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Unit Redaksi IJPE, Gedung FOK, Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Jln. Jenderal Sudirman No. 06, Kota Tengah, Kota Gorontalo, 96128, Gorontalo, Indonesia. Surat Elektronik : redaksiijpe@ung.ac.id Telf/Fax : 0435-821698 / 0435-821698 Phone (Whatshaap) : +6281547458537
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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 142 Documents
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Toksisitas Ekstrak N-heksan Daun Momordica charantia Terhadap Mortalitas Cacing Ascaris suum Rosalind Angkawidjaja, Valerie; Adrianto, Hebert; Darmanto, Arief Gunawan
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.24852

Abstract

The relatively high rate of helminth infections in Indonesia has prompted scientists to explore the potential of plants as natural anthelmintics, aiming to replace synthetic options that are known to have side effects. This study aims to determine the potential of n-hexane extract from Momordica charantia leaves to cause mortality in Ascaris suum. This research is an experimental laboratory using post-test only control group design. There were seven treatment groups in this study, namely 2,500 ppm, 5,000 ppm, 10,000 ppm, 15,000 ppm, and 20,000 ppm of n-hexane extract of Momordica charantia leaves, a negative control group containing 0.9% NaCl, and a positive control group containing 8,000 ppm albendazole. Ascaris suum is obtained from pig intestines. Ascaris suum was incubated for 24 hours at 37oC. Data analysis was done using the pearson correlation and probit analysis. The extract causes Ascaris suum mortality with LC99 of extract = 23,940 ppm. Ascaris suum mortality with high concentration was strongly correlated (Sig. (2-tailed) 0.971). n-hexane extract from Momordica charantia leaves has the potential to cause Ascaris suum mortality.
Formulasi dan Uji Mutu Fisik Sediaan Krim Ekstrak Etanol 96% Rimpang Kunyit sebagai Kandidat Penyembuh Luka Maria Ulfa, Ana
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.30833

Abstract

The use of traditional medicine has become widespread and deeply rooted in various cultures. One of the medicinal plants commonly used for wound healing is turmeric (Curcuma longa). This study aims to formulate and develop a topical cream from the 96% ethanol extract of turmeric rhizome as a wound healer by conducting phytochemical screening and evaluating the stability of the cream preparation. Phytochemical analysis confirmed the presence of active compounds such as alkaloids, flavonoids, saponins, and tannins, which contribute to anti-inflammatory and wound-healing properties. The homogeneity test showed that the cream was uniform, with a distinctive turmeric aroma. The pH value was 5, which aligns with the safe range for skin applications (4.5–6.5). However, the spreadability test result was 3 cm, which is below the standard range of 5–7 cm, indicating that further optimization is needed. In conclusion, the formulated turmeric cream meets several quality standards but requires improvements in formulation, particularly in enhancing its spreadability by optimizing additional ingredients to achieve better performance.
In Silico Study of the Potential of Moringa oleifera Secondary Metabolites as α-Glucosidase Inhibitors Bumulo, Nuraini; Aman, La Ode; Kilo, Jafar La; La Kilo, Akram; Salimi, Yuszda K.; Arviani, Arviani
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.28749

Abstract

This study aims to evaluate the potential of Moringa oleifera secondary metabolites as inhibitors of the α-glucosidase enzyme using an in silico approach. The study employed molecular docking methods. The structure of the α-glucosidase enzyme was obtained from the Protein Data Bank (PDB ID: 3TOP), while the structures of Moringa oleifera secondary metabolites were sourced from the literature. Docking simulations were conducted using AutoDock Vina, and interaction results were analyzed using Discovery Studio. The analyzed parameters included binding affinity values and the interactions between ligands and active site residues of the enzyme. The results showed that several secondary metabolites of Moringa oleifera, such as lutein and 4-(α-L-rhamnopyranosyloxy)benzyl glucosinolate, exhibited strong binding affinity values: -10.93 kcal/mol for lutein and -10.27 kcal/mol for 4-(α-L-rhamnopyranosyloxy)benzyl glucosinolate. Benzyl glucosinolate enhanced the stability of the ligand-protein complex, demonstrating its potential as a more effective α-glucosidase inhibitor compared to acarbose, the currently used antidiabetic drug. Based on molecular docking analysis, the secondary metabolites of Moringa oleifera indicate great potential for further development as antidiabetic agents.
Quality Parameter Analysis, Antioxidant Activity, and FTIR Profile of Turmeric (Curcuma longa L.) from Medan, Sumba, and Papua Noordam, Errol Rakhmad; Rahmat, Deni; Sandhiutami, Ni Made Dwi; Yuliana, Nancy Dewi
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.30494

