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Unit Redaksi IJPE, Gedung FOK, Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Jln. Jenderal Sudirman No. 06, Kota Tengah, Kota Gorontalo, 96128, Gorontalo, Indonesia. Surat Elektronik : redaksiijpe@ung.ac.id Telf/Fax : 0435-821698 / 0435-821698 Phone (Whatshaap) : +6281547458537
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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
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Search results for , issue "Vol 4, No 3 (2024): September-Desember 2024" : 9 Documents clear
Penetapan Kadar Vitamin C dan Aktivitas Antioksidan Hasil Perasan Buah Jambu Biji Kristal Melinda, Reni; Sartika Daulay, Anny; Ridwanto, Ridwanto; Amin Nasution, Muhammad
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28891

Abstract

Vitamin C or ascorbic acid, is a type of water-soluble vitamin derived from hexose. Ascorbic acid contains a chromophore group, which is sensitive to light or forms of electromagnetic radiation. In addition, ascorbic acid functions as an antioxidant and protector against free radicals. Vitamin C is an antioxidant vitamin that can ward off various extracellular free radicals. This antioxidant property comes from the -OH groups number 2 and 3 which are bound to the C atom with a conjugated double bond so that they can donate hydrogen ions to various oxidant compounds, such as free radicals. This study aims to determine the content of secondary metabolites from crystal guava juice (psidium guajava L.), to determine the levels of Vitamin C (psidium guajava L.), and to conduct antioxidant activity tests on crystal guava juice (psidium guajava L.). The stages of this study include sample processing, phytochemical screening, qualitative analysis examination, determining vitamin C levels and determining antioxidant activity using the DPPH method with a UV-Vis spectrophotometer. The results of the study showed that the levels of vitamin C in the squeezed crystal guava flesh were 0.59441 ± 0.00032 mg/g and in the squeezed crystal guava seeds 0.32062 ± 0.00064 mg/g. While the antioxidant activity with the IC50 results of the squeezed crystal guava flesh was 3751.3274 µg/mL in the squeezed crystal guava seeds 2785.2941 µg/mL and as a comparison, vitamin C with IC50 was 4.2539 µg/mL. It can be concluded that the levels of vitamin C in the squeezed crystal guava flesh were higher than in the squeezed crystal guava seeds. The strength of the antioxidant activity was very weak because the sample used was a squeeze obtained by filtering using flannel cloth.
Profil dan Potensi Antikanker Ekstrak Etanol 96% Temu Giring (Curcuma heyneana) Pada Sel MCF-7 Misgiati, Misgiati; Andini, Andini; In Oktavia, Anggraeni; Rosyidah, A’liyatur
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28163

Abstract

The use of natural ingredients for cancer treatment is something that needs to be considered to obtain treatment according to the right molecular target cells with high selectivity with minimal side effects. Temu giring (Curcuma heyneana) has the highest antioxidant activity among the rhizome groups; the content of secondary metabolites is polyphenols and flavonoids. There was a correlation between antioxidant activity and cancer activity. The aim of this study was to examine the profile and anticancer activity of MCF-7 cells treated with a 96% ethanol extract of temu giring. Extraction using the maceration method. The profile of temu giring extract uses chemical reactions and thin layer chromatography. Anticancer testing using the Microculture Tetrazolium Technique assay method. Testing using MCF-7 cells with extract concentrations of 400µL, 200µL, 100µL, 50µL, and 25µL. Extract yield: 5.17%. Secondary metabolites in turmeric extract are flavonoids, terpenoids, polyphenols, and anthraquinones. The metabolites have the ability to inhibit MCF-7 cells. The anticancer potential of MCF-7 cells with IC50 60.38±9.03µL (strong cytotoxicity).
Studi Penggunaan Antidislipidemia Pada Pasien Stroke Iskemik (Penelitian dilakukan di RSUD R.T. Notopuro Sidoarjo) Ilfi Hanna, Az Zahra; Hasmono, Didik; Issaura, Issaura; Syifa, Nailis
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.29326

