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Unit Redaksi IJPE, Gedung FOK, Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Jln. Jenderal Sudirman No. 06, Kota Tengah, Kota Gorontalo, 96128, Gorontalo, Indonesia. Surat Elektronik : redaksiijpe@ung.ac.id Telf/Fax : 0435-821698 / 0435-821698 Phone (Whatshaap) : +6281547458537
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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 142 Documents
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Pengaruh Puasa Ramadhan Terhadap Tekanan Darah Dan Profil Lipid Pada Pasien Hipertensi Studi Kasus : Denpasar Selatan I Wayan Happy Candra Dinata; Dhiancinantyan Windydaca Brata Putri; Gusti Ngurah Agung Windra Wartana Putra; I Gusti Ngurah Mayun
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.21914

Abstract

Hypertension is the most common cardiovascular disease in society. Management of hypertension can be pharmacological and non-pharmacological. One of the nonpharmacological therapies for hypertension is fasting therapy. Ramadan fasting is fasting that is obligatory for Muslims and has been set in the month of Ramadan for one month (29 or 30 days). Fasting changes a person's eating and drinking patterns which affect the body's metabolism which results in increased production of angiotensinogen which impacts blood pressure and increases in High-density Lipoprotein cholesterol. The purpose of this study was to determine the effect of Ramadan fasting on blood pressure and lipid profiles in hypertensive patients. This study used a pre-experimental research design with the One Group Pretest-Posttest model. The sampling method used non-probability sampling with purposive sampling technique. Measurements were taken before the fasting month of Ramadan and one month of fasting. Data analysis using the Wilcoxon test. The results of the study in the form of systolic and diastolic blood pressure before fasting with one month of Ramadan fasting, the mean ± SD respectively were 145 ± 17.45 p-value (0.001); 87.70 ± 9.82 p-value (0.001). For lipid profiles (cholesterol, triglycerides, HDL, LDL) before fasting with one month of Ramadan fasting, the mean ± SD respectively were 181.60 ± 26.63 p-value (0.001); 113.65 ± 43.91 p-value (0.001); 53 ± 7.71) p-value (0.001); 116.30 ± 18.38 p-value (0.001). This study concluded that there was a decrease in systolic and diastolic blood pressure, and an improvement in fasting lipid profile levels during Ramadan fasting in hypertensive patients.
Gambaran Kualitas Hidup Pasien Diabetes Melitus Menggunakan Instrumen DQLCTQ Studi Kasus : Puskesmas X Kota Pontianak Yuda Pratama K; Muhammad Akib Yuswar; Fajar Nugraha
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.19362

Abstract

Diabetes Mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia and abnormalities in carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. In Indonesia, the prevalence of DM is around 4.8%, for the Pontianak City area, DM is included in the top 10 diseases that dominate throughout 2019, which ranges from 12,913 cases. The purpose of this study was to describe the quality of life and characteristics of DM patients using the DQLCTQ. This research is a prospective study, using the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ) questionnaire which consists of several questions that will be filled in by patients suffering from DM at the X Health Center, Pontianak City. The results showed that the quality of life of DM patients at X Health Center was still low, namely 50.98% of patients. This result is due to various factors such as gender, age, education, marital status and occupation. The conclusion from this study is that some DM sufferers at the X Health Center, Pontianak City are still lacking in implementing a healthy lifestyle so that the value of their quality of life is still low.
Uji Aktivitas Antioksidan Gummy Candy Ekstrak Daun Sirih Cina (Peperomia pellucida L. Kunth) dengan Metode DPPH Ni Putu Putri Cahya Anggreni; Ni Putu Refina Dharma Yanti; Kadek Ayu Puspa Pratiwi; Ni Nyoman Wahyu Udayani
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.22117

Abstract

The body's defense that functions to neutralize free radicals is antioxidants. The Peperomia pellucida is a medicinal plant that has secondary metabolite compounds such as alkaloids, flavonoids, saponins, tannins and steroids. Antioxidants in Chinese betel plants are associated with the prevention and treatment of several diseases. The aim of this research was to determine the antioxidant activity contained in Peperomia pellucida and Peperomia pellucida gummy candy preparations. This research uses the main ingredient of peperomia pellucida obtained from the Jembrana district, Bali province. The total weight of the extract obtained was 30 grams. Then the materials used are peperomia pellucida extract gummy candy, DPPH powder, 96% ethanol, chloroform, ammonia, H2SO4, Dragendorf reagent, concentrated HCL, magnesium powder, CH3COOH, iron (III) chloride, distilled water. This research uses the DPPH method in antioxidant testing and phytochemical screening testing in testing peperomia pellucida extract. The results of the phytochemical screening test for peperomia pellucida extract showed positive results in the alkaloid, flavonoid, steroid, saponin and tannin tests. In the results of the antioxidant activity test using the DPPH method, the antioxidant activity results of Chinese betel extract showed an IC50 value of 564,062 ppm. Gummy candy peperomia pellucida extract 100mg/kgBB showed an IC50 value of 904,342 ppm. In gummy candy, peperomia pellucida extract 200mg/kgBB showed an IC50 value of 381.205 ppm. And gummy candy peperomia pellucida extract 400mg/kgBB showed an IC50 value of 347,227 ppm. Based on the research results obtained, it can be said that the IC50 value is very weak. This can be seen from the IC50 value 200 ppm. Based on the results of research, from Chinese betel extract, gummy candy Chinese betel extract doses of 100mg/kgBB, 200mg/kgBB, and 400mg/kgBB which contain the best antioxidants, which are found in gummy candy formula 200 mg/kgBB with results of 347,227 ppm.
Formulasi Gel Ekstrak Buah Tomat (Solanum lycopersicum L.) dengan Variasi Konsentrasi HPMC serta Uji Fisiknya Ilmiyah Setiani; Nur Cholis Endriyatno
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.21186

