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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 5 Documents
 1 
Search results for , issue "Vol. 11, No. 3" : 5 Documents clear
Anthocyanin-Rich Extract from Purple Sweet Potatoes Modified Body Weight, Visceral Fat and Circulatory IL-10 in Stressed-Mice Kurnianingsih, Nia; Rahma, Oktivani Adelathifa; Prayogo, Nabila Putri; Rayhanna, Qanitha Ailsya; Fahanani, Agwin Fahmi; Suprapto, Ratih Paramita; Prakosa, Ardani Galih; Ratnawati, Retty
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

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Abstract

Stress-induced inflammation and oxidative stress mechanisms thus plant bioactive compounds as anti-inflammation and antioxidants are placed as novel strategies to resist the adverse effects of stress. Purple sweet potatoes (PSP) as a rich source of macronutrients and anthocyanin showed health benefits as neuroprotective and metabolic diseases. However, limited research explored the effect of PSP extract on stressed animal models. This study aimed to evaluate the bioactive compound analysis of PSP and the effect on body weight gain (BW), visceral fat (VF), and interleukin-10 (IL-10) of stressed model mice. Adult male BALB/c mice (6-8 weeks) were divided into control (CTRL), and stress (STR), stress+anthocyanin-rich extract (ANC) of PSP dose 10, 20, and 40 mg/kgBW. Stress was exposed as restraint stress for 2 hours/day for 14 days. The ANC was administered once a day orally. The IL-10 was measured by enzyme-linked immunosorbent assay (ELISA). Qualitative plant compound analysis showed the presence of flavonoids, alkaloids, phenolics, glycosides, and tannins in PSP extract. The PSP extract also contains a high level of total anthocyanin, 2468.9 ± 159.38 mg/l, and high antioxidant activity. This study observed tendencies to decrease BW and VF following ANC dose of 10 mg/kgBW treatment. The administration of ANC significantly increased the level of circulatory IL-10 cytokine. In conclusion, an anthocyanin-rich extract of PSP modified BW, VF, and IL-10 levels of restraint-stressed model mice.
Investigating the Bioactivity Potential and Standardization of Two Stingless Bee Propolis from East Kalimantan Kustiawan, Paula Mariana; Syahbana, Muhammad Ali; Pratika, Rika; Ichsan, Muhammad Nor; Mentari, Ika Ayu; Hairunnisa, Indah; Setiawan, Irfan Muris; Syaifie, Putri Hawa; Ramadhan, Donny; Chanchao, Chanpen
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

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Abstract

The standardization of raw materials from nature is essential before they are made into products. Until now, there is still limited information regarding the standardization of propolis from stingless bees. This research aims to determine the bioactivity with standardized specific and non-specific parameters of ethanol extracts from Homotrigona apicalis and Homotrigona fimbriata propolis. The methods include organoleptic tests, tests for water-soluble and ethanol-soluble compound content, drying shrinkage tests, specific gravity tests, water content tests, metal contamination tests, phytochemical screening, and determining total phenolic and flavonoid content. The free radical scavenging capacity was measured using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, and antimicrobial activity against Candida albicans, Propionibacterium acnes, Streptococcus mutans, Salmonella typhi, and Escherichia coli was assessed using the agar well diffusion method. The results indicated that the standardization parameters tested on H. apicalis and H. fimbriata propolis met the standard criteria. Both species contain alkaloids, flavonoids, phenolics, tannins, and saponins. Generally, the propolis extracts from these two stingless bees exhibit potential antioxidant and antimicrobial effects. The total phenolic content for H. apicalis was 0.963 ± 0.041 mg GAE/g, while for H. fimbriata, it was 0.345 ± 0.004 mg GAE/g. The total flavonoid content for H. apicalis was 12.066 ± 0.465 mg QE/g, and for H. fimbriata, it was 9.325 ± 0.031 mg QE/g. All these results can be used as a reference for developing products derived from stingless bees.
Optimization of External Disintegrating Materials in Wet Granulation Formulation of Ondansetron Tablets Permana, Yandi; Tuba, Syahrul; Riyadi, Taufik; Sugindro, Sugindro
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

