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Media Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang
ISSN : 19788495     EISSN : 26551462     DOI : https://doi.org/10.53359/mfi.v17i1
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other
Media Farmasi Indonesia publishes original article in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Chemical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Management Pharmacy, Alternative Medicines.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 197 Documents
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Rasionalitas Penggunaan Antibiotik Empiris pada Pasien Pneumonia di Bangsal Rawat Inap Rumah Sakit Bhakti Wira Tamtama Semarang Savitri, Annisa Aulia; Ni'ma, Neli Syahida; Susatyo, Eko Budi; Nariswara, Febrian; Oktaviani, Sasnia Rahma
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.265

Abstract

Abstrak Pneumonia merupakan salah satu penyakit infeksi saluran pernafasan bawah yang serius karena menjadi penyebab kematian terbesar terutama di negara berkembang. Di Indonesia, pneumonia merupakan salah satu penyebab kematian di rumah sakit dengan persentase prevalensi pada tahun 2013 sebesar 4,5%. Provinsi Jawa Tengah memiliki persentase prevalensi yang lebih tinggi dari nilai nasional yaitu 5,0%. Terapi pneumonia yang disebabkan oleh bakteri adalah antibiotik. Pemilihan antibiotik awal pada pasien yaitu dengan pendekatan secara empiris sebelum didapatkan hasil kultur sensitivitas bakteri. Penelitian ini bertujuan untuk menganalisis rasionalitas penggunaan antibiotik pada pasien pneumonia di Rumah Sakit Bhakti Wirataman dengan luaran klinis. Penelitian ini menggunakan metode penelitian deskriptif analitik dengan rancangan penelitian cross sectional dan pengambilan data secara retrospektif dengan menggunakan rekam medis pasien tahun 2019 ditujukan untuk menganalisis rasionalitas pada penggunaan antibiotik empiris dan untuk mengetahui pengaruh pemilihan antibiotik empiris dengan kesembuhan pasien yang terdiagnosa pneumonia. Hasil penelitian menunjukan rasionalitas penggunaan antibiotik empiris berdasarkan IDSA/ ATS pada pasien pneumonia periode Juni-Desember 2019 menunjukkan ada 95,65% regimen terapi antibiotik yang tidak rasional dan 4,35% regimen terapi antibiotik rasional. Hasil uji analisis statistik menunjukkan hubungan rasionalitas penggunaan terapi antibiotik empiris tidak berkaitan dengan clinical outcome pasien pneumonia di di Rumah Sakit Bhakti Wiratama Semarang. Kata kunci: Antibiotik, Pneumonia, empiris, Drug Related Problem, clinical outcomes. Abstract Pneumonia is a serious lower respiratory tract infection and have been cause of death in developing countries. In Indonesia, pneumonia is one of causes of death in hospitals with a prevalence percentage of 4.5%. Central Java has a prevalence percentage that higher than the nationale average around 5.0%. First line therapy for pneumonia that caused by bacteria is antibiotics. The initial therapy of antibiotics for patients is an empirical approach before bacterial sensitivity culture results. The purpose of this study is to analyze the rationale use of antibiotics in pneumonia patients at Bhakti Wirataman Hospital with clinical outcomes. This research used descriptive analytical research methods with a cross sectional research design and retrospective data collection using patient medical records in 2019 aimed to analyze the rationale use of empirical antibiotics and to determine the effect of choosing empirical antibiotics on the recovery of patients diagnosed with pneumonia. The research results show the rationality of using empiric antibiotics based on IDSA/ATS in pneumonia patients in the period June-December 2019, showing that there were 95.65% irrational antibiotic therapy regimens and 4.35% rational antibiotic therapy regimens. The results of statistical analysis tests show that the rationality of using empirical antibiotic therapy is not related to the clinical outcome of pneumonia patients at the Bhakti Wiratama Hospital, Semarang. Keywords: Antibiotics, Pneumonia, empirical, Drug Related Problems, clinical outcomes. Abstrak Pneumonia merupakan salah satu penyakit infeksi saluran pernafasan bawah yang serius karena menjadi penyebab kematian terbesar terutama di negara berkembang. Di Indonesia, pneumonia merupakan salah satu penyebab kematian di rumah sakit dengan persentase prevalensi pada tahun 2013 sebesar 4,5%. Provinsi Jawa Tengah memiliki persentase prevalensi yang lebih tinggi dari nilai nasional yaitu 5,0%. Terapi pneumonia yang disebabkan oleh bakteri adalah antibiotik. Pemilihan antibiotik awal pada pasien yaitu dengan pendekatan secara empiris sebelum didapatkan hasil kultur sensitivitas bakteri. Penelitian ini bertujuan untuk menganalisis rasionalitas penggunaan antibiotik pada pasien pneumonia di Rumah Sakit Bhakti Wirataman dengan luaran klinis. Penelitian ini menggunakan metode penelitian deskriptif analitik dengan rancangan penelitian cross sectional dan pengambilan data secara retrospektif dengan menggunakan rekam medis pasien tahun 2019 ditujukan untuk menganalisis rasionalitas pada penggunaan antibiotik empiris dan untuk mengetahui pengaruh pemilihan antibiotik empiris dengan kesembuhan pasien yang terdiagnosa pneumonia. Hasil penelitian menunjukan rasionalitas penggunaan antibiotik empiris berdasarkan IDSA/ ATS pada pasien pneumonia periode Juni-Desember 2019 menunjukkan ada 95,65% regimen terapi antibiotik yang tidak rasional dan 4,35% regimen terapi antibiotik rasional. Hasil uji analisis statistik menunjukkan hubungan rasionalitas penggunaan terapi antibiotik empiris tidak berkaitan dengan clinical outcome pasien pneumonia di di Rumah Sakit Bhakti Wiratama Semarang. Kata kunci: Antibiotik, Pneumonia, empiris, Drug Related Problem, clinical outcomes. Abstract Pneumonia is a serious lower respiratory tract infection and have been cause of death in developing countries. In Indonesia, pneumonia is one of causes of death in hospitals with a prevalence percentage of 4.5%. Central Java has a prevalence percentage that higher than the nationale average around 5.0%. First line therapy for pneumonia that caused by bacteria is antibiotics. The initial therapy of antibiotics for patients is an empirical approach before bacterial sensitivity culture results. The purpose of this study is to analyze the rationale use of antibiotics in pneumonia patients at Bhakti Wirataman Hospital with clinical outcomes. This research used descriptive analytical research methods with a cross sectional research design and retrospective data collection using patient medical records in 2019 aimed to analyze the rationale use of empirical antibiotics and to determine the effect of choosing empirical antibiotics on the recovery of patients diagnosed with pneumonia. The research results show the rationality of using empiric antibiotics based on IDSA/ATS in pneumonia patients in the period June-December 2019, showing that there were 95.65% irrational antibiotic therapy regimens and 4.35% rational antibiotic therapy regimens. The results of statistical analysis tests show that the rationality of using empirical antibiotic therapy is not related to the clinical outcome of pneumonia patients at the Bhakti Wiratama Hospital, Semarang. Keywords: Antibiotics, Pneumonia, empirical, Drug Related Problems, clinical outcomes
Effect of Analytical Method on Vitamin C Tablet Levels Stored under Different Temperature Conditions Susanti, Maria Mita
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.272

