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Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 82 Documents
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Uji Efektivitas Ekstrak Etanol Daun Pepaya (Carica papaya L.) terhadap Peningkatan Trombosit pada Mencit Jantan (Mus musculus) yang diinduksi Kloramfenikol Idris, Zulfiah; SR, Muhammad Asri; Wahyuningsih, Sri; Sudirman, Agriawan; Kartika, Amaliah
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.488

Abstract

Telah dilakukan penelitian tentang uji aktivitas ekstrak etanol daun pepaya (Carica papaya L.) terhadap peningkatan trombosit pada mencit jantan (Mus musculus) yang diinduksi kloramfenikol. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol daun pepaya serta dosis efektifnya dalam meningkatkan jumlah trombosit pada mencit jantan yang diinduksi kloramfenikol. Pada penelitian ini dilakukan perlakuan pertama pemberian pakan selama 14 hari, perlakuan kedua dengan pemberian kloramfenikol dosis 30mg/30g BB peroral selama 7 hari dan pakan standar selama 7 hari, perlakuan ketiga pemberian kloramfenikol dosis 30mg/30g BB peroral dan ekstrak etanol daun pepaya 1,5% selama 7 hari, perlakuan keempat pemberian kloramfenikol dosis 30mg/30g BB peroral dan ekstrak etanol daun pepaya 3% selama 7 hari. Hasil penelitian menunjukkan bahwa ekstrak etanol daun pepaya menunjukkan efek dalam meningkatkan jumlah trombosit pada mencit jantan yang diinduksi kloramfenikol.Research has been conducted on the activity test of ethanol extract from papaya leaves (Carica papaya L.) on increasing platelet count in male mice (Mus musculus) induced with chloramphenicol. The purpose of this study was to determine the effect of ethanol extract from papaya leaves and its effective dosage in increasing platelet count in male mice induced with chloramphenicol. In this study, the first treatment involved feeding for 14 days, the second treatment involved administering chloramphenicol at a dose of 30mg/30g body weight orally for 7 days along with standard feed for 7 days, the third treatment involved administering chloramphenicol at a dose of 30mg/30g body weight orally along with 1.5% ethanol extract of papaya leaves for 7 days, and the fourth treatment involved administering chloramphenicol at a dose of 30mg/30g body weight orally along with 3% ethanol extract of papaya leaves for 7 days. The results showed that the ethanol extract of papaya leaves exhibited an effect in increasing platelet count in male mice induced with chloramphenicol.
Efektivitas Penyembuhan Luka Sediaan Patch Kombinasi Beberapa Spesies Sirih Secara in Vivo Ranti, Dalia; Trinovita, Elsa; Praja, Rian Ka; Frethernety, Agnes; Widayati, Ratna
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.960