Abstract

Tomato (Solanum lycopersicum L.) has sunscreen activity because it contains flavonoids and lycopene. At a concentration of 10% tomato fruit extract is photoprotection. Gels can increase the effectiveness and comfort in its use. HPMC selected gelling agent because it produces good physical properties. The purpose of this study was to determine the effect of the concentration of HPMC as a gelling agent on physical properties and formulate a gel preparation of tomato fruit extract. This type of research is experimental, made of three formulas with varying concentrations of 2%, 4%, and 6%. The data obtained were analyzed using One Way Anova with a 95% confidence level. The results showed that the use of HPMC as a gelling agent affected pH, viscosity, adhesion, and spreadability but had no effect on other physical tests. The best formula was produced by formula II with a 2% HPMC concentration with the best physical properties.
Efektivitas Emulsi Ekstrak Rimpang Temulawak Sebagai Amara pada Mencit dengan Teknologi Potrtable Surya Permana; Wildan Wildan; Santi Santi; Nelly Fitriani
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.22409

Abstract

Temulawak rhizome (Curcuma xanthorrhiza Roxb.) is a plant that can increase appetite. The purpose of this study was to determine the concentration of the most effective emulsion working as amara in white male mice (Mus musculus). This study uses a sample extract Temulawak rhizomes (Curcuma xanthorrhiza Roxb.) at concentrations of 10%, 20%, and 30% were emulsified by testing the parameter requirements for evaluating emulsion preparations and their effectiveness as amara against white male mice (Mus musculus) by oral administration and positive control using Curvit syrup and aquadest as negative controls. The results of the physical evaluation of emulsion preparations included organoleptic tests, homogeneity tests, pH tests, viscosity tests and emulsion type tests. Tests for weight gain resulted in the difference between initial body weight and body weight after treatment for 21 days with an average of 1.6 grams at a concentration of 10%, a concentration of  20% of 2.2 grams, and a concentration of 30% of 4.2 grams. Based on statistical tests using one-way ANOVA and post-hoc tests, it can be concluded that the emulsion preparations extract temulawak rhizome (Curcuma xanthorrhiza Roxb.) has amara effectiveness at concentrations of 10%, 20%, and 30%, and at a concentration of 30% the greatest increase in body weight.
Monitoring Efek Samping Obat Antituberkulosis terhadap Pasien Tuberkulosis Paru di Rumah Sakit X Malang Sindi Wahyu Arianti; Agung Permata; Novyananda Salmasfattah; Magdalena Tania Tnesi
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.22194

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis which spreads through the air and can be a major cause of poor health and is even one of the main causes of death throughout the world. The recommended treatment for TB is the use of antibiotics, but some patients experience side effects, both severe and mild. Patients diagnosed with pulmonary TB at X Hospital Malang who experienced pharmacological side effects based on medical record data will be used in this study. There will be 55 pulmonary TB patients in 2022 at X Hospital in Malang. Patients who were more likely to contract TB in this study were men (54.5%) with a maximum age range of 60 years (29.1%), and the most frequent impact was shortness of breath (43.6%). Meanwhile, the number of patients who did not experience side effects was 7.2%. Other effects that often occur are reduced appetite, nausea and coughing. Therefore, side effects that occur when using OAT, both frequent and rare effects, still need to be watched out for by health workers. This needs to be done so that the side effects that occur can be minimized and patient compliance also increases because of the minimal side effects experienced.
Perbaikan Profil Lipid pada Masyarakat Muslim Hiperlipidemia dengan Puasa Ramadhan di Denpasar Selatan Ni Putu Juli Martasari; Dhiancinantyan Windydaca Brata Putri; I Gusti Lanang Made Rudiartha; Putu Yudhistira Budhi Setiawan
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.21913

