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Proceeding of Mulawarman Pharmaceuticals Conferences

mpc
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Published by Universitas Mulawarman

ISSN : - EISSN : 26144778 DOI : https://doi.org/10.25026/mpc

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 612 Documents

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Sintesis 2’-Hidroksi-5’-Kloro-3,5-Dimetoksi-4-Hidroksikalkon Amanuddin Amanuddin; Hanggara Arifian; Agung Rahmadani; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Chalcone are compounds that have 2 aromatic rings connected by 3 carbon atoms which are an ?, ? unsaturated carbonyl system that have various biological activities. 2'-hydroxy-5'-chloro-3,5-dimethoxy-4-hydroxicalcone was synthesized from 2'-hydroxy-5'-chloro acetophenone and syringaldehyde using a NaOH catalyst. This compound was purified using Column Chromatography by isocratic method using n-hexane:ethyl acetate (15:1) as eluent. This compound has a Rf 0.75 and 2.7% of yield.

Pengaruh Variasi Konsentrasi Gelling Agent HEC dalam Sediaan Gel Sariawan Ekstrak Daun Sirih Hitam terhadap Sifat Fisik Gel Imelia Rosalia Libba; Fajar Prasetya; Novita Eka Kartab Putri
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Recurrent Aftose Stomatitis (RAS) or sprue is one of the most common diseases of the oral mucosa. One of the contributing factor is the infection of Streptococcus sanguinis and Candida albicans. Black betel leaf contains a group of secondary metabolites that are used as antimicrobials . Gel is a good conductive preparation on mucouse membran. One of the factors that influence the physical properties of gel is the gelling agent. The purpose of this study was to determine the effect of HEC variation as a gelling agents on the physical properties of black betel leaf extract gel. Black betel leaf extract was obtained by maceration with 70% ethanol solvent. The gel was formulated into four formula with variations in HEC consentration is 1%, 1,5%, 2% and 2,5%. The antimicrobial activity of the extracts used the diffusion method of the wells. Tests of physical properties used organoleptic tests, homogenity, pH, spreadability and viscosity. The results showed that black betel leaf extract at a concentration of 2.5% was able to inhibit Streptococcus sanguinis and Candida albicans. An increase in HEC concentration can cause increase in the viscosity and decrease in the spreadibility, but does not affect organoleptics, homogenity and pH of the preparation. The best formula produced is formula F3 with 2% HEC composition.

Karakteristik Gel Sariawan Ekstrak Daun Sirih Hitam sebagai Antimikroba dengan Variasi Konsentrasi Carbopol Karmila Puspita Sari; Jaka Fadraersada; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Betel plant is a terna plant that can be used as an antifungal, antimicrobial and antioxidant. Black betel leaf is proven to contain secondary metabolites of alkaloids, carotenoids, phenolic compounds, flavanoids, saponins, tannins, steroids, and triterpenoids. Gel preparations are used aimed at prolonging the contact time of the preparation with the target location, extending the absorption time and increasing the therapeutic effect. This study aims to determine the characteristics of gel extract of black betel leaf. Black betel leaf extract was obtained by macerating with 70% ethanol into an oral gel preparation as an antimicrobial with carbopol concentration variations. The results of antimicrobial test showed that 5% concentration of black betel leaf extract could increase the growth of Streptoccus sanguinis with inhibition zone diameter 6.261 ± 1.425mm and Candida albicans with inhibition zone diameter 5.152 ± 0.952mm. Black betel leaf extract gel formula F3 with 1.5% carbopol concentration is the best formula that has greenish black, betel and mint flavored, and has a thick and homogeneous shape. It has a viscosity of 2.266 Pa.s, has a pH of 5.37 and spread power 4.37cm.

Pengaruh Jus Buah Nanas Kombinasi Madu sebagai Penurun Tekanan Darah pada Pasien Hipertensi Lia Angelika; Nurul Annisa; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Hypertension is a disease characterized by an increase in blood pressure in systolic and diastolic blood vessels that exceeds the normal blood pressure on repeated examinations. Pineapple and honey empirically and scientifically can be efficacious for lowering blood pressure. The purpose of this study was to look at the characteristics of age, gender, smoking habits, exercise habits as well as the history of hypertension patient's disease and the effect and effectiveness of the administration of pineapple honey juice to reduce blood pressure in patients with hypertension at UPTD Tresanti Werdha Nirwana Puri Samarinda and on Jl. S.Parman 1 RT. 02 & RT. 03 Kelurahan Gunung Kelua Samarinda. The research design used was the Pretest and Posttest One Design Group, to as many as 9 patients. The study was conducted for 7 days, then every day patients were given treatment in the form of giving pineapple juice as much as 200 grams and 20 mL honey once a day and blood pressure was measured before and after treatment. The results of this study indicate a decrease in blood pressure in hypertensive patients who consume honey combination pineapple fruit juice.

