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Proceeding of Mulawarman Pharmaceuticals Conferences

mpc
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Published by Universitas Mulawarman

ISSN : - EISSN : 26144778 DOI : https://doi.org/10.25026/mpc

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 612 Documents

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Potensi Ekstrak n-Heksana dan Ekstrak Etanol dari Daun Sirih (Piper betle Linn) Sebagai Penghilang Bau Mulut yang Disebabkan Bakteri Staphylococcus aureus: Potential of n-Hexane and Ethanol Extract from Betel Leaves (Piper betle Linn) as a Mouth Remover Caused by Bacteria Staphylococcus aureus Nunung Kurniasih; Assyifa Junitasari; Lilis Nurjanah; Anggita Rahmi Hafsari
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The mouth is an ideal place for the growth and development of microorganisms because the mouth has moisture and a regular intake of food. Microbes found in the mouth, namely Staphylococcus aureus which can cause bad breath, one type of plant that is used as a bad breath remover is betel leaf. Betel leaf (Piper betle Linn) contains chavikol and betlephenol which can inhibit bacterial growth. This study aims to identify the class of compounds in betel leaf that have potential as antibacterial properties against S. aureus bacteria. The betel leaf was dried, then crushed to expand the surface of the sample (simplicia). Simplicia as much as 300 grams of macerated stratified with n-hexane, ethyl acetate and ethanol. The result was evaporated and the weight of each extract was 6.4371 g (n-hexane), 8.8007 g (etylacetate) and 9.2173 g (ethanol). Phytochemical tests and thin layer chromatography (TLC) using eluent n-hexane and ethyl acetate (8: 2) showed that n-hexane extract was thought to contain flavonoids, ethyl acetate extract containing saponins and ethanol extract containing polyphenols. Antibacterial activity test was carried out by using the paper disc diffusion method. Both the n-hexane extract and the ethanol extract of betel leaf showed very strong antibacterial activity, characterized by a diameter of inhibition above 20 mm.

Penambatan Molekul Senyawa Turunan Beta Asaron Sebagai Antimalaria: Molecular Docking of Derivated Compounds of Asaron Beta as an Antimalaria Salahuddin Salahuddin
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Beta Asarone derivatives are known for their potential as antimalarial. In the current study, the quantitave structure-activity relationship (QSAR) and molecular docking on 31 asarone derivatives was performed to search for novel more potent asarone derivatives as antimalaria. The obtained QSAR model was log IC 50 = 2.57917 + 0.019377 (AM1_HF) + 5.82755 (glob) + 0.61384 (log s) + (-1.63312 (mr)) + 0.05564 (vol). Designing new compound of asarone derivatives was performed using the validated QSAR model and the result showed that two compounds, A5 and A18, had better activities than the parent compound (ASN27). Molecular docking study showed that the two compounds were able to interact with crucial amino acid residues in the allosteric site of protein receptor (PDB code: 1CET) through hydrogen bonds and van der Waals interactions. The current study indicated that the two compounds had affinity significantly different to native ligand and might be useful to be advanced in the drug discovery process.

Traditional Medicine Pattern for Self-Medication in Temajuk Village, a 3T (Frontier, Outermost, and Underdeveloped) Region in West Kalimantan Muhammad Akib Yuswar; Eka Kartika Untari; Robiyanto Robiyanto
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Living in a 3T region (frontier, outermost, and underdeveloped) of West Kalimantan, people who live in Temajuk village, have long been practicing self-medication using traditional medicines. Despite the existence of a primary care service in Temajuk, the people’s habit in utilising natural herbal medicine to cure their illness still exists until now. The aim of this study was to identify patterns of traditional medicine as self-medication treatment among Temajuk villagers. This study was a cross sectional descriptive study using 138 participants who met the criteria including aged 20-50 years and have been practising self-medication. The participants were asked to fill a set of questionnaire. The results of this study showed that the average age of participants was 33.86 y.o. They used Piper betle folium mostly (39.86%) in self-medication practice. 44.2% of participants believed in traditional medicine. Fever (22.47%) was the most chosen indications to use traditional medicine for self-medication. 60.87% respondents used traditional plant from their back and 59.42% of them made it into decocta or infusum. Most of participants did not experience any adverse effect (86.96%) during self-medication practice. In brief, this study proved that the practice of self-medication using traditional medicine is often to occur and still important for people in Temajuk village.

