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Zulfiayu Sapiun
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Gedung Jurusan Farmasi Politeknik Kesehatan Kementerian Kesehatan Gorontalo Jln, Taman Pendidikan, Kecamatan Kota Timur, Kota Gorontalo, Gorontalo 96113
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Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 86 Documents
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Overview of Pneumonia Treatment in Hospitalized Geriatric Patients at One of the Gorontalo Provincial Hospitals: Case Report Papeo, ⁠Dizky Ramadani Putri; Kai, Mohamad Nur Fadjri; Isa, Moh. Arya Avrilio; Sumaga, Nabila Natasya; Mursidi, Sitti Rahmawaty Sisilia; Canon, Afifah Aliya
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1445

Abstract

Pneumonia is a common respiratory infection affecting all age groups, particularly the elderly, who are more susceptible due to comorbidities and age-related decline in immune function. This case report aims to evaluate the role of clinical pharmacy in the management of community-acquired pneumonia (CAP) in a geriatric patient. A descriptive qualitative method was conducted through retrospective analysis of medical records, including clinical presentation, diagnostic findings, pharmacological and non-pharmacological interventions, and patient outcomes. The pharmacological therapy included ceftriaxone and azithromycin as antibiotics, mucolytics, bronchodilators, antipyretics, gastrointestinal protection, and vitamin supplementation, with clinical pharmacy involvement in therapy optimization and monitoring. Non-pharmacological strategies involved oxygen therapy, semi-Fowler positioning, effective coughing techniques, and hydration support. The patient showed marked clinical improvement with increased SpO₂ from 95% to 98%, a reduction in respiratory rate from 30 to 22 breaths/minute, and symptom resolution by day four. This report highlights that the integration of clinical pharmacy interventions significantly contributes to effective and safer management of CAP in elderly patients
Overview of Antipsychotic Use in Schizophrenia Patients at the East City Health Center in 2024 Tuloli, Teti Sutriyati; Makkulawu, Andi; Sumaga, Khairunnisa Alya; Madania, Madania; Manno, Mohamad Reski
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1388

Abstract

Schizophrenia is a severe mental disorder that affects individuals and greatly impacts their families and society, with symptoms like hallucinations, delusions, and emotional or thought disturbances that disrupt daily life and well-being. Treatment for schizophrenia usually involves a combination of antipsychotic drug therapy, psychotherapy, and social support. This study aims to determine the description of antipsychotic use, including the type of drug, rules of use, drug dosage, and duration of use in schizophrenia patients at the Kota Timur Health Center. This study used a descriptive observational research design with data collection using a retrospective method. The research data were obtained from secondary data in the form of medical record data from as many as 25 patients with mental illness. The data were processed with Excel and analyzed using SPSS version 26. The results showed that schizophrenia was predominantly suffered by male patients (56%), and more were in the age range of 34-46 years (as many as 48%). The most widely used antipsychotic drugs were a combination of typical and atypical, as many as 92%. The most frequently used type of drug is clozapine with a dose of 25 mg, and the rules of use are 2 x 1/2 as much as 46%. The longest duration of treatment is already in the maintenance phase, which is 96%. Additional drug trihexyphenidyl 2 mg (2 x 1) is used as much as 92%. The most widely used type of therapy is 3-combination therapy, namely Risperidone + THP + Clozapine, as much as 56%. This study was conducted at the East City Health Center, Gorontalo, which is one of the largest primary healthcare facilities in the region and manages a considerable number of schizophrenia patients with limited psychiatric resources. Therefore, the study setting provides important insights into the real-world use of antipsychotic medications in a community-based healthcare center.
Formulation of 70% Ethanol Extract Cream of Ketapang Leaf (Terminalia catappa L.) and Efficacy Test for Cut Wound in Mice (Mus muscullus) Thomas, Nurain; Ramadhani, Fika Nuzul; Rasdianah, Nur; Paneo, Mohamad Aprianto; Toana, Kadaria
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1458

Abstract

A laceration (vulnus scissum) is characterized by straight, regular wound edges, typically resulting from sharp object trauma. Ketapang leaves (Terminalia catappa L.) contain bioactive compounds, including flavonoids, saponins, tannins, sterols, alkaloids, and terpenoids, which possess anti-inflammatory properties and the potential to accelerate wound recovery. This study aimed to evaluate the effectiveness of an extract cream derived from T. catappa leaves on laceration healing in mice (Mus musculus). The extract was obtained via maceration using 70% ethanol, followed by phytochemical screening. The cream base was optimized to meet pharmaceutical standards, with evaluations encompassing organoleptic properties, pH, dispersibility, adhesion, viscosity, and freeze-thaw stability. Three formulations were developed with varying extract concentrations: F1 (15%), F2 (20%), and F3 (25%). The in vivo efficacy test involved five groups of mice. Results indicated that all three formulations met the criteria for physical stability. In terms of healing duration, the negative control group required 21 days, while the positive control group achieved healing in 10 days. Among the treatment groups, F1 (15%) and F2 (20%) showed healing times of 18 and 16 days, respectively. Notably, F3 (25%) exhibited the highest efficacy with a healing time of 10 days, comparable to the positive control. Statistical analysis using One-Way ANOVA confirmed these findings with a p-value < 0.05.
Comparative Antioxidant Capacity of Seed and Fruit Ethanol Extracts of Bitter Melon (Momordica charantia L.) Using FRAP Assay Ariani, Luysi; Rasyid, Faradiba Abdul; Yuliana, Dewi; Rahmawati, Rahmawati; Muflihunna, Andi; Syarif, Rezki Amriati
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1628

