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Victoria Yulita Fitriani
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Proceeding of Mulawarman Pharmaceuticals Conferences
Published by Universitas Mulawarman
ISSN : -     EISSN : 26144778     DOI : https://doi.org/0.30872/mpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 612 Documents
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Efek Aromaterapi Peppermint (Mentha arvensis L.) pada Penurunan Tekanan Darah Tiya Nur Aini; Nur Mita; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1786.024 KB) | DOI: 10.25026/mpc.v12i1.414

Abstract

Mint leaves (Mentha arvensis L.) are an example of a plant that can produce essential oils. The distinctive aroma of mint leaves provides a relaxing effect that affects the blood pressure of hypertensive patients. This study aims to look at the characteristics, patient response, and the effect of presenting peppermint aromatherapy to hypertensive patients at Puskesmas Mamburungan Tarakan. The research method used a quasy experimental research design with one group pretest and posttest design with a sample size of 20 people. The criteria for respondents who were the subject of the study were 50% of the sexes of women and men. The age with the highest proportion is 56-60 years old as much as 50%. The occupation with the highest proportion was housewives as much as 30%. The results of the study of the patient's response to aromatherapy preparations obtained the respondent's preferred level with a proportion of 90%. The effect of giving aromatherapy felt by the respondents was 75% fresh and 25% relaxed. Respondents would prefer it if peppermint oil was made in roll on dosage form (70%), compared to spray form (25%) and diffuser (5%). The results showed that there was an effect of peppermint aromatherapy on systolic blood pressure before the intervention took place with an average of 162,117 mmHg and after intervention it was 150,683 mmHg, diastolic blood pressure before intervention was 98.63 mmHg and after intervention it became 93.23 mmHg. The results of the descriptive research on peppermint aromatherapy are in line with the results of statistical analysis using the wilcoxon method and the paired sample t-test which has a p value of
Kajian Penggunaan Obat Insomnia sebagai Penyakit Penyerta pada Salah Satu Rumah Sakit Khusus Daerah di Kalimantan Timur Serly Monika Putri; Laode Rijai; Risna Agustina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2304.475 KB) | DOI: 10.25026/mpc.v12i1.415

Abstract

Insomnia is a sleep disorder such as dissatisfaction with sleep quality, difficulty in sleeping and maintaining sleep, causing physical and emotional symptoms that affect performance and also cognitivity. The existence of mental disorders such as depression, fatigue and anxiety which culminate in insomnia so that a person does not sleep soundly. The purpose of this study is to determine the characteristics, variations of the diseases that cause insomnia, drug use, and drug interactions that occur. The research method used an observational retrospective method by tracing medical record data at a special regional hospital in East Kalimantan with a total sampling technique during 2019. The results obtained for characteristic data that insomnia was greater for women (57%) at the age of 56-65 years (40%) with primary and junior high school education (30%) who do not work (77%) and who do not have a history of disease (93%) and insomnia due to anxiety (94%). For the variation of insomnia, based on the causes and history of the disease, whether there is anxiety disorder or anxiety. Treatment is done with 87% single therapy, namely using the drugs Alprazolam (8%), Clozapine (41%), Fluoxetine (4%), Risperidone (8%), Lorazepam (8%), Diazepam (11%), Zolpidem tartrate (4%), Amitripthyline (4%), Clonazepam (4%), and Clorpromazin (8%) while 13% uses 2 combination of drug therapy is using combination of Fluoxetine and Amitripthyline (25%), Clozapine and Sertraline (50%), and Maprotiline hydrochloride and Clobazam (25%). The potential interactions are entirely pharmacokinetic interactions of the metabolic phase with major severity of 75% and moderate severity of 25%.
Profil KLT Partisi Etil Asetat Ekstrak Metanol Daun Sirih Hitam (Piper betle L. Var Nigra) Natanael Ramos Parapat; Fajar Prasetya; Sabaniah Indjar Gama; M Arifuddin
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1118.406 KB) | DOI: 10.25026/mpc.v12i1.416

