cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Zulfiayu Sapiun
Contact Email
zulfiayu@poltekkesgorontalo.ac.id
Phone
+6281244521639
Journal Mail Official
jecp@poltekkesgorontalo.ac.id
Editorial Address
Gedung Jurusan Farmasi Politeknik Kesehatan Kementerian Kesehatan Gorontalo Jln, Taman Pendidikan, Kecamatan Kota Timur, Kota Gorontalo, Gorontalo 96113
Location
Kota gorontalo,
Gorontalo
INDONESIA
Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 91 Documents
 6   7   8   9   10 
Overview of Pneumonia Treatment in Hospitalized Geriatric Patients at One of the Gorontalo Provincial Hospitals: Case Report Papeo, ⁠Dizky Ramadani Putri; Kai, Mohamad Nur Fadjri; Isa, Moh. Arya Avrilio; Sumaga, Nabila Natasya; Mursidi, Sitti Rahmawaty Sisilia; Canon, Afifah Aliya
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1445

Abstract

Pneumonia is a common respiratory infection affecting all age groups, particularly the elderly, who are more susceptible due to comorbidities and age-related decline in immune function. This case report aims to evaluate the role of clinical pharmacy in the management of community-acquired pneumonia (CAP) in a geriatric patient. A descriptive qualitative method was conducted through retrospective analysis of medical records, including clinical presentation, diagnostic findings, pharmacological and non-pharmacological interventions, and patient outcomes. The pharmacological therapy included ceftriaxone and azithromycin as antibiotics, mucolytics, bronchodilators, antipyretics, gastrointestinal protection, and vitamin supplementation, with clinical pharmacy involvement in therapy optimization and monitoring. Non-pharmacological strategies involved oxygen therapy, semi-Fowler positioning, effective coughing techniques, and hydration support. The patient showed marked clinical improvement with increased SpO₂ from 95% to 98%, a reduction in respiratory rate from 30 to 22 breaths/minute, and symptom resolution by day four. This report highlights that the integration of clinical pharmacy interventions significantly contributes to effective and safer management of CAP in elderly patients
Overview of Antipsychotic Use in Schizophrenia Patients at the East City Health Center in 2024 Tuloli, Teti Sutriyati; Makkulawu, Andi; Sumaga, Khairunnisa Alya; Madania, Madania; Manno, Mohamad Reski
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1388

Abstract

Schizophrenia is a severe mental disorder that affects individuals and greatly impacts their families and society, with symptoms like hallucinations, delusions, and emotional or thought disturbances that disrupt daily life and well-being. Treatment for schizophrenia usually involves a combination of antipsychotic drug therapy, psychotherapy, and social support. This study aims to determine the description of antipsychotic use, including the type of drug, rules of use, drug dosage, and duration of use in schizophrenia patients at the Kota Timur Health Center. This study used a descriptive observational research design with data collection using a retrospective method. The research data were obtained from secondary data in the form of medical record data from as many as 25 patients with mental illness. The data were processed with Excel and analyzed using SPSS version 26. The results showed that schizophrenia was predominantly suffered by male patients (56%), and more were in the age range of 34-46 years (as many as 48%). The most widely used antipsychotic drugs were a combination of typical and atypical, as many as 92%. The most frequently used type of drug is clozapine with a dose of 25 mg, and the rules of use are 2 x 1/2 as much as 46%. The longest duration of treatment is already in the maintenance phase, which is 96%. Additional drug trihexyphenidyl 2 mg (2 x 1) is used as much as 92%. The most widely used type of therapy is 3-combination therapy, namely Risperidone + THP + Clozapine, as much as 56%. This study was conducted at the East City Health Center, Gorontalo, which is one of the largest primary healthcare facilities in the region and manages a considerable number of schizophrenia patients with limited psychiatric resources. Therefore, the study setting provides important insights into the real-world use of antipsychotic medications in a community-based healthcare center.
Formulation of 70% Ethanol Extract Cream of Ketapang Leaf (Terminalia catappa L.) and Efficacy Test for Cut Wound in Mice (Mus muscullus) Nurain Thomas; Fika Nuzul Ramadhani; Nur Rasdianah; Mohamad Aprianto Paneo; Kadaria Toana
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1458

