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Media Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang
ISSN : 19788495     EISSN : 26551462     DOI : https://doi.org/10.53359/mfi.v17i1
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other
Media Farmasi Indonesia publishes original article in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Chemical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Management Pharmacy, Alternative Medicines.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 197 Documents
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Formulation of Acne Patch from Garcinia mangostana L Peel Extract With a Combination of Chitosan Polymer and HPMC Against Propionibacterium acnes Bacteria Ramadhani, Untia Kartika Sari
Media Farmasi Indonesia Vol. 19 No. 1 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i1.238

Abstract

Garcinia mangostana or Mangosteen has main compounds derived from xanthones, one of them was alpha mangosteen known having antibacterial activity. The purpose of this study was to formulate an acne patch preparation from mangosteen peel extract with a combination of chitosan and HPMC polymer against Propionibacterium acnes bacteria. Acne patches were made by solvent evaporation by using oven at 70 ﹾC. Acne patch preparation was evaluated for physical characteristics, and tested for its antibacterial effectiveness activity. The acne patch formulation was made with the ratio of Chitosan :HPMC: mangosteen peel extract at F1 (800 mg: 400 mg: 120 mg), F2 (900 mg: 300 mg: 120 mg), F3 (800 mg: 400 mg: 240 mg), F4 (900 mg: 300 mg: 240 mg). All formulas have good organoleptic properties, thickness 0,7-0,9 mm, folding resistance>300 times, low vapor transmission rate 0,0030-0,0078 g.cm2/hour, moisture absorption capacity 13-23%, content moisture <10% and uniform active substance ingredient. The patch preparation has antibacterial effectiveness with strong inhibition in the range of 10-20 mm. F1 (800 mg: 400 mg: 120 mg) and F3 (800 mg: 400 mg: 240 mg) have the strongest inhibition with 11,2 and 11,0 mm respectively.
Antibacterial Activity Test of Kersen Fruit Kombucha ( Muntinga Calabura L. ) To Bacteria Staphylococcus Aureus and Escherichia Coli By In Vitro arikha ayu susilowati
Media Farmasi Indonesia Vol. 19 No. 1 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i1.244

Abstract

Bacterial infections of Staphylococcus aureus and Escherichia coli cause diarrhea. Kersen fruit can be used as the basis of kombucha, which has antibacterial benefits. This experimental activity aims to determine the antibacterial activity against Escherichia coli and Staphylococcus aureus. This study used a laboratory experimental method to test the antibacterial activity of Kersen Fruit Kombucha (KFK) at concentrations of 15%, 25%, and 35%, as well as positive control of cotrimoxazole and normal control of aqua pro injection. Antibacterial activity was measured in vitro using the disc diffusion method to compare affected and unaffected areas. The results of the study on Escherichia coli and Staphylococcus aureus bacteria showed that the diameter of the inhibition zone in 15% KFK was 7.07-8.63 mm, 25% KFK showed an inhibition zone diameter of 8.11-9.57 mm; and 35% KFK inhibition zone diameter was 12.07-13.07 mm; for the positive control inhibition zone diameter was 13.07-14.72 mm. 35% KFK has a larger inhibition zone diameter than 15% and 25% KFK. Based on the Kruskal-Wallis statistical test, there was a significant difference. This study aims to determine the antibacterial activity of Kersen fruit kombucha against Staphylococcus aureus and Escherichia coli by measuring the diameter of the inhibition zone
The Relationship Between The Rationality Of Prescribing And The Quality Of Life Of Hypertension Patients At The Central Siantan Health Center In Pontianak Muhammad Akib Yuswar
Media Farmasi Indonesia Vol. 19 No. 1 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i1.251

Abstract

Hypertension is a silent killer disease that can affect the patient's quality of life. There is a need for rational treatment to achieve the success of therapy and the desired quality of life. This study aims to determine the relationship between the rationality of prescribing and the quality of life of hypertensive patients. The study design was an observational cohort. Data were obtained from hypertensive patients at the Puskesmas Siantan Tengah Pontianak who met the inclusion criteria in June-July 2021 using a prospective purposive sampling and collected from medical records, EQ5D5L and VAS questionnaires. The results of the study on 101 samples were obtained; the rationality of prescribing antihypertensive drugs was rational, with the percentage of rationality being the appropriate indication 87,12%; appropriate drug 87.12%; appropriate patient 88.11%; and appropriate dose 88.11%. In addition, 28 patients (27.72%) did not have a problem with the five dimensions with the highest EQ5D5L index of 1,000, while the quality of life, as measured by VAS, had a median value of 60. The results of the Pearson chi-square test showed that there was a relationship between the rationality of prescription and quality of life for hypertensive patients with a significance value ≥ 0.05 using the EQ5D5L (p = 0.688) and VAS (p = 0.583) questionnaires. Conclusion: there is no significant relationship between the rationality of prescribing and the quality of life of hypertensive patients, both using the EQ5D5L and VAS questionnaires.
Benefits of Stevia (Stevia rebaudiana B.) and Sirih (Piper betle L.) Leaves Combination Againts Dental Care karmila, ilah karmila
Media Farmasi Indonesia Vol. 19 No. 1 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i1.256

