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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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Effects of ursodeoxycholic acid and glutathione combination in spleen TNF-α and apoptotic index in rats with cholestasis Danu Darmawan; Endang Sri Lestari; Sigit Adi Prasetyo; Muflihatul Muniroh; Agung Aji Prasetyo
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art6

Abstract

Background: Cholestasis is a disorder of the formation or flow of bile. Among its contributors, tumour necrosis factor (TNF)-α stands out as the most influential inducer of apoptosis. Meanwhile, ursodeoxycholic acid (UDCA) is a valuable agent with choleretic properties, protecting the hepatobiliary system. Glutathione (GSH) enhances endothelial response and prevents liver fibrosisObjectives: This study evaluates the effect of a combination of GSH-UDCA on splenic TNF-α expression and apoptosis index in Sprague Dawley (SD) rats with cholestasisMethods: This experiment with a post-tests-only control group design involving 28 male SD rats. They were randomly into four groups: group (K) with 20 mg UDCA, group 1 (P1) with 10 mg UDCA + 10 mg GSH, group 2 (P2) was given UDCA 20 mg + GSH 15 mg, and group 3 (P3) was given UDCA 30 mg + GSH 20 mg. Cholestasis was obtained by ligation of the common bile duct through a laparotomy. During three weeks of trial, rats were administered daily with UDCA orally and GSH intramuscularly. On day 22, rats were sacrificed and spleen samples were taken for anatomical pathology examination. Results: There were significant differences in TNF-α expression between groups K vs P3; P1 vs P3, and P2 vs P3 (p=0.002). There was a significant difference in the apoptotic index between groups K vs P1 (p<0.001); K vs P2 (p=0.004), and K vs P3 (p=0.005).Conclusions: The UDCA-GSH combination demonstrated a prophylactic effect in SD rats with cholestasis and might be an effective supplemental therapy with UDCA for cholestatic diseases. The difference in TNF-α expression and apoptotic index was lower in SD rats UDCA-glutathione combination group than single dose UDCA. Between TNF-α and the apoptotic index, there is a moderate positive relation.
Diabetic wound and oxidative stress Evy Sulistyoningrum
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art1

Abstract

Immunopathogenesis of dengue virus and Salmonella typhi coinfection Nugraheni, Enny; Sudiro, Tjahjani Mirawati; Nainggolan, Leonard; Fithriyah; Dewi, Beti Ernawati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art12

Abstract

Typhoid, malaria, leptospirosis, dengue virus (DENV), and other arboviruses are endemic in Indonesia. Therefore, it is more likely that DENV and other infectious diseases could be coinfected. More severe symptoms, delayed identification, and ineffective treatment of the illness can all result from Salmonella typhi coinfection. To serve as a principle for clinicians’ considerations while diagnosing and prescribing, we aim to examine the immunopathogenesis of dengue associated with Salmonella typhi coinfection. Dengue virus has the potential to increase both susceptibility and incidence of this coinfection, leading to dengue haemorrhagic fever (DHF) with more severe clinical symptoms. This is explained by regulating impact of coinfection in the presence of gram-negative membrane endotoxin, DENV replication, and lipopolysaccharide (LPS). If Salmonella typhi coinfection is not treated promptly, both dengue and Salmonella typhi can affect several organs and result in significant morbidity and death. Dengue and typhoid immunopathogenesis coinfection are unclear. When dengue monoinfection compared with Salmonella dengue dual infections are related to higher fatality and morbidity rates.
Modified supraauricular approach in recurrent preauricular sinus: A case report Hafiz, Al; Julianda, Wahyu
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art14