Abstract

Stroke is a neurologic deficit resulting from damage to the brain due to disruption of blood flow that occurs suddenly and rapidly. 87% of strokes are ischemic strokes, caused by a lack of oxygen supply to the brain due to embolism, thrombus or atherosclerosis. Blockage of blood flow will disrupt cell function accompanied by necrosis which can then lead to infarction. Antidyslipidemia is given to all ischemic stroke patients as secondary therapy and prevention of recurrent stroke. The use of Antidyslipidemia in ischemic stroke patients improves lipid abnormalities, reduces the occurrence of coronary heart disease, and improves clinical outcomes. This study aim to describe the use pattern of antidyslipidemia in ischemic stroke patients at RSUD R.T. Notopuro Sidoarjo. The type of this research is observational research with retrospective data collection method for the period October 2023 - December 2023 and then analyzed descriptively. The pattern of antidyslipidemia use is a single use pattern, as many as 78 patterns (99%). The most common single use pattern was given atorvastatin (1 x 20 mg) as many as 66 patients (86%). The combination usage pattern given was atorvastatin (1 x 20 mg) po + fenofibrate (1 x 300 mg). The switching use pattern of atorvastatin (1 x 40 mg)po atorvastatin (1 x 20 mg)po was given to 1 patient.
Uji Aktifitas Antioksidan, flavonoid Total dan Formulasi Sediaan Krim Ekstrak Bangle (Zingiber cassumunar) Lailiyah, Munifatul; Andika Saputra, Sony; Aryantini, Dyah
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28181

Abstract

Bangle rhizome (Zingiber cassumunar) is a plant with essential oil, flavonoid, and curcumin content which is efficacious as a traditional medicine and has antioxidant activity. The purpose of this study was to determine the antioxidant activity and test the total flavonoid content contained in the rhizome extract (Zingiber cassumunar) using UV-Vis spectrophotometry. Then a cream preparation was made and tested for physical quality including, organoleptic, homogeneity, pH, adhesive power, and spreadability. The extraction method uses the maceration method of bangle rhizomes (Zingiber cassumunar) using an alcohol solvent until a thick extract is obtained, then a quantitative test is carried out for the content of total flavonoid compounds in the form of determining total flavonoid levels and free radical scavenging activity using the DPPH method. The results showed that the bangle rhizome extract (Zingiber cassumunar) had a yield value of 26.25%. The extract of bangle rhizome (Zingiber cassumunar) has a total flavonoid value of 86.7±0.4 mg QE/g extract, which means it contains high flavonoid compounds and has an IC50 value of 48.29±7.9 (µg/mL) with a powerful category. The physical quality test of the three formulations meets the criteria for physical quality test requirements. The total flavonoid compound content value in the 96% ethanol extract of bangle rhizome (Zingiber cassumunar) is 86.7 mg QE / g extract which means it contains high flavonoid compounds. The IC50 value of the 96% ethanol extract of bangle rhizome (Zingiber cassumunar) is 48.29µg/mL which means it has extreme free radical scavenging activity. Formulations, 1, 2, and 3 meet the physical quality test.
Probabilitas Side Effects of Herbal Medicine di Kota Gorontalo Tuloli, Teti Sutriyati; Madania, Madania; Tungadi, Robert; Sapiun, Zulfiayu
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.27733

Abstract

The probability of side effects of herbal medicine refers to the negative or undesirable impacts that may arise after consuming products made from natural ingredients or plants. This can include various physical reactions, health issues, or unwanted disorders, ranging from mild to severe. It's important to remember that while herbal medicines are often seen as a more natural option, they still have the potential to cause side effects, just like synthetic drugs. The aim of this research is to identify the probability of side effects of herbal medicine. This research is an observational study with a quantitative descriptive research design using a cross-sectional approach. This research method uses the Naranjo Algorithm. The results indicate that based on the assessment of the causality of ADRs, the outcomes obtained are possible (82.47%), probable (10.31%), and doubtful (7.22%).
Formulation of an Antibacterial Peel-Off Gel Mask from Kombucha Fermented with Gerga Orange Peel Infusion (Citrus x aurantium L.) Joevanda, Salsabila; Salsabilla, Navira; Qiftiah, Mariatul; Sani K, Fathnur; Sukmadani Rusdi, Mesa; Efendi, M. Rifqi
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28769

Abstract

Kombucha fermentation transforms complex organic compounds into beneficial substances such as polyphenols, vitamins, minerals, fiber, and probiotics. Gerga orange (Citrus x aurantium L.) peel, rich in bioactive compounds with antibacterial potential, is a promising substrate for kombucha fermentation. This study aimed to develop a fermented kombucha infusion from Gerga orange peel for use in an antibacterial peel-off gel mask and to assess the impact of hydroxypropyl methylcellulose (HPMC) concentrations (2%, 3%, and 4%) on the mask's properties. Extract preparation, organoleptic evaluation, total phenolic content (TPC) analysis, and gel mask formulation were conducted. Antibacterial activity was evaluated against Propionibacterium acnes using the well-diffusion method. Kombucha fermentation increased the TPC of Gerga orange peel infusion (26.53 mgGAE/g vs 25.77 mgGAE/g), imparted a fermentation aroma, and reduced pH from 4 to 2.7. HPMC concentration significantly influenced gel texture, spreadability, drying time, and pH, while color, aroma, and homogeneity remained unaffected. Antibacterial tests showed moderate activity for Formula 1 (2% HPMC; inhibition zone: 9.25 ± 0.35 mm). Stronger antibacterial effects were observed in Formulas 2 (3% HPMC; 13.93 ± 0.49 mm) and 3 (4% HPMC; 14.25 ± 0.71 mm). Kombucha fermentation of Gerga orange peel offers an innovative method for creating antibacterial gel masks. Higher HPMC concentrations improve antibacterial efficacy and physical properties, demonstrating potential against Propionibacterium acnes.
Efektivitas Serum Anti Acne dari Limbah Kulit Durian (Durio Zibethinus Murr.) dengan Pengujian Berbagai Bakteri Saputra, Sony Andika; Lailiyah, Munifatul; Mu'arofah, Binti
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28254