Review: Flavonoid pada Tanaman Kumis Kucing (Orthosiphon stamineus Benth.): Review: Flavonoid Compounds in Orthosiphon stamineus Fahrauk Faramayuda; Silvy Julian; Ari Sr Windyaswari; Totik Sri Mariani; Elfahmi Elfahmi; Sukrasno Sukrasno
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Orthosiphon stamineus has long been used in traditional medicine in East India, Indo China, Southeast Asia, and tropical Australia, where this plant is usually found. Based on the color of the flowers and petals, Orthosiphon stamineus is classified into two varieties: white flowers (white varieties) and purple flowers (purple varieties). Orthosiphon stamineus has traditionally been used to treat hypertension, diabetes, bladder and kidney disorders, gallstones, gout, and rheumatism. The leaves of Orthosiphon stamineus were introduced to Europe and Japan as tea for health. The main compounds possessed by Orthosiphon stamineus are rosmarinic acid, eupatorium, and sinensetin. In addition, several studies have isolated the plant of Orthosiphon stamineus. This journal review aims to review studies related to the content of secondary metabolites, traditional uses, pharmacological activities, and levels of flavonoids contained in plants.

Formulasi dan Uji Mutu Fisik Sabun Padat Ekstrak Kulit Nanas (Ananas comosus L.): Formulation and Physical Quality Test of Pineapple Peel Extract (Ananas comosus L.) Solid Soap Milani Agustina Putri; Elly Purwati; Cikra Ikhda Nur Hamidah Safitri
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Nanas (Ananas comosus L.) merupakan salah satu tanaman di indonesia yang sangat berpotensi untuk dikembangkan karena mempunyai banyak manfaat. Nanas mengandung banyak vitamin B12, vitamin C, vitamin E dan enzim bromelin. Sedangkan kulit nanas yang hanya dianggap sampah yang tidak memiliki manfaat, padahal kulit nanas mengandung enzim bromelin, karotenoid, vitamin C dan flavonoid yang baik bagi kesehatan. Kandungan flavonoid dalam kulit nanas dapat dimanfaatkan sebagai antioksidan, anti alergi, anti inflamasi, dan anti bakteri. Antioksidan kulit nanas dapat dimanfaatkan sebagai pelindung kulit karena dapat mencegah terjadinya radikal bebas dan dapat diaplikasikan dalam bentuk sediaan sabun padat. Penelitian ini bertujuan untuk menghasilkan sabun padat ekstak kulit nanas dan menguji mutu fisik sesuai Standar Nasional Indonesia (SNI). Metode penelitian ini bersifat eksperimental yang terdiri dari pembuatan simplisia dan ekstraksi menggunakan metode maserasi dengan pelarut etanol 70%. Formulasi menggunakan ekstrak kulit nanas dengan konsentrasi 0% (basis), 1% (F1), 3% (F2). Evaluasi karakteristik fisik sabun padat meliputi pengamatan organoleptis, pengujian homogenitas, uji pH, uji daya busa. Sediaan di evaluasi selama 4 minggu, data dianalisis secara deksriptif. Hasil penelitian ini menunjukkan ke tiga formula menghasilkan sabun padat yang homogen, bertekstur padat dan halus, beraroma wangi, Basis (berwarna putih pekat kekuningan), F1 (berwarna putih pekat kekuningan), F2 (berwarna putih pekat kekuningan). Nilai pH pada basis, F1, F2 adalah 9,52 ,9,35, 9,45. Hasil organoleptis pada sediaan sabun padat basis, F1, F2 tidak mengalami perubahan. Nilai homogenitas pada sabun padat basis, F1, F2 tidak mengalami perubahan. Nilai uji daya busa sabun padat basis, F1, F2 tetap stabil. Kesimpulan pada penelitian ini yaitu mutu fisik sediaan sabun padat ekstrak kulit nanas memenuhi syarat SNI dan stabil selama penyimpanan 4 minggu.

