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Unit Redaksi IJPE, Gedung FOK, Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Jln. Jenderal Sudirman No. 06, Kota Tengah, Kota Gorontalo, 96128, Gorontalo, Indonesia. Surat Elektronik : redaksiijpe@ung.ac.id Telf/Fax : 0435-821698 / 0435-821698 Phone (Whatshaap) : +6281547458537
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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 142 Documents
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Pengaruh Ukuran Serbuk Simplisia dan Waktu Maserasi terhadap Aktivitas Antioksidan Ekstrak Kulit Sirsak Riska Yudhistia Asworo; Hanandayu Widwiastuti
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19906

Abstract

Secondary metabolites are one of the active substances in natural materials that are known to contain high antioxidants and are very beneficial for health. In addition to mangosteen, there are also natural ingredients that actually have high antioxidant content, but many people do not know about it, one of which is soursop fruit. In addition to the fruit, the skin of soursop fruit may contain antioxidants that are quite high. The purpose of this study was to determine the effect of different maceration times and powder sizes on the antioxidant activity of secondary metabolite compounds produced from ethanol-aquades extract of soursop fruit peel (Annona muricata L.). This study was conducted quantitatively with a descriptive research design where researchers conducted laboratory research conducted in triplo. This research used particle size variation of 50 mesh, 100 mesh, and 200 mesh and maceration time variation of 24 hours, 30 hours, 36 hours. From this study it can be seen that the difference in powder size and maceration time affects the results of antioxidant activity obtained. The optimum particle variation is using 200 mesh size, which is obtained antioxidant activity of 95.2%. While the optimum maceration time is for 24 hours, the yield is 94%. From this study it can also be seen that the ethanol-aquades extract of soursop fruit peel contains secondary metabolite compounds of triterpenoids, saponins, polyphenols and tannins.
Uji Aktivitas Antibakter Formulasi Sediaan Salep Ekstrak Daun Bidara (Ziziphus mauritania) terhadap Bakteri Staphylococcus aureus shindi pratiwi putri; Al Syahril Samsi; Israini Suriati
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19695

Abstract

Infectious diseases are the highest contributor to morbidity and mortality in developing countries, including Indonesia. This is inseparable from the many pathogenic bacteria that attack humans, causing various diseases. Infection due to Staphylococcus aureus, starting from the entry of bacteria through a wound scratch. Infection will be characterized by tissue damage accompanied by local abscesses such as boils or pimples. As an effort to prevent Staphylococcus aureus bacterial infection, antibacterial ointment preparations are needed that can prevent infection and are practical in their use. In this study, the antibacterial activity test of the ointment formulation of Bidara leaf extract (Ziziphus mauritania) was carried out with concentrations of 40%, 50% and 60% w/v. the test bacteria used was Staphylococcus aureus. This research was conducted using the agar diffusion method. The results showed that the test results for antibacterial ointment preparations with Bidara leaf extract with concentrations of 40%, 50% and 60% w/v fulfilled the results of the organoleptic evaluation test, homogeneity, spreadability test, adhesion test and pH test. The results of the ANOVA analysis showed that the formulation of Bidara leaf extract ointment (Zizyphus mauritania) with a concentration of 50% and 60% w/v had non-significant antibacterial activity with gentamicin sulfate ointment as a positive control against the growth of Staphylococcus aureus bacteria.
Activity of a Gel Combination of Aloe Vera (Aloe Vera (L) Burm.F.) and Snail Mucus (Achatina fulica (Ferussac, 1821)) on Burn Wounds in Male White Rats (Rattus norvegicus) Wistar Strains Artha Yuliana Sianipar; Andre Prayoga; Agrecia Yolanda Nainggolan
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19343

Abstract

Burn injury is produced by thermal stress on the skin tissue. This research aimed to determine the combination of Aloe vera and snail mucus used to treat burns and determine the optimal formula. The research was pure with only a randomized control design, including F1 being given placebo gel, F1 (10%:10%), F2 (10%:15%), F3 (10%:20%), and F4 being given bioplacenton. The gel evaluation and tested for the ability to treat burns on rats for about 21 days. The combination gel made a homogenous formulation with a pH 6 based on pH paper while pH meter results were around 6,27- 6,35 cm, a spread of 5,70-6,60 cm, and a viscosity value of 5.600-7.600 cps that was stable for 3 weeks of storage. This evaluation’s findings are consistent with the provisions of National Standard Indonesia (SNI). The activity optimal combination gel obtained by examining the average diameter and discoloration were 10%:20% (0,5560 cm), 10%:15% (0,8120 cm), 10%:10% (0,9860 cm), bioplacenton (0,4780 cm), and placebo gel (1,5340 cm). On the 21st day, the skin condition of K1, K2, K3, and K4 was normal, however, K0 was not normal. The statistical analysis data is normally distributed (p≥0,05), homogeneous (p≥0,05), and a significant difference in all groups (p0,05). According to the experiment, three gel combination of Aloe vera and snail mucus have an effect on healing burns but 10%:20% (F3) could accelerate the optimal healing process.
Efektivitas Gel Madu Hutan Akasia terhadap Jumlah Fibroblas pada Luka Sayat Tikus Putih (Rattus novergicus) Bimby Irenesia; puan sadila islami; riski dwi utami
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19872

