Garuda - Garba Rujukan Digital

All

Proceeding of Mulawarman Pharmaceuticals Conferences

mpc
Website

Published by Universitas Mulawarman

ISSN : - EISSN : 26144778 DOI : https://doi.org/10.25026/mpc

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 612 Documents

37 38 39 40 41

Penambatan Molekular Senyawa Metabolit Sekunder dari Daun Kelor sebagai Inhibitor Protease Utama dari SARS-CoV-2 Mayda Ariyati; Nur Masyithah; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) merupakan virus penyebab COVID-19. Salah satu kandidat target potensial dari SARS-CoV-2 ialah protease utama (Mpro). Penelitian ini bertujuan untuk mengetahui interaksi antara senyawa dari daun kelor dengan makromolekul Protease Utama SARS CoV-2 dan mengetahui senyawa yang berpotensi sebagai inhibitor Mpro secara in silico dengan studi penambatan molekuler. Struktur dari SARS CoV-2 sebagai molekul target diperoleh dari database PDB (ID: 5R84) 2-cyclohexyl-~{N}-pyridin-3-yl-ethanamidesebagai ligan alami. Analisis penambatan molekuler dilakukan dengan menggunakan AutoDockTools dengan jumlah runs 100 kali. Grid diletakkan pada ligan alami dengan ukuran kotak 40x30x34 dan center 9.812?x-0.257?x20.849? denganspacing 0.375?. Berdasarkan hasil docking dari 22 senyawa metabolit sekunder daun kelor diperoleh 17 senyawa yang memiliki nilai ikatan energy lebih rendah dari ligan alami. Senyawa Quercetin-3-o-glucoside memiliki nilai terendah sebesar -9.35 kkal/mol dibandingkan ligan alami yaitu sebesar -6.56 kkal/mol . Berdasarkan interaksi dari binding site M-pro SARS-CoV-2, senyawa niazimin memiliki interaksi yang mirip dengan ligan alami. Bentuk interaksi yang terjadi adalah adanya ikatan hydrogen dengan residu HIS41, MET49, MET165, CYS145, GLU166, HIS163. Hasil ini menunjukkan bahwa senyawa metabolit sekunder dari daun kelor memiliki aktivitas dalam menghambat protease utama SARS-CoV-2. Tetapi perlu dilakukan perbandingan dengan makromolekul lain.

Upaya Deklorofilisasi Ektrak Etanol Daun Kokang (Lepisanthes amoena) Alexander Mansyuria; Hajrah Hajrah; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Daun kokang (Lapisanthes amoena L) secara empiris digunakan sebagai pembersih tubuh dan wajah oleh masyarakat Suku Dayak dan Kutai sebagai pengganti fungsi sabun. Penelitian ini bertujuan untuk mengetahui metabolit sekunder dan membandingkan pelarut dalam proses deklorofilisasi klorofil pada daun kokang untuk melihat aktivitas antioksidan dan tabir surya. Proses deklorofilisasi dilakukan menggunakan 2 pelarut berbeda yang bersifat non polar untuk menarik senyawa klorofil pada simplisia dan hasil deklorofilisasi di maserasi menggunakan pelarut etanol untuk menarik semua senyawa aktifnya. Ekstrak yang didapatkan langsung diidentifikasi senyawanya, diuji aktivitas antioksidan, dan aktivitas tabir surya. Jumlah rendemen ekstrak daun kokang yang didapat dari 120 g simplisia adalah 20,25 % sedangkan ekstrak daun kokang deklorofilisasi aseton dari 107 g simplisia adalah 18,18%. Hasil penelitian menunjukan bahwa Senyawa yang terkandung pada ekstrak daun kokang ialah flavonoid, saponin, dan tanin. Sedangkan senyawa yang terkandung pada ekstrak daun kokang yang telah dideklorofilisasi menggunakan aseton ialah saponin dan tanin. Jumlah klorofil total yang ditarik oleh pelarut aseton ialah 4,191 mg/ml sedangkan N-heksan sebanyak 1,238 mg/ml. Berdasarkan hasil penelitian yang dilakukan dapat disimpulkan bahwa ekstrak daun kokang mengandung senyawa flavonoid, saponin, tanin, sedangkan ekstrak daun kokang terdeklorofilisasi aseton mengandung senyawa saponin dan tanin. Jumlah rendemen yang didapat adalah 20,25% dan 18,18% serta pelarut yang paling banyak menarik klorofil adalah aseton.