Abstract

Black betel leaves are widely used for various treatments, one of which is oral diseases such as gingivitis and dental caries by Indonesians. The purpose of this study was to determine the class of compounds and to find the best eluent for the separation of compounds from methanol extract. This research begins with extraction using the maceration method withmethanolsolvent. The extract obtained was tested using analytical TLC to find the best eluent. After obtaining the best eluent, the partition extraction of black betel leaf methanol extract was carried out using ethyl acetate. The ethyl acetate soluble and ethyl acetate insoluble extractswere separated then the three extracts were continued with the identification of the compounds by analytical TLC using the two best eluent comparisons that had been done previously and then observed under UV light 254 nm and 366 nm after that sprayed using Dragendorff reagent and FeCl3. The best eluent analysis result of ethyl acetate partition of black betel leaf methanol extract was n-hexane:ethyl acetate (6:4, 3:1) and TLC analysis showed that the compounds contained were alkaloids and phenolic.
Literature Review: Aktivitas Kulit Jeruk dalam Bidang Farmasi Ayu Wulan Dari; Angga Cipta Narsa; Nur Masyithah Zamruddin
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.333 KB) | DOI: 10.25026/mpc.v12i1.417

Abstract

Jeruk manis (Citrus sinensis (L.) Osbeck) adalah buah yang ditanam diiklim tropis ataupun subtropis dan termasuk komoditas buah penting dipasaran baik didalam negeri maupun dunia. Banyaknya permintaan jeruk ini mengakibatkan tingginya jumlah limbah kulit jeruk di Indonesia yang mencapai 309.678 ton pertahun. Kulit buah jeruk biasanya hanya dibuang dan tidak dimanfaatkan dan menjadi sampah yang tidak ada manfaatnya. Tujuan penulisan artikel ini yaitu untuk mengetahui kandungan senyawa metabolit sekunder, aktivitas farmakologis, dan bentuk sediaan yang telah dibuat dari kulit jeruk manis. Metode yang digunakan yaitu studi literaturdengan penelusuran jurnal dan karya tulis ilmiah dengan database Google Scholar, Sematic Scholar, Science Direct, dan Wiley Online Library. Berdasarkan kajian literatur diketahui bahwa kandungan senyawa metabolit sekunder kulit jeruk manis yaitu flavonoid, alkaloid, tanin, glikosida, steroid, karbohidrat, pektin, senyawa fenolik, kumarin, glikosida, saponin, dan terpenoid. Diketahui aktivitas farmakologis pada kulit jeruk manis yaitu sebagai antibakteri (senyawa 1,8-cineole, d-limonene, 5-C-glycosyl flavones: lucenin-2, vicenin-2, stellarin-2, lucenin-2-41- methyl ether and scoparin; one 3-hydroxy-3-methylglutaryl glycolsyl, flavonol: 3-hydroxy-3-methyl-glutaryl glycosyl quercetin), antijamur (senyawa limonene, ?-pinene, ?-pinene, dan ?-myrcere), antioksidan (senyawa neohesperidin, hesperidin, 5-C-glycosyl flavornes: lucenin-2,vicenin-2, stellarin-2, lucenin-2-41- methyl ether and scoparin; one 3-hydroxy-3 methylglutaryl glycosylflavonol: 3-hydroxy-3-methylglutaryl glycosyl quercetin; and one flavone O-glycosides: chrysoeriol7-O-neoesperidoside dan komponen fenolik yaitu polymethoxylated flavones, O-glycosylated flavones, C-glycosylated flavones, O-glycosylated flavonols, O-glycosylated flavanones (glycosylated flavonones), insektisda (senyawa flavonoid, d-limonene, limonoid, saponin, dan tanin), tabir surya (senyawa antranilat dan hesperidin), peluruh steroform (senyawa limonene), antidiabetes (senyawa flavonoid), antikolesterol (senyawa flavonoid dan pektin) dan penyembuh luka (senyawa hesperidine, PMF, limonene, vitamin A, vitamin C , dan vitamin E). Serta bentuk sediaan yang telah dibuat dari kulit jeruk manis yaitu berupa masker peel-off sebagai antibakteri, masker gel sebagai antioksidan, tablet hisap sebagai vitamin C, sabun mandi cair sebagai antioksidan, serta gel untuk penyembuhan luka.
Kajian Literatur Potensi Tanaman-Tanaman Obat Untuk Mengatasi Luka Bakar Maharani Adelia Zeline; Fika Aryati; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.939 KB) | DOI: 10.25026/mpc.v12i1.418