Abstract

Luka merupakan permasalahan kesehatan dengan tingkat kejadian yang sering terjadi di Indonesia. Pemberian terapi berbahan herbal dapat menjadi salah satu alternatif dalam penyembuhan luka. Sirih merah (Piper crocatum) dan sirih hijau (Piper betle L.) mempunyai berbagai senyawa metabolit sekunder yang berperan dalam penyembuhan luka sayatan pada kulit. Penelitian ini bertujuan untuk mengetahui efektivitas sediaan patch kombinasi ekstrak daun sirih merah dan daun sirih hijau terhadap penyembuhan luka sayat. Hewan coba dibagi menjadi 5 kelompok perlakuan yaitu kontrol positif (plaster povidone iodine), kontrol negatif patch tanpa ekstrak, dan kelompok dengan ekstrak pada beberapa konsentrasi (7,5%, 15% dan 30%). Beberapa parameter yang dilakukan dengan pengukuran panjang luka, pengamatan waktu penyembuhan luka dan infeksi lokal berdasarkan kriteria Nagaoka. Sediaan patch kombinasi ekstrak daun sirih merah dan daun sirih hijau secara statistik tidak menunjukkan perbedaan bermakna terhadap efektivitas dalam penyembuhan luka yang dinilai berdasarkan kriteria Nagaoka dengan beberapa parameter penilaian luka. Namun, pengamatan secara makroskopis pada kelompok K2 (konsentrasi 15%) menunjukkan terjadinya penyembuhan luka yang lebih baik dibandingkan dengan kelompok plaster povidone iodine. Wounds are a health problem that is a frequent occurrence in Indonesia. Providing herbal therapy can be an alternative for healing wounds. Red betel (Piper crocatum) and green betel (Piper betle L.) have various secondary metabolite compounds that play a role in healing wounds of skin incisions. This study aims to determine the effectiveness of a combination patch preparation of red betel leaf extract and green betel leaf in healing cuts on the skin. The experimental animals were divided into five treatment groups: positive control (povidone-iodine plaster), negative control patch without extract, and groups with extract at several concentrations (7.5%, 15%, and 30%). Several parameters were measured by measuring wound length and observing wound healing time and local infection based on the Nagaoka criteria. The combination patch preparation of red betel leaf extract and green betel leaf extract did not statistically show a significant difference in effectiveness in wound healing as assessed based on the Nagaoka criteria with several wound assessment parameters. However, macroscopic observation in the K2 group (concentration 15%) showed better wound healing compared to the povidone-iodine plaster group.
In Silico Exploration of Suruhan Leaves (Peperomia pellucida) for Triple-Negative Breast Cancer Therapy Targeting AURKA Rovik, Anwar; Andyra, Vania Uly; Afifah, Laelatul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1119

Abstract

Breast cancer is the most common type of cancer worldwide. One of the most widely used chemotherapeutic agents in the treatment of breast cancer is doxorubicin. However, doxorubicin has been reported to cause side effects. Suruhan (Peperomia pellucida) contains bioactive compounds that might protect against breast cancer cells. This study aims to analyze the bioactive compound activity of Suruhan leaves in triple-negative breast cancer in silico. The study was conducted by reviewing published literature on bioactive compounds in Suruhan leaves, predicting the protein target, analyzing the gene expression in triple-negative breast cancer (TNBC) patients, analyzing the protein interactions, and examining patient survival. There are five common bioactive compounds in Suruhan leaves, including peperomin A; 6,8-dihydroxy kaempferol 3,6,7,4'-tetramethyl ether 8-neohesperidoside; dillapiole; carotol; and pellucidin A. AURKA is a target protein for bioactive compounds that are also overexpressed in TNBC patients. AURKA has strong interactions with many proteins, including TPX2, NEDD9, CCNB2, CDC20, PLK1, BIRC5, INCENP, TACC3, TP53, and MYCN. The AURKA has emerged as a promising target for TNBC therapy.
Efek Ekstrak Etanol 70% Herba Akar Kucing (Acalypha indica L.) dalam Menurunkan Kadar Gula Darah Mencit (Mus musculus) Jantan yang diinduksi Aloksan Nihe, Nur Fauziyah S.; Hartati, Hartati; Nur, Moh. Usman; Husain, Fadli
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.914