Abstract

Ramadan fasting is an activity to refrain from eating and drinking, which is very beneficial for health, one of which is in improving lipid profile levels that are disturbed or commonly called hyperlipidemia because fasting can reduce saturated fatty acid intake, increase fiber intake, reduce carbohydrate and alcohol intake. Hyperlipidemia is a lipid metabolism disorder characterized by an increase or decrease in lipid fraction levels in plasma such as an increase in total cholesterol, LDL, and triglyceride levels and a decrease in HDL levels. This study aims to determine the effect of Ramadan fasting on the lipid profile of hyperlipidemia patients in the Kepaon Islamic village community. This research is a quantitative study, with a pre-experimental research design using the One Group Pretest-Posttest model with purposive sampling taking. The examination includes total cholesterol, LDL, HDL, and triglycerides before and one month after fasting. The results of this study showed significant changes in the form of decreases in total cholesterol, triglycerides, and LDL levels with average values as follows 221.60±40.59 to 189.85±19.27; 149.65±66.07 to 103.10±43.96; and 153.20±34.23 to 116.60±18.91 with a p-value significance of 0.001. And there was an increase in HDL levels with an average value of 38.55±8.89 to 57.10±13.55 with a p-value significance of 0.001. This study can be concluded that Ramadan fasting decreases total cholesterol, triglycerides, and LDL levels and increases HDL levels.
Hubungan Pengetahuan Dengan Kepatuhan Minum Obat Pada Pasien Diabetes Tipe II di RSPAD Gatot Soebroto Raihan Akbar Darmawan; Rika Revina; Retno Yulianti
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.20973

Abstract

Diabetes mellitus is a chronic disease requires a tight management. Two of the factors that facilitate medication adherence are information and knowledge. This research objective was to find the relation between diabetes knowledge and medication adherence degree of type II Diabetes Mellitus at RSPAD Gatot Soebroto. The design of this research was analytic observational with the cross-sectional method. The populations of this research were the type II DM outpatients who went to RSPAD Gatot Soebroto on May 2023 with the total of samples were 64 people. The instruments that were used to measure knowledge and the medication adherence degrees were the Diabetes Knowledge Questionnaire (DKQ-24) and the Morisky-Green Levine Medication Adherence Scale (MGLS). Respondents who have sufficient level of knowledge amounted to 53.1%. Respondents who had a moderate level of medication adherence amounted to 57.8%.  The P value obtained from the result of Somer’s d Gamma test was 0.6. These can be interpreted as no significant relation between knowledge about diabetes and medication adherence degree of Diabetes Mellitus type II at RSPAD Gatot Soebroto.
Analisa Prediksi Farmakokinetik Dan Toksisitas Efek Antikanker Payudara Pada Temulawak (Curcuma Zanthorrhiza) Secara In Silico Errol Rakhmad Noordam
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.22203

Abstract

Cancer is the main cause of death in developing countries. In Indonesia, breast cancer patients rank the most and are the first cause of death from cancer. Cancer treatment is carried out by surgery or by capturing cancer tissue which is then followed by chemotherapy but this can kill normal cells. Curcumin is the largest content in Temulawak (Curcuma zanthorrhiza). The results of docking using molegro virtual docker show that there is a protein bond with the Curcumin ligand, using a form of validation using various functional evaluations available in Sybil2, so it can be said that the docking value of Curcumin can show its anti-breast cancer effect activity.
Evaluasi Rasionalitas Penggunaan Antibiotik pada Neonatus dengan Infeksi Pneumonia Menggunakan Metode Gyssens di Rumah Sakit X Kota Bandung Charisma Juni Kristianti; Duma Turu Allo; Donn Ricky
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.22370

Abstract

Pneumonia is an inflammation of the lung tissue which is usually caused by a bacterial, viral or fungal infection. The disease can affect individuals of any age group, however, children, the elderly, and individuals with weakened immune systems are susceptible to potentially life-threatening pneumonia. Treatment therapy that is often carried out in overcoming the problem of pneumonia infection is by administering antibiotics. Inappropriate administration of antibiotics can cause less effective treatment, increase the risk of nosocomial infections, increase resistance, and side effects of drugs that are harmful to health. Rational use of antibiotics is important to avoid these negative consequences. The aim of this study was to determine the quality of antibiotic use in neonatal patients with pneumonia infections using the Gyssens method approach at Hospital Evaluation of antibiotic use was analyzed using Microsoft Excel. Retrospective design with data collection. Data analysis uses the Gyssens method flow diagram. The results showed that antibiotic use included Amikacin (15%), Amoxicillin (15%), Ampicillin (2%), Ampicillin Sulbactam (19%), Cefotaxime (19%), Ceftazidime (3%), Ceftriaxone (1%), Gentamicin(14%), Imipenem Cilastatin(1%), Meropenem(11%), Metronidazole(8%), Netilmicin(1%), Vancomycin(5%). Based on the research results, the conclusion of this study shows that the irrational use of antibiotics is a serious problem that requires immediate attention and joint action to protect the effectiveness of antibiotics and overall public health.

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