Abstract

Luka bakar adalah suatu macam cedera parah dibanding cedera lainnya, dengan permasalahan yang kompleks dan angka mortalitas maupun morbiditas yang tinggi. Saat ini minat masyarakat Indonesia untuk kembali pada pengobatan tradisional semakin meningkat, karena pengobatan menggunakan ramuan tradisional dari bahan alami lebih murah daripada obat kimia sintetis. Tujuan dari penelitian ini adalah untuk mencari tanaman yang paling berpotensi untuk dikembangkan menjadi sediaan farmasi untuk luka bakar berdasarkan konsentrasi uji dan waktu kesembuhan luka bakar, serta memperkirakan senyawa-senyawa yang diduga aktif mempercepat penutupan luka bakar. Metode penelitian yang dilakukan adalah mengumpulkan skripsi dan jurnal ilmiah secara online yang telah di publikasikan melalui Google Scholar dari tahun 2012-2020 dan dianalisis secara deskriptif. Hasil menunjukkan tanaman obat yang berpotensi mengatasi luka bakar berdasarkan waktu dan persentase kesembuhan yang dibandingkan dengan kontrol positif yaitu daun mengkudu (21 hari, 97%), daun rumput bermuda (21 hari, 80%), daun kitolod (14 hari, 63%), bunga kecombrang (12 hari, 72%), daun kersen (14 hari, 93,3%), herba pegagan (14 hari, 100%), daun jambu biji (20 hari, 100%), daun pepolo (21 hari, 92,5%), kulit buah manggis (21 hari, 83%), daun srikaya (16 hari, 100%), dan daun sukun (19 hari, 100%). Kandungan senyawa dalam tanaman obat yang diduga mempercepat penutupan luka bakar antara lain flavonoid, tanin, saponin, polifenol, alkaloid, vitamin C, vitamin B, triterpenoid dan steroid. Sehingga dapat disimpulkan bahwa tanaman yang berpotensi untuk dikembangkan menjadi sediaan farmasi yaitu herba pegagan, daun jambu biji, daun srikaya, dan daun sukun.
Kajian Literatur Mengenai Tingkat Keamanan Tanaman Kelor (Moringa Oleifera L.) dari Hasil Uji Toksisitas Akut dan Subkronis Frety Aula Nur Islamika; Fika Aryati; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.63 KB) | DOI: 10.25026/mpc.v12i1.419

Abstract

Kelor (Moringa oleifera L.) merupakan tanaman yang kaya nutrisi dan bermanfaat bagi manusia. Kandungan nutrisi kelor tersebar ke seluruh bagian tanaman dari daun, kulit batang, bunga, biji, hingga akar yang dapat dimanfaatkan sebagai pengobatan penyakit maupun kekurangan nutrisi. Penelitian ini bertujuan mengetahui tingkat keamanan tanaman kelor dari hasil uji toksisitas akut dan subkronis. Metode penelitian yang digunakan ialah kajian literatur dengan cara mengambil original artikel melalui search egine google scholar tanaman kelor dengan range tahun 2011-2020 kemudian dianalisis secara deskriptif. Hasil kajian literatur menunjukkn bahwa tanaman kelor bagian daun, kulit batang, dan akar pada uji toksisitas akut menggunakan tikus dan mencit didapatkan hasil bahwa nilai LD50 pada akar 15,9-17,8 g/kg, pada daun >3000 mg/kg,dan pada kulit batang praktis tidak toksik dalam dosis tunggal, kemudian untuk uji toksisitas sub-kronik menggunakan tikus didapatkan hasil bahwa relatif aman digunakan, namun perlu didiperhatikan jika digunakan dalam waktu yang lama, kemudian pada parameter tes hematologi, kreatinin, dan urea tidak terjadi perbedaan yang signifikan dengan nilai p tidak lebih dari 0,05 (p?0,05) dibandingkan dengan kontrol. Berdasarkan hasil mengkaji data uji toksisitas akut dan sub-kronik dapat disimpulkan bahwa tanaman kelor praktis tidak toksik dan relatif aman digunakan, namun jika digunakan dalam jangka panjang perlu diperhatikan.
Kajian Literatur Toksisitas Tanaman Ruku-Ruku (Ocimum sanctum L.) Andi Asti Ainun; Risna Agustina; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (112.39 KB) | DOI: 10.25026/mpc.v12i1.420

