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Proceeding of Mulawarman Pharmaceuticals Conferences

mpc
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Published by Universitas Mulawarman

ISSN : - EISSN : 26144778 DOI : https://doi.org/10.25026/mpc

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

LINGKUP DAN TUJUAN Lingkup naskah mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 612 Documents

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Formulasi dan Uji Mutu Fisik Sabun Herbal Padat Ekstrak Kulit Batang Kayu Manis (Cinnamomum burmanni): Formulation and Physical Quality Test of Solid Herbal Soap Cinnamon (Cinnamomum burmanni) Bark Extract Dewinta Hesti Dwi Nurani; Elly Purwati; Cikra Ikhda Nur Hamidah Safitri
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Researchers have conducted research on the 1% 3% concentration of cinnamon bark extract (Cinnamomum burmanii.) For the manufacture of herbal solid soap preparations and tested the physical quality of herbal solid soap preparations. Cinnamon has antibacterial properties. This study aims to determine the extract of cinnamon bark (Cinnamomum burmanii.) Can be used as solid soap with a concentration of 1%, 3% which meets the requirements of the physical quality test which includes pH test, foam power test, organoleptic test, and homogeneity test. The design of this research is experimental research and the data were analyzed descriptively. Cinnamon bark extract was obtained from the maceration process with 70% ethanol. Making herbal solid soap formulations and soap making using the Cold Process method. The treatment in this study the concentration method added was 1% 3%. The homogeneity test showed that the three solid soap formulations of cinnamon bark extract (Cinnamomum burmanii) remained homogeneous as indicated by the absence of coarse grains or particles on the surface of the herbal solid soap for cinnamon bark extract (Cinnamomum burmanii.) High stability of the foam with a height of 9cm and a pH value. already in accordance with SNI 06 - 3532 - 2016 with a pH value of 9-11 the organoleptic test shows different results.

Pengaruh Lama Penyimpanan Ekstrak Etanol Daun Sirih Hitam (Piper betle L. var Nigra) Terhadap Aktivitas Antibakteri: The Effect of Storage Time Extract Etanol Black Betel Leaf (Piper betle L. var Nigra) To Antibacterial Activity Falencia Ega Aprillia; Mirhansyah Ardana; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Black Betel Leaf (Piper betle L. var Nigra) contains compounds that act as antibacterials, namely alkaloids, flavonoids, saponins, tannins, steroids and phenolic compounds. Acne or acne vulgaris is an inflammatory reaction in the sebaceous follicles, which is caused by the Propionibacterium acnes bacteria. This study aims to prove that black betel leaf (Piper betle L. var Nigra) has antibacterial activity and has a long-lasting effect on the ethanol extract of black betel leaf against propionibacterium acne. The method includes sample extraction with 70% ethanol and then followed by antibacterial testing with the well method. In addition, the extract was prepared into a test solution and stored for 7 days at room temperature. The results of antibacterial testing using well diffusion can be concluded that the ethanol extract of black betel leaves with a concentration of 5%, 10%, 15%, 20% has the ability to inhibit the growth of propionibacterium acne bacteria. The effect of the extract storage time on day 7 had the largest inhibition zone.

Formulasi Lip Balm Minyak Almond dan Ekstrak Biji Kesumba Keling (Bixa orellana L.) Sebagai Pewarna Alami: Lip Balm Formulation of Almond Oil and Kesumba Keling (Bixa orellana L.) Seed Extract as Natural Colorants Hafifah Sarwanda; Nurul Fitriani; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

