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Proceeding of Mulawarman Pharmaceuticals Conferences

mpc
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Published by Universitas Mulawarman

ISSN : - EISSN : 26144778 DOI : https://doi.org/10.25026/mpc

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 612 Documents

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Formulasi Sediaan Lipbalm Ekstrak Bawang Tiwai (Eleutherine Americana Merr) Sebagai Pelembab Bibir: Lipbalm Formulation of Tiwai Onion Extract (Eleutherine Americana Merr) as Lip Moisturizer Mutiara Citra Refordayanti; Novita Eka Kartab Putri; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Tiwai onion (Eleutherine Americana Merr) is a typical Kalimantan plant that is known to have various benefits. Local people use tiwai onions as a remedy for various types of diseases and plants which are provided as colorants in food or in cosmetic products because they have a red color caused by anthocyanin pigments. This study aims to make a lipbalm formulation from the extract (Eleutherine Americana Merr). The method used is experimental research methods. The test of the extract reaction was in the form of organoleptic, pH and solubility. The results obtained were the extract of tiwai onion extract in the form of organoleptic (color: brick red, thick extract, distinctive odor of tiwai onion), pH (5.86), solubility (soluble in ethanol, methanol and distilled water) which was in accordance with the parameters with Deng The results of the tiwai onion extract which can be formulated in lipbalm formulations (F1, F2, F3) have homogeneity in accordance with the parameters, the appropriate pH is F1 (5.79-6.20), F2 (5.87-6). , 21), and F3 (5,91-6,14) and for F1 organoleptics (color: milk orange, oleum rosae distinctive aroma, soft and smooth texture), F2 (color: light orange, oleum rosae distinctive aroma, soft texture and smooth, and F3 (color: orange, distinctive aroma of oleum rosae, soft and smooth texture). It can be neglected that tiwai onion extract can be formulated in lipbalm preparations.

Optimasi Basis Masker Gel Peel-Off dan Uji Stabilitas Fisik Sediaan Masker Gel Peel-Off dari Ekstrak Daun Sirih Hitam (Piper betle L. VAR. NIGRA): Optimization of Peel-Off Gel Mask Base and Physical Stability Test of Peel-Off Gel Mask from Black Betel Leaf Extract (Piper betle L. VAR. NIGRA) Nadira Yuli Istiana; Nurul Fitriani; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Gel peel-off masks have many advantages, namely that besides being easy to apply, this masks can also produce good release and penetration of active substances. Black betle (Piper betle L. var. Nigra) is a type of plant that has been studied to have good antibacterial activity against several types of bacteria, including Staphylococcus aureus. The aim of this study was to determine the best formulation for the gel mask and to determine the stability of the preparation of the gel peel-off mask after addition of black betel leaf extract (Piper betle L. var. Nigra). The optimization of the gel-base was carried out by formulating a gel peel- off mask preparation using carbopol in 4 different concentrations, namely F1 0.5%, F2 1%, F3 1.5% and F4 2%, then carried out a physical evaluation of the preparation including organoleptic tests, homogeneity, pH, dispersibility, adhesion, viscosity and drying time. After getting the best gel-base formula, black betle leaf extract was added, and the preparation was again performed for physical evaluation. The result of the optimization of the base gel peel-off mask obtained a base with the characteristics of a transparent white gel, homogeneous, characteristic aroma, thick, pH 5.37, adhesion 18 seconds ? 1 minute, spreading 4,5-7 cm cm, time drying time 14-19 minutes and viscosity of 3,987-26,164 Pa.s. The average results of the physical stability test of the preparation of the gel peel-off mask after the addition of black betle leaf extract were dark green, homogeneous, distinctive rose aroma, thick form, pH 5.6, adhesion 19 seconds, spread 6.4 cm, drying time 17 minutes, viscosity 3.251 Pa.s and absence of syneresis.

