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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN IKUTAN PASCA IMUNISASI COVID-19 Hoirun Nisa; Putri Kurniawati; Rifka Qatrunnida; Dadang Mulyono
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art5

Abstract

Background: Evidence indicates that COVID-19 vaccines are effective at helping to prevent serious infection and risks of hospitalization due to COVID-19. Seven types of vaccines have been used in Indonesia. Adverse events following immunization (AEFI) may occur after the COVID-19 vaccination. Objective: This study aimed to determine factors associated with AEFI of the COVID-19 vaccination.Methods: This cross-sectional study included 160 respondents who had been vaccinated against COVID-19. Data were collected by using google form distributed through social media from October 12-20, 2021. Multivariate analysis was performed by using a logistic regression test.Result: The incidence of AEFI of the COVID-19 vaccination was 69.4%, and the AEFI symptoms were lower in the second dose of COVID-19 vaccine than the first dose. Poor dietary habits were associated with higher risks of the AEFI (OR=2.34 CI 95% 1.14-4.80). The second vaccine dose was related to decreased risks of the AEFI (OR=0.35 CI 95% 0.13-0.92).Conclusion: The incidence of AEFI of the COVID-19 vaccination was quite high, and the common AEFI was systemic symptoms. Dietary habits and vaccine doses were associated with the AEFI of the COVID-19 vaccination. These findings suggest that poor dietary habits may increase the risks of the AEFI, and decreased risks of the AEFI may be experienced in the second dose of COVID-19 vaccine. Further studies are warranted to explore the effects of both doses of COVID-19 vaccines on the AEFI.
Tuberkulosis Kutis Verukosa pada Pasien Tuberkulosis Paru Mimi Maulida; Nanda Earlia; Vella Vella; Karamina Maghfirah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art13

Abstract

Cutaneous tuberculosis is a skin disorder caused by Mycobacterium tuberculosis, commonly classified according to its spreading route into endogenous, exogenous, and hematogenous, with distinct skin morphology and histopathological findings. Tuberculosis verrucosa cutis is a classification form of cutaneous tuberculosis, a paucibacillary disease caused by exogenous reinfection (inoculation) after sensitization on an immunocompromised individual. Management of cutaneous TB is generally similar to the management of pulmonary TB. In this paper, we presented a case of 62 years old male with a purplish rough patch on the right dorsum of the foot that began 1,5 years. There is a history of trauma and pulmonary TB. On the right dorsum of the foot, we identified a verrucous lesion with a livid base, irregular with the size of 6x3 cm. The diagnosis is established based on clinical features and histopathology evaluation. The patient received treatment with antituberculosis medication, topical mupirocin ointment 2%, and vaseline petroleum jelly. Improvement of the lesions was observed after the patient completed the intensive phase in two months of treatment with antituberculosis drugs.
A male Covid-19 convalescent plasma donor with long existence of SARS-Cov-2 antibodies: a case report Teguh Triyono; Usi Sukorini; Andri Christianalusi; Sri Mulatsih; Hans Vrielink
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art12

Abstract

Covid-19 Convalescent Plasma (CCP) was one of alternative therapy for Covid-19 patients. The use of convalescent plasma as an adjunct therapy must consider its efficacy, benefits, and risk, both for the patient and the donor. Convalescent Plasma was produced from purified human plasma. Convalescent Plasma was a passive immunity which provide active antibodies. CCP give immunity to the patient through the transfusion of a survivor’s antibodies. We were reporting a case of male CCP donor with long existence of SARS-Cov-2. This donor performed up to 16 donations, which was an unusual case in CCP donor. The SARS-CoV-2 antibody titer was analyzed using Elecsys® Anti-SARS-CoV-2 (Roche Diagnostics). The SARS-CoV-2 antibody showed high level of total SARS-CoV-2 antibodies, with the Cut off Indexes (COI) anti SARS-Cov-2 antibody were still quite high (132 U/mL). The highest donor antibody COI (204.6 U/mL) was seen in 11th donation at 6 months after recovery, while the lowest antibody COI (130.8 U/mL) was in 15th donation at 7 months after recovering. Evaluation of donor health status were performed after the 16th donation and analyzed as well. In conclusion, 16 CCP donations of 600 mL resulting in 48 units of 200 mL plasma in 8 months was safe for the donor, with the SARS-Cov-2 antibody titer remained high in the whole period.
EFEK SAMPING OBAT YANG TIDAK BERHUBUNGAN DENGAN KEPATUHAN PENGOBATAN PASIEN KUSTA DI SUBANG Tinalda Nur Amelia Wijaya; Meiyanti Meiyanti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art4