Uji Aktivitas Antidiare Madu dan Kombinasi Madu dengan Infusa Daun Jambu Biji (Psidium guajava L.) terhadap Mencit Rany Silvi Mova Kalanarky; Fajar Prasetya; Nurul Annisa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diarrhea is a major cause of death in developing countries where changes in movement in the normal intestine are characterized by increased water content, volume, or frequency of bowel movements. This study aims to determine the antidiarrheal activity of honey and the combination of honey with guava leaf (Psidium guajava L.) infusion on mice. The method used is the protection method induced by Oleum Ricini. The results showed that honey 20 g / kgBB and a combination of honey 20g / kgBB with 30% Guava Leaf Infusion can provide antidiarrheal activity in mice.

Zebrafish (Danio rerio) Sebagai Model Hewan Coba pada Pengujian Aktivitas Obat Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Perkembangan metode penelitian menggunakan hewan coba sering terkendala pada aspek 3R (reduce, replace, refinement). Untuk melakukan skrining aktivitas peneliti sering dihadapkan pada pilihan menggunakan hewan coba golongan rodent dalam jumlah banyak. Sedangkan pilihan menggunakan larva udang menawarkan pilihan jenis pengujian yang terbatas. Penelitian ini bertujuan mengkaji keunggulan dan kelemahan metode uji aktivitas menggunakan model zebrafish (Danio rerio). Penelitian dilakukan secara metaanalisis menggunakan berbagai literatur yang diakses dari Pubmed, Sciencedirect, dan Google Scholar. Metode pengujian menggunakan zebrafish menunjukkan keunggulan pada pengamatan perilaku setelah pemberian bahan uji, terutama yang berkaitan dengan sistem saraf. Sedangkan untuk pengujian aktivitas terhadap jantung, pengamatan perilaku fisik kurang menunjukkan perbedaan yang berarti, namun penelusuran aktivitas terhadap otot jantung dapat dilakukan dengan metode pewarnaan histopatologi. Pengamatan molekular tersebut mampu menunjukkan kemampuan kontraksi dan relaksasi otot jantung. Pengamatan pada fungsi pengaturan tekanan darah dan fungsi sistem pencernaan juga dapat terpantau jelas jika menggunakan model zebrafish transgenik. Model zebrafish hasil rekayasa ini dapat terlihat bening sehingga ritme kerja organ dalamnya terrekam menghasilkan data pengamatan yang valid. Sehingga, untuk penelitian skrining uji aktivitas suatu bahan, penggunaan zebrafish menjadi salah satu pilihan yang tepat.

Potensi Sari Kurma (Phoenix dactylifera) sebagai Peluruh Kristal Kalsium Oksalat Secara In Vitro Wilujeng Ayu; Wisnu Cahyo Prabowo; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Dates (Phoenix dactilyfera) contain chemical compositions that can be used as traditional medicine for Calcium oxalate of kidney stone decay. Compound in palm juice can make Calcium oxalate dissolving is flavonoid and calium . The purpose of this study was to determine the effect of Palm dates juice dissolving calcium oxalate to determine the relationship between the concentration of dates palm juice with calcium solubility in kidney stones. To test its activities carried out in vitro using calcium oxalate which incubated for 3 hours with shaken out every 20 minutes at 37oC Determination of the solubility of calcium in date palm juice is by weighs insoluble calcium oxalate. Palm's juice concentration is divided into 60%, 50%, 40%, 30% and 20%. The results of these concentrations can be concluded that the juice of dates has the activity of dissolving calcium oxalate from kidney stones with average result weight in sequence 0.02 + 0.005 g; 0.02 + 0.005 g; 0.03 + 0.005 g; 0.04 + 0.005 g and 0.05 + 0.005 g. Positive control (batugin elixir) 60%, 50%,40%, 30% and 20% with in sequence result 0.08 + 0.001 g; 0.08 + 0.001 g; 0.08 + 0.005 g; 0.09 + 0.005 g; and 0.1 + 0.005 g. Negative Control result 0.11 g. The results obtained from the standard deviation are 0.031. Calcium oxalate that is not dissolved at most in the sample is 20% with an average of 0.05 + 0.005 g and the positive control is 20% of the batugine with an average of 0.1 + 0.005 g.Based on the weighing of calcium oxalate from each concentration the higher the concentration will cause the least insoluble calcium oxalate.

