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Unit Redaksi IJPE, Gedung FOK, Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Jln. Jenderal Sudirman No. 06, Kota Tengah, Kota Gorontalo, 96128, Gorontalo, Indonesia. Surat Elektronik : redaksiijpe@ung.ac.id Telf/Fax : 0435-821698 / 0435-821698 Phone (Whatshaap) : +6281547458537
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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 142 Documents
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Uji Aktivitas Antioksidan Ekstrak Etanol Sirih Cina (Pepperomia pellucida) dengan Metode DPPH (1,1-diphenyl-2-picrylhydrazyl) Ni Putu Refina Dharma Yanti; Ni Putu Putri Cahya Anggreni; Kadek Ayu Puspa Pratiwi; Ni Nyoman Wahyu Udayani; Ketut Agus Adrianta
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.22417

Abstract

Free radicals play an important role in pathological processes and tissue damage. The pepperomia pellucida plant is often used as a traditional medicine, known to have antibacterial, anti-inflammatory, hypoglycemic, antifungal, antimicrobial, anticancer, antioxidant, antidiabetic and antihypertensive activity. Excessive free radicals can attack vulnerable compounds such as lipids and proteins which can cause various diseases. The Pepperomia pellucida plant is a plant that contains secondary metabolites such as alkaloids, flavonoids, saponins, tannins and steroids. The aim of this research was to determine the antioxidant activity of Pepperomia pellucida ethanol extract with variations of 70% and 80%. The results of the DPPH (1,1-diphenyl-2-picrylhydrazyl) ethanol extract of Pepperomia pellucida extract in the 70% variation showed IC50 = 24.50981 ppm and the 80% variation showed IC50 = 30.49915 ppm. Based on the research results of the two variations of ethanol, it was found that the best IC50 result was Pepperomia pellucida ethanol extract with a variation of 70% because it had a smaller IC50 result than the 80% ethanol variation, namely with an IC50 figure = 24.50981 ppm. The results of the phytochemical screening of the ethanol extract of pepperomia pellucida indicated positive results from several tests, namely alkaloids, flavonoids, steroids, saponins and tannins.
Penetapan Kadar Vitamin C dan Aktivitas Antioksidan Hasil Perasan Buah Jambu Biji Kristal Melinda, Reni; Sartika Daulay, Anny; Ridwanto, Ridwanto; Amin Nasution, Muhammad
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28891

Abstract

Vitamin C or ascorbic acid, is a type of water-soluble vitamin derived from hexose. Ascorbic acid contains a chromophore group, which is sensitive to light or forms of electromagnetic radiation. In addition, ascorbic acid functions as an antioxidant and protector against free radicals. Vitamin C is an antioxidant vitamin that can ward off various extracellular free radicals. This antioxidant property comes from the -OH groups number 2 and 3 which are bound to the C atom with a conjugated double bond so that they can donate hydrogen ions to various oxidant compounds, such as free radicals. This study aims to determine the content of secondary metabolites from crystal guava juice (psidium guajava L.), to determine the levels of Vitamin C (psidium guajava L.), and to conduct antioxidant activity tests on crystal guava juice (psidium guajava L.). The stages of this study include sample processing, phytochemical screening, qualitative analysis examination, determining vitamin C levels and determining antioxidant activity using the DPPH method with a UV-Vis spectrophotometer. The results of the study showed that the levels of vitamin C in the squeezed crystal guava flesh were 0.59441 ± 0.00032 mg/g and in the squeezed crystal guava seeds 0.32062 ± 0.00064 mg/g. While the antioxidant activity with the IC50 results of the squeezed crystal guava flesh was 3751.3274 µg/mL in the squeezed crystal guava seeds 2785.2941 µg/mL and as a comparison, vitamin C with IC50 was 4.2539 µg/mL. It can be concluded that the levels of vitamin C in the squeezed crystal guava flesh were higher than in the squeezed crystal guava seeds. The strength of the antioxidant activity was very weak because the sample used was a squeeze obtained by filtering using flannel cloth.
Profil dan Potensi Antikanker Ekstrak Etanol 96% Temu Giring (Curcuma heyneana) Pada Sel MCF-7 Misgiati, Misgiati; Andini, Andini; In Oktavia, Anggraeni; Rosyidah, A’liyatur
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28163