Abstract

Vitamin C tablets are commonly consumed by the public as antioxidant supplements. Vitamin C is highly susceptible to oxidation, which is accelerated by factors such as heat, light, alkali, enzymes, oxidizers, and the presence of copper and iron catalysts. Oxidation will be inhibited if vitamin C is left in an acidic state or at low temperatures. However, many vitamin C tablets are not stored according to recommended conditions due to inadequate temperature control during storage or distribution, leading to changes in their vitamin C levels. Vitamin C levels can be analyzed using the Iodimetry method and UV-Vis spectrophotometry. This study aims to determine the effect of the analysis method on the content of vitamin C tablets stored at various temperature variations. This is an experimental research. The independent variable of this study is the analytical method of determining vitamin C content and the dependent variable of this research is the content of vitamin tablets stored at low temperature (2-6°C), room temperature (27-30°C), and high temperature (48°C). Quantitative analysis of vitamin C levels was conducted using both iodimetry and UV-Vis spectrophotometry methods. The highest vitamin C content was found in the analysis of levels using the UV-Vis spectrophotometry method. Statistical analysis shows significant differences, indicating that the method of analyzing the levels of vitamin C tablets stored under varying temperature conditions affects the levels of vitamin C tablets.
Effect of Disintegrating Agents on Red Ginger (Zingiber officinale Roxb) Dry Extract Fast Disintegrating Tablets Using Direct Compression Method RAHMAWATI, TIAS EKA
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.278

