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<![CDATA[Isolasi Bakteri Termofilik dari Tanah Hutan Mangrove ]]>
<![CDATA[Fidhia Rara Lande]]>;
<![CDATA[Wahyu Widayat]]>;
<![CDATA[Yurika Sastyarina]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v10i1.383
<![CDATA[Mangrove forest soil is a habitat and source of diversity of microorganisms, including thermophilic bacteria. The utilization of thermophilic bacteria has been carried out in the pharmaceutical field, especially as a source of raw materials for pharmaceutical products. This study aims to provide an overview of the population of thermophilic bacteria found in mangrove forest soils. Soil samples were obtained by random stratification with a depth of 5-10 cm at 9 points from 3 strata. The isolation media used were Starch Casein Agar (SCA), and the groups of bacteria determined by using the Gram staining method. The selected thermophilic bacteria from mangrove forest soil totaling 64 isolates consisted of Gram-negative that divides into 20 bacilli, 9 cocci, 6 vibrios, and Gram-positive consisted of 26 bacilli, 3 cocci. The highest population of thermophilic bacteria from mangrove forest soils was Gram-negative as many as 35 isolates.]]>
<![CDATA[Pengaruh Berbagai Metode Ekstraksi dari Ekstrak Etanol Umbi Bawang Tiwai (Eleutherine americana Merr) terhadap Rendemen Ekstrak dan Profil Kromatografi Lapis Tipis ]]>
<![CDATA[Ayida Mawarda]]>;
<![CDATA[Erwin Samsul]]>;
<![CDATA[Yurika Sastyarina]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v11i1.384
<![CDATA[The bulb of Eleutherine americana Merr is a typical Kalimantan plant that has many medicinal properties. Many studies have been carried out with various extraction methods used to determine the compounds contained in the bulb of Eleutherine americana Merr. This study aims to determine the effect of the method and the extraction time on the yield value and thin layer chromatography profile (TLC) of the bulb of Eleutherine americana Merr extract. The extraction method uses 96% ethanol solvent using the maceration method for 2 weeks and ultrasonic bath method with time variables of 10, 20 and 30 minutes. The yield of maceration extract was 12% and the ultrasonic bath method was 12.5%, 17.5%, and 15% (10, 20, 30 minutes). In the TLC test there were no differences in the spot patterns of the two extraction methods. So it can be concluded that the extraction method affects the yield of extract but does not affect the extract compound content seen from the TLC spot pattern.]]>
<![CDATA[Seleksi Parameter yang Mempengaruhi Sintesis Kalkon dengan Metode Plackett-Burman ]]>
<![CDATA[Indah Silvia Sugiyamin]]>;
<![CDATA[Harra Ismi Farah]]>;
<![CDATA[Agung Rahmadani]]>;
<![CDATA[Angga Cipta Narsa]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v11i1.385
<![CDATA[Chalcone is a compound that has various biological activities. The organic synthesis approach has been widely used to obtain chalcone compouds. The aim of this research is to select the main parameters which influence chalcone synthesis. This study was conducted using Plackett-Burman experimental design. Of eleven parameters used, eight of them showed a significant effect on the yield of chalcones namely temperature, reaction time, mole number of benzaldehyde, volume of acetophenone solvent, incubation time, volume of distilled water, volume of benzaldehyde solvent, catalyst volume and dummy. In addition, the highest yield is 32.43%.]]>
<![CDATA[Optimasi Formula Spray Gel Ekstrak Bawang Tiwai (Eleutherine americana (Aubl) Merr) ]]>
<![CDATA[Maulidya Maulidya]]>;
<![CDATA[Fika Aryati]]>;
<![CDATA[Yurika Sastyarina]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v11i1.386
<![CDATA[The ethanolic extract from the bulb of Eleutherine americana has the potential for anti-inflammatory activity to be developed into a preparation that is a practical spray gel to use. The aim of this study is to made a spray gel containing ethanolic extract from the bulb of Eleutherine americana. Spray gel preparation was prepared by varying the concentration of Carbopol as a gelling agent with a concentration of F1 (0.4%), F2 (0.6%), and F3 (0.8%) with active substances and evaluated physical stability. Data from the results of physical stability testing in statistical analysis. Organoleptic test results and homogenity of ethanolic extract from the bulb of Eleutherine americana spray gel from all formulas showed stable, pH was in the range of 5.2-6.1 and Viscosity in formulas 1, 2, and 3 were respectively 0.65-1323 (Pa.s ) this condition is still within the range of viscosity of spray gel formulation, and have a spread pattern. While the formula 2 and 3, the viscosity is not eligible.]]>