Abstract

Momordica charantia L. (bitter melon) is traditionally consumed as both food and medicine in Indonesia. Its fruit and seeds contain bioactive compounds such as saponins, flavonoids, polyphenols, and unsaturated fatty acids with recognized antioxidant potential. This study compared the antioxidant activity of ethanol extracts from bitter melon seeds and fruit using the Ferric Reducing Antioxidant Power (FRAP) assay. Extraction was conducted by ultrasound-assisted extraction (UAE) with ethanol as solvent, and antioxidant activity was expressed as quercetin equivalents (mg QE/g extract). The seed extract showed an antioxidant value of 8.680 mg QE/g, while the fruit extract exhibited 8.626 mg QE/g. The statistical analysis showed that the p-value was greater than 0.05, indicating no significant difference between the two extracts. This suggests that both extracts exhibit comparable antioxidant activity. These results highlight that both seeds and fruit of M. charantia may serve as promising natural antioxidant sources for functional food and pharmaceutical applications.
Effectiveness of Ethanol Extract Dosage of Arabian Bidara Leaf (Zizphus spina-christi (L.) Desf.) on Reduction of Hypercholesterolemia in Mus musculus Valenata, Valenata; Patricia, Gaby Ayu; Ngibad, Khoirul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1449

Abstract

Hypercholesterolemia is one of the main risk factors for cardiovascular disease, which is characterized by increased cholesterol levels in the blood. The leaves of Ziziphus spina-christi (Arabian bidara) are known to contain flavonoids, saponins, tannins, and alkaloids that have the potential to provide antihypercholesterolemia effects. This study aimed to evaluate the effectiveness of ethanol extract of Z. spina-christi leaves on the reduction of total cholesterol in hypercholesterolemia mice. Extraction is carried out by the maceration method using 96% ethanol and produces a yield of 3.8%. A total of 36 male mice were divided into six groups (n=6): negative control, positive control (propylthiouracil induction), drug control (simvastatin), and three extract treatment groups with doses of 14, 28, and 56 mg/20 g BB. The treatment was given orally for four days, then cholesterol levels were analyzed using the enzymatic method CHOD-PAP. The results showed that the positive control cholesterol levels increased significantly (189.3 ± 6.2 mg/dL) compared to the negative control (112.7 ± 10.3 mg/dL). The administration of the extract lowered cholesterol levels gradually: 170.4 ± 6.3 mg/dL (10%), 159.6 ± 7.6 mg/dL (15.7%), and 147.3 ± 11.7 mg/dL (22.2%). Simvastatin decreased more (117.7 ± 12.5 mg/dL; 37.8%). It was concluded that bidara arabic leaf extract has antihypercholesterolemia potential with a multifactorial mechanism, although its effectiveness is lower than that of simvastatin.
Optimization of HPMC Concentration in Psidium guajava Leaf Extract Floating Tablets Achmad, Nurafni Annisa; Nasir, Ardiansyah Jumaedi; Sapra, Amriani; Khairi, Nur; Ali, Nurul Ulfah
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1639

Abstract

Psidium guajava L. leaves have been empirically used in traditional medicine due to their flavonoid content, which exhibits antibacterial and anti-ulcer activities. A floating drug delivery system is intended to prolong gastric residence time and thereby enhance therapeutic effectiveness in the treatment of gastric ulcers. This study aimed to investigate the effect of varying concentrations of hydroxypropyl methylcellulose (HPMC) on the physical characteristics of floating tablets containing Psidium guajava leaf extract. The leaf extract, at a dose of 350 mg, was formulated into floating tablets using three HPMC concentrations: 10% (F1), 20% (F2), and 30% (F3). The tablets were evaluated for weight uniformity, hardness, friability, disintegration time, and floating properties. The results showed that all formulations complied with pharmacopeial requirements for weight uniformity, hardness (10-20 kg), friability (<1%), and disintegration time (<60 min). However, formulation F1 exhibited a longer floating lag time of 7200 s and failed to meet the floating ability criterion. Increasing HPMC concentration significantly affected tablet hardness, friability, and floating properties (p < 0.05). Formulation F2 demonstrated the most favorable characteristics, with hardness of 10.61 kg, friability of 0.69%, floating lag time of 60 s, and floating duration >12 h. In conclusion, HPMC concentration significantly influenced the physical and floating properties of Psidium guajava leaf extract floating tablets, with a 20% HPMC concentration providing the most optimal formulation characteristics.

Page 9 of 9 | Total Record : 86

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