Optimasi Basis Hand Sanitizer Gel Richardus Rayendra Euriko; Sabaniah Indjar Gama; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Optimasi basis hand sanitizer gel merupakan upaya untuk menemukan formula basis gel yang optimum secara fisiko-kimia. Penelitian ini bertujuan untuk mengetahui konsentrasi basis hand sanitizer gel yang optimum. Hand sanitizer gel dibuat dalam tiga formula dengan tiga konsentrasi Carbopol 940 yang berbeda yaitu A,B dan C. Basis gel yang digunakan yaitu Carbopol 940. Optimasi basis gel meliputi evaluasi organoleptik, homogenitas, pH, daya sebar, daya lekat dan viskositas. Optimasi dilakukan selama 7 hari. Penelitian ini merupakan eksperimental laboratorium. Hasil yang diperoleh pada evaluasi uji organoleptik adalah diamati warna yang bening, bentuk sediaan semisolid dan bau Carbopol 940. Uji homogenitas untuk mengetahui homogenitas gel dengan tidak adanya butiran kasar yang tidak terlarut, Uji pH diperoleh yaitu pH sediaan gel yaitu stabil pada pH 7. Uji daya sebar diperoleh kisaran diameter yaitu 5,3-5,7 cm. Uji daya lekat diperoleh hasil yaitu lebih dari 1 detik dan memenuhi kriteria sediaan gel. Uji viskositas menunjukan viskositas gel berada pada kisaran 1.206 cps - 1,820 cps. Hasil evaluasi basis handsanitizer gel yang optimum diperoleh jika memiliki kualitas fisik yang baik dan memenuhi kriteria sediaan gel. Berdasarkan hasil evaluasi pada optimasi basis handsanitizer gel diperoleh basis gel Carbopol 940 dengan konsentrasi A telah memenuhi kriteria pembuatan sediaan gel.

Terapi Kombinasi Air Perasan Daging Buah Mengkudu (Morinda citrifolia L.) dan Mentimun (Cucumis sativus L.) untuk Menurunkan Tekanan Darah pada Pasien Hipertensi Novia Anggraini; Wisnu Cahyo Prabowo; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Noni (Morinda citrifolia L.) and cucumber (Cucumis sativus L.) fruit are plants that have antihypertensive activity. The active ingredient scopoletin, anthosianin, xeronin in noni and high potassium in cucumber can lower blood pressure. This study aims to determine the characteristic description, hedonic quality test and the effect of giving a combination noni and cucumber squeezed water flesh of fruit on reduction in the systolic and diastolic blood pressure of hypertension patients in Muara Jawa District, East Kalimantan. The research method used was quasi experimental and research procedures measuring pre and post test being given treatment for 7 days. The highest percentage of respondents collected data obtained are aged 36-45 years as much as 45%, women70%, junior high school education 45%, family history 60%, frequent exercise habits 55% and normal BMI 45%. The highest percentage of sample hedonic quality test collected data obtained are the flavor test was sweet by 65%, the aroma test was sharp by 75% and the texture test was soft by 75%. The results of statistical tests using the paired sample t-test method showed a significant decrease in systolic blood pressure p = 0.000 < ? (0.05) of 12.3 mmHg and diastolic blood pressure p = 0.000 < ? (0.05) of 5.4 mmHg. Based on the results of the study, it can be concluded that giving a combination noni and cucumber squeezed water flesh of fruit can have reduced effect on systolic and diastolic blood pressure of hypertension patients.