Abstract

The use of natural ingredients for cancer treatment is something that needs to be considered to obtain treatment according to the right molecular target cells with high selectivity with minimal side effects. Temu giring (Curcuma heyneana) has the highest antioxidant activity among the rhizome groups; the content of secondary metabolites is polyphenols and flavonoids. There was a correlation between antioxidant activity and cancer activity. The aim of this study was to examine the profile and anticancer activity of MCF-7 cells treated with a 96% ethanol extract of temu giring. Extraction using the maceration method. The profile of temu giring extract uses chemical reactions and thin layer chromatography. Anticancer testing using the Microculture Tetrazolium Technique assay method. Testing using MCF-7 cells with extract concentrations of 400µL, 200µL, 100µL, 50µL, and 25µL. Extract yield: 5.17%. Secondary metabolites in turmeric extract are flavonoids, terpenoids, polyphenols, and anthraquinones. The metabolites have the ability to inhibit MCF-7 cells. The anticancer potential of MCF-7 cells with IC50 60.38±9.03µL (strong cytotoxicity).
Antifungal Activity of Hair Dyes Gel from Henna Leaves and Clove Flower Jamilatun, Makhabbah; Dewi Utami, Evi; Tolkhah, Ronal
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.27246

Abstract

Henna leaves and clove flowers contain natural dyes that can be used as hair dye. Apart from that, it can also overcome dandruff problems because these plants contain antifungal activity. This study aims to determine the physical properties and antifungal activity of hair dyes gel extract from henna leaves and clove flowers. Research methods include preparing raw materials for henna leaves and clove flowers, making extracts of henna leaves and clove flowers, hair dyes gel formulation, physical properties testing, and antifungal activity testing. The hair dyes gel consists of 4 formulas, with a ratio of henna leaves and clove flowers in F0 without extract, F1 (10%: 2%), F2 (20%: 4%), and F3 (30%: 6%). Test parameters include physical properties tests which include organoleptic tests, homogeneity tests, pH tests, adhesion tests, coloring effectiveness tests, and antifungal activity tests against Candida albicans. The results of the physical properties test of the hair dyes gel showed that the combination of henna leaves extract and clove flowers can be used as a natural hair dye.  The results of the hair dyes gel inhibition test at F0 was 12.77 mm, F1 was 25.97 mm, F2 was 29.80 mm, and F3 was 32.68 mm. The gel formula that provides the best color was F3, which provides the most striking color, namely dark brown, and offers antifungal activity of 32.68 mm, with a very strong category.
Studi Penggunaan Antidislipidemia Pada Pasien Stroke Iskemik (Penelitian dilakukan di RSUD R.T. Notopuro Sidoarjo) Ilfi Hanna, Az Zahra; Hasmono, Didik; Issaura, Issaura; Syifa, Nailis
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.29326

Abstract

Stroke is a neurologic deficit resulting from damage to the brain due to disruption of blood flow that occurs suddenly and rapidly. 87% of strokes are ischemic strokes, caused by a lack of oxygen supply to the brain due to embolism, thrombus or atherosclerosis. Blockage of blood flow will disrupt cell function accompanied by necrosis which can then lead to infarction. Antidyslipidemia is given to all ischemic stroke patients as secondary therapy and prevention of recurrent stroke. The use of Antidyslipidemia in ischemic stroke patients improves lipid abnormalities, reduces the occurrence of coronary heart disease, and improves clinical outcomes. This study aim to describe the use pattern of antidyslipidemia in ischemic stroke patients at RSUD R.T. Notopuro Sidoarjo. The type of this research is observational research with retrospective data collection method for the period October 2023 - December 2023 and then analyzed descriptively. The pattern of antidyslipidemia use is a single use pattern, as many as 78 patterns (99%). The most common single use pattern was given atorvastatin (1 x 20 mg) as many as 66 patients (86%). The combination usage pattern given was atorvastatin (1 x 20 mg) po + fenofibrate (1 x 300 mg). The switching use pattern of atorvastatin (1 x 40 mg)po atorvastatin (1 x 20 mg)po was given to 1 patient.
Uji Aktifitas Antioksidan, flavonoid Total dan Formulasi Sediaan Krim Ekstrak Bangle (Zingiber cassumunar) Lailiyah, Munifatul; Andika Saputra, Sony; Aryantini, Dyah
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28181