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Abstract

Inadequate management of chemotherapy-induced side effects, including nausea and vomiting, can impact the healing response of cancer patients. Ondansetron, a preferred medication for the treatment, is classified as a biopharmaceutic classification system (BCS) class II drug, which limits its bioavailability. To enhance its solubility, sodium starch glycolate (SSG) and pregelatinized starch (PG) are used as super disintegrants. This study investigates the impact of these super disintegrants on ondansetron dissolution and identifies the optimal formulation. Ondansetron tablets were prepared using the wet granulation method, with nine formulations varying in SSG and PG concentrations (0%, 1%, 3%, 5%, and 7%). The tablets underwent physical and chemical quality evaluations. The results indicate that ondansetron dissolution improved with SSG and PG at concentrations of 1% and 3% but decreased at higher concentrations (5% and 7%). Statistical analysis revealed significant differences in dissolution fraction parameters and efficiency across varying SSG and PG concentrations (p < 0.05). The optimal formulation for enhancing ondansetron dissolution was found to be with 3% PG, achieving a dissolution efficiency value of 79.88% + 0.11%.
Roselle and Red Ginger: A Potential Combination of Medicinal Plants for Hypertension Therapy Yunas, Ranum Wanudya; Rahmawati, Siti Irma; Saputri, Fadlina Chany; Bayu, Asep; Chianese, Giuseppina; Putra, Masteria Yunovilsa
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

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Abstract

Hypertension is a prevalent cardiovascular condition that significantly increases the risk of heart disease and stroke. Effective management is essential to prevent severe complications. Roselle (Hibiscus sabdariffa L.) and red ginger (Zingiber officinale var. rubrum) are two medicinal plants known for their antihypertensive properties. Roselle contains bioactive compounds such as anthocyanins that exhibit vasodilatory and angiotensin-converting enzyme (ACE) inhibition, while red ginger is rich in gingerols and shogaols, which possess anti-inflammatory and vasodilatory properties. The complementary mechanisms of action of these two plants, including ACE inhibition, antioxidant activity, and modulation of vascular tone, result in a more pronounced antihypertensive effect when used together. By targeting multiple pathways, the combination allows for more effective blood pressure control, which could lead to improved patient outcomes. The purpose of this study is to provide a detailed review of the evidence supporting the use of roselle and red ginger in combination as a potential therapeutic approach for hypertension. This review aims to identify gaps in the existing research and suggest directions for future studies. Understanding the synergistic effects of these plants can help in developing more effective herbal therapies that leverage their combined benefits. Further research is needed to confirm these findings through more in-depth preclinical and clinical studies. Investigations should focus on optimizing dosages, understanding long-term safety, and establishing standardized protocols for combination therapy. This review serves as a foundation for future research and encourages the integration of traditional herbal medicine into modern hypertensive management strategies, promoting a holistic approach to cardiovascular health.
Utilizing Water Hyacinth (Eichhornia crassipes) from Srandakan Bantul, Indonesia for ‘Bright Fever Patch’ as an Alternative Children’s Fever Therapy Niswara, Anggita Kamalia; Kusrinanti, Nabillah Ainun; Firdaus, Rizqi Amalia; Ikhsanudin, Azis
Pharmaceutical Sciences and Research Vol. 11, No. 3
Publisher : UI Scholars Hub

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Abstract

In 2022, Indonesia experienced a public health crisis involving acute kidney failure in children, traced to paracetamol syrup contaminated with ethylene glycol and diethylene glycol. This underscores the urgent need for safer antipyretic alternatives. This study investigates the antipyretic potential of transdermal patches formulated with ethanol extract of water hyacinth (Eichhornia crassipes) leaves sourced from Srandakan, Bantul, Yogyakarta. Extract concentrations of 0.8%, 1.0%, and 1.2% were tested, alongside a negative control (no extract) and a positive control (paracetamol). The patches underwent evaluations for organoleptic properties, weight uniformity (0.41±0.02 to 0.52±0.02 g), thickness (0.36±0.03 to 0.41±0.03 mm), water absorption (5.95%±0.04 to 17.45%±0.04), folding endurance (all >300 times), and pH (4.05±0.03 to 4.20±0.04). Antipyretic activity was assessed in vivo using Wistar rats. The 1.2% extract patch (F3) showed a temperature reduction of 57.45±14.31% at 180 minutes, while paracetamol achieved 74.07±11.38%. Although paracetamol showed greater efficacy, the extract patch acted faster. Both paracetamol and extract patch were statistically significant compared to placebo (p<0.001). Although paracetamol exhibited a stronger antipyretic effect than the extract patch, this difference was not statistically significant (p=0.847). These findings support the further development of the water hyacinth extract patch as a promising antipyretic alternative, with potential improvements through the enhancement of the formulation and the development of a slow-release system.

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