Abstract

The preauricular sinus (PAS) also known as the fossa fistula sac or depression is located near the external auricle at the posterior end of the stalk of the ascending helix. Most cases of PAS are asymptomatic and do not require treatment. Surgery is performed if there are signs of infection or recurrence. Incomplete PAS resection is the most common cause of recurrence. The real problem with surgical resection of PAS is the high recurrence rate after sinusectomy. We report the case of a 22-year-old woman who complained of a mass in her left ear that was enlarging for the past 3 months. The patient had previously undergone two operations at the same site but they were recurrent. Physical examination revealed a non-hyperemic painful cystic mass. A few days after the operation the patient recovered and the pain in front of his left ear disappeared. The patient can close his eyes and lift his forehead symmetrically and show no signs of infection. A follow-up examination 1-2 weeks after surgery in the Department of Ear Nose Throat Head and Neck Surgery (ENT-HNS) showed that the general condition of the patient was good and there were no signs of infection. After 6 months the patients ears returned to normal and there was no recurrence 6 months after surgery. There is a scar along the leading edge of the helix. The patient was diagnosed with a recurrent PAS complicated by a preauricular cyst and treated with sinusectomy using a modified supraauricular approach and resection of the preauricular cyst. Sinusectomy with a modified supraauricular approach is an effective technique and is superior to simple sinusectomy due to its low recurrence rate with minimal complications and superior aesthetic appearance. This modified supraauricular approach achieved excellent functional and aesthetic results in this patient.
Intake of F-100 and honey as an effort to improve the nutritional status of children with pediatric tuberculosis Machfudz, Soeroyo; Rachmawaty, Farida Juliantina; Sabila, Aflifia Birruni
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art6

Abstract

Background: Stunting remains a significant nutritional challenge in Indonesia. If malnutrition in children is not addressed appropriately, it can lead to stunting. Children under five years old with pediatric tuberculosis (TB) are particularly susceptible malnutrition. Specific interventions are needed to prevent stunting in this vulnerable group.Objective: The study aimed to improve the nutritional status of children with pediatric TB to prevent stunting. Methods: This study included 44 children under five years old with pediatric TB, who were patients at a private hospital and clinic. The subjects were divided into four groups of 10-12 children based on their arrival for treatment. Group A received standard medicine, F-100, and pure honey; Group B received standard medicine and F-100; Group C received standard medicine and pure honey; and Group D received only standard medicine. The F-100 and pure honey were administered once daily. Each group was followed up for six weeks. Weight and height were measured before and after the intervention. Statistical analysis was performed with a 95% confidence level.Results: Administration of F-100 and/or honey significantly increased Z scores for height-for-age, weight-for-age, and weight-for-length/height between the pre-test and post-intervention (p < 0.05). Conversely, no significant improvement was observed in children receiving only standard medication (p > 0.05). The differences in Z score increases between groups, however, were not statisticallysignificant. Overall, the intervention reduced the prevalence of wasting (36.4% to 22.75%) and stunting (36.4% to 29.5%)Conclusion: Supplementation with F-100 and honey improved nutritional outcomes but did not show statistically significant differences between groups. Further research is recommended to explore the effects of increased frequency and duration of supplementation.
Non-communicable disease risk factors and Covid-19 antibody levels after vaccination Wea, Brigitta Yuliana; Hananta, Linawati; Astiarani, Yunisa
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art3