<![CDATA[Optimasi Polivinilalkohol (PVA) Sebagai Basis Sediaan Gel Antijerawat ]]>
<![CDATA[Nur Aprilianti]]>;
<![CDATA[Hajrah Hajrah]]>;
<![CDATA[Yurika Sastyarina]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v11i1.387
<![CDATA[The gel is one of the preparations that are considered suitable for skin conditions with excessive sebaceous gland function. Polyvinylalcohol (PVA) is one of the gelling agents that can from a layer or film that is very strong and plastic to give good contact between the drug and the skin. This study aims to find the best concentration of polyvinylalcohol (PVA) as a gel base. Each formula was made using four variations of polyvinylalcohol (PVA) concentrations of 6%, 8%, 10%, and 12% and tested the physical properties that include organoleptic test, pH, homogeneity, spreadability, and viscosity. The results showed that the optimum of base formula contains a concentration of polyvinylalcohol (PVA) base of 6% and 8%.]]>
<![CDATA[Uji Aktivitas Antibakteri Ekstrak Etanol Daun Andong Merah terhadap Eschericia coli dan Staphylococcus aureus ]]>
<![CDATA[Reca Indiyen]]>;
<![CDATA[Fika Aryati]]>;
<![CDATA[Angga Cipta Narsa]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v11i1.388
<![CDATA[Infection disease is one of the most common diseases in the world. Infection can be caused by bacteria Escherichia coli and Staphylococcus aureus which are now resistant to some antibiotics, so new agents are needed to overcome antibiotic resistance. Red andong leaves are empirically efficacious for treating wounds, hemorrhoids, inflammation, diarrhea and stopping bleeding (hemostasis). This study aims to determine the yield of ethanol extracts red andong leaves and determine the antibacterial activity of ethanol extracts of red andong leaves against Escherichia coli and Staphylococcus aureus. The research began with the process of extracting red andong leaves by maceration method, then carried out antibacterial testing by the well diffusion method. The results showed the extract concentrations of 10%, 30%, and 50% were able to inhibit the growth of Escherichia coli and Staphylococcus aureus. The biggest antibacterial activity of red andong extract was obtained at a concentration of 50% with a inhibition zone of 17,836 mm (Staphylococcus aureus) and 9,012 mm (Escherichia coli).]]>
<![CDATA[Aktivitas Ekstrak Etanol Umbi Bawang Tiwai (Eleutherine americana (Aubl.) Merr) terhadap Kelarutan Kalsium Batu Ginjal secara In Vitro ]]>
<![CDATA[Triani Yastuti Kuling]]>;
<![CDATA[Jaka Fadraersada]]>;
<![CDATA[Yurika Sastyarina]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v11i1.389
<![CDATA[Kidney stones are a disease that occurs due to the deposition of compounds that are difficult to dissolve because the body lacks fluids. Bawang Tiwai (Eleutherine americana (Aubl.) Merr) is an endemic Dayak plant in Kalimantan which has been traditionally used as traditional medicine dayak’s people. One of the active components is flavanoid which can dissolve kidney stones. This study aims to determine the concentration activity of the bawang tiwai roots extract to dissolve kidney stone calcium. The extract was made by maceration method using ethanol 96%. The extraction activity testing used 5 treatments namely 1 ppm, 2 ppm, 3 ppm, negative control (distilled water) and positive control (elixir stone). Kidney stones were then added as much as 10 mg to each treatment. After the addition of kidney stones in each treatment incubation for 3 hours at 37 ?. Calcium solubility activity was seen by using a UV-Visible spectrophotometer by measuring the absorbance value of each test concentration. The results showed that the 3 ppm concentration was the optimal concentration in dissolving kidney stone calcium in vitro.]]>