Abstract

Tanaman akar kucing (Acalypha indica L.) merupakan tanaman yang biasanya digunakan oleh masyarakat untuk mengatasi penyakit diabetes. Tanaman ini memiliki kandungan senyawa flavonoid dan alkaloid yang diduga memiliki efek terhadap penurunan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui konsentrasi ekstrak etanol herba akar kucing yang efektif dalam menurunkan kadar gula darah pada mencit (Mus musculus) jantan setelah diinduksi aloksan. Penelitian ini merupakan penelitian berjenis eksperimental laboratorium dengan kelompok perlakuan dosis yang berbeda yaitu F1 (5 mg), F2 (10 mg), dan F3 (15 mg) dan sebagai kontrol positif (K+) digunakan obat glibenklamid dan dilakukan pengukuran kadar gula darah menggunakan glukometer terhadap mencit jantan. Hasil penelitian menunjukkan penurunan kadar gula darah terjadi pada mencit yang telah diberikan ekstrak etanol herba akar kucing setelah 7 hari pengamatan dengan selisih penurunan yaitu F1 41 mg/dl (33,06%), F2 57 mg/dl (45,72%), F3 64 mg/dl (57,06%). Hasil uji One Way Anova menggunakan SPSS 25.0 menunjukkan bahwa terdapat perbedaan yang signifikan diantara 4 perlakuan tersebut dengan control positif. Kesimpulannnya bahwa semua konsentrasi ekstrak etanol herba akar kucing memiliki kemampuan dalam menurunkan kadar gula darah pada mencit dengan konsentrasi yang paling efektif adalah kelompok F3 15 mg (57,06%).The Acalypha indica L. is a plant that is usually used by people to treat diabetes. This plant contains flavonoid and alkaloid compounds, which are thought to have an effect on reducing blood glucose levels. This study aims to determine the concentration of the ethanol extract of the Acalypha indica herb that is effective in reducing blood sugar levels in male mice (Mus musculus) after being induced by alloxan. This research is a laboratory experimental type study with different dose treatment groups, namely F1 (5 mg), F2 (10 mg), and F3 (15 mg), and as a positive control (K+), the drug glibenclamide was used, and blood sugar levels were measured using a glucometer against male mice. The results showed that a decrease in blood sugar levels occurred in mice that had been given an ethanol extract of Acalypha indica herb after 7 days of observation, with a difference in the decrease, namely F1 41 mg/dl (33.06%), F2 57 mg/dl (45.72%), and F3 64 mg/dl (57.06%). The results of the one-way ANOVA test using SPSS 25.0 showed that there were significant differences between the four treatments and the positive control. The conclusion was that all concentrations of Acalypha indica herb ethanol extract had the ability to reduce blood sugar levels in mice, with the most effective concentration being the F3 15 mg group (57.06%).
Identifikasi dan Penetapan Kadar Flavonoid Ekstrak Etil Asetat Daun Mimba (Azadiractha indica A. Juss) Metode Spektrofotometri UV- Vis Utami, Yuri Pratiwi; Imrawati, Imrawati; Mustarin, Rahmah; Mus, Suwahyuni; Jariah, Ainun
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1049

Abstract

Flavonoid terdiri dari 15 molekul yang tersusun dalam susunan C6-C3-C6 yang merupakan senyawa polifenol. Senyawa ini berbentuk kerangka karbon dan terurai menjadi dua set: C6 dan C3. Daun mimba (Azadiractha indica A. Juss) mengandung flavonoid yang memiliki sifat antioksidan, antibakteri, dan antikanker. Penelitian ini bertujuan untuk mengidentifikasi kelompok senyawa dalam daun mimba (Azadirachta indica A. Juss) dan menentukan kadar flavonoidnya. Ekstraksi dilakukan menggunakan teknik maserasi dengan pelarut etil asetat untuk mendapatkan ekstrak yang kemudian diuji melalui skrining fitokimia. Pengukuran kadar flavonoid dilakukan dengan metode spektrofotometri UV-Vis. Dari hasil ekstraksi, diperoleh rendemen ekstrak sebesar 5,83%. Hasil skrining fitokimia menunjukkan adanya kandungan flavonoid dan alkaloid. Kadar flavonoid ditentukan menggunakan kuersetin sebagai standar pembanding, dengan persamaan garis y = 0,0739x + 0,0776. Kesimpulannya, ekstrak etil asetat mengandung flavonoid dengan kadar 1,183 ± 0,018%.Flavonoids consist of 15 molecules arranged in a C6-C3-C6 configuration, which are polyphenolic compounds. These compounds form a carbon framework and are divided into two sets: C6 and C3. Neem leaves (Azadirachta indica A. Juss) contain flavonoids that have antioxidant, antibacterial, and anticancer properties. This study aims to identify the group of compounds in neem leaves (Azadirachta indica A. Juss) and determine their flavonoid content. Extraction was carried out using the maceration technique with ethyl acetate as a solvent to obtain an extract that was then tested through phytochemical screening. Flavonoid content was measured using the UV-Vis spectrophotometric method. The extraction process yielded an extract with a percentage of 5.83%. Phytochemical screening results indicated the presence of flavonoids and alkaloids. The flavonoid content was determined using quercetin as a reference standard, with the equation y = 0.0739x + 0.0776. In conclusion, the ethyl acetate extract contains flavonoids with a concentration of 1.183 ± 0.018%.
Current Understanding of Mycobacterium tuberculosis Drug Resistances and Diagnostics in Indonesia: A Review Rahayu, Ayu; Rovik, Anwar; Turnip, Oktaviani Naulita
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1121