Kajian Literatur: Aktivitas Antibakteri Ekstrak Herba Suruhan (Peperomia pellucida L.) Ayu Rahmawatiani; Dewi Mayasari; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Suruhan (Peperomia Pellucida L.) is one of the weed plants that grow wild in humid environments. This plant is commonly found in Indonesia and has been used by the community as a medicinal plant. The secondary metabolites contained oh suruhan are saponins, phenols, flavonoids, and tannins. These compounds are thought to provide antibacterial activity. The purpose of writing this literature review is to determine the compound of secondary metabolites, the antibacterial activity of the extract, and the effective concentration as an antibacterial agent. The method used is literature review by searching journals database with the Google Scholar, PubMed, and Scient Direct. Based on the literature review, the secondary metabolites contained are flavonoids, tannins, steroids, phenols, saponins, glycosides, anterquinone, pellucidin A, stigmasterol, and fucosterol. The antibacterial activity test showed that the extract was able to inhibit gram-positive bacteria such as Bacillus subtilis, Propionibacterium acne, and Staphylococcus aureus, as well as gram-negative bacteria, such as Klebsiella pneumoniae, Shigella dysentriae, Pseudomonas aeruginosa, Pseudomonas fluoescens, Escherichia coli, and Salmonella typhi. The activity produced by gram-negative bacteria is more sensitive than gram-positive bacteria. While the effective concentrations of n-hexane extract against gram-positive and gram-negative bacteria were 10 mg/mL and 200 mg/L, the resulting inhibition zone diameters were 17.9 mm and 18 mm.

Pengaruh Pemberian Jus Buah Pepaya (Carica papaya L.) terhadap Penurunan Kadar Malondialdehid dan Asam Urat Janette Rindana Paranoan; Harra Ismi Farah; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Malondialdehyde (MDA) is a biomarker of oxidative stress due to the presence of free radicals in the body. Papaya fruit contains vitamin C and ?-carotene which are useful as antioxidants. This study aims to determine the initial description of MDA levels in urine and uric acid in smoker and non-smoker respondents and to determine changes in urinary MDA and uric acid levels after administration of papaya fruit juice (Carica papaya L). The research method used was experimental with a pre-post test design. The results obtained at the initial MDA level of urine of smokers and non-smokers were an average of 2.504 nmol / mL and 1.821 nmol / mL and the results obtained after giving the juice on day 7 were 1.455 nmol / mL and 0.992 nmol / mL . Meanwhile, the initial uric acid levels of each respondent were 9.6 mg / dL and 8.4 mg / dL and the results obtained after giving the juice on day 7 were 7.8 mg / dL and 6.8 mg / dL. . So it can be concluded that the provision of papaya fruit juice can reduce the levels of MDA in urine and uric acid.

Evaluasi Ketepatan Antipsikotik pada Pasien Skizofrenia di Instalasi Rawat Inap Rumah Sakit Jiwa Daerah Atma Husada Mahakam Samarinda Khofifah Nurwahidah Balqis; Mukti Priastomo; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Schizophrenia is a psychotic mental disorder that causes psychiatric symptoms, such as confusion in thinking, emotions, perceptions, and deviant behavior. The purpose of this study was to determine the characteristics, pattern of use of antipsychotic drugs, and evaluation of the accuracy of antipsychotics for schizophrenia patients in the inpatient installation of RSJD Atma Husada Mahakam Samarinda including the right indication, the right patient, the right drug selection, the right dose, the right frequency and the right duration. administration based on Pharmacotherapy Handbook Tenth Edition Algorithms and Formularium schizophrenia at RSJD Atma Husada Mahakam Samarinda. This type of research is observational. The data collection was done retrospectively with the sampling technique with total sampling on medical records at RSJD Atma Husada Mahakam Samarinda. The results of The most prescribed antipsychotics in schizophrenia patients was the administration of a single antipsychotic risperidone (21.51%), and the administration of a clozapine-risperidone combination antipsychotic (20.43%). Accuracy of antipiscotic use with precise parameters of indication, patient, drug selection, dose, frequency of administration and exact duration of administration based on the Pharmacotherapy Handbook Tenth Edition Algorithms and formulary at RSJD Atma Husada Mahakam Samarinda is 100% accurate from the 93 drug prescriptions studied.

Page 38 of 62 | Total Record : 612

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Home Page

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Contact Name Rolan Rusli

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Phone +6285222221907

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Editorial Address Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location Kota samarinda, Kalimantan timur INDONESIA

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Contact Name
Rolan Rusli

Contact Email
rolan@farmasi.unmul.ac.id

Phone
+6285222221907

Journal Mail Official
admin@farmasi.unmul.ac.id

Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location
Kota samarinda,

Kalimantan timur

INDONESIA