Abstract

Turmeric (Curcuma longa L.) has long been used as a medicinal plant because it contains bioactive compounds with various health benefits. This research aims to analyze the quality parameters, antioxidant activity and Fourier Transform Infrared (FTIR) spectrum of turmeric originating from Medan, Sumba and Papua. The water content test shows that turmeric extract from Sumba has a water content of 8.55%, better than extracts from Medan and Papua. The highest yield was found in turmeric from Sumba (18.55%). Antioxidant activity testing shows that turmeric extract from Sumba has the strongest antioxidant activity with an IC50 value of 23.74 ppm. FTIR analysis shows the presence of hydroxyl groups (O-H) in the wave number range of 3500-3200 cm⁻¹ and C-H bonds at 3000-2800 cm⁻¹ in all samples. The results of this research show that turmeric from Sumba has better quality than turmeric from Medan and Papua.
Cost-Effectiveness Analysis of Third-Generation Cephalosporin Antibiotics in the Treatment of Typhoid Fever at Tangerang Selatan General Hospital Widya Pratama, Mochammad; Winarni, Gandes; Ayu Utari, Luthfinawa
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.30254

Abstract

Typhoid fever is an acute systemic infectious disease caused by Salmonella typhi bacteria that infect through contaminated food or drink. In the treatment of typhoid fever, antibiotic therapy is needed. Third-generation cephalosporin antibiotics are antibiotics used as second-line treatment in typhoid fever. Differences in antibiotic use can increase costs incurred by patients, so a cost-effectiveness analysis is needed to determine the most effective and efficient treatment. The purpose of this study was to determine the cost effectiveness of third-generation cephalosporin antibiotics in patients with typhoid fever hospitalized in South Tangerang City Hospital in 2023. The research method in this study is descriptive method with purposive sampling technique. This research design uses a non-experimental design. This study was conducted in April-May 2024 at the South Tangerang City Hospital using secondary data in the form of medical record data and medical cost data as research instruments. The number of samples in this study were 127 samples that met the inclusion criteria. The third-generation cephalosporin antibiotics used were ceftriaxone and cefixime. Cost-effectiveness is expressed in ACER (Average Cost-Effectiveness Ratio) which is obtained from the average total direct medical costs divided by the average clinical outcome. The results showed the ACER value of cefixime Rp.767,866/day for length of hospitalization and Rp.1,122,611/day for fever-free time, ACER value of ceftriaxone Rp.711,349/day for length of hospitalization and Rp.985,726/day for fever-free time, ACER value of ceftriaxone + cefixime antibiotic combination Rp.763,054/day for length of hospitalization and Rp.1,051.146/day for fever-free time. The conclusion of this study is that the most cost-effective third-generation cephalosporin antibiotic is ceftriaxone.
Effect of Eurycoma longifolia Jack Root Extract on Sperm pH and Morphology in Nicotine-Exposed Rats Irenesia, Bimby; Afri Yati, Umaimah; Utami, Riski Dwi; Marwan, Deinike Wanita
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.30157