Ekstraksi Polifenol Total dari Herba Suruhan (Pepperomia pellucida (L)Kunth.) menggunakan Malic Acid-Glucose Based Microwave Assisted Extraction Muhammad Safruddin; Nur Mita; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

This study aims to determine the effect of the use of malic acid-glucose based microwave assited extraction (MAE) methods on total polyphenol extraction from suruhan herbs (Pepperomia pellucida (L) Kunth.). Samples that have been dried in the extraction using solvents (green solvent) Malic Acid-Glucose with a ratio of 1: 2, 1:3 and 1: 4 g/g in several conditions including, microwave strength 30% for 5 minutes with a sample ratio and a solvent of 1:14 g/mL. Then the extract solution obtained was measured in total polyphenol levels using the folin ciocalteu (FC) reagent and the absorbance was measured at a wavelength of 658 nm using a UV-vis spectrophotometer. Based on the results of the study obtained levels of polyphenols from each condition of the solvent used is 85 mg GAE/g sample (1 : 2 g/g solvent), 696 mg GAE/ g sample (1:3 g / g solvent) and 317 mg GAE /g sample (1: 4 g / g solvent). From this study it can be concluded that the method of malic acid-glucose based microwave assited extraction can be used to extract polyphenol compounds from Suruhan herbs quickly, easily and efficiently.

Efektivitas Asam Mefenamat terhadap Penurunan Nyeri Dismenore Berdasarkan Numeric Rating Scale Kiki Fitria Anggraeni; Nurul Fitriani; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Dismenore pada remaja adalah hal yang wajar untuk dirasakan ketika siklus menstruasi datang. Asam mefenamat merupakan terapi farmakologis yang sering digunakan oleh perempuan dismenore untuk mengurangi ketidaknyamanan nyeri haid dengan menginhibisi enzim siklooksigenase (COX-2) yang dapat mencegah pembentukan asam arakidonat serta prostaglandin yang akan menstimulasi kontraksi atau nyeri saat haid. Tujuan penelitian ini untuk mengetahui seberapa besar efektivitas asam mefenamat terhadap penanganan dismenore dengan penilaian skala NRS. Metode penelitian dengan quasi experimental terdiri dari 2 kelompok uji-kontrol dengan penilaian nyeri pretest-postest berdasarkan skala NRS. Berdasarkan hasil uji statistik Wilcoxon rata-rata penurunan 4,50 dari data pretest-postest kelompok uji sedangkan pada kelompok kontrol rata-rata penurunan 2,50 pada data pretest-postest kelompok kontrol. Hasil perbandingan tiap kelompok (uji-kontrol) nilai signifikansi p=0,002 (p

Pengaruh Pemberian Madu terhadap Kolesterol Total Mega Ulfiyah Noor; Fajar Prasetya; Febrina Mahmudah
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Honey contains Vitamin C which is a natural antioxidant which can have the effect of lowering total cholesterol levels in the blood. This study aims to determine the characteristics of gender, age, and occupation of hypercholesterolemic respondents and to determine the effect of honey administration on reducing total cholesterol levels of hypercholesterolemic respondents in Palaran District, Samarinda. The research method used is quasy experimental and research procedures by measuring before and after being given treatment. Data collection on the characteristics of respondents obtained the highest percentage of women as much as 80%, age 46-55 years as much as 40%, and housewives as much as 75%. The results of descriptive analysis of total cholesterol levels in the pre-test gave an average result of 224.9 mg / dL and the post-test gave an average result of 202.1 mg / dL. Based on the research results, it can be concluded that honey can have an effect on reducing total cholesterol levels in the blood.

Observasi Klinik Pemberian Jus Buah Naga Merah (Hylocereus polyrhizus) dan Jambu Biji (Psidium guajava) Terhadap Peningkatan Kadar Hemoglobin Wanita Menstruasi Suci Aprisilia Kartika; Risna Agustina; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Anemia is a condition when the blood hemoglobin level is less than normal because to iron deficiency. Red dragon fruit (Hylocereus polyrhizus) and guava (Psidium guajava) are sources of iron which can increase blood hemoglobin levels. The purpose of this study to determine the effect of dragon fruit juice and guava juice on increasing blood hemoglobin levels for menstruating women. The design of this research was Quasy Experimental Pre-Post Design which was conducted in two test groups. The first grup was given dragon fruit juice and the second group was given guava juice. Sampling was determined by purposive sampling based on inclusion and exclusion criteria. The hemoglobine level was using the Easy Touch GCHB tool and analyzed by the Paired Sample T-Test. The results showed that the effect of dragon fruit and guava juice on the hemoglobin level of menstruating women before the intervention in first group test was 11.5 g / dl, second group test was 10.5 g / dl and after the intervention the average was 13.6 g / dl and 13.5 g / dl. Based on the results of the Paired Sample T-Test statistical analysis which has a p value