Abstract

Oral health is the most important part, to improve its hygiene by maintaining teeth. Cavities are a common problem. Betel leaf as an antibacterial. Stevia leaves as bacteriostatic and bactericidal also eliminate the cause of tooth decay and gingivitis. The purpose of the study was to determine the antibacterial activity of toothpaste combined with betel leaf extract with stevia leaves against the growth of Streptococcus mutans bacteria. The study used an experimental method consisting of making betel leaf and stevia leaf extracts using the maceration method. Preparation of toothpaste with a combination of betel leaf extract with stevia leaves at a concentration of 15% with the ratio of betel leaves and stevia leaves, namely formula 1 (5%: 10%), formula 2 (7.5%: 7.5%), formula 3 (10%: 5%). Testing antibacterial activity by measuring the clear zone using the disc paper method with blood agar media. Data analysis using ANOVA and Paired T test. The results of the study obtained formula (5%: 10%) clear zone of 16.42 mm, formula (7.5%: 7.5%) of 17.24mm, formula (10%: 5%) of 17.94mm, positive control of 18.66mm, negative control of 2.75mm. Conclusion 10:5 combination toothpaste has antibacterial activity.
Antioxidant Activity Of Nanoemulsion Of Beet Fruit Extract Using The Dpph Method Nisa, Farhatun
Media Farmasi Indonesia Vol. 19 No. 1 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i1.257

Abstract

Free radicals are one of many forms of reactive oxygen sorts known for having unpaired electrons. The presence of free radicals in the body can cause damage such as premature aging, characterized by the appearance of wrinkles. This damage can be countered with antioxidant compounds. Beetroot is one of the fruits with antioxidant properties due to the presence of betacyanin compounds from the flavonoid group. This research aims to identify the antioxidant activity and IC50 value of beetroot (Beta vulgaris L.) extract nanoemulsion formulations using the DPPH method. Nanoemulsion formulations were prepared with varying concentrations of beetroot extract at 1% (X1), 3% (X2), and 5% (X3) to determine which concentration has the best antioxidant activity. Quality evaluation of the nanoemulsion formulations was also conducted, including organoleptic tests, pH tests, and homogeneity tests. The results showed that the beetroot extract nanoemulsion formulations have antioxidant activity and meet the requirements for physical properties and formulation stability. Nanoemulsion formulations with 5% (X3) beetroot extract content exhibited the best antioxidant activity with an IC50 value of 136.475 ppm.
Utilization of Herbal Medicine for Hemorrhoids Nur Laili Kurniawati Rofiqoh; Norainny Yunitasari
Media Farmasi Indonesia Vol. 19 No. 1 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i1.261

Abstract

Hemorrhoids is a disease characterized by swollen blood vessels in the rectum or anus. This disease is caused by low consumption of fiber, spicy foods and alcoholic drinks. Symptoms that can be experienced by hemorrhoid sufferers are the appearance of lumps and bleeding when defecating. One treatment for this disease is through the use of herbal medicine, namely purple leaves. The aim of this research is to prove whether people now also use purple leaves as a treatment for hemorrhoids. This type of research is non-experimental using survey methods. The instrument used was a questionnaire. The research results show that the majority of hemorrhoid sufferers (80%) use purple leaves to reduce hemorrhoid symptoms. The price of purple leaf medicine is very competitive with conventional hemorrhoid medicine, so that 52% of hemorrhoid sufferers consume purple leaf regularly (although not when experiencing hemorrhoid symptoms).
Overview of Polypharmacy and Drug Interactions in Chronic Kidney Disease Patients at Siloam Hospitals Lippo Village Pramitaningastuti, Anastasia
Media Farmasi Indonesia Vol. 19 No. 1 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i1.271

Abstract

Patients diagnosed with CKD in Indonesia have increased from 2% in 2013 to 3.8% in 2018. Polypharmacy is commonly found in CKD patients, especially in CKD patients with comorbidities. CKD with comorbidities will make the treatment more complex and expensive. This study was conducted to assess the relationship between polypharmacy and drug interactions in CKD patients. Data analysis was carried out descriptively on CKD patients at "X" Hospital in the period October to December 2022 and data were displayed in the form of tables and graphs. The results showed that the majority of patients with chronic kidney disease (CKD) were aged 46-65 years with 42 patients (50.0%). Chronic kidney disease (CKD) patients who get prescriptions for more than 5 drugs are 80 (95.2%) patients. Comorbidities that often occur in chronic kidney disease (CKD) patients are hypertension with 62 (19.62%) patients, diabetes mellitus with 29 (9.18%) patients, and coronary heart disease with 27 (8.54%) patients. From 84 patients, there were 626 potential drug interactions including 152 (24.28%) drug interactions with minor severity, 434 (69.33%) drug interactions with moderate severity, and 40 (6.39%) drug interactions with major severity. CKD patients who have one or more comorbidities will increase the risk of polypharmacy and an increased risk of drug interactions.
Phytochemical Screening And Sun Protection Factor (Spf) Evaluation Of Butterfly Pea Flower (Clitoria Ternatea L.) Extract Lip Tint Product Ramayani, Septiana Laksmi
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.231