Abstract

Infertility is the inability of couples of childbearing age (PUS) to conceive offspring. Male infertility can be caused by several trigger factors, one of which is smoking. One of the ingredients contained in cigarettes is nicotine which can cause free radicals. As a result of free radicals, there is damage to spermatozoa DNA. The sterol and isoprenoid content in pasak bumi can prevent infertility in men. both of these ingredients are necessary for the synthesis of steroid hormones. Steroid hormones play a critical role in spermatozoa development. The objective of this study to determine the effect of administering pasak bumi root extract on the pH and sperm morphology of male Wistar rats exposed to nicotine. This research is experimental with a posttest-only control design. The research was carried out for 51 days and the analysis used was the one way anova test. In the results of the spermatozoa pH examination, there was no influence in the treatment group or control group, whereas in the morphology examination there was an influence or difference at doses of 50, 100, and 200 100 mg/kgBW with (p-value 0.05). Pasak bumi root extract (Eurycoma longifolia Jack) on the morphology of spermatozoa in male Wistar rats exposed to nicotine. In research, the pH of pasak bumi root extract (Eurycoma longifolia Jack) had no effect on the pH of spermatozoa exposed to nicotine.
Application of Fourier Transform Infrared Spectroscopy (FTIR) for Quantitative Analysis of Pharmaceutical Compounds Faturachman, Gavriel Fauzan; Ramanda, Ajeng Ayu; Maharani, Sinta; Latif, Larasati Ainun; Belo, George Arthurito Goncalves; Ayubi, Seno Grafi Al
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.23309

Abstract

Fourier Transform Infrared Spectroscopy (FTIR) is an infrared spectroscopy equipped with a Fourier transform for detection and analysis of spectral results. This method is used to qualitatively and quantitatively analyze organic and inorganic molecules with a wavenumber range of 14000 cm-1–10 cm-1. Based on these wavenumbers, the infrared region is divided into three regions, namely near infrared, mid infrared, and far infrared. The tool used in this method is an FTIR spectrophotometer whose working principle based on the interaction between the energy and the material. This method are fast, non-destructive, simple sample preparation, ease of use, using little solvent so it is environmentally friendly when compared to other HPLC and spectroscopic methods. But the sampling space in this method is relatively small so that it can block infrared rays. The research method that used is systematic literature review (SLR) from 20 research articles in national and international journals with publication years between 2005-2023. Based on the results of quantitative analysis of amoxicillin, pentoxyphylline, ciprofloxacin, diclofenac sodium, sodium ceftriaxone, ibuprofen, valsartan, and cefadroxil compounds in drugs can be analyzed using this method because they include organic compounds and are analyzed in the mid infrared. All concentrations of compounds analyzed meet the content requirements according to the Indonesian Pharmacopoeia IV Edition, which is not less than 90% and not more than 110%.
The Effect of Patikan Kebo (Euphorbia hirta) Herbal Extract on Collagen Levels in the Kidney and Heart of Fibrotic Rats Pahmi, Khairil; Rahim, Adelia Riezka; Musanip, Musanip; Sahrul Hudha, Lalu; Triani, Eva; Halim, Amran
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.28940

Abstract

Noncommunicable diseases (NCDs) are the leading cause of death worldwide. There are around 36 million deaths every year. An example of NCD, a non-communicable disease, is hypertension. Excessive consumption of sodium chloride (NaCl) is the main factor that can cause hypertension and organ fibrosis. A natural ingredient that has the potential to act as an antifibrosis agent against fibrosis is quercetin by increasing PPAR-γ expression. Based on research, one of the plants that contains quercetin is the herb of Patikan Kebo (Euphorbia hirta Linn). Collagen is a protein biomarker of fibrosis synthesized via the PPAR-γ signaling pathway. The aim of this research was to determine the organ protective effect of administration of Patikan Kebo herbal extract against renal fibrosis and heart in Wistar rats (Rattus norvegicus) induced with 1.5% NaCl. The method involved 15 male Wistar rats aged 2.5 months with a body weight of 100-150 grams, which were divided into three groups (KI: control; KII: induced by 1.5% NaCl; KIII: induced by 1.5% NaCl + Patikan Kebo extract 200 mg/kg body weight. The induction was carried out for 8 consecutive weeks. On day 56, the kidneys and heart were removed in groups I and II, while in group III the treatment with the Patikan-Kebo extract from Patikan-Kebo at a dose of 200 mg/kg body weight was continued for 28 days in Group III. Specifically, for group III, kidneys and heart were collected on day 84 after treatment with Patikan kebo extract on day 84. Collagen was stained with Giemsa stain. Data were analyzed using a Kruskal-Wallis test. The difference is considered significant if the probability value is p0.05. The result showed that there were significant differences between the control and treatment groups. Patikan Kebo extract can reduce collagen in rats with induced fibrosis with 1.5% NaCl.
Implementation of Drug Information Services at Colomadu II and Jaten II Health Centers, Karanganyar Regency Sudarwati, Vivid Latri; Peranginangin, Jason Merari; Antoro, Sutopo Edy
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.29938