Kombinasi Fraksi Etil Asetat Jahe Merah (Zingiber officinale var. Rubrum) dan Jahe Emprit (Zingiber officinale var. Amarum) Sebagai Antioksidan Yelfiani Li'lak Todingan; Hajrah Hajrah; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Red ginger and emprit ginger are plants that are known to have flavonoid compounds with various benefits including antioxidants. This study aims to determine the total flavonoid levels of the ethyl acetate fraction of red ginger and emprit ginger and the IC50 value using the DPPH (2,2-Diphenyl-1-Picrylhydrazil) method. The highest level of total flavonoids in the ethyl acetate fraction in red ginger was 4,434 mgQE/g extract while in ginger emprit was 11,072 mgQE/g extract. The combination of the ethyl acetate fraction of red ginger and emprit ginger showed very strong antioxidant activity with an IC50 value of 19,027 ppm (1:1 combination), 17,649 ppm (1:2 combination), and 13,711 ppm (2:1 combination).

Pemberian Kombinasi Buah Alpukat (Persea americana) dan Rebusan Air Daun Salam (Syzygium polyanthum) Terhadap Penurunan Tekanan Darah pada Pasien Hipertensi Wanda Millenia Alwie; Nur Masyithah; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Avocado and bay leaves contain flavonoids which can have an effect on lowering blood pressure. This study aims to determine the characteristics of hypertension patient respondents including age, gender, education, occupation, family history and antihypertensive drugs consumed and to determine the effect of giving a combination of avocado juice and bay leaf water boiled in Samarinda Ulu District. The research method used was a quasi-experimental design and research procedures by measuring before and after treatment. The collection of data on the characteristics of respondents obtained the highest percentage is the category of female gender as much as 67%, age 56-60 years as much as 42%, elementary education as much as 33%, work housewife 58%, having a family history of 75 % and the antihypertensive drug that was consumed by amlodipine was 100%. The results of data analysis using the independent sample T test showed that the p-value for the control-treatment systolic group and the control-treatment diastolic group was 0.000 (p-value

Page 39 of 62 | Total Record : 612

37 38 39 40 41

Filter by Year

2015 2023

Filter By Issues

All Issue Vol. 18 (2023): Proc. Mul. Pharm. Conf. Vol. 17 (2023): Proc. Mul. Pharm. Conf. Vol. 16 (2022): Proc. Mul. Pharm. Conf. Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.) Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf. Vol. 12 (2020): Proc. Mul. Pharm. Conf. Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 9 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 8 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 7 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 6 (2017): Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 5 (2017): Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 4 (2016): Proceeding of Mulawarman Pharmaceuticals Conferences (Prosiding Seminar Nasional Kefa Vol. 3 (2016): Spesial Issue of Mulawarman Pharmaceuticals Conference Proceeding (Prosiding Semnas T Vol. 3 (2016): Proceeding of Mulawarman Pharmaceuticals Conferences (Prosiding Seminar Nasional Kefa Vol. 2 (2015): Proceeding of Mulawarman Pharmaceuticals Conferences (Prosiding Seminar Nasional Kefa Vol. 1 (2015): Proceeding of Mulawarman Pharmaceuticals Conferences (Prosiding Seminar Nasional Kefa More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Rolan Rusli

Contact Email
rolan@farmasi.unmul.ac.id

Phone
+6285222221907

Journal Mail Official
admin@farmasi.unmul.ac.id

Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location
Kota samarinda,

Kalimantan timur

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Rolan Rusli

Contact Email rolan@farmasi.unmul.ac.id

Phone +6285222221907

Journal Mail Official admin@farmasi.unmul.ac.id

Editorial Address Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location Kota samarinda, Kalimantan timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Rolan Rusli

Contact Email
rolan@farmasi.unmul.ac.id

Phone
+6285222221907

Journal Mail Official
admin@farmasi.unmul.ac.id

Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location
Kota samarinda,

Kalimantan timur

INDONESIA