Abstract

Tuberculosis is a significant global infectious disease cause of mortality, with 25% of the world's population caused by Mycobacterium tuberculosis (Mtb). The highest case recorded was 821,200 cases in 2023 over one decade. Drug resistance significantly impacts tuberculosis treatment and has been observed since the first drug discovery, streptomycin. In Indonesia, drug-resistant tuberculosis (DR-TB) is a significant public health issue, with an estimated 24,666 cases recorded in 2022. A comparative literature search was conducted using various articles, including research studies, guidelines, narrative reviews, reports, and meta-analyses, with the inclusion criteria for reference sources including ten years of published articles. Drug resistance in TB can reduce treatment success rate and increase therapy duration. In the result, several general mechanisms proposed for drug resistance in Mtb include efflux pump, enzyme inactivation, permeability barrier, mutations in drug-target genes, and epigenetics. Currently, TB treatment in Indonesia involves combination therapy using three or more types of drugs, such as rifampicin and isoniazid. The International Standard for TB Care (ISTC) serves as the basis for TB diagnosis in Indonesia, which involves a combination of clinical and laboratory tests. Early diagnosis and universal access to the Drug Susceptibility Test (DST) are crucial for TB resistance. In Indonesia, several diagnostic methods, such as sequencing, PCR testing, Gene Xpert, and culture, can be used to identify TB resistance. Understanding the mechanisms of drug resistance and developing effective diagnosis strategies for TB resistance is crucial for managing global infection.
Phytochemical Study of Green Meniran Herb (Phyllanthus niruri L.) and Red Meniran Herb (Phyllanthus urinaria L.) in Jekan Raya Sub-district of Palangka Raya City, Central Kalimantan Province Damiti, Sukmawati; Mashar, Harlyanti Muthma’innah; Yusuf, Baharuddin
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.891

Abstract

Kalimantan is one of the islands in Indonesia that is famous for its rich biodiversity. Knowledge about the use of traditional medicine using plants has been passed down from generation to generation among the ethnic natives of Kalimantan. One of the typical Kalimantan plants that is efficacious as traditional medicine and contains various potential secondary metabolites is meniran. Based on ethnobotanical studies in Central Kalimantan, meniran is boiled to treat fever, dysentery, jaundice, malaria, therefore further research is needed for the chemical content of meniran which is efficacious. This study aims to determine the phytochemical of green meniran herb (Phyllanthus niruri L.) and red meniran herb (Phyllanthus urinaria L.). Determination of plant samples was carried out for both types of meniran. Then processing, extraction and identification of chemical content. The yield values of each extract obtained were 7.40% and 8.76%. As for the results of phytochemical studies, green and red meniran herb both contain alkaloid, tannins and flavanoids, but green meniran is indicated to have steroid content and red meniran contains triterpenes. Secondary metabolites possessed by these two types of meniran plants are beneficial for health, including as antioxidants, antibacterial, antiviral, anticancer and a number of pharmacological activities that are significant in improving one's health and minimizing the risk of infection by pathogens. However, further research is needed to test the activity of the content of these two types of meniran as a basis for the manufacture of traditional medicines.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Paper Soap Ekstrak Etanol Daun Bidara Arab (Ziziphus spina-christi L.) Terhadap Bakteri Staphylococcus epidermidis Junita, Nurfitria; Awaluddin, Nurhikmah; Nadjamuddin, Mirfaidah; Wahid, Hilmiati
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1043

