizer spray containing active isolates of P. betle leaves against Pseudomonas aeruginosa and Staphylococcus aureus. P. betle leaves were extracted using the sonication method with 96% ethanol as solvent. The compounds were separated using conventional chromatography and characterized by Fourier Transform Infrared (FTIR) spectroscopy. Antibacterial activity was evaluated at concentrations of 1%, 1.5%, and 2% using the inhibition zone method. The most active isolate was subsequently formulated into a hand sanitizer sprays. The results showed that a yellow isolate (10 mg) was obtained from P. betle leaves. FTIR characterization indicated the presence of OH, CH, C=O, and sp² CH functional groups. The antibacterial activity test demonstrated that the 1% isolate concentration produced the largest inhibition zone, measuring 9.97 mm against P. aeruginosa and 10.6 mm against S. aureus. The formulated hand sanitizer spray exhibited significantly higher inhibition zones of 19.37 mm against P. aeruginosa and 20.9 mm against S. aureus, while also meeting acceptable physical stability parameters. These findings suggest that green betel leaf isolate has potential as a natural antibacterial agent in hand sanitizer sprays.

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