lip balm is a preparation used on the lips as a moisturizer and lip protector. there have been many innovations lip balm with moisturizers and dyes natural ingredients. In general, the lip balms on the market use chemicals that can cause irritation. Therefore, almond oil is used which is a natural oil as an emollient and the kesumba keling Plant is a natural dye derived from the extraction of the kesumba keling seeds. The method used was experimental research, namely the formulation of lip balm with various concentrations of almond oil. 5%, 10%, 15%, and 20% and stability testing of preparations covering organoleptic, homogeneity, pH, dispersibility, which was carried out for 28 days, in addition to that, the melting point test was carried out. The results obtained in the organoleptic test were reddish orange in color, a distinctive odor of lip balm, with a semi-solid consistency. Result of Homogeneity test is the absence of coarse grains (homogeneous). The result of pH test is pH of the lip balm preparation stable at pH 5. The result of spreadability test is a diameter range of 2.5 - 4 cm. And the result of melting point test is a range of 54 - 580C. Based on the evaluation results, the lip balm has better physical quality and is stable in the 20% almond oil lip balm formulation.

Uji Aktivitas Minyak Atsiri Daun Pala (Myristica fragrans Houtt.) Sebagai Antibakteri: Activity Test of Nutmeg Leaf Essential Oil (Myristica fragrans Houtt.) as Antibacterial Halimathussadiah Halimathussadiah; Dewi Rahmawati; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Antibacterials are compounds that are useful in controlling bacterial growth that can harm humans and avoid pathogens that can be a source of disease for the body. Nutmeg essential oil (Myristica fragrans Houtt.) Is known to contain various compounds including flavonoids, alkaloids, phenols and terpenoids which can be used as antibacterial agents. The purpose of this study was to determine the activity of nutmeg essential oil as an antibacterial. The antibacterial test method uses the well diffusion method using a 6 mm buffer. Nutmeg essential oil is made in 4 concentration series, namely F1 (40%), F2 (60%), F3 (80%), F4 (100%), 10% DMSO control. The data analysis method is a descriptive method in the form of data that is presented in the form of tables and figures. The results of the antibacterial activity test showed that the essential oil of nutmeg leaves had antibacterial activity against Escherchia coli, Staphylococcus aureus, Vibrio cholerae, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus epidermidis in the best concentrations, namely 100% respectively of 6.79mm ? 0.67; 5.56mm ? 0.18; 6.75mm ? 0.82; 14.61mm ? 1.10; 17.03 mm ? 3.90; 5.39mm ? 0.75; control there is no antibacterial activity. The response of each bacteria was medium-strong and the best concentration was taken from the highest concentration because the higher the essential oil concentration of nutmeg leaves, the greater the bacterial inhibitory activity.

Simulasi Docking Senyawa Napthoquinones Umbi Bawang Tiwai (Eleutherine americana Merr.) terhadap Bakteri Mycobacterium tuberculosis: Docking Simulation of Umbi Bawang Tiwai Napthoquinones Compound (Eleutherine americana Merr.) against Mycobacterium tuberculosis bacteria Irmayanti Irwan; Hajrah Hajrah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Bawang tiwai (Eleutherine americana Mirr.) is a plant empirically used as an antituberculosis. This plant is thought to have potential because having a compound naphthoquinone potential antituberculosis seen from the average value of the MIC between 206,6 and 12.5 ?M. This study aims to examine a model of the interaction of compounds derived naphthoquinone of bawang tiwai against the side of the fastener from the bacterium Mycobacterium tuberculosis. The method used is docking molecular using AutoDock tools, and Biovia 2020, the prediction of physicochemical which refers to the law of the five Lipinski of using pkCSM online tool. The receptor proteins used were InhA (PDB: 2X23) and the test ligands of elecanacin, eleutherin, eleutherol, and isoeleutherin. The results show that the four compounds comply with Lipinski's five laws, and the docking analysis data is the value of free bond energy (?G) of the four compounds, respectively, -5.82, -4.80, - 5.06, -5.52. The ?G value is below the natural ligand, namely -8, 19, and no hydrogen bonding interaction. It can be concluded that the four naphthoquinone derivative compounds in bawang tiwai lack the potential to bind to the binding site of the Mycobacterium tuberculosis bacteria.