Abstract

Daun bidara Arab (Ziziphus spina-christi L.) mengandung senyawa kimia berupa saponin, alkaloid, tanin dan flavonoid yang berkhasiat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui apakah ekstrak daun bidara Arab dapat diformulasikan dalam bentuk sediaan paper soap dan melihat serta mengukur aktivitas antibakteri terhadap pertumbuhan bakteri Staphylococcus epidermidis. Desain penelitian ini merupakan penelitian eksperimen laboratorium dengan evaluasi uji mutu fisik yang melalui Cycling Test serta pengujian aktivitas antibakteri dengan metode difusi teknik paper disk dengan menggunakan 3 konsentrasi yaitu 5%, 10%, 15% dan dua kontrol pendukung yaitu kontrol negatif dimana sediaan tanpa ekstrak juga kontrol positif yaitu paper soap. Hasil penelitian uji mutu fisik sediaan paper soap menunjukkan bahwa sediaan memenuhi syarat standar sediaan sabun dan memiliki aktivitas antibakteri dengan konsentrasi paling efektif yaitu konsentrasi 15% dengan diameter zona hambat yang terbentuk 6,9 mm termasuk kategori sedang.Ziziphus spina-christi L. contain chemical compounds such as saponins, alkaloids, tannins, and flavonoids that have antibacterial properties. This study aims to determine whether extracts from Ziziphus spina-christi L. leaf can be formulated into paper soap preparations and to assess whether these preparations exhibit antibacterial activity against the growth of Staphylococcus epidermidis. The design of this research is a laboratory experimental study, evaluating physical quality tests through the Cycling Test and testing antibacterial activity using the paper disk diffusion method with three concentrations: 5%, 10%, and 15%, as well as two control groups: a negative control (preparation without extract) and a positive control (paper soap). The results of the physical quality test of the paper soap preparation indicate that it meets the standard criteria for soap preparations and exhibits antibacterial activity, with the most effective concentration being 15%, which formed an inhibition zone diameter of 6.9 mm, classified as moderate.
Indeks Massa Tubuh Berhubungan dengan Hiperurisemia pada Pasien Tuberkulosis Paru Putra, Oki Nugraha; Mufarridan, Syagafa; Saifudin, Muhammad Arif; U, Shafira Maulida Fitria; Kurniawati, Aisyah Fitri
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1106