Abstract

A lip tint is a cosmetic preparation that colors lips while shielding them from UV light and free radical damage. The butterfly pea blossom is one plant that possesses sunscreen properties and can be used as a natural dye. The purpose of this study is to ascertain how the concentration of butterfly pea flower extract affects the SPF activity of lip tint products containing this extract. This study's design is entirely random, making it an experimental investigation. The in vitro SPF test results using Uv-Vis spectrophotometry show that at a concentration of 5%, 1.618162 SPF falls into the less group; at a concentration of 10%, 4.770857 SPF falls into the medium category; and at a concentration of 15%, 6.1224069 SPF falls into the extra category. The SPF value of lip tint preparations is influenced by the varied concentrations of butterfly pea flower extract, as indicated by the statistical analysis results, which indicate significant variations between the three concentrations (p<0.05).
Formulasi Dan Penetapan Nilai Spf Secara In Vitro Lotion Ekstrak Etanol Daun Buas-Buas (Premna serratifolia L.) Shabrina, Ayu
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.242

Abstract

Ekstrak etanol daun buas-buas memiliki kadar flavonoid tinggi yang dapat berfungsi menangkal radikal bebas dan mampu menyerap sinar UV baik UV A dan UV B sehingga mengurangi intensitasnya pada kulit. Penelitian ini bertujuan untuk memformulasikan dan mengetahui aktivitas tabir surya dari sediaan lotion ekstrak etanol daun buas-buas. Uji aktivitas tabir surya dilakukan dengan metode spektrofotometer UV-Vis dengan panjang gelombang 290-320 nm. Ekstrak etanol daun buas-buas diformulasikan dalam sediaan lotion dengan variasi konsentrasi ekstrak etanol daun buas-buas (F1: 1%, F2: 2%, F3: 3%). Lotion diuji sifat fisik meliputi organoleptik, viskositas, daya sebar, pH, homogenitas, tipe lotion dan kemampuan proteksi. Hasil penelitian menunjukkan bahwa ekstrak etanol daun buas-buas dapat diformulasikan menjadi sediaan lotion, dimana ketiga formula lotion dengan variasi konsentrasi ekstrak etanol daun buas-buas 1%, 2% dan 3% menghasilkan sediaan berwarna hijau kecoklatan, berbau khas oleum citri, semi solid, homogen, emulsi tipe M/A, memenuhi persyaratan pH, viskositas, daya sebar dan memberikan proteksi. Hasil uji aktivitas tabir surya secara berturut-turut yaitu 10,50±0,10; 26,11±0,25; 34,60±0,73, dengan nilai SPF tertinggi yaitu 34,60±0,73 pada konsentrasi 3% yang termasuk kategori proteksi ultra.
Analyzis The Effect Of Antipsychotic Therapy On Levels Of Ast And Alt At Dr. Radjiman Widodiningrat Lawang Mental Hospital Aditya, Martanty
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.248

Abstract

Antipsikotik merupakan terapi lini pertama pada skizofrenia yang dapat memperbaiki gejala psikosis. Penggunaan antipsikotik secara jangka panjang dapat menyebabkan kerusakan hati atau disebut sebagai Drug Induced Liver Injury (DILI). Tujuan dari penelitian ini adalah untuk mengetahui gambaran deskriptif penggunaan antipsikotik, untuk mengetahui pengaruh antipsikotik terhadap DILI serta untuk mengetahui pengaruh karakteristik responden dengan DILI. Rancangan studi dilakukan secara case control dengan pengambilan secara restrospektif mulai Januari hingga Mei 2023 di Rumah Sakit Jiwa Dr. Radjiman Wediodiningrat Lawang. Pada penelitian ini terdapat 56 rekam medis yang memenuhi kriteria inklusi. Data dianalisis secara deskriptif dan analitis dengan uji chi-square. Gambaran deskriptif yang mendapatkan terapi klorpromazin tunggal dan kombinasi terdapat 22 responden, sedangkan terapi risperidon tunggal dan kombinasi terdapat 34 responden. Didapatkan hasil tidak terdapat pengaruh penggunaan antipsikotik dengan kejadian DILI (p-value=0,752). Analisis karakteristik responden dengan kejadian DILI pada jenis kelamin (p-value=0,055), usia (p-value=0,155) dan penggunaan obat lain (p-value=0,078) terhadap peningkatan kadar AST dan/ ALT.

Page 17 of 20 | Total Record : 197

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