Abstract

Background: Indonesia is currently contributing to the third highest incidence of leprosy in the world. Leprosy sufferers who do not undergo regular treatment have risk in transmitting the disease to others. Moreover, it may also cause disability problems and social impacts. Objective: This study aims to analyse relationships between drug side effects, subject characteristics and adherence to treatment of leprosy patients.Method: This was an observational analytic study with a cross-sectional research design with a sample of 115 leprosy patients. This study was conducted at four Puskesmas (Community Health Centre) of Sukasari sub-district, Subang from October to December 2021. Its data was collected by using a questionnaire consisting of patient characteristics; the MMAS-8 questionnaire was used to assess levels of the adherence and the side effects. Then the data were analysed by Chi-Square and Fisher's Exact test, with a significance level of 0.05.Results: The results of this study revealed that 60 (52.2%) of the subjects were categorized in the medication adherence with a score of 0 and 22 (19.1%) of them were relatively high adherence with a score of 1-2. Most of the 93.9% of subjects experienced drug side effects while undergoing the leprosy treatment. There was no significant relationship between drug side effects (p=0.442), genders (p=0.848), ages (p=0.275), education levels (p=0.134), types of occupations (p=0.847) and adherence to treatment of leprosy patients. Conclusion: Several factors such as drug side effects, ages, genders, education levels and occupations were not significantly related to medication adherence in the leprosy patients.
PERBANDINGAN RIWAYAT PEMBERIAN ASI EKSKLUSIF DAN MPASI TEPAT WAKTU PADA BALITA MALNUTRISI DAN NUTRISI NORMAL Elman Boy; Rudi Iskandar Hasibuan; Ashil Muhammad Abdul Rasyid; Nugraha Ilhamsyah; Cut Shanaz Dhiya Shafira; Annisa Fitri Hendewi; Raudatul Husna Pranata; Putri Maulia Amami Harun
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art8

Abstract

Background: Breast milk and complementary feeding are important sources of nutrition in the first 1000 days of life, so nutritional deficiencies in this period of life cause problems in both short and long terms. Hence, investigating the association between breastfeeding, complementary feeding history, and toddlers’ nutritional status is important.Objective: This study aims to assess the influence of exclusive breastfeeding and timely complementary feeding on the nutritional status of children under five.Methods: This cross-sectional study was conducted in a Public Health Centre (Puskesmas) in Medan, North Sumatera. Data regarding the toddlers’ height and weight were obtained through direct measurements, whereas information about breastfeeding and complementary feeding history was gathered through interviews with the toddlers’ mothers. Chi-square analysis was performed for statistical analysis.Results: The study involved 50 toddlers, 30 boys and 20 girls. Among them, 58% received both exclusive breastfeeding and timely complementary feeding, while 42% did not. Among toddlers who received exclusive breastfeeding and timely complementary feeding, 82.7% demonstrated normal nutritional status, whereas 10% experienced malnutrition. Conversely, in toddlers not given exclusive breastfeeding and timely complementary foods, only 38% had normal nutrition, with the remaining 62% facing malnutrition. There was an association between exclusive breastfeeding, timely complementary feeding, and toddlers’ nutritional status (P < 0.05). Toddlers receiving exclusive breastfeeding had 7.8 times higher odds of experiencing normal nutritional status compared to those without it. Similarly, toddlers exposed to timely complementary feeding had 4.3 times higher odds of experiencing normal nutrition.Conclusion: Exclusive breastfeeding and timely complementary feeding played an important role in the nutritional status of toddlers.
EFEK PAPARAN ASAP BIOMASSA GAMBUT TERHADAP STRESS OKSIDATIF PADA TIKUS WISTAR Uly Astuti Siregar Uly Astuti Siregar; May Valzon; Fitrianti; Arif Budianto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art2