Abstract

Tanaman ruku-ruku merupakan tanaman yang memiliki berbagai manfaat dan khasiat bagi kesehatan. Seluruh bagian tanaman ruku-ruku dapat digunakan untuk mengatasi berbagai macam penyakit. Penelitian ini bertujuan untuk mengetahui keamanan tanaman ruku-ruku dari hasil uji toksisitas umum maupun khusus. Metode penelitian yang digunakan ialah dengan mengkaji literatur yang diperoleh melalui google scholar dan pubmed dari tahun 2002-2020 kemudian dianalisis secara deskriptif. Hasil kajian literatur menunjukkan bahwa ekstrak daun maupun seluruh bagian tanaman ruku-ruku untuk toksisitas akut ialah relatif tidak membahayakan dengan nilai LD50 >7g/kgBB terhadap mencit dan >15g/kgBB terhadap tikus. Untuk toksisitas sub-akut dinyatakan aman karena tidak adanya perbedaan yang signifikan terhadap berat badan, parameter hematologi, dan biokimia serta histopatologi jaringan (hati, ginjal, limpa, jantung, dan testis/ovarium). Toksisitas khusus untuk uji reproduksi tidak memiliki efek yang merugikan terhadap sistem reproduksi hewan coba termasuk total kelahiran, rasio jenis kelamin, dan jumlah anak yang hidup pada hari ke-0 dibandingkan dengan kelompok kontrol, indeks kesuburan hewan coba betina, fekunditas, dan kehamilan serta indeks kesuburan hewan coba jantan. Berdasarkan hasil uji toksisitas umum dan khusus, tanaman ruku-ruku dinyatakan aman dan tidak memiliki efek yang merugikan bagi tubuh.
Studi Literatur: Efek Pemberian Obat Herbal terhadap Penderita COVID-19 Cyntia Bella Anggraini; Dewi Mayasari; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.13 KB) | DOI: 10.25026/mpc.v12i1.421

Abstract

COVID-19 is a disease that has never been identified in the human body before and is highly contagious. Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Due to the high number of casualties due to COVID-19, many ways have been done to treat the outbreak of this virus. One of them is the use of herbal medicines from plants that are believed to cure people with COVID-19. This study aims to describe the impact of herbal medicine on patients with Covid-19. Literature search using PubMed, ScienceDirect and Google Scholar. Literature search strategy using keywords Traditional Chinese medicine, Chinese medicine, Chinese herbal medicine, COVID-19, new coronavirus pneumonia, SARS-CoV-2. The results obtained, namely from 10 literature show that herbal treatment can reduce symptoms of Covid-19 and boost the immune system. The use of herbal medicines for COVID-19 needs to be considered carefully to support the limited scientific data.
Studi Literatur: Aktivitas Antidiabetes Bawang Dayak (Eleutherine americana) dan Serai (Cymbopogon citratus) Miranda Aurora Pratiwi; Febrina Mahmudah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.951 KB) | DOI: 10.25026/mpc.v12i1.422

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. The Indonesian government is currently advising the public to consume traditional-based medicines because of their low side effects. One of the traditional medicines used is lemongrass and dayak onions. This study aims to determine the chemical compound content and antidiabetic activity of lemongrass and dayak onions. The research method used is the literature review method. Data searches were performed online on the PubMed, Science Direct, Google, Elsevier, and Google Scholar databases as well as other journal search websites. The scientific journals used are scientific journals published in the last 13 years. From 9 literature that has been studied, it shows that dayak onion tubers identify the presence of tannin compounds, saponins, flavonoids, alkaloids, steroids, terpenoids, glycosides, and anthraquinones while lemongrass contains tannin compounds, saponins, flavonoids, alkaloids, steroids, terpenoids, essential oils, phenolic, anthraquinones, carbohydrates, and glycosides. From 14 literature it is known that dayak onion tubers and lemongrass have antidiabetic activity. Compounds that have anti-diabetic activity properties include flavonoids, tannin and alkaloids contained in dayak onion and lemongrass, other than that essential oils contained in lemongrass.
Studi Literatur: Aktivitas Senyawa [6]?Gingerol dari Rimpang Jahe (Zingiber officinale) sebagai Imunomodulator Nanda Uswatun Hasanah; Dewi Rahmawati; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (238.149 KB) | DOI: 10.25026/mpc.v12i1.423

Abstract

Immunomodulator is a substance that can change or affect the body's immune system to normal. One of the plants that has immunomodulatory activity is ginger rhizome. Ginger rhizome (Zingiber officinale) is a tribe of Zingiberaceae which is widespread in Southeast Asia, empirically used as a cooking spice and traditional medicine to treat various medical conditions such as diabetes, arthritis, rheumatism, soreness, sore throat, constipation, indigestion, hypertension, dementia, fever, infectious diseases, and helminthiasis. The purpose of this study is to examine the literature regarding the compound [6] -Gingerol from ginger rhizome which has immunomodulatory activity. This research method is a literature study conducted by an online search process using the Google Chrome application, journals obtained on the ScienceDirect, PubMed, and Google Scholar. The journals are national and international journals without any publication time limit for cited journals. There are 7 pieces of literature showing that the compound [6] -Gingerol from ginger rhizome (Zingiber officinale) has activity as an immunomodulator.

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