Abstract

Red ginger (Zingiber officinale Roxb) is one of the medicinal plants that is effective as a medicine for nausea and vomiting. One of the techniques for developing traditional medicinal products is to make fast disintegrating tablets (FDT). This research aims to compare the effect of these various disintegrating materials on the physical properties of FDT. FDT red ginger extract is made using the direct compression method. The tablets obtained were physically evaluated including weight uniformity, hardness, friability, and disintegration time. The statistical results using the one-way ANOVA test show that between tablet formulas there are significant differences in tablet disintegration time with differences in the type of disintegrating agent. The data obtained shows that all formulas meet the physical properties test requirements for tablets. The tablet formula using crospovidone produces tablets with high hardness, low friability, and fast disintegration time
Relationship Between Appropriateness Of Medicine Selection And Therapy Outcome In Outpatients Of Hypertension At Dr. Moewardi Surakarta Hospital Shela Novita Devi; Niken Luthfiyanti; Kharisma Jayak Pratama; Tiara Ajeng L
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.280

Abstract

Hypertension is a degenerative disease characterized by blood pressure that exceeds the standard limit of >140/90 mmHg, which can cause diseases such as heart, eyes, kidneys, brain and blood vessels. Drug selection is one of the factors that is very important because it can help the success of therapy. The purpose of this study was to determine the relationship between the accuracy of drug selection and therapeutic outcomes in outpatient hypertension patients at Dr Moewardi Surakarta Hospital using 100 medical record data with retrospective study and using data analysis techniques in the form of univariate test methods, bivariate tests and chi-square tests . The results showed that patients who received treatment with the suitable indication, right drug, correct dose and proper patient criteria were Ninety-two patients (92%). The relationship between the accuracy of drug selection and therapeutic outcomes in outpatient hypertension patients at RSUD Dr Moewardi Surakarta shows a p-value of 0.030 (p <0.05), so Ho is rejected, meaning that there is a significant relationship in the accuracy of antihypertensive drug selection with therapeutic outcomes in the form of achieving blood pressure targets based on JNC VIII in 2014.
Overview of the Knowledge Level of Pharmaceutical Technical Personnel on the Prevention of Covid-19 in Balikpapan City Fitri Handayani
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.292

Abstract

Coronavirus disease 19 is a disease caused by a new type of coronavirus, COVID-19. This virus has been declared a pandemic and can spread rapidly through direct human contact. COVID-19 has an impact on pharmaceutical services, especially Pharmaceutical Technical Personel (PTP), therefore it is important to describe the level of knowledge of PTP in preventing COVID-19 in Balikpapan City. The purpose of this study is to describe the level of knowledge of pharmacy technical personnel on COVID-19 prevention in Balikpapan City. This research uses quantitative method, this type of research is descriptive (non-experimental) observational with cross sectional approach. The data of this study were obtained from the research subjects, namely pharmacy technicians working in Balikpapan City through questionnaires. Data analysis method is bivariate analysis and univariate analysis to see the frequency of PTP knowledge level in Balikpapan City on COVID-19 prevention. The results showed that there is a relationship between PTP characteristics on place of work, education, and age with knowledge level on COVID-19 prevention. Meanwhile, PTP characteristics on gender and type of job have no relationship with the level of knowledge on COVID-19 prevention in Balikpapan City. The knowledge level of PTP on COVID-19 prevention in Balikpapan City is obtained by 6.50% in good category, 24.80% in fair category, and 68.70% in poor category.
Formulation and Characteristics of Hydrogel Patch Containing Pineapple Peel (Ananas comosus L.) Ethanol Extract Anisah Putri Yuana Sari; Putik Titian Citra Hening; Marshanda Nikita; Ahmad Maulana Al Fatah; Fajrina Rizqi Riyadi; Ihsanti Dwi Rahayu
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.296