Optimasi Metode Ekstraksi Daun Sirih Hitam (Piper Sp.) Terhadap Kandungan Metabolit Sekunder: Optimization of Extraction Method of Black Betel Leaf (Piper Sp.) Against Secondary Metabolite Content Jamal Habibullah; Risna Agustina; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The black betel plant (Piper Sp.) Has been empirically used by the public for a treatment. This plant has the potential to be developed into pharmaceutical products made from natural ingredients, so an extraction method is needed that can be used as a standard in the development of this plant. The research aims to determine the effect of stirring speed, solid-liquid ratio and sample surface area in the extraction method and to determine the profile of the extraction method. the optimum black betel leaf based on the yield parameters of the extract and the TLC profile. This research is an experimental study conducted by extracting black betel leaves using the maceration method which is influenced by several conditions, namely, with a stirring speed of 300 rpm; 400 rpm; 500 rpm, 1: 5 solid to liquid ratio; 1:10; 1:15 and the surface area of the chopping sample using a blender; 1x1 cm; 2x2 cm. Then the extract yield was calculated and the TLC profile observations were made. The results showed that the stirring speed, the solid-liquid ratio and the surface area of the sample affected the yield of the extract. However, the stirring speed and surface area of the sample did not affect the stain pattern on the TLC profile, while the liquid solid ratio affected the stain pattern on the TLC profile, and the optimum extraction method for the extract yield on black betel leaf was stirring speed of 300 rpm, solid to liquid ratio. ratio of 1:15 and the surface area of the chopped sample using a blender.

Formulasi Sediaan Lip Cream dengan Pewarna Alami Ekstrak Buah Senggani (Melastoma malabathricum L.): Lip Cream Formulation with Natural Coloring Senggani Fruit Extract (Melastoma malabathricum L.) Khoiriyah Anbar Mufidah; Febrina Mahmudah; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Senggani (Melastoma malabathricum L.) is a wild plant that has anthocyanin compounds which are red, purple and blue pigments in plants that can be used as natural dyes. So, to increase the use value of the senggani plant, senggani fruit extract is used as a natural coloring agent in lip cream preparations. Senggani fruit was extracted, then formulated. The quality of the preparation is determined through evaluation of physical characteristics (organoleptic test, homogeneity test, dispersion test, adhesion test, viscosity test and pH test), physical stability test (freeze thaw method and room temperature) for 16 days, evaluation of the safety of the irritation test (method patch test) and acceptability (hedonic test method). The results obtained were the lip cream preparation formula using senggani fruit extract with a concentration of 5%, 10%, and 15% producing purple, reddish purple, and purplish red colors, respectively. The results of the evaluation of the physical characteristics of all preparations included the aroma of rose flowers, semisolid consistency, homogeneous and has a viscosity, dispersibility, adhesion, and pH that meet the pharmaceutical requirements of lip cream preparations. The results of the physical stability test of the three formulas showed that all preparations were stable, with organoleptic, homogeneity, pH, and viscosity that met the range and there was no phase separation. The results of the irritation test of the preparations showed that the preparations did not irritate and the results of the acceptability of the preparations in terms of color and texture of the preparations were preferably panelists at a concentration of 10% and in terms of aroma, preferably panelists at a concentration of 5%.

Uji Aktivitas Mukolitik Perasan Daun Miana (Plectranthus scutellarioides (L.) R.Br.) Secara In Vitro: Mucolytic Activity Test of a Squeeze of Miana leaves (Plectranthus scutellarioides (L.) R.Br.) by in Vitro Krismayani Krismayani; Fajar Prasetya; Febrina Mahmudah
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Mucolytics are drugs that can dilute airway secretions by preventing mucoprotein and mucopolysaccharide threads from being sputum. Empirically, the juice of miana leaves is used by the Toraja people to treat cough with pHlegm. There has been no testing of miana leaf juice as a mucolytic agent, therefore this study was conducted to see the mucolytic activity of miana leaf juice. The test was carried out in vitro using bovine intestinal mucus as a negative control and acetyl as a positive control. Mucolytic activity can be seen from the decrease in viscosity produced by each test sample. Samples were tested using a Rheosys viscometer with a temperature and pH that matched the pHysiological conditions of the body. The results showed that the concentration of 1% miana juice had a large mucolytic activity, compared to concentrations of 0.5%, 1.5, and 2%. The results of pHytochemical screening showed that miana leaf juice was positive for saponins and flavonoids which were thought to work in decreasing the viscosity of mucus.