Abstract

Durian skin waste contains flavonoid compounds, triterpenoid tannins and alkaloids which have anti-bacterial activity that causes acne. This research aims to determine the characteristics of the anti-acne serum preparation formula from durian (Durio Zibethinus Murr) skin waste, the anti-bacterial activity and the stability of the preparation. The research method was preceded by making simplicia powder for the inner skin, which was then extracted using the maceration method with 96% ethanol solvent. The extract obtained was used as a preparation formula with concentrations of 5, 10 and 15%. The serum preparations obtained were evaluated for physical quality, tested for antibacterial activity and product stability during storage as well as freeze and thaw tests. The organoleptic results showed that the higher the concentration of the extract in the brown preparation, the homogeneity test showed that the serum was homogeneous. The pH test before and freeze and thaw test was found to be 5.45-5.87 and the pH was 5.20-5.74. The spreadability test before and after the freeze and thaw test was 8.15-8.88 cm and 7.78-8.4 cm. The anti-bacterial test showed that at a concentration of 15% in the serum preparation formulation the results were the same as the positive control with the MIC (MIC) value. Minimum Barrier) with P.acne, Staphylococcus aureus, Pseudomonas bacteria with barrier values of 18 mm, 18 and 15 mm. Based on the research results, it can be concluded that the durian skin extract serum preparation has good quality characteristics and has activity against acne-causing bacteria.
Toksisitas Ekstrak N-heksan Daun Momordica charantia Terhadap Mortalitas Cacing Ascaris suum Rosalind Angkawidjaja, Valerie; Adrianto, Hebert; Darmanto, Arief Gunawan
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.24852

Abstract

The relatively high rate of helminth infections in Indonesia has prompted scientists to explore the potential of plants as natural anthelmintics, aiming to replace synthetic options that are known to have side effects. This study aims to determine the potential of n-hexane extract from Momordica charantia leaves to cause mortality in Ascaris suum. This research is an experimental laboratory using post-test only control group design. There were seven treatment groups in this study, namely 2,500 ppm, 5,000 ppm, 10,000 ppm, 15,000 ppm, and 20,000 ppm of n-hexane extract of Momordica charantia leaves, a negative control group containing 0.9% NaCl, and a positive control group containing 8,000 ppm albendazole. Ascaris suum is obtained from pig intestines. Ascaris suum was incubated for 24 hours at 37oC. Data analysis was done using the pearson correlation and probit analysis. The extract causes Ascaris suum mortality with LC99 of extract = 23,940 ppm. Ascaris suum mortality with high concentration was strongly correlated (Sig. (2-tailed) 0.971). n-hexane extract from Momordica charantia leaves has the potential to cause Ascaris suum mortality.
Formulasi dan Uji Mutu Fisik Sediaan Krim Ekstrak Etanol 96% Rimpang Kunyit sebagai Kandidat Penyembuh Luka Maria Ulfa, Ana
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.30833

Abstract

The use of traditional medicine has become widespread and deeply rooted in various cultures. One of the medicinal plants commonly used for wound healing is turmeric (Curcuma longa). This study aims to formulate and develop a topical cream from the 96% ethanol extract of turmeric rhizome as a wound healer by conducting phytochemical screening and evaluating the stability of the cream preparation. Phytochemical analysis confirmed the presence of active compounds such as alkaloids, flavonoids, saponins, and tannins, which contribute to anti-inflammatory and wound-healing properties. The homogeneity test showed that the cream was uniform, with a distinctive turmeric aroma. The pH value was 5, which aligns with the safe range for skin applications (4.5–6.5). However, the spreadability test result was 3 cm, which is below the standard range of 5–7 cm, indicating that further optimization is needed. In conclusion, the formulated turmeric cream meets several quality standards but requires improvements in formulation, particularly in enhancing its spreadability by optimizing additional ingredients to achieve better performance.

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