Abstract

Bangle rhizome (Zingiber cassumunar) is a plant with essential oil, flavonoid, and curcumin content which is efficacious as a traditional medicine and has antioxidant activity. The purpose of this study was to determine the antioxidant activity and test the total flavonoid content contained in the rhizome extract (Zingiber cassumunar) using UV-Vis spectrophotometry. Then a cream preparation was made and tested for physical quality including, organoleptic, homogeneity, pH, adhesive power, and spreadability. The extraction method uses the maceration method of bangle rhizomes (Zingiber cassumunar) using an alcohol solvent until a thick extract is obtained, then a quantitative test is carried out for the content of total flavonoid compounds in the form of determining total flavonoid levels and free radical scavenging activity using the DPPH method. The results showed that the bangle rhizome extract (Zingiber cassumunar) had a yield value of 26.25%. The extract of bangle rhizome (Zingiber cassumunar) has a total flavonoid value of 86.7±0.4 mg QE/g extract, which means it contains high flavonoid compounds and has an IC50 value of 48.29±7.9 (µg/mL) with a powerful category. The physical quality test of the three formulations meets the criteria for physical quality test requirements. The total flavonoid compound content value in the 96% ethanol extract of bangle rhizome (Zingiber cassumunar) is 86.7 mg QE / g extract which means it contains high flavonoid compounds. The IC50 value of the 96% ethanol extract of bangle rhizome (Zingiber cassumunar) is 48.29µg/mL which means it has extreme free radical scavenging activity. Formulations, 1, 2, and 3 meet the physical quality test.
Probabilitas Side Effects of Herbal Medicine di Kota Gorontalo Tuloli, Teti Sutriyati; Madania, Madania; Tungadi, Robert; Sapiun, Zulfiayu
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.27733

Abstract

The probability of side effects of herbal medicine refers to the negative or undesirable impacts that may arise after consuming products made from natural ingredients or plants. This can include various physical reactions, health issues, or unwanted disorders, ranging from mild to severe. It's important to remember that while herbal medicines are often seen as a more natural option, they still have the potential to cause side effects, just like synthetic drugs. The aim of this research is to identify the probability of side effects of herbal medicine. This research is an observational study with a quantitative descriptive research design using a cross-sectional approach. This research method uses the Naranjo Algorithm. The results indicate that based on the assessment of the causality of ADRs, the outcomes obtained are possible (82.47%), probable (10.31%), and doubtful (7.22%).
Evaluation of Sunflower Seed Oil Emulgel with Carbopol 940: Physical Properties and Moisturizing Effectiveness Anggraeni, Wulan; Al-Hakim, Nur Achsan; Maharani, Nur Intan
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.29584

Abstract

Sunflower seed oil is sourced from Helianthus annuus L., which is a plant that is extremely rich in essential fatty acids and antioxidants, so it can be used as a natural moisturizer that helps prevent, reduce, and protect skin from dryness. The purpose of this study was to evaluate the effect of variations in Carbopol 940 concentration on the physical properties and moisture effectiveness of sunflower seed oil emulgel dosage forms. The formulas were made into 3 formulas, with each concentration of Carbopol 940 for each formula, namely F1 (1%), F2 (1.5%), and F3 (2%). Furthermore, organoleptic, homogeneity, pH, viscosity and spreadability tests were carried out, as well as irritation and moisture effectiveness tests. The results of statistical analysis using one-way ANOVA showed a significant difference (P 0.05) which clarified that F1 provided an optimal increase in skin moisture (50.00%) compared to F2 (42.75%) and F3 (45.55%) and had good and stable physical properties evaluation results. In addition, increasing the concentration of Carbopol 940 in F2 and F3 can increase viscosity, but this actually affects the stability of the physical properties and moisture effectiveness of the preparation. This research concluded that F1 is the best formula and this study provides important information for the development of effective and stable skin moisturizing products, with recommendations for the use of effective concentrations of Carbopol 940 in the formulation of emulgel dosage forms.
Formulation of an Antibacterial Peel-Off Gel Mask from Kombucha Fermented with Gerga Orange Peel Infusion (Citrus x aurantium L.) Joevanda, Salsabila; Salsabilla, Navira; Qiftiah, Mariatul; Sani K, Fathnur; Sukmadani Rusdi, Mesa; Efendi, M. Rifqi
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28769