Abstract

Background: Indonesia ranks third in the world regarding air pollution due to forest and land fires; most of the land burned is a peatland. Particulate matter (PM) 2.5 is the largest component of the total smoke particles. Short-term and long-term exposure to PM2.5 remains a hazard to human health.Objective: This study aims to examine the effect of exposure to peat biomass smoke on serum malondialdehyde (MDA) levels and body weight of Wistar rats.Methods: Experimental animals were randomly divided into three groups: Control group (C) is not given treatment, and treatment groups (X1 and X2) are exposed to smoke from peat biomass of 100 g and 150 g of biomass for 60 seconds per day for 14 days. The body weight was examined before and after treatment, while Serum MDA levels were examined after treatment.Results: The results showed significant differences (p < 0.05) in serum MDA levels between groups. The highest serum MDA levels were found in group X2 (3.03 ± 0.185 nmol/ml), followed by group X1 (2.67 ± 0.212 nmol/ml) compared to the control group (2.24 ± 0.476 nmol/ml). In contrast, increasing body weight between groups did not show a significant difference.Conclusion: Exposure to PM 2.5 from peat biomass smoke increases oxidative stress in experimental animals.
Transcystic versus transcholedochal laparoscopic common bile duct exploration: Choosing the right approach – A Case Series Singgih Annas Fuadhi; Adeodatus Yuda Handaya; Agus Barmawi; Imam Sofii; Nurcahya Setyawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art15

Abstract

Laparoscopic common bile duct exploration (LCBDE) is a relevant therapeutic option in managing cholecysto-choledocholithiasis. The success of this procedure is highly dependent on selecting an appropriate method, either transcystic or transcoledocal. Intraoperative choledochoscopy proves its importance in evaluating the condition of the choledochal duct and sphincter of Oddi. In this case series, we report 2 cases of patients with complaints of right upper abdominal pain and jaundice. Both patients were diagnosed with multiple cholecysto-choledocholithiasis at Dr. Sardjito Hospital, Yogyakarta. The interventional measures applied to both patients were transcystic and transcoledocal exploration. In the first patient, the transcystic method was chosen because the cystic duct was widening up to 9 mm in diameter. While in the second patient, the transcoledocal method was taken because the diameter of the cystic duct was still within normal limits. The duration of surgery in transcystic surgery was shorter than in transcoledocal surgery, with a time ratio of 129 minutes versus 162 minutes. Postoperatively, both patients were discharged on the second day after the procedure, and both experienced recovery without any significant complications. Overall, LCBDE has been shown to be safe to perform. The one-stage surgical approach has been shown to reduce the risk of complications, cost, and duration of treatment required. The choice between the transcystic or transcoledocal method should be based on each patient’s clinical condition.
Photochemical and bioactivity examination of fractionated saluang belum root extract (Lavanga sarmentosa) on in-vitro human sperm motility Silvani Permatasari; Syarpin; Dwi Ari Pujianto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art3