Abstract

A laceration (vulnus scissum) is characterized by straight, regular wound edges, typically resulting from sharp object trauma. Ketapang leaves (Terminalia catappa L.) contain bioactive compounds, including flavonoids, saponins, tannins, sterols, alkaloids, and terpenoids, which possess anti-inflammatory properties and the potential to accelerate wound recovery. This study aimed to evaluate the effectiveness of an extract cream derived from T. catappa leaves on laceration healing in mice (Mus musculus). The extract was obtained via maceration using 70% ethanol, followed by phytochemical screening. The cream base was optimized to meet pharmaceutical standards, with evaluations encompassing organoleptic properties, pH, dispersibility, adhesion, viscosity, and freeze-thaw stability. Three formulations were developed with varying extract concentrations: F1 (15%), F2 (20%), and F3 (25%). The in vivo efficacy test involved five groups of mice. Results indicated that all three formulations met the criteria for physical stability. In terms of healing duration, the negative control group required 21 days, while the positive control group achieved healing in 10 days. Among the treatment groups, F1 (15%) and F2 (20%) showed healing times of 18 and 16 days, respectively. Notably, F3 (25%) exhibited the highest efficacy with a healing time of 10 days, comparable to the positive control. Statistical analysis using One-Way ANOVA confirmed these findings with a p-value < 0.05.
Comparative Antioxidant Capacity of Seed and Fruit Ethanol Extracts of Bitter Melon (Momordica charantia L.) Using FRAP Assay Luysi Ariani; Faradiba Abdul Rasyid; Dewi Yuliana; Rahmawati Rahmawati; Andi Muflihunna; Asni Amin; Rezki Amriati Syarif
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1628

Abstract

Momordica charantia L. (bitter melon) is traditionally consumed as both food and medicine in Indonesia. Its fruit and seeds contain bioactive compounds such as saponins, flavonoids, polyphenols, and unsaturated fatty acids with recognized antioxidant potential. This study compared the antioxidant activity of ethanol extracts from bitter melon seeds and fruit using the Ferric Reducing Antioxidant Power (FRAP) assay. Extraction was conducted by ultrasound-assisted extraction (UAE) with ethanol as solvent, and antioxidant activity was expressed as quercetin equivalents (mg QE/g extract). The seed extract showed an antioxidant value of 8.680 mg QE/g, while the fruit extract exhibited 8.626 mg QE/g. The statistical analysis showed that the p-value was greater than 0.05, indicating no significant difference between the two extracts. This suggests that both extracts exhibit comparable antioxidant activity. These results highlight that both seeds and fruit of M. charantia may serve as promising natural antioxidant sources for functional food and pharmaceutical applications.
Effectiveness of Ethanol Extract Dosage of Arabian Bidara Leaf (Zizphus spina-christi (L.) Desf.) on Reduction of Hypercholesterolemia in Mus musculus Valenata Valenata; Gaby Ayu Patricia; Khoirul Ngibad
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1449

Abstract

Hypercholesterolemia is one of the main risk factors for cardiovascular disease, which is characterized by increased cholesterol levels in the blood. The leaves of Ziziphus spina-christi (Arabian bidara) are known to contain flavonoids, saponins, tannins, and alkaloids that have the potential to provide antihypercholesterolemia effects. This study aimed to evaluate the effectiveness of ethanol extract of Z. spina-christi leaves on the reduction of total cholesterol in hypercholesterolemia mice. Extraction is carried out by the maceration method using 96% ethanol and produces a yield of 3.8%. A total of 36 male mice were divided into six groups (n=6): negative control, positive control (propylthiouracil induction), drug control (simvastatin), and three extract treatment groups with doses of 14, 28, and 56 mg/20 g BB. The treatment was given orally for four days, then cholesterol levels were analyzed using the enzymatic method CHOD-PAP. The results showed that the positive control cholesterol levels increased significantly (189.3 ± 6.2 mg/dL) compared to the negative control (112.7 ± 10.3 mg/dL). The administration of the extract lowered cholesterol levels gradually: 170.4 ± 6.3 mg/dL (10%), 159.6 ± 7.6 mg/dL (15.7%), and 147.3 ± 11.7 mg/dL (22.2%). Simvastatin decreased more (117.7 ± 12.5 mg/dL; 37.8%). It was concluded that bidara arabic leaf extract has antihypercholesterolemia potential with a multifactorial mechanism, although its effectiveness is lower than that of simvastatin.
Optimization of HPMC Concentration in Psidium guajava Leaf Extract Floating Tablets Nurafni Annisa Achmad; Ardiansyah Jumaedi Nasir; Amriani Sapra; Nur Khairi; Nurul Ulfah Ali
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1639