Pengaruh Pemberian Jus Daging Buah Jambu Biji (Psidium guajava) Terhadap Penurunan Kolesterol Pada Pasien Hiperkolesterolemia: The Administration Effect from Guava Fruit Juice (Psidium guajava) Towards Cholesterol Reduction on Hypercholesterolemia Patients Nadiyah Amalia Aprilliani; Hajrah Hajrah; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Red guava (Psidium guajava) fruits contain lots of vitamin C with 183,5 mg/ 100g. Vitamin C has been researched to have an antioxidant activity that can lower total cholesterol levels. This study aims to analyze meat guava juice's effect in reducing total cholesterol levels in hypercholesterolemia patients in Samarinda. The research method is quasi-experimental, pre-test and post-test with control design, with purposive sampling as a sampling method. In the study research, as many as ten people were divided into two groups, group one was given a dose of 250 g once a day, and group two was given a dose of 125 g twice a day and both treatments were given 14-days. Cholesterol data is taken by strip-test method and data analysis using paired T-Test. The analysis results obtained a p-value for the treatment group one of 0.018, for treatment group two of 0,00, and the difference between groups one and two of 0,00. The analysis results showed p-value

Penambatan Molekuler Senyawa Metabolit Sekunder Bawang Dayak (Eleutherine bulbosa) Sebagai Penghambat Dipeptidil Peptidase IV (DPP-4): Molecular Binding of Secondary Metabolite Compounds of Dayak Onion (Eleutherine bulbosa) As Dipeptidyl Peptidase IV (DPP-4) Inhibitors Nur Ainah; Mukti Priastomo; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetes is a frightening disease that threatens people's lives, because almost every 10 seconds in the world, people die from complications of this disease. A new DM treatment approach in the creatinase system that inhibits dipeptidyl peptidase IV (Dpp-4) has been developed, and has been shown to effectively increase insulin secretion, maintain pancreatic -integration, and slow gastric emptying. antidiabetic, namely inhibition of the -glucosidase enzyme in one of its compounds and has not been found to inhibit the Dpp-4 enzyme. This study aims to determine the potential of the compounds in Dayak onions as inhibitors of the Dpp-4 enzyme. The method used is molecular anchoring or in silico because the research time is short and the cost is cheaper than in vitro or in vivo. The software used is autodock which is a device that can attach ligand molecules to receptor macromolecules. Then visualized using discovery studio 2020 and other devices to support tethering such as chemdraw and chimera 1.4. vidagliptin as an antidiabetic which has activity against inhibiting Dpp-4 inhibitors was used as a standard. The grid is placed on natural ligands with a box size of 52? x 28? x 26? and a center of 40,926? x 50,522? x 35,031? with a spacing of 0.375?. Based on the docking that has been done, the secondary metabolite compounds in Dayak onions have a low bond energy value, with the lowest value being -8.46 kcal/mol and the highest -5.54 with different values of inhibition constant and bond form. Eleuthoside C has the lowest bond energy of -8.46 and has the most similar interaction with natural ligands. The bond that occurs is the type of hydrogen bonding at the residues of Phe357, Arg125, Arg358, Tyr666, Tyr662, and Glu205. With this, Dayak onions have antidiabetic activity but further docking still needs to be done to see other compounds in Dayak onions as Dpp-4 inhibitors.

Analisis Perubahan Kadar Sianida dan Aktivitas Sitotoksik pada Umbi Singkong Segar yang Diolah Menjadi Tape: Analysis of Changes in Cyanide Levels and Cytotoxic Activity in Fresh Cassava Tubers Processed into Tape Rahmat Budiman; Laode Rijai; Erwin Samsul
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Cassava in Indonesia is the third staple food after rice and corn. In addition, cassava can also be used as a process for other food products such as cassava tape, cassava crackers, opak, getuk, tapioca flour and cassava ejects. Besides containing carbohydrates, cassava also contains cyanide which is a poisonous compound. Cyanide acid is able to cause respiratory distress to death by inhibiting the performance of the respiratory enzymes, causing disturbances in the respiratory system. This study aims to determine changes in cyanide levels and cytotoxic activity in cassava tuber preparations. Qualitative analysis was performed using FeCl3 and AgNO3 reagents, quantitative tests used argentometric titration method. Meanwhile, the cytotoxic test used the Brine Shrimp Lethality Test (BSLT) method. The cyanide content test results obtained in fresh cassava were 41,56 mg, which was categorized as quite toxic, the toxicity level of fresh cassava was classified as toxic, namely 505.82 ppm. Whereas on the processed tape, the test results showed negative results containing cyanide. Cassava tuber cytotoxic test is classified as non-toxic, which is equal to 4216.96 ppm.