Upaya Pembuatan Cashew Nut Shell Liquid Sebagai Bahan Baku Produk Farmasi: Efforts to Make Cashew Nut Shell Liquid as Raw Material for Pharmaceutical Products Maria Saena Puru; Nur Masyithah Zamruddin; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Cashew (Anacardium occidentale L) is one of the plantation commodities which has a high economic value. However, the utilization is still limited to the cashew, while the shells have not been used as a product. The purpose of this study was to obtain cashew nut shell liquid (CNSL) oil from cashew nut shells. Furthermore, efforts were made to purify CNSL which could be used as an opportunity for the use of cashew nut shell oil in the pharmaceutical field. This research was conducted experimentally with the Soxhlet extraction method using n-hexane solvent and concentrated using a rotary evaporator. The analysis carried out included yield, viscosity, acid number, specific gravity and pH while the analysis of CNSL purification efforts included screening, management and use of ice cubes. The results obtained were yield (%) 29.76 ? 4.133, acid number (mg KOH / gr) 129.70 ? 10.927, specific gravity (g / ml) 1.086 ? 0.0009, viscosity (cps) 464.79 ? 42.959 and pH 6.13 ? 0.134. The way of purification efforts carried out by physical processes, use, use of ice cubes did not show significantly different results. It can be said that cashew nut shell oil can be used as raw material for pharmaceutical products from the amount of oil yield obtained and requested in the next research to find out more suitable methods for CNSL purification.

Aktivitas Antibakteri Ektrak Batang Bagore (Caesalpinia bonduc (L.) ROXB): Antibacterial Activity of Bagore Stem Extract (Caesalpinia bonduc (L.) ROXB) Muhammad Fauzi Zainal Abidin; Risna Agustina; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Bagore (Caesalpiniabonduc (L.) Roxb) from the Febaceae / caesalpiniaceae family is a thorny shrub. This plant is reported to have some activity and also has metabolites of alkaloids, flavonoids, saponins, tannins and triterpenoids. The purpose of this study was to determine the antibacterial activity of bagore stem extract. The extraction method used is the maceration method using ethanol solvent and the yield of 5.5% bagore stem extract followed by the determination of secondary metabolites. The stem extract was found to have positive results of flavanoid and saponin compounds which have antibacterial activity. Testing for the inhibition of Streptococcus aureus and Propionibacterium acnes as gram-positive bacteria and Escherichia coli as gram-negative bacteria using the well diffusion method. The extract concentrations used were 10%, 20%, and 30%, and the negative control used water and ethanol. the results of antibacterial tests against Streptococcus aureus bacteria obtained the respective inhibition zone diameters; 11,836 mm; 13,671 mm and for Propionibacterium acnes bacteria obtained the diameter of the inhibition zone for each success; 10,781 mm; 13,169 mm; 14,190 mm, while the Escherichia coli bacteria obtained the respective inhibition zone diameter; 10,552 mm; 13,436 mm; 14,036 mm

Page 43 of 62 | Total Record : 612

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Home Page

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Contact Name Rolan Rusli

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Editorial Address Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

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Abstract

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Abstract

Contact Name
Rolan Rusli

Contact Email
rolan@farmasi.unmul.ac.id

Phone
+6285222221907

Journal Mail Official
admin@farmasi.unmul.ac.id

Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119

Location
Kota samarinda,

Kalimantan timur

INDONESIA