Abstract

Background: Non-communicable diseases (NCDs) have been identified as predictors of the severity of Coronavirus Disease 2019 (Covid-19). Some factors like smoking, alcohol consumption, and physical inactivity, which are associated with NCDs, may potentially hinder the efficacy of vaccines, reducing their ability to prevent the severity and complications of infectious diseases such as the Covid-19. Objective: This study investigated the NCD, risk factors associated with the levels of quantitative antibodies after the second Covid-19 vaccination.Methods: A cross-sectional study was conducted at a Covid-19 vaccination centre in Jakarta. Ninety subjects, aged ≥18, completed demographic and NCDs risk factor questionnaires. Blood samples were collected and analysed by using the electro chemiluminescence immunoassay analyser (ECLIA) method to measure quantitative antibody levels 30 days after 2nd Covid-19 vaccination. The bivariate analysis was performed to explore associations among the variables. The logistic regression was subsequently performed to identify the factors that remained independent in influencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody status. Results: The mean value of antibody level in this study was 191 U/ml. The results indicated that 35.5% (n=32) of respondents had SARS-CoV-2 antibody levels below average. The regression results suggested that the odds of having higher antibody levels were reduced for individuals with hypertension (Adjusted Odd Ratio [AOR] = 0.74, p value = 0.022), diabetes (AOR = 0.82, p value = 0.038) comorbidities accompanied with smoking (AOR = 0.55, p value = 0.044), drinking alcohol (AOR = 0.92, p value = 0.030), and low physical activity levels (AOR = 0.67, p value = 0.043). Conclusion: The study found that 35.5% of participants had SARS-CoV-2 antibody levels below the average. Factors such as hypertension, diabetes, comorbidities with smoking, alcohol consumption, and low physical activity were associated with reduced odds of higher antibody levels.
Association between material and design used in a ureteral stent with complication in ureteral catheterisation: A systematic review Pakpahan, Karimul Abdi; Birowo, Ponco; Rasyid, Nur; Atmoko, Widi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art13

Abstract

The double-J stent is one of the ureteral catheters with curved ends for fixation. Since its introduction in 1978, catheterisation using a double-J stent has become one of the most frequently performed procedures in urology. However, double-J stents may lead to various complications, causing patient discomfort, pain, and bladder symptoms. Technological advancements in stent design aim to minimise these complications and enhance comfort. This review aimed to determine the association between the material and design used in ureteral stents and complications in ureteral catheterisation. We conducted a systematic review following the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) checklist. Screening based on specific inclusion criteria was employed to select potential studies. A database search yielded a total of 124 studies. Nine full texts were evaluated for eligibility, resulting in the exclusion of one paper. Our findings indicate that ureteral stent insertion significantly increases the frequency of pain and urinary symptoms while decreasing overall health. The choice of materials and design plays a crucial role in minimising pain and improving the quality of life for patients. Physical properties such as firmness and tensile strength also affect the quality of life, with higher firmness and tensile strength causing lower quality of life. Stent material and design choice were context-dependent. Using soft stents and specialised soft distal pigtails has been shown to reduce patient stent-related symptoms. Silicone stents showed the least bladder symptoms than polymeric stents. Polymeric stents also showed no difference in utility from metallic stents for long-term usage.
Correlation between platelet indices and preeclampsia with severe features Fuady, Dzicky Rifqi; Yudatmo, Unggul; Ghazali, Muhammad Farid; Rosdiana, Dian; Arjadi, Fitranto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art6

Abstract

Backgrounds: Pre-eclampsia is a pregnancy-related syndrome with a 2-8% prevalence worldwide. In Indonesia, its incidence was 128,273 (5.3%) cases that caused 30-40% of maternal deaths. In 2021, at Karawang General Public Hospital, there are 43% cases of pre-eclampsia with 3% of complication. The pathophysiology is related to the inflammatory and coagulation system that includes platelets. Thus, platelet indices as indicators for platelet changes could be potential laboratory markers for pre-eclampsia.Objective: To examine the relationship between the platelet indices and pre-eclampsia severe features at the Karawang General Public HospitalMethods: The six months cross-sectional study was conducted at the Karawang General Public Hospital for pre-eclampsia pregnant women with at least 28 weeks of gestational age. The pre-eclampsia criteria were blood pressure higher or equal to 140/90 mmHg and qualitative proteinuria dipstick +1. The subjects were divided into two groups: pre-eclampsia with severe features and without severe features. Severe features criteria were thrombocytopenia, impaired liver function, renal insufficiency, pulmonary edema, new onset headache, and visual disturbances. Pregnant women have their blood platelet indices checked in the form of platelet crit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR). Data were analyzed with descriptive analysis (percentage), cut-off analysis, ROC curve, AUC analysis, bivariate Chi-square analysis, and multivariate logistic regression analysis.Results: There was a significant difference (p < 0.05) in the value of PCT, MPV, PDW, and P-LCR between pregnant pre-eclampsia women with severe features and pregnant pre-eclampsia women without severe features. P-LCR has the best sensitivity (52.9%) and specificity (98.9%).Conclusions: There was a significant change in the value of the platelet indices (PCT, MPV, PDW, P-LCR) in pregnant pre-eclampsia women with severe features at the Karawang General Public Hospital.
Surgical treatment options in chronic subdural hematoma: A literature review Husodo, Kharisma Ridho; Suryonurafif, Akhmad
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art11