Uji Stabilitas Kombinasi Gel Lidah Buaya (Aloe vera (L.) Webb) dan Madu dengan Menggunakan 2 Basis Na-CMC Berbeda: Stability Test of Combination of Aloe Vera (Aloe vera (L.) Webb) and Honey Gel Using 2 Different Na-CMC Bases Rifki Ilmy Fahlevi; Adam M. Ramadhan; Fika Aryati
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Aloe vera (L.) Webb and honey have been used medicinally in several cultures for thousands of years to have antibacterial and anti-inflammatory properties. Gel dosage formulations can be done with several types of ingredients by taking into account the selection of the gelling agent used. This study aims to determine the stability of a gel preparation made from the active combination of aloe vera extract and honey with 2 different Na CMC bases, namely 5 grams (F1) and 2.5 grams (F2). Aloe vera is extracted by maceration method and then made into a gel preparation according to the predetermined formulation. The combination gel formulation of aloe vera extract and honey was evaluated based on organoleptic test, viscosity test, preparation pH, homogeneity, and dispersibility. The results showed that the homogeneity and pH of the preparations were in accordance with the specified criteria, but the viscosity and spreadability tests did not meet the specified criteria. The organoleptic results of the two formulas have a yellowish brown color, a slightly pungent odor and a slightly sticky texture. It was concluded that the best gel in the dosage formulation used in this study was a gel based on 5 grams of Na CMC (F1).

Optimasi Basis Sabun Padat Transparan Menggunakan Minyak Zaitun dan Pengaruh Konsentrasi Sukrosa Terhadap Transparansi Sabun: Optimization of Transparent Solid Soap Base Using Olive Oil and the Effect of Sucrose Concentration on Soap Transparency Risma Dwi Novianti; Wisnu Cahyo Prabowo; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Transparent solid soap has a luxurious, classy, and attractive appearance so it is often sold as a souvenir which is relatively expensive but still has a unique and exclusive appearance. In the process of making transparent soap, sugar (sucrose) functions to form transparency on the soap. Olive oil is one of the potential raw materials for soap making because it has a high content of oleic acid which is good for skin health. This study aims to formulate a transparent solid soap based on raw materials of olive oil and lintut leaf essential oil that meets the characteristics of transparent solid soap and soap quality requirements in accordance with SNI (1994). Sucrose as a transparent agent for soap is concentrated into 14%, 18%, and 22%. Then the base optimization was carried out by varying olive oil and 30% NaOH in three formulations. The results showed that the sucrose concentration was 22% which resulted in the most transparent preparation. Then the evaluation of base optimization shows that all formulas have good characteristics and only formula 2 (18% olive oil and 12% NaOH) fulfills all the soap quality requirements according to SNI (1994).

Formulasi Sediaan Patch Bukal Ekstrak Daun Sirih Hitam (Piper betle L. var Nigra ): Buccal Patch Preparation Formulation of Black Betel Leaf Extract (Piper betle L. var Nigra) Risma Indah Ardiyana; Novita Eka Kartab Putri; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Black betel is one of the native plants from Indonesia which has many benefits for treating various diseases, one of which is for oral diseases such as thrush. This study aims to determine the formula of black betel buccal patch (Piper betle L. var Nigra) which is stable and has good patch activity and to know the formula for buccal patch preparation which is effective as a canker sore and fulfills the characteristics of a good pharmaceutical preparation. The black betel leaf extract was made using the maceration method with 70% ethanol as a solvent. Patches were made based on the extract concentration (0.5%, 1%, 2%) using chitosan as the polymer matrix. The results showed that the best buccal patch was owned at concentrations of 0.5% and 1%. The higher the extract content, the higher the weight, thickness, folding endurance, and swelling index.