<![CDATA[Karakteristik Rumput Banto (Leersia hexandra Sw.) Berdasarkan Makroskopik dan Mikroskopik ]]>
<![CDATA[Wa Ode Rungaya Ningsih Komala]]>;
<![CDATA[Nur Mita]]>;
<![CDATA[Yurika Sastyarina]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v11i1.390
<![CDATA[Banto (Leersia hexandra Sw.) is a weed that is often used as animal feed, which is used to remove toxins in the body. The research to study the characteristics of Banto macroscopically and microscopically. A macroscopic test were carried out directly on the physical properties of Banto. Then a microscopic test of Bantos powder simplicia was conducted using a microscope. The result of the macroscopic examination of Banto show that Banto has smooth stem segments, roots on the stem segments, height can reach 1 m, leaf width reaches 0,4 cm-1 cm, leaf length is 5 cm-23 cm, the sides are rough and have sharp edges. For the results of the microscopic examination of fresh grass at 40× magnification and 100× magnification showed the presence of epidermis, stomata, and chlorophyll. The result of microscopic study of Banto simplicia at 40× magnification and 100× magnification showed the presence of epidermis and chlorophyll.]]>
<![CDATA[Uji Aktivitas Ekstrak Alang-Alang (Imperata cylindrica L) sebagai Peluruh Kalsium Batu Ginjal secara In Vitro ]]>
<![CDATA[Istnaini Reiza Fatimah]]>;
<![CDATA[Mahfuzun Bone]]>;
<![CDATA[Yurika Sastyarina]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v11i1.391
<![CDATA[Kidney stones are a disease caused by existence urine sediment in the kidneys and urinary tract which clog the urinary tract so that when urinating it causes pain. One alternative to be used to treat kidney stone disease is traditional treatment using herbal plants that are widespread in Indonesia. The plants that is widespread in Indonesia, Imperata that grow wild in forests, fields, lawns and roadside in sunny dry areas. The research was aimed to find secondary metabolites and activity of Imperata extract ethanol on calcium solubility of kidney stones. Kidney stones from the reaction between calcium chloride and potassium oxalate. The extract was obtained from the maceration process using 96% ethanol solvent. The test of secondary metabolites by adding chemical reagents to the extract and activity test by making 3 series of extract concentrations, namely 1%, 3% and 5%. 100 mg kidney stones were inserted in the extract solution than incubated for 3 hours (370C). The filtrate was measured dissolved calcium levels using a UV-Visible spectrophotometer at ? 499 nm. The result show that Imperata positive containing flavonoids, alkaloids, tanins, steroids and triterpenoids, and have an effect in dissolving kidney stone calcium in vitro where the best concentration of ethanol extract of Imperata is 5% concentration with dissolved calcium levels of 301,450 ppm.]]>
<![CDATA[Pengaruh Induksi Tukak Lambung Menggunakan Aspirin terhadap Kerusakan Jaringan Mukosa Lambung Mencit ]]>
<![CDATA[Widya Vergiana Oktrinorma]]>;
<![CDATA[Niken Indriyanti]]>;
<![CDATA[Nur Masyithah Z]]>
<![CDATA[ Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences ]]>
Publisher : <![CDATA[Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia ]]>
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DOI: 10.25026/mpc.v11i1.392
<![CDATA[Gastric ulcer is a condition of damage to the gastric mucosa accompanied by an inflammatory process. Gastric mucosal damage can be induced by various factors, one of which is non-steroidal anti-inflammatory drugs (NSAIDs). The purpose of this study was to assess the appropriate dose and time as a cause of damage to the gastric mucosa of mice due to exposure to aspirin. Before being induced, mice were fasted for 24 hours, white mice DDY strains (Deutschland, Denkenand and Yoken) were divided into 3 groups namely normal groups, aspirin 14 mg / 20 g BW (1 day), aspirin 14 mg / 20 g BW (2 days) orally. The results showed that the aspirin induced group 14mg / 20g BW had the most significant weight loss of mice, and showed the most severe epithelial tissue damage to the gastric mucosa with mucosal integrity score based on Barthel Manja criteria, namely 1. It can be concluded that the right dose of aspirin as an induction of damage to the gastric mucosa of mice is a dose of 14mg / 20 g BW (2 days).]]>