Formulasi dan Uji Aktivitas Gel Anti Jerawat Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi Linn): Formulation and Activity Test of Anti Acne Gel Ethanol Contained Extract of Starfruit Leaves (Averrhoa bilimbi Linn) Akhmad Ifda Hanip; Dewi Mayasari; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Averrhoa bilimbi Linn is a plant that is used by the local community as an itchy and acne remedy. Secondary metabolite content of ethanol extract of Starfruit leaves (Averrhoa bilimbi Linn) can inhibit the growth of acne bacteria. The purpose of this study was to determine the best concentration in the manufacture of anti-acne gel formulations of ethanol extract of Starfruit leaves (Averrhoa bilimbi Linn) using HPMC base. Extract concentrations were made of 5%, 7.5%, and 10%. After antibacterial tests, the extract concentration used was 7.5% with a inhibition zone of 11.17 mm P.acnes bacteria and 11.30 mm S.aureus bacteria. Anti-acne gel ethanol extract of starfruit leaves (Averrhoa bilimbi Linn) made 3 replication formulas with extract levels FR1 (7.5%), FR2 (7.5%) and FR3 (7.5%). The results showed that the color of the dark green preparation, distinctive smell, thick, no syneresis, ph 4.7-6.2, scatter power 4.6-5.2 cm, clinginess 6-22 seconds and viscosity of 11-20 Pa.s. Antibacterial activity tests on P.acnes showed a inhibition zone of 10.1-10.73 mm and S.aureus showed a inhibition zone of 10.35-10.93 mm. So, it was concluded that the formulation of anti-acne gel was able to inhibit the growth of P.acnes and S.aureus bacteria and meet physical characteristics.

Isolasi dan Karakterisasi Kitin dari Limbah Cangkang Kerang Asia (Corbicula fluminea): Isolation and Characterization of Chitin from Asian Shell Waste (Corbicula fluminea) Ameilia Rachmadianty; Fika Aryati; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Chitin compounds are compounds that can be found from various animals of the Crustaceae group, for example such as crabs, shrimp, and shellfish. The purpose of this study was to find out the chitin content and chitin characteristics of asian shell waste (Corbicula fluminea). The stage of chitin insulation includes the process of deproteination using Sodium Hydroxide 3.5%, and the next process is the process of demineralization using Hydrochloric Acid 1 N. From the results of the isolation obtained chitin characterization in the form of chitin yield is 82.75%, with a grayish-white powder texture, and odorless, it perfectly soubled in Hydrochloric Acid 1 N, has a water content of 0.1764% and ash content of 58.0753%.

Uji Kualitatif Aktivitas Radikal Bebas DPPH dari Daun Penggugut (Knema pallens W.J.deWilde): Qualitative Test of DPPH Radical Scavenging Activity from Penggugut Leaves (Knema pallens W.J.deWilde) Annisa Anugrah Putri; Hifdzur Rashif Rija’i; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Penggugut (Knema pallens W.J. deWilde) is an endemic plant from Kalimantan belongs to Myristicaceae or the nutmeg family. Penggugut can be found in habitats like lowland forest, sandy forests and mangroves. The efficacy and activity of penggugut especially the leaves, have not been widely known or studied. So that make the purpose was to know about the percentage yield of extract and fraction from penggugut leaves and to know the activity of Radical Scavenging DPPH from penggugut leaves. The methods used include extraction, liquid-liquid fractination and TLC by spraying DPPH. The results there are percentage of yield : methanol extract is 8,04%, n-hexane fraction is 28,9%, ethyl acetate fraction is 7,83% and n-butanol fraction is 9,8%. In the qualitative test, it was found that the spots have activity of Radical Scavenging were marked with yellow spots on a purple background, there are in the methanol extract have 4 spots with Rf values (0,07; 0,14; 0,29; 0,43), the n-hexane fraction have 3 spots with Rf values ??(0,1; 0,21; 0,43), the ethyl acetate fraction have 5 spots with Rf values ??(0,07; 0,17; 0,29; 0,43; 0,53) and the n-butanol fraction did not get any spots.