Abstract

Abstract Pineapple peel (Ananas comosus L.) contains bioactive compounds such as flavonoids and the enzyme bromelain, which possess antioxidant, anti-inflammatory, antibacterial, and anticancer properties, and the ability to accelerate wound healing. Hydrogel patches, as a formulation for transdermal delivery, are effective in wound healing due to their hydrophilic properties that maintain moisture and prevent bacterial infection in open wounds. This study aims to develop and test the characteristics of hydrogel patch formulations containing ethanol extracts of pineapple peel with varying concentrations of 10%, 20%, and 30%, compared to a control (hydrogel patch without pineapple peel extract). A series of evaluation tests were conducted to assess the patch characteristics, including organoleptic tests, pH, absorbency, weight uniformity, swelling ratio, patch thickness, and folding endurance. The results showed that the concentration of pineapple peel extract affects the hydrogel patch characteristics. The higher the extract concentration, the darker the patch color, but the pH, absorbency, and swelling ratio decrease. Patches with higher extract concentrations also showed an increase in weight. Absorbency tests indicated that none of the formulas met the acceptance criteria (<10%), with absorbency results of 22.97%, 11.60%, and 21.95% for 10%, 20%, and 30% extract concentrations, respectively, and 23.43% for the control. Swelling ratio and thickness tests showed the best results for the control, followed by the 10%, 20%, and 30% extract concentrations. The folding endurance test showed that the control and 10% extract formula had good results (>300 folds), while higher extract concentrations reduced the folding endurance of the hydrogel patch .Keywords: extract, pineapple peel, hydrogel patch, formulation, patch characteristics
Development of Pineapple Skin Extract Hydrogel Patch Applications (Ananas comosus L.) as Wound Dressing in Diabetic Ulcers in Mice (Mus musculus) Putik Titian Citra Hening; Anisah Putri Yuana Sari; Marshanda Nikita; Ahmad Maulana Al Fatah; Fajrina Rizqi Riyadi; Ihsanti Dwi Rahayu
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.297

Abstract

Abstrak Diabetes melitus merupakan penyakit gangguan metabolisme kronis yang disebabkan oleh tingginya kadar glukosa darah. Salah satu komplikasi yang sering terjadi pada penderita diabetes melitus adalah ulkus diabetikum. Penelitian menunjukkan bahwa kulit nanas mengandung flavonoid, yaitu senyawa aktif yang bersifat antiinflamasi dan antimikroba, yang dapat mempercepat penyembuhan luka. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian patch hidrogel yang mengandung ekstrak kulit nanas (Ananas comosus L.) sebagai pembalut luka pada tikus putih (Mus musculus) jantan yang mengalami ulkus diabetikum. Penelitian ini melibatkan beberapa tahap, meliputi ekstraksi kulit nanas, pembuatan patch hidrogel, uji aktivitas antibakteri, dan pemberian patch hidrogel pada hewan uji. Penelitian ini menggunakan 20 ekor tikus putih jantan galur Deutschland Denken Yoken (DDY) yang dibagi menjadi 5 kelompok. Kelompok kontrol negatif mendapat patch hidrogel tanpa ekstrak, sedangkan kelompok kontrol positif mendapat Winner Hydrocolloid Dressing. Kelompok perlakuan I, II, dan III masing-masing diberi patch hidrogel dengan ekstrak kulit nanas 10%, 20%, dan 30%. Hasil penelitian menunjukkan bahwa plester hidrogel dengan ekstrak kulit nanas mempercepat penyembuhan luka pada model ulkus diabetik. Uji aktivitas antibakteri menunjukkan aktivitas antimikroba yang signifikan terhadap Staphylococcus aureus, yang umum ditemukan pada ulkus diabetik. Aplikasi plester hidrogel mengurangi peradangan dan memperbaiki struktur jaringan kulit pada hewan uji, menunjukkan potensi plester hidrogel ekstrak kulit nanas sebagai pembalut luka alternatif yang efektif untuk ulkus diabetik. Kata kunci: ulkus diabetikum, ekstrak kulit nanas, patch hidrogel, pembalut luka
The Effectiveness Test of Tembelekan (Lantana camara L.) Leaf Extract Gel for Cuts Healing in Male White Mice Khonsa
Media Farmasi Indonesia Vol. 20 No. 1 (2025): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v20i1.288