Formulasi dan Uji Mutu Fisik Sediaan Sabun Padat Ekstrak Biji Alpukat (Persea americana): Formulation and Physical Quality Test of Solid Soap Extract of Avocado Seeds Sintya Zagita; Elly Purwati; Cikra Ikhda Nur Hamidah Safitri
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Research on avocado seed extract (Persea americana.) At 1% and 3% concentrations for the manufacture of solid soap preparations and physical quality testing of solid soap preparations has been carried out. Avocado seeds have the ability as an antioxidant which can inhibit the main factor in the aging process. This study aims to determine that avocado seed extract (Persea americana.) Can be used as a solid soap with a concentration of 1% and 3% which meet the physical quality test requirements which include pH test, foam power test, organoleptic test, and homogeneity test. The design of this research is experimental research. Avocado seed extract was obtained from the maceration process with 70% ethanol and phytochemical screening was carried out. Making soap formulation is done by calculating using the Lye Calculator and making soap using the Cold Process method. The research results were processed using descriptive analysis. The treatments in this research were the concentration methods added were 1% and 3%. The homogeneity test showed that the three solid soap formulations of avocado seed extract (Persea americana.) Were still homogeneous as indicated by the absence of coarse grains or particles on the surface of the avocado seed extract (Persea americana.) Solid soap which was seen in plain view on the solid soap without the addition of the extract and the concentration of 3%. Meanwhile, the concentration of 1% looks like it is semi-homogeneous. The organoleptic results showed different forms, the formula without the addition of extract and a concentration of 1% had a solid form while the formula with a concentration of 3% had a solid and hard form. The formula without the addition of the extract and the concentration of 1% has a distinctive aroma of lux soap while the formula with a concentration of 3% has a distinctive aroma of avocado seed leaves which is more concentrated, the color of the preparation in each formula is different, influenced by variations in the concentration of mango leaf extract. The high stability of the foam with a height of 9cm and a pH value is in accordance with SNI 06 - 3532 - 2016 with a pH value of 9-11.

Uji Antioksidan Daun Kokang (Lepisanthes amoena) dengan Metode DPPH: Antioxidant Analysis of Kokang Leaves (Lepisanthes amoena) Using DPPH Method Siti Anisah Nur Fajriyati; M Arifuddin; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Kokang Leaf (Lepisanthes amoena) as a traditional cosmetic for the Dayak Benuaq and Tunjung tribe is very important to be developed in medicine because it is contain secondary metabolites as antioxidants. This research was conducted with the aim of knowing the yield of kokang leaves (Lepisanthes amoena), the profile of TLC, and knowing the fraction with the greatest antioxidants in kokang leaves (Lepisanthes amoena). The research used DPPH, KLT, and yield calculation method. The yield obtained in ethanol extract 96% = 23%; N-Hexan = 9.448%; Ethyl Acetate = 1.37%; Ethanol 70% = 9.95%. TLC test results using N.Hexan : Ethyl Acetate (2: 1) eluent and then sprayed with 10% H2SO4, in 96% ethanol extract there were 7 stains, N-Hexan Fraction 9 stains, Ethyl Acetate Fraction 5 stains, and Ethanol Fraction 70 % 1 stain. The qualitative test results after spraying DPPH on TLC, there were yellow spots on a purple background indicating antioxidant activity. The IC50 results were obtained in 96% Ethanol Extract 6.8171 ppm, N-Hexan Fraction 10.0184 ppm, Ethyl Acetate Fraction 5.0107 ppm, and Ethanol 70% Fraction 24.7343 ppm. Based on the results above, it can be concluded that the ethyl acetate extract has the highest antioxidant activity with 5.0107 ppm being able to inhibit DPPH radicals.

Page 44 of 62 | Total Record : 612

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Contact Name Rolan Rusli

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Editorial Address Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location Kota samarinda, Kalimantan timur INDONESIA

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Contact Name
Rolan Rusli

Contact Email
rolan@farmasi.unmul.ac.id

Phone
+6285222221907

Journal Mail Official
admin@farmasi.unmul.ac.id

Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location
Kota samarinda,

Kalimantan timur

INDONESIA