Pengaruh Waktu Fermentasi Sari Kulit Buah Naga Merah (Hylocereus polyrhizus) Terhadap Total Bakteri Asam Laktat (BAL): Effect of Fermentation Time of Red Dragon Fruit Peel Juice (Hylocereus polyrhizus) on Total Lactic Acid Bacteria (LAB) Aprilia Wulandari; M. Arifuddin; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Fermentation process decomposes lactose into lactic acid and various other components with success parameters seen from the pH value and Total Lactic Acid Bacteria. The purpose of this research is to analyze the effect of the fermentation time of the Red Dragon Fruit peel extract on the pH value and lactic acid bacteria. The method includes the process of extracting samples and pasteurizing the juice and then proceeding with fermentation with variations of 3, 4, 5, and 6 days at 37ºC. In addition, the extract was prepared into a test solution with graded dilutions for further testing of totaled LAB using the Total Plate Count (TPC) method. The best pH value is showing in the 5-day fermentation time, which is 3.82 and the best LAB value is showing in the 6-day fermentation time, which is 18 x . The results showed that the time of fermentation affected the pH and LAB value.

Uji Aktivitas Antibakteri Asap Cair Daun Mangga Kuweni (Mangifera odorata) terhadap Propionibacterium acnes: Antibacterial Activity Test of Liquid Smoked Leaves of Mango Kuweni (Mangifera odorata) against Propionibacterium acnes Bagaskara Adi Nugroho; Adam M. Ramadhan; Novita Eka Kartab Putri
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Liquid smoke is the result of condensation or vapor condensation produced by direct or indirect combustion of materials containing cellulose, lignin, hemicellulose, and other carbon compounds. The function of liquid smoke is as an antioxidant and antibacterial. The purpose of this study was to determine the percent yield obtained, the secondary metabolites contained in the liquid smoke, and the bacterial inhibitory activity of the liquid smoke of the leaves of Mango Kuweni (Mangifera odorata). The method used in this research is pyrolysis and distillation for the manufacture of liquid smoke. As for the antibacterial test using the agar diffusion method with paper discs. The results showed that the yield obtained from the manufacture of liquid smoke grade 3 was 26.87%, grade 2 was 17.91%, and grade 1 was 14.33%. Secondary metabolites contained in the liquid smoke of the leaves of Mango Kuweni (Mangifera odorata) are Flavonoids, Alkaloids, and Phenols. The results of antibacterial testing using the bacteria Propionibacterium acnes showed inhibitory activity of 20% concentration of 4.4 mm (weak), 30% concentration of 4.76 mm (weak), 40% concentration of 5.21 mm (weak) and positive control, namely clindamycin of 15.27 mm (strong).

Page 46 of 62 | Total Record : 612

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Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

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Home Page

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Contact Name Rolan Rusli

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Editorial Address Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location Kota samarinda, Kalimantan timur INDONESIA

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Contact Name
Rolan Rusli

Contact Email
rolan@farmasi.unmul.ac.id

Phone
+6285222221907

Journal Mail Official
admin@farmasi.unmul.ac.id

Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location
Kota samarinda,

Kalimantan timur

INDONESIA