Abstract

Pirazinamid merupakan salah satu obat antituberkulosis yang digunakan pada fase intensif. Salah satu efek samping pirazinamid yaitu peningkatan kadar asam urat yang seringkali disertai dengan nyeri sendi. Penelitian ini bertujuan untuk menganalisis faktor yang berhubungan dengan hiperurisemia dan faktor-faktor yang berpengaruh terhadap nyeri sendi pada pasien tuberkulosis (TB) paru fase intensif. Penelitian ini menggunakan desain kohort prospekif. Penelitian ini dilakukan di Puskesmas Perak Timur dan Puskesmas Wonokusomo, Surabaya selama bulan Februari hingga Juli 2023. Tiga ml darah pasien TB paru diambil untuk pemeriksaan kadar asam urat sebelum dan setelah dua bulan pengobatan fase intensif. Dua puluh pasien TB paru yang memenuhi kriteria inklusi dimasukkan ke dalam penelitian. Sebanyak 13 (65%) pasien mengalami peningkatan kadar asam urat yang signifikan di akhir fase intensif, dari 5,25 ± 1,98 mg/dl menjadi 9,43 ± 1,98 mg/dl, p-value 0,000. Delapan (61,5%) dari 13 pasien dengan peningkatan kadar asam urat disertai dengan nyeri sendi. Indeks massa tubuh (IMT) berhubungan dengan hiperurisemia (p-value 0,024, r = 0,624). Kadar asam urat ≥ 6,5 mg/dl secara signifikan berpengaruh terhadap terjadinya nyeri sendi, p-value 0,017. IMT berhubungan dengan hiperurisemia pada pasien TB. Kadar asam urat ≥ 6,5 mg/dl menjadi satu-satunya variabel yang berpengaruh terhadap terjadinya nyeri sendi pada pasien TB yang menjalani pengobatan pada fase intensif. Pengukuran asam urat secara periodik diperlukan terutama pada pasien TB dengan IMT yang besar (gemuk atau obesitas).Pyrazinamide is one of the antituberculosis drugs used in the intensive phase. One of the side effects of pyrazinamide is an increase in uric acid levels, often accompanied by joint pain. This study aims to analyze the factors associated with hyperuricemia and the factors that affect joint pain in pulmonary tuberculosis (TB) patients in the intensive phase. It was a prospective cohort study. This study was conducted at Puskesmas Perak Timur and Puskesmas Wonokusomo, Surabaya, from February to July 2023. Three ml of blood from pulmonary TB patients was withdrawn to measure uric acid levels before and after two months of intensive phase treatment. Twenty pulmonary TB patients who met the inclusion criteria were included in the study. Thirteen (65%) patients significantly increased uric acid levels at the end of the intensive phase, from 5.25 ± 1.98 mg/dl to 9.43 ± 1.98 mg/dl, P-value 0.000. Eight (61.5%) of the 13 patients with elevated uric acid levels were accompanied by joint pain. Body mass index (BMI) was associated with hyperuricemia (p-value 0.024, r = 0.624). Uric acid levels ≥ 6.5 mg/dl significantly influenced the occurrence of joint pain, with a P-value of 0.017. BMI is associated with hyperuricemia in TB patients. A uric acid level ≥ 6.5 mg/dl is associated with joint pain in TB patients undergoing treatment in the intensive phase. Periodic uric acid measurements are needed, especially in TB patients with a high BMI (overweight or obese).
Anti-Inflammatory Activity Test of Ethanol Extract of Kencur Rhizome (Kaempferia galanga L.) on Male White Mice (Mus musculus L.) Induced Carrageenan Khasanah, Nisfi Lailatul; Riyanta, Aldi Budi; Susiyarti, Susiyarti
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.949

Abstract

Inflammation needs to be addressed, considering that inflammation is a local protective response caused by tissue damage. This condition can indeed be overcome by consuming chemical drugs, one of which is in the NSAIDS group, namely diclofenac sodium, but chemical drugs have many negative effects, including nonsteroidal anti-inflammatory drugs and steroids. Therefore, there has been the creation of anti-inflammatory drugs using natural ingredients, especially plants. For generations, Indonesian people have used kencur as an edema medicine. This study aims to examine the anti-inflammatory properties of kencur ethanol extract rhizomes. This study tested anti-inflammatory activity through regeninduced suppression of foot edema in male white mice. In this study, 15 eligible mice aged 2–3 months and weighing 20–30 grams were divided into 5 treatment groups. Three separate doses of galangal rhizome extract—50 mg/kgBW, 150 mg/kgBW, and 250 mg/kgBW—were used in the test. Ethanol extract of kencur rhizomes at a dose of 250 mg/kgBW can reduce edema in male white mice produced by carrageenan by 1% and show possible anti-inflammatory properties, according to the results of studies tested by measuring edema using a digital caliper.

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