Abstract

Kombucha fermentation transforms complex organic compounds into beneficial substances such as polyphenols, vitamins, minerals, fiber, and probiotics. Gerga orange (Citrus x aurantium L.) peel, rich in bioactive compounds with antibacterial potential, is a promising substrate for kombucha fermentation. This study aimed to develop a fermented kombucha infusion from Gerga orange peel for use in an antibacterial peel-off gel mask and to assess the impact of hydroxypropyl methylcellulose (HPMC) concentrations (2%, 3%, and 4%) on the mask's properties. Extract preparation, organoleptic evaluation, total phenolic content (TPC) analysis, and gel mask formulation were conducted. Antibacterial activity was evaluated against Propionibacterium acnes using the well-diffusion method. Kombucha fermentation increased the TPC of Gerga orange peel infusion (26.53 mgGAE/g vs 25.77 mgGAE/g), imparted a fermentation aroma, and reduced pH from 4 to 2.7. HPMC concentration significantly influenced gel texture, spreadability, drying time, and pH, while color, aroma, and homogeneity remained unaffected. Antibacterial tests showed moderate activity for Formula 1 (2% HPMC; inhibition zone: 9.25 ± 0.35 mm). Stronger antibacterial effects were observed in Formulas 2 (3% HPMC; 13.93 ± 0.49 mm) and 3 (4% HPMC; 14.25 ± 0.71 mm). Kombucha fermentation of Gerga orange peel offers an innovative method for creating antibacterial gel masks. Higher HPMC concentrations improve antibacterial efficacy and physical properties, demonstrating potential against Propionibacterium acnes.
Efektivitas Serum Anti Acne dari Limbah Kulit Durian (Durio Zibethinus Murr.) dengan Pengujian Berbagai Bakteri Saputra, Sony Andika; Lailiyah, Munifatul; Mu'arofah, Binti
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28254

Abstract

Durian skin waste contains flavonoid compounds, triterpenoid tannins and alkaloids which have anti-bacterial activity that causes acne. This research aims to determine the characteristics of the anti-acne serum preparation formula from durian (Durio Zibethinus Murr) skin waste, the anti-bacterial activity and the stability of the preparation. The research method was preceded by making simplicia powder for the inner skin, which was then extracted using the maceration method with 96% ethanol solvent. The extract obtained was used as a preparation formula with concentrations of 5, 10 and 15%. The serum preparations obtained were evaluated for physical quality, tested for antibacterial activity and product stability during storage as well as freeze and thaw tests. The organoleptic results showed that the higher the concentration of the extract in the brown preparation, the homogeneity test showed that the serum was homogeneous. The pH test before and freeze and thaw test was found to be 5.45-5.87 and the pH was 5.20-5.74. The spreadability test before and after the freeze and thaw test was 8.15-8.88 cm and 7.78-8.4 cm. The anti-bacterial test showed that at a concentration of 15% in the serum preparation formulation the results were the same as the positive control with the MIC (MIC) value. Minimum Barrier) with P.acne, Staphylococcus aureus, Pseudomonas bacteria with barrier values of 18 mm, 18 and 15 mm. Based on the research results, it can be concluded that the durian skin extract serum preparation has good quality characteristics and has activity against acne-causing bacteria.

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