Abstract

Background: Saluang belum (Lavanga sarmentosa) is one of Kalimantan's typical plants, which is as efficacious as a traditional medicine to increase sexual activity and male fertility. Based on previous studies, the content of flavonoid and steroid in 70% ethanol extract of L. sarmentosa were able to affect sperm quality of mice. Studies related to L. sarmentosa are still limited for phytochemical test and their bioactivity on human spermatozoa motility in vitro.Objective: This study is to perform phytochemical tests of compound content in fractionation with eluents of high and low polarity, namely methanol and chloroform, and then to test their bioactivity on the motility of human spermatozoa in vitro.Methods: L. sarmentosa was extracted with 96% ethanol and fractionated by using a vacuum chromatography column with chloroform and methanol as the eluent. Then obtained samples were analysed by a quantitative phytochemical test. The samples used in-vitro human spermatozoa were divided into eleven groups: control group, group administered with L. sarmentosa extract eluent chloroform of 10, 50, 100, 500, and 1000 ng/mL, and same concentration with extract eluent methanol. Furthermore, the sperm motility was analysed by using a Computer Assisted Sperm Analyser (CASA). Results: The methanol and chloroform fraction of L. sarmentosa root extract contained metabolites, namely terpenoids, flavonoids, steroids, alkaloids, saponins, and tannins. The sperm motility increased significantly at the treatment group of the methanol and chloroform fractions compared to the control group. There was a significant difference between the sperm motility incubated with methanol and that with chloroform fraction at concentration 500 and 1000 ng/mL.Conclusion: The results of sperm motility were higher in the methanol fraction than those in the chloroform fraction.
Quality of the peat water and its association with public health problems in the community of the Danau Tundai area Nawan Nawan; Hopelyanza Priskila; Herlina Eka Shinta; Septi Handayani; Ravenalla Abdurahman
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art7

Abstract

Background: Communities in the Danau Tundai Area, Palangka Raya City, Central Kalimantan Province, Indonesia still use peat water for their daily water needs. The use of peat water is one of the things that need to be considered because disease transmission can occur through water with poor quality and will cause health problems in the Danau Tundai community.Objective: This study aimed to determine the quality of peat water in the Danau Tundai Area and to identify the association between the quality of peat water and public health problems in the Danau Tundai AreaMethods: Water samples taken were analyzed physically, chemically, and biologically by government water quality regulations. The primary data source in this study was a questionnaire to obtain data on peat water use and health problems among the people of Danau TundaiResults: Results indicated that peat water quality of the Danau Tundai Area didn’t meet the Ministry of Health standard for drinking water because the physical appearance was brown, tasted, and smells. The chemical analyses also showed that the levels of KMnO4 were 257.5 mg/L, Fe 0.66 mg/L, pH 4.02, Dissolved Oxygen (DO) 5.9 mg/L, Biological Oxygen Demand (BOD) 18.6 mg/L, and Chemical Oxygen Demand (COD) 156.9 mg/L. Those levels were higher than the cut-off points set by Ministry of Health. The public health problems that mostly experienced was itching (75.3%), stomachache (66.7%), and yellow teeth (61.3%). Simple linear regression showed a positive significant association between quality of peat water (based on individual perception) and public health problems in the Danau Tundai area (p = 0.000).Conclusion: Peat water quality of the Danau Tundai Area didn’t meet the Ministry of Health standard for drinking water, and the quality of peat water had a significant association with health problems Danau Tundai communities.
The role of red-cell distribution width (RDW) and mean platelet volume (MPV) as biomarkers of community-acquired pneumonia (CAP) severity Edy Purwanto; Reza Ishak Estiko; Firdausia Rahma Putri; Linda Rosita; Rahma Yuantari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art11

Abstract

Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality worldwide. Red-cell distribution width (RDW) and mean platelet volume (MPV) are two parameters included in complete blood count (CBC). It is simple, inexpensive, and widely available in any hospital. Many previous studies have shown that RDW and MPV can be used as supporting biomarkers for CAP, but the study in this area remains limited. This study aims to investigate the relationship between RDW and MPV with the severity of CAP and their potential as biomarkers. We conducted a scoping review of original articles using PubMed, Springer Link, Taylor and Francis, EBSCO, Cochrane Library, Google Scholar, Medline, Science Direct, Wiley, and Portal Garuda. Only articles published between 2012 and 2022 in English or Indonesian were included. Out of 11,852 articles reviewed, only 18 met the criteria for the focus on using RDW, MPV, or both as biomarkers for CAP. The details of these studies, including their research design, internal and external validity, and key results, are presented. The results show that increased RDW and MPV levels correlate with higher morbidity and mortality rates among CAP patients. Elevated levels of RDW (>14%) and MPV (>8.1 fL) can predict and acts as a biomarker of CAP severity. Thus, measuring RDW and MPV may give physicians a way to anticipate the outcomes for patients with CAP, helping them make and implement decisions, either alone or in combination with other established methods.

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