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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
Arjuna Subject : -
Articles 355 Documents
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Analisis Asam Valproat dalam Plasma Secara Kromatografi Gas Susanti, Ani; Harahap, Yahdiana; Harmita, Harmita
Majalah Ilmu Kefarmasian Vol. 7, No. 3
Publisher : UI Scholars Hub

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Abstract

Valproic acid is an anticonvulsant drug that works by increasing the levels of γ-aminobutyric acid (GABA). Determination of valproic acid is quite difficult because it has no chromophore groups in its structure. Aa analytical method using gas chromatography (GC) with flame ionization detector for the determination of valproic acid in human plasma has been developed and optimized. Valproic acid was extracted from plasma by liquid-liquid extraction method using diethyl ether. The optimum analysis conditions for valproic acid in plasma were achieved by regulated gas chromatography injector and detector at a temperature of 250oC and temperature programming with an initial temperature of 70oC and 5oC temperature increasing per minute until a temperature of 100oC, then held for 1 minute. Then the temperature was increased by 2°C per minute until the column temperature to 150oC. The optimum conditions of analysis took 32 minutes. In the concentration range from 40.0 to 100.0 µg/mL yielded a linear calibration curve with correlation coefficient (r) of 0.9894. Accuracy (% diff) of this method was -13.67% to 12.33% with precision (CV) between 9.33% to 14.92%, and relative recovery test was 86.33% to 112.33%.
Analisis Kandungan Ion Flourida pada Sampel Air Tanah dan Air PAM Secara Spektrofotometri Astriningrum, Yodifta; Suryadi, Herman; Azizahwati, Azizahwati
Majalah Ilmu Kefarmasian Vol. 7, No. 3
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Abstract

Fluoride ion is one of the compounds that are known to have benefits in the prevention of dental caries when used in certain concentrations, but also hasnegative effects that may cause the occurrence of dental and bone fluorosis when the intake was in excessive concentration. One of the fluoride intakes comes fromwater that is consumed. The aim of this research was to identify and measurefluoride ion levels in groundwater and piped water that used as drinking water consumption in the community. Measurement of fluoride ion concentration isdone by using visible spectrophotometry at the maximum wavelength of 586 nmusing the sodium 2-parasulfophenylazo 1,8-dihydroxy-naphthalene-3,6disulfonate (SPADNS)-zirconil acid reagent. This method was optimized by thesearch of range of absorption which stable for 10 minutes after reagent addition.The limit of detection, limit of quantitation, and coefficient of variation forfluoride ion were 0.0452 mg/L, 0.1506 mg/L, and 0,63%, respectively. While therecovery of fluoride ion in sample were in the range of 90,50-102,04%. The measurement results of the samples showed levels of fluoride ions in groundwaterand piped water varied between 0.05 to 0.78 mg/L. This range was still within allowed levels according the rules of Indonesian health ministers No.492/MENKES/PER/IV/2010 where the maximum allowable fluoride concentration is 1.5 mg/L.
Pengaruh Kombinasi Hidroksipropil Metilselulosa-Xanthan Gum sebagai Matriks Pada Profil Pelepasan Tablet Teofilin Lepas Terkendali Iskandarsyah, Iskandarsyah; Sutriyo, Sutriyo; Hayati, Dian
Majalah Ilmu Kefarmasian Vol. 7, No. 3
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Abstract