Abstract

Psidium guajava L. leaves have been empirically used in traditional medicine due to their flavonoid content, which exhibits antibacterial and anti-ulcer activities. A floating drug delivery system is intended to prolong gastric residence time and thereby enhance therapeutic effectiveness in the treatment of gastric ulcers. This study aimed to investigate the effect of varying concentrations of hydroxypropyl methylcellulose (HPMC) on the physical characteristics of floating tablets containing Psidium guajava leaf extract. The leaf extract, at a dose of 350 mg, was formulated into floating tablets using three HPMC concentrations: 10% (F1), 20% (F2), and 30% (F3). The tablets were evaluated for weight uniformity, hardness, friability, disintegration time, and floating properties. The results showed that all formulations complied with pharmacopeial requirements for weight uniformity, hardness (10-20 kg), friability (<1%), and disintegration time (<60 min). However, formulation F1 exhibited a longer floating lag time of 7200 s and failed to meet the floating ability criterion. Increasing HPMC concentration significantly affected tablet hardness, friability, and floating properties (p < 0.05). Formulation F2 demonstrated the most favorable characteristics, with hardness of 10.61 kg, friability of 0.69%, floating lag time of 60 s, and floating duration >12 h. In conclusion, HPMC concentration significantly influenced the physical and floating properties of Psidium guajava leaf extract floating tablets, with a 20% HPMC concentration providing the most optimal formulation characteristics.
Molecular Docking of Avocado Leaf (Persea americana) Chemical Compounds againts Angiotensin Converting Enzyme Alyavayza Putri Monoarfa; Rizky Resvita R Bahi; Moh. Rivaldi Mappa
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1529

Abstract

Angiotensin-Converting Enzyme (ACE) plays a key role in the pathogenesis of hypertension by converting angiotensin I into the vasoconstrictive angiotensin II. Avocado leaves (Persea americana) are known to exhibit antihypertensive activity through ACE inhibition, comparable to that of captopril. However, the molecular interaction of compounds identified in avocado leaves with ACE has not been extensively investigated in silico. This study aimed to explore the molecular mechanisms of identified compounds in avocado leaves in inhibiting ACE through molecular docking analysis. Docking simulations were performed between the identified compounds and the ACE protein target (PDB ID: 1O86). The compounds were identified from preliminary studies and screened for potential biological activity using PASS Online. Out of 19 compounds screened, 14 showed predicted antihypertensive activity. The best docking results were observed for trans-tiliroside (ΔG –8.39 kcal/mol), quercitrin (ΔG –8.32 kcal/mol), and ficumegasoside (ΔG –8.26 kcal/mol). These three compounds demonstrated strong binding affinity towards ACE, indicating their potential as natural ACE inhibitors. The findings suggest that trans-tiliroside, quercitrin, and ficumegasoside could serve as promising candidates for the development of antihypertensive therapies derived from natural products.
Profile of Antidepressant Use and Drug Interactions among Psychiatric Outpatients at RSUD Ainun Habibie Nabila Husnunnisa Ismail; Teti Sutriyati Tuloli; Nur Rasdianah; Mohamad Aprianto Paneo
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1447