Abstract

The study of natural products as an alternative medicine to speed up the cuts healing process has become a popular topic of scientific research. One of the plants is Tembelekan (Lantana camara L.) leaves. Its formulation into a gel form can increase drug release. This study aims to determine the effectiveness of Tembelekan leaf extract gel preparations for healing cut wounds in male white mice. The method used in this research was an experimental method on 5 groups with 5 mice in each group. The positive control group was given Bioplacenton®, the negative control group was given gel base, and the treatment group was given 10%, 15%, and 20% Tembelekan leaf extract gel. The gel was applied to the wound twice a day and the observation used Linkert scale. Based on the results of the Kruskal Wallis test, an Asymp.Sig value of 0,030 < 0,050 was obtained, indicating that Tembelekan leaf extract gel was effective in healing cuts. Tembelekan leaf extract gel with varying concentrations of 10%, 15% and 20% has an effect of healing cuts in male white mice. The fastest healing of cuts occurred within 9 days with Tembelekan leaf extract gel with a concentration of 20%. Keywords: Tembelekan, cuts, wound healing, gel, effectiveness test
Optimization Of Sodium Croscarmellose And Sodium Starch Glycolate In Orally Disintegrating Tablets (Odt) Acetosal Endang Diyah Ikasari
Media Farmasi Indonesia Vol. 20 No. 1 (2025): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v20i1.289

Abstract

Acetosal is a drug that is included in the NSAID class which has anticoagulant properties. Acetosal has low bioavailability due to first-pass effect metabolism, so it is formulated in ODT form to increase the bioavailability of acetosal. This research aims to determine the effect of croscarmellose sodium and sodium starch glycolate concentrations as superdisintegrants on the physical characteristics of acetosal ODT and to determine the concentrations of croscarmellose sodium and sodium starch glycolate as superdisintegrants that produce acetosal ODT with optimum physical characteristics. The ratio formula for CCS and SSG obtained from design expert 10.0.1 using the simplex lattice design method, namely FI (0:6); FII (3:3); FIII (6:0); FIV (4.5:1.5); FV (6:0); FVI (0:6); FVII (3:3); FVIII (1.5:4.5). Based on the research results, the optimum ODT formula for acetosal was obtained with a concentration of CCS 1.232% and SSG glycolate of 4.768%. The optimum formula test results obtained a flow rate of 19.706 grams/second, MC 2.574%, compressibility 24.00%, hardness 3.70 kg, friability 0.668%, disintegration time 40.574 seconds, wetting time 46.002 seconds, and dissolution 95.142%. Based on the t-test between theoretical and experimental results, the results show that the results are not significantly different so they are said to be valid.
Antibacterial Activity Of Hydrogel Plasters Of Red Betel Leaves Extract (Piper Ornatum) And Porang Flour As Gelling Agent Against Staphylococcus Aureus Husnun Hanifah
Media Farmasi Indonesia Vol. 20 No. 1 (2025): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v20i1.293

Abstract

Wounds require treatment to prevent infection by covering, one of which is by using a plaster. Hydrogel plaster has flexible, transparent, and soft properties that are non-irritating, providing a soothing and cooling effect. Red betel leaves have germicidal, antioxidant, fungicidal, and antifungal properties and play a role in the wound healing process. The aim of this study was to determine the flavonoid content of red betel extract, physical quality and antibacterial activity of red betel extract hydrogel plaster and porang flour against Staphylococcus aureus bacteria. The type of research used was quantitative research with descriptive design. The method used was spectrophotometry to determine flavonoid levels and the pitting diffusion method for antibacterial activity. Red betel leaves extract has flavonoid content of 14.846 ± 0.17 mg QE/g. Three formulas of hydrogel plaster were made, namely F0, F1 and positive control. The physical quality of the hydrogel plaster includes organoleptic tests on 3 formulas which are in the form of solid preparations, soft and elastic, transparent and dark brown in color, distinctive odor of red betel leaves, pH 4.5-7, thickness 0.630-0.673 mm not more than 1 mm, f olding resistance >200 times, and drying shrinkage of 1.002-1.006% meeting the requirements <9.29%. The antibacterial activity test shows that the hydrogel plaster has antibacterial activity against Staphylococcus aureus bacteria at F0 of 0.00 mm with a very weak inhibition zone category and F1 of 19.47 mm strong category, positive control of 21.43 mm very strong and on red betel extract of 20.5 mm strong category.

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