Theophylline is a bronchodilator used for the treatment of bronchial asthma and other respiratory diseases. Theophylline has a narrow therapeutic index (10-20 µg/ml) and relatively short elimination half-life (6,19 ± 0,031 hours). Causes rapid elimination rate of theophylline should be given periodically to maintain drug levels in blood for the desired therapeutic effect can be achieved. The preparation of theophylline controlled release is expected to produce blood concentrations of theophylline in a more stable. The physical properties of tablets and drug release from matrix systems are influenced by the nature of the composition of the matrix. This research, theophylline controlled release tablets were made by combination of xanthan gum and HPMC as matrix composition. Combination of HPMC and xanthan gum was supposed to produce tablets with the required pysical properties and ability to extend the releasing period of theophylline from matrix system. HPMC-xanthan gum compositions used in formulation were 1:4, 1:1, and 4:1. Based on the evaluation of the physical properties carried out on the tablet, it was found out that the three formulas fit the requirements for ideal tablet. The increasing of xanthan gum concentration in the formula was proportional with the improvement of mass flowability and tablet hardness. Evaluation of the releasing profile of theophylline from matrix system had been conducted in vitro by dissolution test. Based on the test, it was found out that all combinations have variation in releasing profile. The increasing of HPMC concentration in formula will extend the releasing time of theophylline. The difference in releasing profile of Retaphyl SR® with formula 1, 2, and 3 because of differences in raw materials that form the matrix.
Pembuatan Matriks dari Kompleks Polielektrolit Kitosan Pektin untuk Sediaan Tablet Mengapung Sagita, Erny; Anwar, Effionora; Surini, Silvia
Majalah Ilmu Kefarmasian Vol. 7, No. 3
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Abstract

Chitosan is a natural cationic polymer. That cationic property makes chitosan can form polyelectrolite complex (PEC) with anionic polymer. In this research, pectin was used as anionic polymer that interact ionically with chitosan. The aim of this research is to produce and characterize chitosan-pectin PEC that would be used as matrix in floating tablet. The solutions of chitosan and pectin 0,3% w/v were mixed in ratio 1:9, 3:7, 1:1, 7:3 and 9:1 with pH of the solution 4,5 and 5,0. The best condition to produce PEC was in pH 5,0 with ratio of chitosan and pectin = 3:7. The differences between chitosan-pectin PEC characteristic and its origin polymer were shown by functional group analysis, thermal analysis, swelling capacity and gel strength. The PEC was then used as matrix in floating tablet.
Aktivitas Antiplasmodium in vivo fraksi N-butanol kulit batang Mahoni (Swietenia mahagoni) dan Asam Klorogenat Lukmayani, Yani; Supriyatna, Supriyatna; P. S, Glorida; Muis, Abdul
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Abstract

An antiplasmodial activity of n-butanol fraction from mahoni bark extract (Swietenia mahagoni Jacq.) and pure compound chlorogenic acid were investigated on white male miceSwiss derivated strain which were infected by Plasmodium berghei ANKA strain. Samplewere administrated i.p ., which n-butanol fraction with convertion dose 100, 200 and 400 mg/kgBW and chlorogenic acid with dose 0,01; 0,1; 1 and 10 mg/kg BW respectively for a period of 4days, consecutively started one day after parasit inoculation.Parasit persentage was counted daily (H0 to H4).The best aniplasmodial activity was shown by n-butanol fraction with convertion dose 200mg/kg BW (fraction dose 81,89 mg/ kg BW )with inhibition persentage 45.05% and chlorogenic acidwith dose 10 mg/kg BW with inhibition persentage 55,51%.
Faktor Penentu Permeasi Transdermal:Tinjauan Berdasarkan Hukum Fick I Binarjo, Annas
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Abstract

Transdermal drug delivery may be an alternative to overcome the problems of oral administration, such as fluctuations drugconcentration in the blood. Only several drugs have a good transdermal permeation ability, thus some efforts are needed to improve it. Transdermal permeation follows pasive diffusion mechanism. Therefore, Fick Law I must be concidered in improving transdermal permeation of the drug. This review aims to determine the factors associated with the transdermal permeation based on Fick's law I. Chemical compounds to enhance transdermal permeation (Chemical penetration enhancers) can be used to increase the diffusion coefficient (D), the partition coefficient (k), the rate of drug in the donor compartment (Cd), membrane thickness (h), and extensive contact of drug with the skin (S).
Studi Disolusi Terbanding Tablet Komparator dan Generik Glibenklamida 5 MG Menggunakan Parameter Difference Factor (f2) dan Similarity Factor (f1) Sutriyo, Sutriyo; Aeni, Siti Nur; Sundarsih, Sundarsih
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Abstract