Abstract

Chronic subdural hematoma (cSDH) is one of the most common neurosurgery cases in daily practice. Chronic subdural hematoma is clot formation in the subdural space between the dura mater and the arachnoid layer. Due to its progression, clinical presentation of cSDH mostly appears 4 to 8 weeks after a traumatic brain injury. It is the duration needed for the hematoma to grow large enough to cause severe neurological symptoms such as decreased consciousness, hemiparesis, and other signs and symptoms of increased intracranial pressure. There are three main options to treat cSDH. Conservative treatment, surgical treatment, and embolization of the middle meningeal artery (MMA) are widely used to manage this condition. Predominantly, surgical treatments used by neurosurgeons around the world are craniotomy, burr hole (BH) craniostomy, and twist drill (TD) craniostomy. Each of these procedures has advantages and disadvantages. This literature review aimed to consider the characteristics of several treatment options for cSDH and their technique. This review recommends BH craniotomy due to its benefits based on its complication and recurrence rates. Burr Hole craniotomy has a lower complication rate than craniotomy and a lower recurrence rate than TD craniotomy. Twist drill craniotomy is selectively considered for certain patients since this procedure is commonly performed at the bedside without general anesthesia. Craniotomy is recommended as a treatment option for persistent recurrence of cSDH or patients with massive subdural hematoma.
Mosquito control activities associated with dengue hemorrhagic fever in Indonesia: A literature review Puspita, Yashinta Dwi; Sulistiyani, Sulistiyani; Darundiati, Yusniar Hanani; Dewanti, Nikie Astorina Yunita
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art13

Abstract

Dengue Hemorrhagic Fever (DHF) is an endemic disease. It has become a public health concern. Mosquito control activities are needed to control vectors and prevent DHF. Therefore, we conduct a literature review of mosquito control activities associated with DHF in Indonesia. This study applies the selected articles using PRISMA (Preferred reporting items for systematic reviews and meta-analyses), and they are sourced from Science Direct, Google Scholar, Scopus, ProQuest, Ebscohost, and Portal Garuda. The criteria for the selected articles are full-text articles, published in 2015-2020, and those which are published in national journals SINTA 2 or international journals. This study reviewed 683 articles, out of which were selected for further examination. The key variables, such as draining water containers, covering water containers, burying and recycling used containers, using mosquito repellent, using larvacide , keeping larva-eating fish, having mosquito repellent plants, installing wire mesh on ventilation, showed significant correlation with Dengue Hemorrhagic Fever (DHF) incidence. Among the selected articles, 38.89% employed cross-sectional design, and the rest belonged to case-control studies. Most articles have variable draining water containers (55.56%), 50% covers water containers, 80% have a significant association between draining water containers and DHF incidence, and 66.67% have a significant association between covering water containers and DHF incidence. Most articles show that not implementing PSN (Pemberantasan sarang nyamuk) or PSN 3M (Pemberantasan sarang nyamuk, menguras, menutup, mengubur plus) is associated with the incidence of DHF and is a risk factor for the occurrence of DHF. On the other hand, the implementation of PSN or PSN 3M Plus will be a protective factor.

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