Abstract

Drug Information Service (DIS) is an activity provided by pharmacists to patients. However, some aspects of DIS are often not implemented, resulting in non-compliance and failure of therapy in patients. Health center pharmacists often do not explain to patients about the side effects, interactions and contraindications of drugs. This study aims to determine the implementation of drug information services in health care facilities in two health centers in Karanganyar Regency, namely Colomadu II and Jaten II Health Centers. This study is a cross-sectional study conducted in July and August 2023 at two health centers in Karanganyar Regency, Indonesia, namely Colomadu II and Jaten II Health Centers. This study used a survey questionnaire given to patients seeking treatment at Colomadu II and Jaten II Health Centers. This study involved a total of 50 participants, with the same number of respondents from both Colomadu II and Jaten II Health Centers. The results of this study indicate that the DIS given to patients at the Health Center, in six aspects of information, namely name, preparation, dosage, use, storage, drug indications have been (100%) conveyed, but four of the ten indicators, namely contraindications, stability, side effects, and drug interactions have not been provided optimally (below 100%). that there is no significant difference in the two health centers in each variable because the p value 0.05. Based on the results of statistical analysis, it was found that there was no significant difference in the implementation of Drug Information Services between Colomadu II and Jaten II Health Centers in the implementation of PIO drug storage (p = 1.00), drug contraindications (p = 0.556), drug stability (p = 0.728), drug side effects (p = 0.222), and drug interactions (p = 0.095). This needs to be a concern for Pharmacists and pharmacy staff at the Health Center to support the safety of drug use and successful treatment.
Yellow Pumpkin Fruit Extract (Cucurbita moschata D) in Cream Preparation as a Facial Moisturizer Fauzia, Rizki Rahmah; Nafi'ah, Rahma; Widyaningsih, Hanum
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.26842

Abstract

Indonesia is a tropical country that has a fairly high exposure to sunlight, but excessive sun exposure can cause skin damage such as dry skin with prevalence of 41,2% to 99,1% in the elderly adult population  . Therefore, it is necessary to make products that function to moisturize the skin. Yellow pumpkin is an alternative ingredient that can be used as a skin moisturizer because it contains flavonoid compounds, tannins, saponins, alkaloids, and triterpenoids. The novelty in this study is that no one has researched yellow pumpkin fruit extract cream as a facial moisturizer, different measurement methods, substitution of ingredients in the formula from VCO to MCT and the addition of preservatives and fragrances. This study aims to determine the effectiveness of facial moisturizers, yellow pumpkin fruit extract creams, and the physical quality of preparations. In this study, the researcher used an experimental method. The extraction process uses a maceration method with a solvent of 96%, then a cream formula is made with a concentration of yellow pumpkin fruit extract of 5%, 10%, and 15%. The evaluation of facial moisturizing cream preparations includes organoleptis tests, homogeneity tests, pH tests, dispersion tests, adhesion tests, viscosity tests, and irritation tests. The tool used to measure skin moisture is Skin Analyzer CR-302 by looking at the percentage of moisture. The results of the effectiveness test of yellow pumpkin extract facial moisturizing cream (Cucurbita moschata D) for 28 days of use had a moisture percentage of 44.00% at an extract concentration of 5%, 48.67% at an extract concentration of 10%, and 55.00% at an extract concentration of 15%. The higher the concentration of the extract, the better the moisture level. The results of the effectiveness test of yellow pumpkin fruit extract cream preparations (Cucurbita moschata D) have effectiveness as a skin moisturizer with a sig value (0.008 0.050). The conclusion showed that the preparation of the moisturizing cream of yellow pumpkin fruit extract (Cucurbita moschata D) with the best concentration at a concentration of 15%. The preparation of the moisturizing cream of yellow pumpkin fruit extract (Cucurbita moschata D) meets the requirements of the evaluation test.

Page 13 of 15 | Total Record : 142

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