Abstract

Cuts are wounds caused by sharp objects such as knives, swords, razors and glass. According to data from the Arifin Achmad Regional General Hospital, Riau Province, it was noted that the most common type of wound in sharp violence was a cut (66.7%). When a wound occurs, the wound healing process occurs, namely: inflammation, proliferation, and remodeling. During the proliferative phase, fibroblasts influence the reepithelialization process that closes the wound. Handling cuts using acacia honey because acacia honey in wound healing has anti-inflammatory, antibacterial and antioxidant activities. Knowing the effectiveness of acacia honey gel on the number of fibroblasts in white rat (Rattus novergicus) incision wounds. This type of research is an experimental study design with a randomized posttest only control group design that uses acacia honey on cuts in white rats (Rattus novergicus). There was no significant difference between each treatment group: 20% acacia honey gel, 60% acacia honey gel, 80% acacia honey gel, positive control (povidone iodine) and negative control (gel without honey). Giving acacia honey gel could not increase the number of fibroblasts in white rat (Rattus novergicus) incision wounds.
Uji Sifat Fisik pH Dan Viskositas Pada Emulsi Ekstrak Bintangur (Calophyllum soulattri Burm. F.) Tiara Bella Pratiwi; Siti Nani Nurbaeti; Meri Ropiqa; Inarah Fajriaty; Fajar Nugraha; Hadi Kurniawan
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19466

Abstract

Bintangur (Calophyllum soulattri Burm. F.) is a type of medicinal plant that has quite a lot of benefits such as antioxidant, anti-inflammatory and antibacterial, so it is important to develop it into a dosage form. Emulsions are preparations containing liquid medicinal ingredients or drug solutions dispersed in a liquid carrier. Emulsion preparations are preparations that are more easily absorbed when administered orally. Evaluation of the physical properties of the emulsion was carried out from organoleptic, pH, and viscosity parameters to produce good physical properties because they affect the resulting therapeutic effect. 150 mL of the preparation was made and evaluated for the physical properties of the organoleptic test, pH test, and viscosity test. The pH of the preparation must correspond to the pH of the oral preparation, namely 5-7, and the resulting viscosity must not be too runny or too thick because it is difficult to redisperse. The organoleptic test results of the bintangur extract emulsion had a characteristic yellow-brown color and the aroma of coconut oil with a bitter-sweet taste. The pH test results of the bintangur extract emulsion entered the range for oral preparations 5-7 with an average of 5.936 and the viscosity of the bintangur extract emulsion was 114.2 cP.
Hubungan Jumlah Peresepan Obat Terhadap Potensially Inapropriate Medications Berdasarkan Beers Criteria 2019 Pasien Diabetes Mellitus Kumala Sari Poespita Dewi Wahyuni; Esti Ambar Widyaningrum; Erni Anika Sari; Dwitania Noerhalizah
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19752

Abstract

Diabetes melitus can lead to complications if not controlled, the risk of complications in geriatric patiens can lead to an increase in the number of drugs prescribed, so that many geriatric receive polypharmacy drugs. Polypharmacy can be used as a factors to describe Potentially Inappropriate Medications. Potentially Inappropriate Medications are the potential for inappropriate drug use which causes a risk of side effects where there are alternative drug options for the same therapy. This study was to determine the number of drug prescribing for Potentially Inappropriate Medications based on the 2019 Beers Criteria. This studi was an observational descriptive study using retrospective data. The sample used was 195 prescriptions for patients with diabetes mellitus in the period October-December 2020 with purposive sampling technique. Characteristics of the data using the contingency coefficient correlation test. The number of drug prescriptions obtained, a total of 68.21% of patients received 5 kinds of drugs in one prescription based on the assessment of the incidence of Potentially Inappropriate Medications, there were 92.82% of prescriptions indicate an incidence of Potentially Inappropriate Medications. The highest number of Potentially Inappropriate Medications received was category one namely 50,38%. There are difference in the categories of Potentially Inappropriate Medications that patients receive due to diseases suffered by geriatricians where disease that affect many organs cause geriatricians to receive many drugs in health services. Based on a p-value of 0,000 there is a statistically significant relationship between the amount of drug administration with Potentially Inappropriate Medications.
Formulasi Self Nano-Emulsifying Drug Delivery System (SNEDDS) Ibuprofen dengan VCO dan Kombinasi Surfaktan Muhamad Handoyo Sahumena; Suryani Suryani
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.20405