Dissolution testing is an essential requirement for the development, establishment of in Vitro dissolution and in Vivo performance (I VIV R), registration and quality control Of solid oral dosage forms. The objective of the present study was to compare dissolution profile of glibenclamide 5 mg tablet between generic and inovator product from commercial market, using independent model. Samples of glibenclamide 5 mg tablets was used on the batch number are the Same design for each other product. The dissolution test were perfoming using USP 23 apparatus 2, in pH 7,40 buffer phosphate, employing 900 ml of dissolution medium at a temperature of 37 ±0,5 ˚C and an agitation rate of 75 rpm with spesification performed at 15, 30, 45, 60 and 120 minutes. Comparison between dissolution profiles was achieved using a difference factor (f1) and simmilarity factor (f2) methods in inovator product and generic \ product. The results showed that dissolution profiles of product B (generic) has similar with product A (inovator) where difference factor (f1) value is 5,53% and simmilarity factor (f2) is 99,29 %
Uji Aktivitas Penghambatan Enzim Alfaglukosidase Pada Beberapa Tanaman Suku Euphorbiaceae Elya, Berna; Katrin, Katrin; Bangun, Anastasia
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Abstract

Diabetes mellitus (types 1 and 2) is recognized as a serious global health problem that characterized by hyperglycemia. Type 2 diabetes is more common in diabetic populations. In type 2 diabetes mellitus, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals. Avoiding the adverse effects of current agents, it is still necessary to search alternative for better options. Plants have been a rich source of α-glucosidase inhibitors. In this research, screenings based on chemotaxonomic approach to determine the class of chemical constituents and to know α-glucosidase inhibiting activity of some plants from Euphorbiaceae. The simplisia powder was extracted using ethanol 80% by reflux. Measurement of inhibitory activity of α-glucosidase performed using a spectrophotometer UV-VIS. In vitro assays of α-glucosidase activity showed 14 extracts had IC50 values of between 2.34 µg/mL and 64.78 µg/mL, which were lower than that of acarbose (117.20 µg/mL). Leaves extract from Antidesma celebicum had the highest α-glucosidase inhibiting activity with an IC50 of 2.34 µg/mL. The results of phytochemical screening in 15 extracts generally contain glycosides, terpenoids/ sterols, tannins, saponins and alkaloids.
Uji Stabilitas Fisik Losio Yang Mengandung Fraksi Diklorometana Ekstrak Metanol Kulit Buah Manggis (Garcinia mangostana L.) Apriyanti, Elis; Jufri, Mahdi; Elya, Berna
Majalah Ilmu Kefarmasian Vol. 9, No. 3
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Abstract

Mangosteen pericarp (Garcinia mangostana L.) contains some of xanthones derivates which have antioxidant activity.Those compounds prevent formation of free radicals that cause premature aging. Dichloromethane fraction from methanol extract of mangosteen pericarp has very strong antioxidant activity. Dicholomethane fraction of mangosteen pericarp was formulated into lotion dosage form with different concentration 0.01; 0.05; and 0.25%.. Physical stability of lotion was evaluated by cycling test, centrifugal test, and stored the lotions at low temperature (4±2˚C), room temperature (27±2˚C), dan high temperature (40±2˚C). The result showed that the lotions stable at each strorage condition and cycling test. However, the result of centrifugal test showed separation phase of lotions.
Pemberian Vaksin Melalui Tanaman Transgenik Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 1, No. 1
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Abstract

Vaccines have played an important role in preventive medicine since Edward Jenner discovered that cowpox induced protection against human smallpox. Until recently, a vaccination has meant a needle in the arm. However, with the increasing need for inexpensive, easily administered vaccines, along with the improvements in genetic engineering, the concept of edible vaccines is fast becoming reality. This is especially important in developing countries, where it is estimated that three to five million children die each year from common diseases, which could have easily been prevented with the proper vaccination. Compared to traditional lab-synthesized vaccines, plants are capable of producing proteins at lower cost, and need not be isolated for injection. Plant-based vaccines are also safer than traditional vaccines because they use selected sub-units of the disease rather the attenuated whole disease-causing organism.

Page 10 of 36 | Total Record : 355

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