Abstract

Mental disorders are commonly treated with antidepressants, antipsychotics, or their combination. Although combination therapy may improve therapeutic outcomes, it also increases the risk of potential drug–drug interactions (DDIs), which can affect drug efficacy and safety. This study aimed to evaluate the prescribing profile of antidepressants and the potential DDIs among patients attending the Mental Health Outpatient Clinic at Ainun Habibie Hospital. A retrospective descriptive study was conducted using medical records. Patients were selected through purposive sampling, and 161 records met the inclusion criteria. Potential DDIs were identified and classified according to their mechanism and severity. Of the 161 medical records reviewed, 160 patients (99.38%) had at least one potential DDI. A total of 479 potential interactions were identified, including 116 (24.22%) pharmacokinetic and 364 (75.83%) pharmacodynamic interactions. Pharmacodynamic interactions consisted of 353 (73.54%) synergistic and 11 (2.29%) antagonistic effects. Based on severity, 106 (22.13%) interactions were classified as major, 371 (77.45%) as moderate, and 2 (0.42%) as minor. The most common potential DDIs were clozapine–fluoxetine (44 cases, 9.17%), Merlopam–Sandepril (42 cases, 8.75%), and trihexyphenidyl–risperidone (38 cases, 7.92%). Potential DDIs were highly prevalent among psychiatric outpatients, with pharmacodynamic interactions of moderate severity predominating. Routine medication review and monitoring are essential to reduce the risk of clinically significant DDIs and improve patient safety.
Flavonoid Quantification in Fruits and Seeds of Momordica charantia L. by UV-Vis Spectrophotometry Novia Ardana F. Hamim; Dewi Yuliana; A. Muflihunna; Faradiba Abdul Rasyid; Rahmawati Rahmawati; Rezki Amriati Syarif
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1629

Abstract

Momordica charantia L. (bitter melon) is a medicinal plant widely recognizedfor its bioactive compounds, particularly flavonoids, which exhibit potentantioxidant properties. This study aimed to quantify the total flavonoidcontent in the fruits and seeds of M. charantia using UV-Visspectrophotometry and quercetin as a standard compound. Samples wereextracted with 70% ethanol and analyzed by the aluminum chloride–potassium acetate colorimetric method at the specific absorptionwavelength, using quercetin as the standard. The results demonstrated thatthe fruit's average flavonoid content was 2.261 mg QE/g extract, whereasthe seeds contained 2.906 mg QE/g extract. These findings indicate that theseeds possess the same flavonoid concentration as the fruit, highlightingtheir potential as a valuable natural source of antioxidant compounds.
Acute Toxicity Test of Bougainvillea glabra Choisy Leaf Extract Against Artemia salina Leach Larvae Using the Brine Shrimp Lethality Test Method Nur Fadilla; Muhammad Asri SR; Nurfitria Junita; Suryanita Suryanita
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 2 (2026): August 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i2.1526

Abstract

Bougainvillea plants are often referred to as paper flowers because the texture of the petals resembles paper. The leaves of this plant contain several metabolite compounds, such as alkaloids, flavonoids, saponins, and tannins, that have potential as anticancer. This study aims to determine the acute toxicity and LC50 value of paper flower leaf extract (Bougainvillea glabra Choisy) to shrimp larvae (Artemia salina Leach) using the Brine Shrimp Lethality Test (BSLT) method. This research method is experimental research with phytochemical screening testing and an acute toxicity test of B. glabra Choisy leaf extract against shrimp larvae (Artemia salina Leach) with the BSLT method. The results of this study showed that the phytochemical screening of B. glabra leaf extract contained alkaloid, flavonoid, saponin, and tannin compounds, with an LC50 value of 225.94 μg/mL. It is concluded that paper flower leaf extract has a toxic effect on Artemia salina Leach larvae because the LC50 value is 225.94 μg/mL with a moderate toxic category.

Page 9 of 10 | Total Record : 91

 6   7   8   9   10 

Filter by Year

2021 2026


Reset
Filter By Issues
All Issue Vol 6, No 2 (2026): August 2026 Vol 6, No 1 (2026): February 2026 Vol 5, No 2 (2025): August 2025 Vol 5, No 1 (2025): February 2025 Vol 4, No 2 (2024): August 2024 Vol 4, No 1 (2024): February 2024 Vol 3, No 2 (2023): August 2023 Vol 3, No 1 (2023): February 2023 Vol 2, No 2 (2022): August 2022 Vol 2, No 1 (2022): February 2022 Vol 1, No 2 (2021): August, 2021 Vol 1, No 2 (2021): Agustus, 2021 Vol 1, No 1 (2021): February, 2021 Vol 1, No 1 (2021): Februari, 2021 More Issue