Abstract

Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) class of propionic acid derivatives which has potent anti-inflammatory and antipyretic activity. The solubility of ibuprofen is disadvantageous because it is practically insoluble and has poor dissolution. The aim of this study was to overcome the solubility of ibuprofen through a stable SNEDDS formula. One way to overcome the solubility of ibuprofen is to prepare nanoemulsions using the Self-Emulsifying Drug Delivery System (SNEDDS) technique. SNEDDS is a form of preemulsion drug which spontaneously forms nanoemulsion when it encounters the aqueous phase in the digestive tract. Parameters for the success of the SNEDDS formula include emulsification time, stability, and droplet size using a particle size analyzer (PSA). The SNEDDS formulation was carried out by mixing span 80 and tween 20, PEG 400 and VCO as the oil phase. The characteristics of SNEDDS ibuprofen include homogeneity of SNEDDS, clarity, transmittance, emulsification time, and droplet size. The composition of the optimum formula for SNEDDS ibuprofen is 1 mL of VCO; 1 mL PEG; 7 mL tween 20; 1 mL span 80. The formula shows good homogeneity, is clear with emulsification time of 15 seconds, transmittance is 92.69%, and droplet size is 221.9 nm.
Preparasi dan Karakterisasi Sistem Pembawa Liposom dari Ekstrak Etanol Daun Miana (Coleus atropurpureus L. Benth) Muhamad Handoyo Sahumena; Suryani Suryani; Widya Pratiwi
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.20414

Abstract

Miana (Coleus atropurpureus L. Benth) is a plant in the ornamental plant group that has benefits for the body. The part of the plant that is efficacious as medicine is on the leaves with a brownish red color. However, extracts from miana leaves are hydrophilic, making it difficult to penetrate biological membranes which are rich in lipids and difficult to use topically. One way to overcome this problem is by making liposome carrier systems. Liposomes are carrier systems consisting of phospholipids and cholesterol with the ability to encapsulate hydrophilic and hydrophobic compounds. Parameters for the success of the liposome formula include vesicle shape, high adsorption efficiency and liposome vesicle size using a particle size analyzer (PSA). The liposome formula was obtained through the thin layer hydration method using phosphatidylcholine and cholesterol. The composition of the optimum liposome formula of miana leaf ethanol extract is 0.2% phosphatidylcholine and 0.4% cholesterol. The optimum formula obtained is a complex spherical structure, efficiency entrapment 92.91%, vesicle size 573.6 nm and polydispersity index is 0,505.
Tingkat Pengetahuan Pasien Rawat Inap Tentang Penggunaan Antibiotik di Rumah Sakit X Kota Palopo Indra Indra; Hurria Hurria; Suhandra Makkasau
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.20196

Abstract

Antibiotics are the drugs most widely used in infections caused by bacteria where oral route antibiotics are the first choice in infection therapy. Various studies have found that around 40-62% of antibiotics are used inappropriately, including for diseases that actually do not require antibiotics. The problem that often occurs is the lack of knowledge of inpatients about the proper use of antibiotics. This research was conducted to determine the level of knowledge of inpatients about the use of antibiotics, using a cross sectional descriptive method. Data was taken secondary through filling out a questionnaire. A total of 92 inpatients at x Hospital in Palopo City were selected as volunteers using the accidental sampling method. Data was processed using the Statistical Product and Servicer Solution (SPSS) application with the chi-square test. The results obtained from 92 respondents, as many as 16.3% of respondents had a low level of knowledge, 56.5% of respondents had a sufficient level of knowledge and 27.2% of respondents had a high level of knowledge. There is a relationship between the last level of education (p value 0.000 0.05), with the level of knowledge in using antibiotics. The conclusion of this study is that the level of knowledge of inpatients at x Hospital in Palopo City is quite adequate, namely 56.5%.
Perbandingan Perlindungan Minyak Jintan Hitam, Minyak Argan dan Minyak Zaitun terhadap Enzim Hati Tikus Akibat Diet Tinggi Lemak Liska Alfaaizin; Aryadi Arsyad; Yulia Yusrini Djabir
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.20104

Abstract

High-fat diet has become one of the risk factors of liver dysfunction due to accumulation of fat in the liver cells. This disorder might be triggered by increased reactive oxygen species (ROS) activity with high-fat consumption. This study aimed to compare protective effect of natural antioxidants black cumin oil, argan oil and olive oil on liver function in wistar rats fed with high-fat diet. Male wistar rats (n = 24) were divided into four treatment groups. Group 1 (negative control) was not given any oil treatment (0,5 ml/g bw), group 2 was given black cumin oil (0,4 ml/g bw), group 3 was given argan oil (0,5 ml/g bw) and group 4 was given olive oil (0,5 ml/g bw). All rats were fed a high-fat diet of 10 gr/day for 2 months. The analysis of liver function tests was performed before and after treatment. With high-fat diet, the negative controls had SGOT of 93.05 ± 47.91 UI/I and SGPT of 43.10 ± 14.64 UI/l.  Administration of black cumin oil markedly reduced SGOT (62.05 ± 30.67 UI/l) and SGPT levels (28.81 ± 10.60 UI/l) (P0.05). Argan oil can not reduce SGOT levels (97.92 ± 35.07 UI/l) but can reduce SGPT levels (51.67 ± 15.84 UI/l). Olive oil can not reduce SGOT levels (67.38 ± 29.31 UI/l) but can reduce SGPT levels (50.19 ± 9.70 UI/l). It was concluded that administration of black cumin is more effective to reduce SGOT and SGPT levels in rats with high-fat diet compared to argan oil and olive oil treatments.

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